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Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment

Acta Pharmaceutica Sinica B 2023年第12期13卷 5107-5120页

作者： Yan Zhang Haiyun Zhang Faquan Zhao Zhengping Jiang Yuanlu Cui Meitong Ou Lin Mei Qiangsong Wang Tianjin Key Laboratory of Biomedical Materials Institute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China State Key Laboratory of Component-based Chinese Medicine Research Center of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China

Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke.The development of new approaches to simultaneously diminish oxidative stress and resist mitochondrial dysfunction is urgently needed.Inspired by the overproduced reactive oxygen species(ROS)at ischemic neuron mitochondria,multifunctional nanoparticles with ROS-responsiveness and mitochondrial-targeted(SPNPs)were engineered,achieving specific targeting delivery and controllable drug release at ischemic penumbra.Due to the nose-to-brain pathway.SPNPs which were encapsulated in a thermo-sensitive gel by intranasal administration were directly delivered to the ischemic penumbra bypassing the blood-brain barrier(BBB)and enhancing delivery efficiency.The potential of SPNPs for ischemic stroke treatment was systematically evaluated in vitro and in rat models of middle cerebral artery occlusion(MCAO).Results demonstrated the mitochondrialtargeted and protective effects of SPNPs on H2O2-induced oxidative damage in SH-SY5Y cells.In vivo distribution analyzed by fuorescence imaging proved the rapid and enhanced active targeting of SPNPs to the ischemic area in MCAO rats.SPNPs by intranasal administration exhibited superior therapeutic efficacy by alleviating oxidative stress,diminishing infammation,repairing mitochondrial function,and decreasing apoptosis.This strategy provided a multifunctional delivery system for the effective treatment of ischemic injury,which also implies a potential application prospect for other central nervous diseases.

关键词： Ischemic stroke Inflammation Mitochondrial targeted Multifunctional nanocarriers Nose-to-brain pathway Oxidative stress Puerarin ROs-Responsiveness

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High temperature H_(2)S selective oxidation on a copper-substituted hexaaluminate catalyst: A facile process for treating low concentration acid gas

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Chinese Chemical Letters 2022年第3期33卷 1279-1282页

作者： Xin Xu Ganggang Li Fenglian Zhang Guoxia jiang zhengping Hao Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China National Engineering Laboratory for VOCs Pollution Control Material&Technology Research Center for Environmental Material and Pollution Control TechnologyUniversity of Chinese Academy of SciencesBeijing 101408China

H_(2)S selective catalytic oxidation technology is a prospective way for the treatment of low concentration acid gas with simple process operation and low investment. However, undesirable results such as large formation of SO_(2) and catalyst deactivation inevitably occur, due to the temperature rise of fixed reaction bed caused by the exothermic reaction. Catalyst with high activity in wide operating temperature window, especially in high temperature range, is urgently needed. In this paper, a series of copper-substituted hexaaluminate catalysts (LaCu_(x), x = 0, 0.5, 1, 1.5, 2, 2.5) were prepared and investigated for the H_(2)S selective oxidation reaction at high temperature conditions (300-550℃). The LaCu_(1) catalyst exhibited excellent catalytic performance and great stability, which was attributed to the best reductive properties and proper pore structure. Besides, two facile deep processing paths were proposed to eliminate the remaining H_(2)S and SO_(2) in the tail gas.

关键词： Low concentration acid gas H_(2)S selective oxidation High temperature Hexaaluminate catalyst

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Inflammation-induced CD69^+ Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1

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Science China(Life Sciences) 2016年第12期59卷 1259-1269页

作者： Xiang Zhang Zhengping Jiang Yan Gu Yanfang Liu Xuetao Cao Yanmei Han National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University National Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical Sciences

