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环状RNA在消化系统肿瘤中的研究进展

现代肿瘤医学 2017年第17期25卷 2855-2858页

作者：李正龙李鑫恒郑汪洋李景林王志东崔云甫姜兴明哈尔滨医科大学附属第二医院胆胰外科黑龙江哈尔滨150086

环状RNA(circular RNA,circRNA)作为非编码RNA(non-coding RNA,ncRNA)家族中的新成员,具有诱捕微小RNA(microRNA,miRNA)、调控相关基因表达、参与转录拼接等重要功能。近年来,随着对circRNA的研究不断深入,其在诸多疾病发生发展过程中... 详细信息

环状RNA(circular RNA,circRNA)作为非编码RNA(non-coding RNA,ncRNA)家族中的新成员,具有诱捕微小RNA(microRNA,miRNA)、调控相关基因表达、参与转录拼接等重要功能。近年来,随着对circRNA的研究不断深入,其在诸多疾病发生发展过程中所发挥的重要作用不断被揭示。消化系统肿瘤作为发病隐匿且预后相对较差的一大类疾病一直威胁着人类健康。随着对消化系统肿瘤认识的加深,关于其分子水平的诊断和治疗研究逐步成为新热点。本文将就circRNA与消化系统肿瘤的相关性,以及其潜在临床价值做一简要综述。

关键词：非编码RNA 环状RNA 竞争性内源RNA 消化系统肿瘤

Application of computational fluid dynamics simulation for submarine oil spill

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Acta Oceanologica Sinica 2018年第11期37卷 104-115页

作者： YANG zhenglong YU Jianxing li Zhigan CHEN Haicheng JIANG Meirong CHEN Xi State Key Laboratory of Hydraulic Engineering Simulation and Safety School of Civil EngineeringTianjin UniversityTianjin 300072China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240China Offshore Oil Engineering Co.Ltd. China National Offshore Oil Corporation(CNOOC)Tianjin 300451China CNOOC Research Institute Co.Ltd. China National Offshore Oil Corporation(CNOOC)Beijing 100028China

Computational fluid dynamics （CFD） codes are being increasingly used in the simulation of submarine oil spills. This study focuses on the process of oil spills, from damaged submarine pipes, to the sea surface, using numerical models. The underwater oil spill model is developed, and a description of the governing equations is proposed, along with modifications required for the particalization of the control volume. Available experimental data were introduced to evaluate the validity of the CFD predictions, the results of which proved to be in good agreement with the experimental data. The effects of oil leak rate, leak diameter, current velocity, and oil density are investigated, by the validated CFD model, to estimate the undersea leakage time, the lateral migration distance, and surface diffusion range when the oil reaches the sea surface. Results indicate that the leakage time and lateral migration distance increase with decreasing leak rates and leak diameter, and increase with increasing current velocity and oil density. On the other hand, a large leak diameter, high density, high leak rate, or fast currents result in a greater surface diffusion range. The findings and analysis presented here will provide practical predictions of oil spills, and guidance for emergency rescues.

关键词： oil spill computational fluid dynamics (CFD) oil particles current velocity

长链非编码RNAHOTTIP在消化系统肿瘤中的调控作用

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国际外科学杂志 2017年第8期44卷 568-572页

作者：姜兴明王志东郑汪洋李景林李正龙李鑫恒崔云甫哈尔滨医科大学附属第二医院胆胰外科哈尔滨150086

长链非编码RNA是非编码RNA家族中的重要成员，其在机体诸多生理病理过程中所发挥的重要调控作用正日益凸显。长链非编码RNAHoTrIP定位于HOXA基因5’末端的长链非编码RNA，目前已发现其在多种消化系统恶性肿瘤中呈异常上调表达并调控肿... 详细信息

长链非编码RNA是非编码RNA家族中的重要成员，其在机体诸多生理病理过程中所发挥的重要调控作用正日益凸显。长链非编码RNAHoTrIP定位于HOXA基因5’末端的长链非编码RNA，目前已发现其在多种消化系统恶性肿瘤中呈异常上调表达并调控肿瘤的发生、发展。本文就消化系统肿瘤中长链非编码RNAHOTVIP调控作用的研究现状进行综述。

