检索结果-南通市图书馆

Chinese Chemical Letters 2024年第8期35卷 471-474页

作者： Xiangqian Cao Chenkai Yang Xiaodong zhu Mengxin Zhao Yilin Yan zhengnan Huang Jinming Cai Jingming zhuang Shengzhou Li Wei Li Bing Shen Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Nanomedicine&Shanghai Key Lab of Cell Engineering Naval Medical UniversityShanghai 200433China

Bladder cancer is a common malignant tumor of the urinary system with the potential to be treated by nano drug delivery *** current work describes the synthesis and characterization of a novel nanomaterial to construct a nano-carrier based on 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphatecholine(POPC)loaded doxorubicin(DOX)and embedded with gold nanoparticles and poly(N-isopropyl acry-lamide)(PNIPAM)(GNPS@PNIPAM-POPC-DOX,GPPD).The dual-sensitive nanosystem gives simultaneous photothermal treatment and chemotherapy for bladder *** vitro and in vivo properties were as-sessed using bladder cancer cell lines and mice and GPPD system distribution,tumor inhibition,and biocompatibility are *** system had favorable stability,low biological toxicity,controlled re-lease efficiency,photothermal synergistic action,efficient photothermal transition,and favorable tumor suppressive *** a result,GPPD is a potential therapeutic approach for bladder cancer.

关键词： Doxorubicin Gold nanoparticles Thermosensitive polymer Photothermal therapy Bladder cancer

Mussel-inspired Methacrylic Gelatin-dopamine/Ag Nanoparticles/Graphene Oxide Hydrogels with Improved Adhesive and Antibacterial Properties for Applications as Wound Dressings

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 512-521页

作者：宿正楠 HU Yanru MENG Lihui OUYANG Zhiyuan LI Wenchao zhu Fang XIE Bin 吴庆知 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Material and Engineering Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China

A novel strategy was developed to prepare the methacrylic gelatin-dopamine(GelMA-DA)/Ag nanoparticles(NPs)/graphene oxide(GO) composite hydrogels with good biocompatibility,mechanical properties,and antibacterial ***-inspired DA was utilized to modify the GelMA molecules,which imparts good adhesive performance to the ***,interfacial enhancer,not only improves mechanical properties of the hydrogels,but also provides anchor sites for loading Ag NPs through numerous oxygencontaining functional groups on the *** experimental results show that the GelMA/Ag NPs/GO hydrogels have good biocompatibility,and exhibit a swelling rate of 202±16%,the lap shear strength of 147±17 kPa,and compressive modulus of 136±53 kPa,in the case of the Ag NPs/GO content of 2 mg/*** activity of the hydrogels against both gram-negative and gram-positive bacteria is dependent on the Ag NPs/GO content derived from the release of Ag^(+).Furthermore,the GelMA/Ag NPs/GO hydrogels possess good adhesive ability,which is resistant to highly twisted state when stuck on the surface of *** results demonstrate promising potential of the GelMA-DA/Ag NPs/GO hydrogels as wound dressings for biomedical applications in clinical and emergent treatment.

关键词： GelMA dopamine,graphene oxide adhesion antibacterial ability

在线全文

学校读者我要写书评

暂无评论

陕西省高等教育“十一五”发展规模预测

辽宁教育研究 2007年第6期 9-12页

作者：徐智德朱征南西安外事学院陕西西安710077 陕西省教育厅陕西西安710003

陕西高等教育学龄人口在2000—2020年间的变化为单峰曲线,2008年为高峰,人口为403.35万人。预测2010年高等教育在校生为120万人,毛入学率约30%。"十一五"期间规模扩大新增配套办学条件需经费73亿元,其中民办高校需16亿元。高等学校专任... 详细信息

陕西高等教育学龄人口在2000—2020年间的变化为单峰曲线,2008年为高峰,人口为403.35万人。预测2010年高等教育在校生为120万人,毛入学率约30%。"十一五"期间规模扩大新增配套办学条件需经费73亿元,其中民办高校需16亿元。高等学校专任教师在总量上可满足发展的需要,但在结构上需要调整,在质量方面需要提高。