Kupffer cells,tissue-resident macrophage lineage cell,are enriched in vertebrate liver.The mouse F4/80^+ Kupffer cells have been subclassified into two subpopulations according to their phenotype and function:CD68^+ subpopulation with potent reactive oxygen species(ROS) production and phagocytic capacities,and CD11b^+ subpopulation with a potent capacity to produce T helper 1 cytokines.In addition,CD11b^+ Kupffer cells/macrophages may be migrated from the bone marrow or spleen,especially in inflammatory conditions of the liver.For analyzing diverse Kupffer cell subsets,we infected mice with Listeria monocytogenes and analyzed the phenotype variations of hepatic Kupffer cells.During L.monocytogenes infection,hepatic CD69^+ Kupffer cells were significantly induced and expanded,and CD69^+ Kupffer cells expressed higher level of CD11 b,and particularly high level of membrane-bound TGF-β1(mTGF-β1) but lower level of F4/80.We also found that clodronate liposome administration did not eliminate hepatic CD69^+ Kupffer cell subset.We consider the hepatic CD69^+ Kupffer cell population corresponds to CD11b^+Kupffer cells,the bone marrow-derived population.Hepatic CD69^+ Kupffer cells suppressed Ag-nonspecific and OVA-specific CD4 T cell proliferation through mTGF-β1 both in vitro and in vivo,meanwhile,they did not interfere with activation of CD4 T cells.Thus,we have identified a new subset of inflammation-induced CD69^+ Kupffer cells which can feedback inhibit CD4 T cell response via cell surface TGF-β1 at the late stage of immune response against infection.CD69^+ Kupffer cells may contribute to protect host from pathological injure by preventing overactivation of immune response.

关键词： Kupffer 房间有免疫力的规定 CD69 TGF-1 Listeria monocytogenes

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Sulfur resource recovery based on electrolytic manganese residue calcination and manganese oxide ore desulfurization for the clean production of electrolytic manganese

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Chinese Journal of Chemical Engineering 2020年第3期28卷 864-870页

作者： Dong Sun Lin Yang Ning Liu Wenju jiang Xia jiang Jianjun Li Zhengyou Yang zhengping Song College of Architecture and Environment Sichuan UniversityChengdu 610065China National Engineering Research Center for Flue Gas Desulfurization Sichuan UniversityChengdu 610065China Ningxia Tianyuan Manganese Industry Group Co.Ltd Zhongwei 755103China

An environmentally friendly and resource-conserving route to the clean production of electrolytic manganese was developed,in which the electrolytic manganese residue(EMR)was initially calcined for cement buffering;then the generated SO2-containing flue gas was managed using manganese oxide ore and anolyte(MOOA)desulfurization;at last,the desulfurized slurry was introduced to the electrolytic manganese production(EMP).Results showed that 4.0 wt%coke addition reduced the sulfur of calcined EMR to 0.9%,thereby satisfying the cement-buffer requirement.Pilot-scale desulfurization showed that about 7.5 vol%of high SO2 containing flue gas can be cleaned to less than 0.1 vol%through a five-stage countercurrent MOOA desulfurization.The desulfurized slurry had 42.44 g·L-Mn2+and 1.92 g·L-1 S2 O62-,which was suitable for electrowinning after purification,and the purity of manganese product was 99.93%,satisfy the National Standard of China YB/T051-2015.This new integrated technology fulfilled 99.7%of sulfur reutilization from the EMR and 94.1%was effectively used to the EMP.The MOOA desulfurization linked the EMP a closed cycle without any pollutant discharge,which promoted the cleaner production of EMP industry.

关键词： Electrolytic manganese residue Manganese oxide ore desulfurization Sulfur recycling Cleaner production

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An anonymous and efficient remote biometrics user authentication scheme in a multi server environment

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Frontiers of Computer Science 2015年第1期9卷 142-156页

作者： Peng jiang Qiaoyan WEN Wenmin LI zhengping JIN Hua ZHANG State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China

As service demands rise and expand single-server user authentication has become unable to satisfy actual application demand. At the same time identity and password based authentication schemes are no longer adequate because of the insecurity of user identity and password. As a result biometric user authentication has emerged as a more reliable and attractive method. However, existing biometric authentication schemes are vulnerable to some common attacks and provide no security proof, some of these biometric schemes are also either inefficient or lack sufficient concern for privacy. In this paper, we propose an anonymous and efficient remote biometric user authentication scheme for a multi-server architecture with provable security. Through theoretical mathematic deduction, simulation implementation, and comparison with related work, we demonstrate that our approach can remove the aforementioned weaknesses and is well suited for a multi- server environment.

