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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUAliZATION FRAMEWORK OF KNOWLEDGE GRAPH

Frontiers of Agricultural Science and Engineering 2023年第2期10卷 306-332页

作者： Xing li Chunyan GUO Yumei YAN lijuan LV Siqi li Wenxin GUO zhengnan li Minhui li College of Pharmacy Baotou Medical CollegeBaotou 014040China Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Hohhot 010110China Inner Mongolia Academy of Chinese and Mongolian Medicine Hohhot 010010China College of Pharmacy Qiqihar Medical UniversityQiqihar 161000China Department of Basic Science Tianjin Agricultural UniversityTianjin 300384China Agricultural College Inner Mongolia Agricultural UniversityHohhot 010110China

To help in the prevention of large-scale loss of agricultural production caused by crop pests,a visual analysis was performed on the main research areas,key countries,organizational cooperation,citation sources and current trends in pest research by searching the literature of Web of Science database and using CiteSpace 5.8.R3 and VOSviewer 1.6.18 software.Additionally,the effects and mechanisms of natural products with anti-insect activity were summarized through visual analysis.According to the bibliometric analysis,keywords such as mortality(232 occurrences),natural enemy(232 occurrences)and spinosad(110 occurrences)were common,and insecticides and natural enemies of pests were the main methods for killing pests.However,pesticide use exhibits numerous limitations.Co-occurring terms in visualization analysis mainly included residue(193 occurrences),detection(153 occurrences),degradation(133 occurrences),recovery(103 occurrences),pyrethroid(97 occurrences)and pesticide residues(65 occurrences).Thus,pesticides cannot fundamentally solve food security;pesticides also pollute the environment and endanger human health.Therefore,green and efficient pesticides that can replace synthetic pesticides are urgently needed.Natural products have recently gained attention in Brazil,China,the USA and other countries because they are green and pollution-free,and new natural pesticides have been developed.This visual analysis combined data mining with literature review and summarize the anti-pest activities and mechanisms of action of natural products.This information provides a foundation and ideas for researchers to study the application and development of natural products in pest control.

关键词： anti-pest activity crop protection insect pest natural product visual analysis

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Mussel-inspired Methacrylic Gelatin-dopamine/Ag Nanoparticles/Graphene Oxide Hydrogels with Improved Adhesive and Antibacterial Properties for Applications as Wound Dressings

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 512-521页

作者：宿正楠 HU Yanru MENG lihui OUYANG Zhiyuan li Wenchao ZHU Fang XIE Bin 吴庆知 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Material and Engineering Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China

A novel strategy was developed to prepare the methacrylic gelatin-dopamine(GelMA-DA)/Ag nanoparticles(NPs)/graphene oxide(GO) composite hydrogels with good biocompatibility,mechanical properties,and antibacterial activity.Mussel-inspired DA was utilized to modify the GelMA molecules,which imparts good adhesive performance to the hydrogels.GO,interfacial enhancer,not only improves mechanical properties of the hydrogels,but also provides anchor sites for loading Ag NPs through numerous oxygencontaining functional groups on the surface.The experimental results show that the GelMA/Ag NPs/GO hydrogels have good biocompatibility,and exhibit a swelling rate of 202±16%,the lap shear strength of 147±17 kPa,and compressive modulus of 136±53 kPa,in the case of the Ag NPs/GO content of 2 mg/mL.Antibacterial activity of the hydrogels against both gram-negative and gram-positive bacteria is dependent on the Ag NPs/GO content derived from the release of Ag^(+).Furthermore,the GelMA/Ag NPs/GO hydrogels possess good adhesive ability,which is resistant to highly twisted state when stuck on the surface of pigskin.These results demonstrate promising potential of the GelMA-DA/Ag NPs/GO hydrogels as wound dressings for biomedical applications in clinical and emergent treatment.

关键词： GelMA dopamine,graphene oxide adhesion antibacterial ability

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甲状腺结节的危险因素

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中华内科杂志 2024年第6期63卷 535-539页

作者：赵薇李欣宇高政南大连理工大学附属中心医院内分泌代谢科大连116033

甲状腺结节是临床常见的甲状腺疾病,其中甲状腺癌占8%~16%。甲状腺结节及甲状腺癌的发病率呈明显升高趋势,公认的危险因素有年龄、性别、遗传、电离辐射等。还存在一些有争议、新发现的影响因素,如碘营养、代谢因素、生活方式、环境污... 详细信息

甲状腺结节是临床常见的甲状腺疾病,其中甲状腺癌占8%~16%。甲状腺结节及甲状腺癌的发病率呈明显升高趋势,公认的危险因素有年龄、性别、遗传、电离辐射等。还存在一些有争议、新发现的影响因素,如碘营养、代谢因素、生活方式、环境污染等。对其危险因素进行系统梳理,有助于全面认识疾病,以及制定有效精准的筛查防治策略。