关键词：消化系统肿瘤预后综述长链非编码RNA HOTTIP

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SNHG1在肿瘤中的表达和作用

现代肿瘤医学 2019年第8期27卷 1425-1429页

作者：黄立宁周原世李正龙李景林姜兴明崔云甫哈尔滨医科大学附属第二医院胆胰外科黑龙江哈尔滨150086

长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度大于200 nt的不编码蛋白质的RNA分子。近年来研究发现长链非编码RNA在诸多肿瘤的发生发展过程中发挥重要作用。小核糖体管家基因RNA 1(small nucleolar RNA host gene 1,SNH... 详细信息

长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度大于200 nt的不编码蛋白质的RNA分子。近年来研究发现长链非编码RNA在诸多肿瘤的发生发展过程中发挥重要作用。小核糖体管家基因RNA 1(small nucleolar RNA host gene 1,SNHG1)是由11号染色体上作为18s核糖体RNA重要组成部分的UHG基因转录而来的lncRNA。随研究不断深入,SNHG1在多种肿瘤中(胶质瘤、食管癌、胃癌等)的异常表达以及其对肿瘤恶性生物学行为的调控作用逐渐被揭示。SNHG1功能较为复杂并在肿瘤中通过多种机制发挥致癌作用,并且SNHG1的高表达预示着患者不良预后。本文结合国内外最新报道,对SNHG1在肿瘤中的表达水平及作用进行简要综述。

关键词：长链非编码RNA SNHG1 肿瘤预后恶性生物学行为

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Tpl2在肿瘤发生发展中的研究进展

中国医师杂志 2017年第6期19卷 946-949页

作者：李景林郑汪洋李鑫恒李正龙王志东姜兴明崔云甫哈尔滨医科大学附属第二医院胆胰外科哈尔滨150001

Tpl2是丝裂原活化蛋白激酶（MAPK）家族中重要的三级激酶，在MAPK途径等多种信号通路中发挥重要作用。近年来，大量研究发现Tpl2在多种肿瘤呈异常表达并参与调控肿瘤的发生发展，有望成为新型的肿瘤标志物和治疗靶点。因此，揭示肿瘤中T... 详细信息

Tpl2是丝裂原活化蛋白激酶（MAPK）家族中重要的三级激酶，在MAPK途径等多种信号通路中发挥重要作用。近年来，大量研究发现Tpl2在多种肿瘤呈异常表达并参与调控肿瘤的发生发展，有望成为新型的肿瘤标志物和治疗靶点。因此，揭示肿瘤中Tpl2的调控作用及其机制，将为肿瘤的诊断和治疗提供可行的理论依据与潜在的干预靶点。

关键词：丝裂原激活蛋白激酶激酶类肿瘤综述

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小脑变性相关蛋白1反义转录物的研究进展

中国医师进修杂志 2018年第1期41卷 82-85页

作者：郑汪洋李正龙李景林李鑫恒王志东崔云甫姜兴明哈尔滨医科大学附属第二医院胆胰外科 150086

环状RNA是一类缺乏5′末端帽子和3′末端多聚核苷酸尾共价结合的单链RNA环状分子。作为非编码RNA的新成员，环状RNA较其他线性RNA分子具有不同物种间更保守、不易被RNA酶降解、不同组织间特异分布且含量较高等优点。因此，环状RNA替代... 详细信息

环状RNA是一类缺乏5′末端帽子和3′末端多聚核苷酸尾共价结合的单链RNA环状分子。作为非编码RNA的新成员，环状RNA较其他线性RNA分子具有不同物种间更保守、不易被RNA酶降解、不同组织间特异分布且含量较高等优点。因此，环状RNA替代其他线性RNA成为新的研究热点。作为目前研究较多的环状RNA分子，小脑变性相关蛋白1反义转录物（CDR1as）拥有74位微小RNA-7结合位点；其不仅可通过竞争性内源RNA途径阻碍微小RNA-7功能还可以大量储存微小RNA-7并适时释放。CDR1as可稳定存在于血浆外泌体中并与诸多疾病预后指标相关。

