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Ovarian aging:mechanisms and intervention strategies

Medical Review 2022年第6期2卷 590-610页

作者： zhengmao zhu Wanxue Xu Lin Liu Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Department of Genetics and Cell Biology College of Life ScienceNankai University94 Weijing RoadTianjin 300071China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijingChina Tianjin Union Medical Center Institute of Translational MedicineNankai UniversityTianjin 300000China

Ovarian reserve is essential for fertility and influences healthy aging in *** maternal age correlates with the progressive loss of both the quantity and quality of *** molecular mechanisms and various contributing factors underlying ovarian aging have been *** this review,we highlight some of critical factors that impact oocyte quantity and quality during *** cell and follicle reserve at birth de-termines reproductive lifespan and timing the menopause in female *** diminishing ovarian reserve leads to premature ovarian aging or *** oocyte quality with increasing age could result from chromosomal cohesion deterioration and misaligned chromosomes,telomere shortening,DNA damage and associated genetic mutations,oxidative stress,mitochondrial dysfunction and epigenetic *** also discuss the intervention strategies to delay ovarian *** the efficacy of senotherapies by antioxidants against reproductive aging and mitochondrial therapy are *** oocytes and ovarioids could be rejuvenated from pluripotent stem cells or somatic *** propose directions for future *** couples increasingly begin delaying parenthood in life worldwide,understanding the molecular mechanisms during female reproductive aging and potential intervention strategies could benefit women in making earlier choices about their reproductive health.

关键词： mitochondrial therapy oocyte quality oocyte quantity ovarian aging ovarioids senotherapy

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Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer

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Journal of Genetics and Genomics 2014年第4期41卷 187-195页

作者： Zhiqian Zhang zhengmao zhu Baotong Zhang Weidong Li Xin Li Xiao Wu Lijuan Wang Liya Fu Li Fu Jin-Tang Dong Department of Genetics and Cell Biology Nankai University College of Life Sciences Key Laboratory of Breast Cancer Research Department of Breast Cancer Pathology and Research LaboratoryCancer Hospital of Tianjin Medical University Department of Hematology and Medical Oncology Emory University School of MedicineEmory Winship Cancer Institute

The q24 band of chromosome 8 （8q24） is frequently amplified in human cancers including breast cancer, and several SNPs （single nucleotide polymorphisms） at 8q24, including rs13281615, have been identified for their association with cancer risks. These SNPs are in a ＂gene desert＂ region, and their functions in cancer development remain to be illustrated, although several of the SNPs appear to influence the genes in the ＂desert＂ in a long-range manner, including the v-myc avian myelocytomatosis viral oncogene homolog （MYC） and the non- protein coding plasmacytoma variant translocation 1 （PVT1）, both of which have been implicated in human cancers. In the current study, we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer. In addition to confirming the association of the GG genotype of rs 13281615 with breast cancer risk, we found that germline GG genotype was significantly associated with estrogen receptor （ER） positivity, higher tumor grade and higher proliferation index. We also found frequent somatic mutations （22/121 or 18.2%） of this SNP in breast cancer. Interestingly, the majority of the mutations （17/22 or 77%） involved a G→ A change, resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers. Furthermore, PVT1 expression was increased in cancers, and the increase was associated with the GG genotype of rs13281615. These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression, and that during oncogenesis, ＂protective＂ mutations could occur.

关键词： rs13281615 Mutation PVT1 Breast cancer

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Establishment of a highly efficient hematopoietic differentiation model from human embryonic stem cells for functional screening

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Science China(Life Sciences) 2013年第12期56卷 1147-1149页

作者： PANG SuLei WU QingQing TIAN Sha SU Pei BAI Yang GAO Jie YANG YiQing LIU Xin zhu zhengmao XU YuanFu ZHOU JiaXi State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical College College of Life Sciences Nankai University

Human embryonic stem cells （hESCs） have been successfully differentiated into hematopoietic progenitor cells with colony formation capacity and further into various kinds of blood cells including erythrocytes, megakaryocytes, neutrophils, nature killer cells and T lymphocytes . Nevertheless, the differentiation efficiency is extremely low. The differentiation usually involves complex steps such as embryonic body formation or co-culture with stromal cells, causing inconsistencies and difficulties in dissection of its molecular mechanisms [8,9]. Therefore, it is essential to establish a well-defined hematopoietic differentiation model that is independent of serum and stromal cells and much easier to manipulate genes for functional screening, thus the underlying molecular mechanism of hematopoietic differen- tiation of hESCs could be dissected more easily.