关键词：甲状腺结节甲状腺癌危险因素

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu lixin Shi Qing Su Xuefeng Yu li Yan Guijun Qin Xulei Tang Gang Chen Min Xu Tiange Wang Zhiyun Zhao zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo li Chen Qiang li Zhen Ye Yinfei Zhang Chao liu Youmin Wang Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with CKD.We included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life behavior.Using isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD prevalence.Leisure-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working population.In stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long sleepers.More pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active way.The U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical activity.The divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy

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Science China life Sciences 2024年第8期 1549-1562页

作者： Peidong Zhang Peiwei li Muya Tang Ryan C.Gimple liang Huang Jing Yue Qiuhong Shen Yiwei Du Qian Zhang zhengnan Yang Haihuai He Kailin Yang linjie Zhao Shengtao Zhou Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOEState Key Laboratory of BiotherapyWest China Second HospitalSichuan University and Collaborative Innovation Center Physician Scientist Training Program Department of MedicineWashington University School of Medicine Department of Neurosurgery State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation Center Department of Radiation Oncology Taussig Cancer CenterCleveland Clinic

Mechanics shape cell and tissue plasticity and maintain their homeostasis.In cancers,mechanical signals regulate cancer hallmarks via mechanotransduction pathways,such as proliferation,metastasis and metabolic reprogramming.However,comprehensive characterization of mechanotransduction pathway genes and their clinical relevance across different cancer types remains untouched.Herein,we systematically portrayed the alterations of mechanotransduction pathway genes across 31 cancer types using The Cancer Genome Atlas(TCGA)databases.All the cancer types could be categorized into 6 subtypes based upon the transcriptional pattern of mechanics pathway genes.Each subtype has its own unique molecular expression pattern,mutation landscapes,immune infiltrates,and patient clinical outcome.We further found that the responses of two subtypes of cancers,one with the optimal outcome and the other with the worst prognosis,to a classical mechanotherapeutic agent(Fasudil,Rho A/ROCK inhibitor) were totally different,indicating that our cancer stratification system based upon mechanotransduction pathway genes could inform clinical responses of patients to mechanotherapeutic agents.Collectively,our study provides a novel pan-cancer landscape of the mechanotransduction pathways and underscores its potential clinical significance in the prediction of clinical prognosis and therapeutic responses to mechanotherapy among cancer patients.

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基于PCHD模型的MMC-APF无源控制策略

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电测与仪表 2024年第2期61卷 173-178页

作者：李征南唐忠史晨豪陈寒上海电力大学电气工程学院上海200090

由于无源滤波器只能消除特定次谐波,传统有源电力滤波器耐压水平较低,使其只能应用在低压配电网,同时由于电平数较少导致补偿精度受限。文中选择基于(Modular Multilevel Converter,MMC)的有源电力滤波器为研究对象,同时利用MMC-APF的... 详细信息

由于无源滤波器只能消除特定次谐波,传统有源电力滤波器耐压水平较低,使其只能应用在低压配电网,同时由于电平数较少导致补偿精度受限。文中选择基于(Modular Multilevel Converter,MMC)的有源电力滤波器为研究对象,同时利用MMC-APF的无源性提出一种基于端口受控耗散哈密顿(Port-controlled Hamiltonian with Dissipation,PCHD)模型的非线性无源控制策略(Passivity-Based Control,PBC)。通过MMC-APF系统的数学模型推导出基于PCHD的无源模型;利用互联法和阻尼分配法设计了相应的无源控制器;通过子摸块电容、环流控制、无源控制得到系统调制信号。仿真结果表明,设计的基于PCHD模型的PBC策略能够将系统控制在较低的谐波标准下,相较于传统PI控制策略具有更好的谐波补偿性能和更快的响应速度。

关键词：模块化多电平变流器有源电力滤波器 PCHD模型无源控制

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Algebraic-Differential Attacks on a Family of Arithmetization-Oriented Symmetric Ciphers

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Journal of Systems Science & Complexity 2023年第6期36卷 2681-2702页

作者： li zhengnan WU Baofeng liN Dongdai Institute of Information Engineering Chinese Academy of SciencesBeijing100085China State Key Laboratory of Cryptology Beijing100878China School of Cyber Security University of Chinese Academy of SciencesBeijing100049China

Motivated by applications in advanced cryptographic protocols,research on arithmetizationoriented symmetric primitives has been rising in the field of symmetric cryptography in recent years.In this paper,the authors focus on on the collision attacks for a family of arithmetization-oriented symmetric ciphers GMiMCHash.The authors firstly enhance the algebraically controlled differential attacks proposed by introducing more variables.Then,combining algebraic attacks and differential attacks,the authors propose algebraic-differential attacks on GMi MCHash.This attack method is shown to be effective by experiments on toy versions of GMi MCHash.The authors further introduce some tricks to reduce the complexities of algebraic-differential attacks and improve the success probability of finding collisions.