关键词：陕西高等教育 “十一五” 预测

在线全文

学校读者我要写书评

暂无评论

用不等接收功率法计算CATV的光路

电视技术 1999年第5期23卷 46-48页

作者：朱铮南王大庆乌鲁木齐富迪电子设备厂 830000

提出ＣＡＴＶ中ＨＦＣ光纤的不等接收功率法，并给出其计算方法。

关键词：等接收功率法不等接收功率法光功率 CATV

Optimization of extraction and purification method of GSTCT1 fragment of CaV1.2 channel

在线全文

学校读者我要写书评

暂无评论

Optimization of extraction and purification method of GSTCT1...

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Kang Ze Li Songlin zhuo Caili Yu Jiahui zhu Xudong Li Mo Sun Shengnan zhu zhengnan Feng Rui Hao Liying China Medical University

L-type Ca channel（LTCC） is a kind of voltage-dependent Ca channel,expressing in excitable cells,such as skeletal muscles,heart and ***1.2（α subunit of LTCC） mainly distributed in the cardiomyocytes,regulates the intracellular calcium signaling *** we know,the C-terminal of Cav1.2 could interact with various intracellular *** aim of the study was to improve the

关键词： Optimization of extraction and purification method of GSTCT1 fragment of CaV1.2 channel

The High Open Possibility of LTCC in Myocardial Hypertrophy Rats

在线全文

cnki会议

学校读者我要写书评

暂无评论

The High Open Possibility of LTCC in Myocardial Hypertrophy ...

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Li zhuo Li Songlin zhu zhengnan Zhao Meimi zhuo Caili Yu Jiahui zhu Xudong Sun Shengnan Li Mo Hao Liying China Medical University

Myocardial hypertrophy is a kind of compensatory myocardial *** studies found that patients with myocardial hypertrophy mainly accompanied with over expression of Ca/Calmodulindependent protein kinases Ⅱ.Cardiomyocytes in hypertrophy rats usually accompany with increasing Cainflux.L-type Ca channel（LTCC） was the main pathway for Ca to enter the ***

关键词： The High Open Possibility of LTCC in Myocardial Hypertrophy Rats

在线全文

cnki会议

学校读者我要写书评

暂无评论

面向团购的组合双边拍卖机制

南京理工大学学报 2018年第6期42卷 700-706页

作者：孙茂圣朱正楠朱俊武王建东南京航空航天大学计算机科学与技术学院江苏南京211106 扬州大学信息化建设与管理中心江苏扬州225127 扬州大学信息工程学院江苏扬州225127

针对云资源分配和频谱拍卖资源分配定价问题,该文设计了面向团购的真实组合双边拍卖机制。引入了单位差的概念,通过单位差的值决定赢者买家。单位差表现了买家总竞价和需求对应的卖家的总成本在每单位商品上的差别。在筛选赢者买家过程... 详细信息

针对云资源分配和频谱拍卖资源分配定价问题,该文设计了面向团购的真实组合双边拍卖机制。引入了单位差的概念,通过单位差的值决定赢者买家。单位差表现了买家总竞价和需求对应的卖家的总成本在每单位商品上的差别。在筛选赢者买家过程中直接选定与之匹配的最小成本的卖家作为赢者卖家。通过VCG(Vickrey-Clark-Groves)二价支付思想使用重叠买家的单位差计算买家的支付,并分摊交付于想匹配的卖家,避免了买家通过虚假报告信息获得更高的效用。理论分析和模拟实验表明,该文机制满足个体理性、预算平衡的经济属性。

关键词：团购组合双边拍卖分配定价单位差

在线全文

学校读者我要写书评

暂无评论

高职院校学生思想状况与思想政治课教学策略

湖北成人教育学院学报 2017年第6期23卷 52-55页

作者：朱正南闽北职业技术学院福建南平353011

在高职院校,学生中存在着自我要求不高,进取精神不足,自律意识缺乏,学业基础薄弱,自卑感强的现象。思想政治课教师要围绕他们思想状况,牢记立德树人的崇高使命,紧紧贴近实际、贴近生活、贴近学生,优化教学内容,改进教学方式,不断激发学... 详细信息