关键词：肿瘤标记,生物学综述小脑变性相关蛋白1反义转录物

Ultrathin poly(cyclocarbonate-ether)-based composite electrolyte reinforced with high-strength functional skeleton

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Journal of Energy Chemistry 2023年第6期81卷 603-612,I0013页

作者： Xiaojiao Zheng Da Xu Ning Fu zhenglong Yang Shanghai Key Laboratory of D&A for Metal-Functional Materials School of Materials Science and EngineeringTongji UniversityShanghai 200092China School of Chemical and Environmental Engineering Anyang Institute of TechnologyAnyang 455000HenanChina

Composite polymer electrolytes(CPEs)are considered to be the most promising to break through the performance and safety limitations of traditional lithium-ion batteries because of their excellent electrochemical and mechanical *** at the performance limitations of the most common polyether matrix such as poly(ethylene oxide)(PEO),a novel poly(cyclocarbonate-ether)polymer matrix was prepared by in-situ thermal curing,the weaker interaction between its C=O bond and li^(+)can promote the rapid transport of li^(+).Adding ionic liquid and active filler LLZTO to the matrix can synergistically reduce the crystallinity of matrix and promote the dissociation of lithium *** addition,a 3D functional skeleton made of polyacrylonitrile(PAN)and lithium fluoride(liF)can greatly improve the mechanical strength of polymer matrix after cold pressing,and li F is also conducive to interface *** thickness of the optimal sample(VP6L/CPL)was only 25μm,and its ionic conductivity,lithium ion transference number,and electrochemical stability window were as high as 7.17×10^(-4)S cm^(-1)(25℃),0.54 and 5.4 V,respectively,while the mechanical strength reaches 6.1 MPa,which can fully inhibit the growth of lithium *** excellent electrochemical performance and mechanical strength enable the assembled li|VP6L/CPL|li battery to be continuously charged for over 200 h and cycled stably for more than 2300 h,and li|VP6L/CPL|LFP battery can be stably cycled for more than 400 and 550 cycles at 1 C(40℃)and 0.5 C(25℃),respectively.

关键词： Composite polymer electrolytes Polymer matrix 3D functional skeleton Plasticization Synergistic effect

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一种评价一侧采空巷道稳定性的新方法

山东矿业学院学报 1998年第3期17卷 290-294页

作者：王同旭马其华李正龙高洪亮山东矿业学院采矿工程系兴隆庄煤矿

一侧采空巷道稳定性不仅与支承压力分布有关，而且与煤体受破坏程度有关。本文提出了能综合反映上述两方面影响的“等效稳定性系数法”，并推导给出了等效稳定性系数的计算式。

关键词：采空巷道稳定性评价等效稳定性系数矿井

High-fidelity structured illumination microscopy by point-spread-function engineering

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light(Science & Applications) 2021年第5期10卷 812-823页

作者： Gang Wen Simin li Unbo Wang Xiaohu Chen zhenglong Sun Yong liang Xin Jin Yifan Xing Yaming jiu Yuguo Tang Hui li Jiangsu Key Laboratory of Medical Optics CAS Center for Excellence in Molecular Cell ScienceSuzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhouJiangsu 215163China Academy for Engineering and Technology Fudan UniversityShanghai 200433China The Center for Microbes Development and HealthKey Laboratory of Molecular Virology and ImmunologyInstitute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China

Structured illumination microscopy(SIM)has become a widely used tool for insight into biomedical challenges due to its rapid,long-term,and super-resolution(SR)***,artifacts that often appear in SIM images have long brought into question its fidelity,and might cause misinterpretation of biological *** present HiFi-SIM,a high-fidelity SIM reconstruction algorithm,by engineering the effective point spread function(PSF)into an ideal ***-SIM can effectively reduce commonly seen artifacts without loss of fine structures and improve the axial sectioning for samples with strong *** particular,HiFi-SIM is not sensitive to the commonly used PSF and reconstruction parameters;hence,it lowers the requirements for dedicated PSF calibration and complicated parameter adjustment,thus promoting SIM as a daily imaging tool.

关键词： HiFi illumination function