关键词：人胚胎干细胞造血祖细胞分化筛选模型人类胚胎干细胞嗜中性粒细胞自然杀伤细胞

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Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands

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Journal of Genetics and Genomics 2019年第3期46卷 119-131页

作者： Gui Ma Ang Gao Yinan Yang Yuan He Xi Zhang Baotong Zhang Zhiqian Zhang Mei Li Xing Fu Dan Zhao Rui Wu Leilei Qi Qingxia Hu Juan Li Liya Fu zhengmao zhu Jin-Tang Dong Department of Genetics and Cell Biology College of Life Sciences Nankai University Department of Hematology and Medical Oncology School of Medicine Winship Cancer Institute Emory University Ningbo Institute of Medical Sciences

Progesterone(Pg)/progesterone receptor(PR) signaling drives mammary gland side-branching and alveologenesis, but the mechanisms through which Pg/PR signaling functions remain to be *** in vitro and in vivo models and histological and molecular analyses, we determined the role of Zfhx3 transcription factor in mammary gland development driven by Pg/PR signaling. Postnatal deletion of Zfhx3 in mouse mammary epithelial cells attenuated side-branching morphogenesis and alveologenesis. These effects were undetectable in the absence of Pg/PR signaling. During the estrus cycle, Zfhx3 expression corresponded to that of Pg, being at the highest level at the diestrus stage; Zfhx3 deletion inhibited mammary gland branching more potently at diestrus than estrus stage. Loss of Zfhx3 not only attenuated the expansion of stem/progenitor cells driven by Pg/PR signaling, but also impaired the function of Pg/PR signaling in the transcriptional activation of multiple genes. In addition, Pg/PR signaling significantly expanded PR-and Zfhx3-positive epithelial cells, and induced the physical association of ZFHX3 with PR. These findings establish Zfhx3 as an integral transcription factor of Pg/PR signaling in driving side-branching and alveologenesis during mammary gland development.

关键词： Mammary gland Zfhx3/Atbf1 Pregnancy Ductal side-branching Alveologenesis Progesterone-progesterone receptor signaling

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山羊葡萄球菌致感染性心内膜炎1例

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中华心血管病杂志 2024年第11期52卷 1324-1326页

作者：朱正茂李昱于雪北京医院心血管内科国家老年医学中心中国医学科学院老年医学研究院北京100730 北京医院急诊科国家老年医学中心中国医学科学院老年医学研究院北京100730

感染性心内膜炎是一种少见但死亡率较高的疾病,其致病菌多为金黄色葡萄球菌、草绿色链球菌等。山羊葡萄球菌最早分离于山羊奶中,是一种过氧化氢酶阳性、凝固酶阴性的微生物,其导致感染性心内膜炎的病例较罕见。该文报道1例山羊葡萄球菌... 详细信息

感染性心内膜炎是一种少见但死亡率较高的疾病,其致病菌多为金黄色葡萄球菌、草绿色链球菌等。山羊葡萄球菌最早分离于山羊奶中,是一种过氧化氢酶阳性、凝固酶阴性的微生物,其导致感染性心内膜炎的病例较罕见。该文报道1例山羊葡萄球菌所致感染性心内膜炎,以期提高临床对该疾病的认识,加强对该微生物早期感染的预防和治疗。

关键词：心内膜炎,细菌性山羊葡萄球菌感染性心内膜炎

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药物涂层球囊治疗冠状动脉分叉病变的研究进展

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中国医学前沿杂志（电子版） 2024年第2期16卷 6-12页

作者：朱正茂于雪北京协和医学院研究生院北京100730 北京医院心血管内科国家老年医学中心北京协和医学院中国医学科学院北京100730

冠状动脉分叉病变占所有冠状动脉介入治疗病例的15%~20%,其介入治疗策略的选择仍具争议。作为冠状动脉粥样硬化性心脏病介入治疗领域的新器械,药物涂层球囊逐渐被应用于分叉病变的介入治疗中,起到了简化操作程序、保护分支血管的作用。... 详细信息

冠状动脉分叉病变占所有冠状动脉介入治疗病例的15%~20%,其介入治疗策略的选择仍具争议。作为冠状动脉粥样硬化性心脏病介入治疗领域的新器械,药物涂层球囊逐渐被应用于分叉病变的介入治疗中,起到了简化操作程序、保护分支血管的作用。本文就药物涂层球囊在分叉病变介入治疗中的有效性及安全性的最新证据进行综述。