在高职院校,学生中存在着自我要求不高,进取精神不足,自律意识缺乏,学业基础薄弱,自卑感强的现象。思想政治课教师要围绕他们思想状况,牢记立德树人的崇高使命,紧紧贴近实际、贴近生活、贴近学生,优化教学内容,改进教学方式,不断激发学生自我提高、自我发展的内在潜力,积极探索有利于学生良好行为习惯养成的思想政治课社会实践教学形式,促进知行合一,努力构建起符合高职学生实际与高职人才培养规律相适应的思想政治课教学模式。

关键词：高职生思想状况思想政治课教学教育改革

Calmodulin Mutant CaM-F142L May Induce the Changes of the Ca2+-depentment Regulation by Its Decreased Binding to CaV1.2 channel

在线全文

学校读者我要写书评

暂无评论

Calmodulin Mutant CaM-F142L May Induce the Changes of the Ca...

2019年中国生理学会心血管生理学术研讨会

作者： Jingyang Su Ming Lei zhengnan zhu Xuanxuan Sun Qinghua Gao Rui Feng Dongxue Shao Xuefei Sun Liying Hao Department of Pharmaceutical toxicology School of PharmacyChina Medical University Institute of Cardiovascular Research of Southwest Medical University Department of Physiology Graduate School of Medical and Dental SciencesKagoshima University

It is reported that calmodulin(CaM) mutations are associated with severe long QT syndrome(LQTS),and induced a weakening of Ca-dependent inactivation(CDI) of Cav1.2 *** refers to the prolonged period of QT interval in the electrocardiogram,the clinical manifestation of recurrent syncope or sudden ***-F142 L is a critical missense variant associated with LQTS,which located in EF-hand IV region of ***,the interaction of CaM-F142 L and Cav1.2 channel remaining *** our previous study,we have already found that CaM-WT can bind with N terminus(NT) and C terminus(CT) of Cav1.2 channel under deferent *** this study,we tried to check the combining of the mutant with the Cav1.2 channel in ***,the 142 th amino F was mutated into L of the wild type CaM by using the site-specific mutagenesis *** the GST-CaM-F142 L fusion protein was purified by GS-4 B *** Protease was applied to cut off the *** we utilized GST pull-down assay to explore the interaction between CaM-F142 L and Cavl.2 channel protein fregments compared with *** found that CaM-F142 L still have the ability to bind with different Cav1.2 channel fregments(CT1,PreIQ and NT) at different *** binding of CaM-F142 L to CTl/PreIQ/NT were decreased compared to CaM-WT in high Caconcentration(2 mM,10μM) and in a protein-concentration dependent *** maximal binding(B) and the K value of CaM-F142 L to CT1,PreIQ and NT were reduced in≈2 mM,10μM [Ca].These data imply that the identified LQTS-associated variants CaM-F142 L disrupts the binding with cardiac Cav1.2 channel,which may attenuate Cav1.2 inactivation through the loss of CDI.

关键词： Calmodulin mutant Cav1.2 channel Binding Long QT syndrome

The Effect of Redox on Cav1.2 Calcium Channel Binding to CSL and dDCT

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Effect of Redox on Cav1.2 Calcium Channel Binding to CSL...

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Lei Shuai Hu Huiyuan Sun Xuanxuan Zhou Shi Wang Yifei Zhang Fang Liu Jiaxin Li Songlin zhu zhengnan Hao Liyang China Medical University

Many studies have shown that the imbalance of redox status plays an important role in hypertension,heart failure,atherosclerosis,diabetes,myocardial hypertrophy and other cardiovascular ***,the underlying mechanisms are not fully *** the previous study,it has been found that calpastatin domain L (CSL) and the fragment of distal C-terminal domain (dDCT) of Cav1.2 could regulate the Cav1.2 calcium channel function,while their pathophysiological roles are

关键词： CSL The Effect of Redox on Cav1.2 Calcium Channel Binding to CSL and dDCT