关键词： Algebraic attacks collisions differential attacks GMiMCHash Grobner basis

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广义信贷与货币政策传导——兼论宏观审慎评估体系

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征信 2024年第2期42卷 79-92页

作者：范云朋刘正南刘赟德李林桦中国社会科学院金融研究所北京100710 北京大学数学科学学院北京100871 中国社会科学院大学应用经济学院北京102488 澳大利亚国立大学商学院堪培拉ACT2601

中国人民银行推出的宏观审慎评估体系将广义信贷作为重要的审慎监管指标。广义信贷更加客观地反映了中国金融体系的变化,丰富和拓宽了货币政策传导,在宏观审慎、微观监管和金融稳定中发挥着越来越重要的作用。因此,基于融资结构和融资... 详细信息

中国人民银行推出的宏观审慎评估体系将广义信贷作为重要的审慎监管指标。广义信贷更加客观地反映了中国金融体系的变化,丰富和拓宽了货币政策传导,在宏观审慎、微观监管和金融稳定中发挥着越来越重要的作用。因此,基于融资结构和融资溢价的理论模型对中国货币政策的广义信贷传导机制进行了实证检验,验证了广义信贷渠道传导存在的两个必要条件。我国货币政策广义信贷渠道传导的存在,在一定程度上说明了货币政策和宏观审慎政策协调的必要性和可行性,为二者之间的协调发展提供了一定的研究基础。

关键词：广义信贷货币政策传导融资结构融资溢价宏观审慎评估体系

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一批微生物超标面膜中日勾维多细菌源菌的分离鉴定及毒力与耐药性分析

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微生物学通报 2024年第5期51卷 1600-1613页

作者：王银环李珏郑小玲王征南余佳珍浙江省食品药品检验研究院浙江杭州310052 药品微生物检测与预警重点实验室浙江杭州310052 浙江省药品接触材料质量控制研究重点实验室浙江杭州310052

【背景】近年来,由不可接受微生物污染引发的化妆品召回案件层出不穷,现有法规《化妆品安全技术规范》(2015年版)中微生物检测指标不完善,难以满足化妆品产品质量控制和评价的需要。【目的】对2022年化妆品国家级监督抽检中一批微生物... 详细信息

【背景】近年来,由不可接受微生物污染引发的化妆品召回案件层出不穷,现有法规《化妆品安全技术规范》(2015年版)中微生物检测指标不完善,难以满足化妆品产品质量控制和评价的需要。【目的】对2022年化妆品国家级监督抽检中一批微生物超标面膜中污染菌进行分离鉴定,并探讨采用多种手段进行鉴定的准确性,判断是否为不可接受微生物,同时,针对污染菌进一步开展安全性评价。【方法】参照《化妆品安全技术规范》(2015年版)对微生物超标面膜中污染菌进行分离纯化后,分别采用VITEK 2 Compact全自动生化鉴定系统、基质辅助激光解吸电离飞行时间质谱(matrix assisted laser desorption ionization-time of flight mass spectrometry,MALDI-TOF MS)和16S rRNA基因测序技术对污染菌进行鉴定,并进一步开展毒力基因、耐药基因安全性评价分析。【结果】3种技术均可鉴定出面膜中污染菌为不可接受微生物——日勾维多细菌源菌。高通量测序发现该菌携带52种毒力基因,预测含其他毒力相关基因429种,提示该菌具有极大的安全隐患。同时检测到该菌携带24种耐药基因,可能对青霉素、头孢菌素、万古霉素、四环素和氨基糖苷类等24种(类)抗生素耐药,检测到多重耐药基因10种,耐药机理多与产生外排泵有关。提示该菌存在一定的多重耐药安全风险。【结论】本研究从一批微生物超标面膜中分离到日勾维多细菌源菌,为不可接受微生物。该菌具有极大的产毒能力,且具有一定的多重耐药安全隐患,应考虑经风险评估后将该菌纳入微生物检测指标。

关键词：不可接受微生物微生物超标面膜日勾维多细菌源菌分离鉴定毒力基因耐药基因

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制药用水系统中主要微生物类型及控制措施

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中国现代应用药学 2024年第3期41卷 415-419页

作者：李樱红张林爽李珏郑小玲王征南王银环陈君豪洪亮陶巧凤陈欢浙江省食品药品检验研究院 NMPA微生物检测与预警重点实验室浙江省药品接触材料质量控制研究重点实验室杭州310052 台州市药品检验研究院浙江台州318000 杭州微数生物科技有限公司杭州311231

目的对制药用水中主要微生物类型及控制措施进行分析,为制药用水系统的有效控制提供指导。方法分析饮用水、纯化水、注射用水中主要微生物种类、丰度及其危害性,并探讨制药用水中微生物的控制措施。结果制药用水中主要微生物类型存在差... 详细信息

目的对制药用水中主要微生物类型及控制措施进行分析,为制药用水系统的有效控制提供指导。方法分析饮用水、纯化水、注射用水中主要微生物种类、丰度及其危害性,并探讨制药用水中微生物的控制措施。结果制药用水中主要微生物类型存在差异,洋葱伯克霍尔德菌复合体和皮氏罗尔斯顿菌是潜在的条件致病菌,可造成生物安全隐患。结论制药企业可通过建立各级水系统微生物数据库及常见微生物菌种库,应基于警戒限和行动限进行趋势分析,从而加强对水系统中微生物的控制。

关键词：制药用水微生物洋葱伯克霍尔德菌复合体皮氏罗尔斯顿菌控制措施

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