关键词： biometrics remote authentication multi-server architecture smart card

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nduced pluripotent stem cell （iPSCs） and their application n immunotherapy

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Cellular & Molecular Immunology 2014年第1期11卷 17-24页

作者： Zhengping Jiang Yanmei Han Xuetao Cao National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University Shanghai China

The ever-improving technology to generate induced pluripotent stem cells （iPSCs） has increased their potential use as novel candidates for disease modeling, drug screening, regenerative medicine and cell therapy. Indeed, iPSCs offer extensive capacity for self-renewal without the ethical concerns faced by embryonic stem cells （ESCs）. With respect to potential applications in the immune system, many studies provide evidence to support that there are exclusive advantages to using iPSCs over other systems. Both hematopoietic stem cells and several types of mature immune cells have successfully been reprogrammed to iPSCs and vice versa, paving a path toward our ability to effectively model patient-specific diseases and provide potentially alternative cell sources for transfusion medicine. Despite these potential advances, some limitations regarding the use of iPSCs in the clinic still remain, including the immunogenicity of iPSCs and their derivatives, which is currently under debate in the field. In this review, we mainly focus on discussing the recent progress being made in the latest differentiation methods and clinical implications of iPSCs with respect to the immune system. Additionally, current issues regarding the clinical application of iPSCs are addressed, especially the controversy surrounding immunogenicity, along with various other perspectives.

关键词： differentiation hematopoietic cell immunogenicity immunotherapy induced pluripotent stem cells

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Characteristic investigation of trilayered Cu/Al8011/Al1060 composite:Interface morphology, microstructure, and in-situ tensile deformation

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Progress in Natural Science:Materials International 2021年第5期31卷 679-687页

作者： Mahmoud Ebrahimi Guoping Liu Chuanwei Li Qudong Wang Haiyan jiang Wenjiang Ding Fengling Su zhengping Shang National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong University Institute of Materials Modification and Modeling School of Materials Science and Engineering Shanghai Jiao Tong University Sichuan Winner Special Electronic Materials Co. Ltd. jiangsu Zhongse Composite Materials Co. Ltd.

In this work, Cu/Al8011/Al1060 trilayered composite with an ultrathin copper layer was fabricated successfully by the hybrid process of cast-rolling and hot-roll-bonding. The effects of heat treatment were investigated on the microstructure and mechanical behavior of the composite. The results showed that annealing temperatures above 300°C led to the formation of new intermetallic compounds that joined their initial counterparts. Also, the interface growth was fast above 340°C. It was found that the annealing temperature of 320°C led to the optimal tensile properties of the composite. Through rolling, hard-brittle IMCs imposed intense plastic strains on the surrounding regions, resulting in further grain refinement of both metals in the vicinity of the interface. Although the kernel average misorientation of the trilayered composite was almost identical with the Cu/Al8011 bimetal,its amount was considerably decreased after heat treatment, as the distorted structure changed into a nearly strain-free one using the restoration phenomenon. The SEM-based in-situ tensile test showed that crack initiation occurred within the IMCs and propagated into the Cu strip, leading to its early fracture. However, the strengthdisplacement curve during in-situ tensile deformation did not decrease significantly due to the ultrathin copper layer.

关键词： Heat-treatment Intermetallic compounds Mechanical properties Kernel average misorientation Microstructure analysis Crack initiation

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澳大利亚教师职业伦理规范建设及启示

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比较教育学报 2023年第1期 133-147页

作者：姜来王正平华南农业大学珠江学院广州510900 上海师范大学跨学科研究中心上海200234

在过去的三十多年中,澳大利亚为促进教育现代化进程,相继发表了多个全国性教育发展宣言和指导文件,确定了以正直、尊重、责任、公正和尊严为主要内容的教师职业伦理规范的核心价值理念。澳大利亚教师职业伦理规范建设着眼于教师职业专... 详细信息