关键词：冠状动脉分叉病变经皮冠脉介入术药物涂层球囊

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档案部门参与政务服务档案数据治理的法治进路

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档案 2024年第9期 64-69页

作者：朱正茂江苏师范大学江苏徐州221000

在数字化转型的背景下,档案形态正从传统纸质向电子数据转变。在“互联网+”的背景下,档案部门在需长期保存政务服务档案数据治理中发挥着关键作用。然而,当前政务档案数据治理实践中存在一些问题,如档案法律体系与数据法律体系衔接不... 详细信息

在数字化转型的背景下,档案形态正从传统纸质向电子数据转变。在“互联网+”的背景下,档案部门在需长期保存政务服务档案数据治理中发挥着关键作用。然而,当前政务档案数据治理实践中存在一些问题,如档案法律体系与数据法律体系衔接不足、档案部门数字行政监督能力缺失、政务档案数据利用的监管机制尚待完善等。为解决上述问题,从法治化角度可以采取推动档案与数据法律体系的协同优化、档案部门职能明晰与协同合作、提升数字行政监督能力,重构以档案部门为核心的治理体系、完善档案利用的监管机制的方式以推动其法治化进程。

关键词：档案部门政务服务档案档案数据

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读悟:感悟式语文教学的前提和基础

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池州师专学报 2007年第2期21卷 130-131页

作者：朱正茂桐城市教育局教研室安徽桐城231400

语文课堂教学,是基于文本的教学,引导学生正确“读懂”文本,是进行感悟式教学的一般要求。学生自读和教师导读,都离不开“悟”。读悟是感悟式语文教学的前提和基础。

关键词：阅读教学自读导读读悟

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New insight into the origin and evolution of the flora and fauna of Hainan Island, China

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Science China Earth Sciences 2025年第1期68卷 52-61页

作者： Hua zhu Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants

The origin of the biota of Hainan Island, China, remains a fundamental scientific problem. Comparative studies on the biota, geological tectonics, and paleomagnetism proposed that during the Eocene, Hainan Island connected Vietnam and Guangxi, and then moved to the southeast to reach its present location. This review mainly discusses its biota origin from molecular phylogeny and palaeobotanical research. The formation and evolution of the biological groups of Hainan Island were identified via research on their genomes, phylogeny, and molecular biogeography. This research showed that the genera and species that appeared and diverged early in their evolution(i.e., before the Miocene) can be explained by the land connection between Hainan Island, Vietnam, and Guangxi during the Eocene-Oligocene. According to Southeast Asian tectonic theory, in the Middle Miocene(at about 15 million years ago), Hainan Island had moved to its present position. The population and genetic divergence of species with late divergence times(after 15 Ma) can be reasonably explained by the close proximity(or land connection) between Hainan Island and the Leizhou Peninsula, enabling genetic communication between Hainan Island and the Chinese mainland, but have exceptional cases. Conclusions have been obtained through palaeobotanical studies, showing that in the Eocene-Oligocene period, southwest China and Hainan Island had subtropical vegetation and flora. However, the fossil group in southeast China(in Maoming, near present-day Hainan Island) in the Late Eocene indicated a tropical rainforest vegetation and flora. This suggests that in the Paleogene, Hainan Island may have been located near or on the southwest border of Guangxi and northern Vietnam, rather than in its present location. The floristic division of the flora of Hainan Island basically presents a northeast-southwest inclined distribution pattern. This pattern can be explained by the counterclockwise rotation of Hainan Island during i

关键词： Molecular phylogeny Biogeography Paleobotany Origin of flora and fauna Hainan Island of China

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高校实验室接地管理探究

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实验技术与管理 2024年第11期41卷 221-225页

作者：刘钊朱正茂史清风华北电力大学实验室管理处北京102206 华北电力大学基建处北京102206

实验室接地主要在实验室基础建设和装修改造过程中实施,是高校实验室管理中极易忽视的重要环节。为做好实验室接地精细化管理,文章从接地的重要性出发,讨论了实验室接地种类和独立接地对提升精密仪器信噪比的作用,并分析了接地不当或缺... 详细信息

实验室接地主要在实验室基础建设和装修改造过程中实施,是高校实验室管理中极易忽视的重要环节。为做好实验室接地精细化管理,文章从接地的重要性出发,讨论了实验室接地种类和独立接地对提升精密仪器信噪比的作用,并分析了接地不当或缺失的风险。文章提出了满足仪器设备使用需求的降低接地电阻解决方案,在实验室运行管理中可通过检查表对实验室接地情况进行检查,确保接地系统持续有效。

关键词：实验室精细化管理接地检查表

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