在过去的三十多年中,澳大利亚为促进教育现代化进程,相继发表了多个全国性教育发展宣言和指导文件,确定了以正直、尊重、责任、公正和尊严为主要内容的教师职业伦理规范的核心价值理念。澳大利亚教师职业伦理规范建设着眼于教师职业专业化的发展目标,以核心价值理念为指导,从教师与学生、教师与家长、教师与教师集体等人际关系入手,提出教师职业伦理道德的基本规范和具体要求,其基本经验能够为我国新时代教师职业伦理规范的建设和完善提供有益启示。

关键词：澳大利亚教师职业伦理道德教师职业伦理规范核心价值理念师德建设

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蒸压养护碱激发矿渣混凝土中钢筋早期锈蚀状况

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建筑材料学报 2018年第2期21卷 222-227页

作者：姜正平明维苏州科技大学土木工程学院江苏苏州215011 广东宏基管桩有限公司广东中山528427

对比了采用不同拌和用水(自来水、海水)及不同种类的砂(河砂、淡化海砂、海砂)拌和的碱激发矿渣混凝土(AASC)和普通水泥混凝土(OPCC)在模拟海水浸泡过程中的强度变化,同时通过电化学法加速钢筋锈蚀,研究了AASC中钢筋早期锈蚀状况.结果表... 详细信息

对比了采用不同拌和用水(自来水、海水)及不同种类的砂(河砂、淡化海砂、海砂)拌和的碱激发矿渣混凝土(AASC)和普通水泥混凝土(OPCC)在模拟海水浸泡过程中的强度变化,同时通过电化学法加速钢筋锈蚀,研究了AASC中钢筋早期锈蚀状况.结果表明:在Cl-侵蚀过程中,经蒸压养护的AASC表现出比OPCC更高的强度和更优异的耐腐蚀性能;在42d测试龄期时,OPCC中钢筋锈蚀情况明显比AASC严重,钢筋失重率约为5.0%~9.0%,而AASC的钢筋失重率仅为0.2%~1.5%;同时还借助扫描电镜SEM测试方法分析探索了蒸压养护下AASC性能提高的机理.

关键词：碱激发矿渣混凝土蒸压养护钢筋锈蚀海水海砂

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Human hepatocellular carcinoma-infiltrating CD4+CD69+Foxp3-regulatory T cell suppresses T cell response via membrane-bound TGF-β1

Human hepatocellular carcinoma-infiltrating CD4+CD69+Foxp3-r...

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第十四届全国肿瘤生物治疗大会

作者： Yanmei Han Yan Gu Zhengping Jiang Yanfang Liu National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University

Tumors can recruit, induce and expand regulatory T cells(Tregs) to suppress anti-tumor immune responses for survival and progression. The complicated tumor-related Treg subsets and their functional mechanisms are not fully addressed yet. We have previously identified a novel CD4+CD69+CD25-Foxp3- Treg subset in tumor-bearing mice, which suppresses CD4 T cell response via membrane-bound TGF-β1(mT GF-β1) and then promotes tumor progression. In hepatocellular carcinoma patients, here we identified tumor-infiltrating human CD4+CD69+ Tregs which represent 7.2% of tumor-infiltrating CD4 T cells, significantly higher than conventional CD4+CD25+Foxp3+ Tregs. They expressed mT GF-β1, PD-1 and CTLA-4, but not CD25 or Foxp3, only produced a little IL-10 and TGF-β1. More importantly, they significantly suppressed CD4 T cell response via mT GF-β1 in vitro. Furthermore, the percentage of these CD4+CD69+ Tregs in tumor tissue was significantly correlated with tumor progression, with more pronounced at late stage of cancer patients. Thus we have identified a tumor-induced new population of human CD4+CD69+ Tregs in cancer patients, with phenotype of CD25-Foxp3-mT GF-β1+CTLA-4+PD-1+, and these Tregs can suppress anti-tumor immune response via mT GF-β1. Our results not only enrich the family of Treg subsets, providing new mechanistic insight to tumor-induced immune suppression in human, but also suggest a potential target for cancer immunotherapy.

关键词： regulatory T cells CD69 transforming growth factor-β1 tumor immune escape hepatocellular carcinoma

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