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Food Bioscience 2023年第2期52卷 281-289页

作者： zhengli lin Junwen Lai Ping He Leiman Pan Yizhe Zhang Mengmeng Zhang Hui Wu College of Food Sciences and Engineering South China University of TechnologyGuangzhou510640PR China College of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringDongsha Street 24GuangzhouGuangdong510225China

Maca is an edible functional plant with antihypertensive ***,there is still no clear understanding of angiotensin-converting enzyme(ACE)inhibitory substances in *** the present study,six novel angiotensin-converting enzyme inhibitor(ACEI)peptides(RSRGVFF,LGHPVFRNK,HGSCNYR,KANLGFRF,GGGHKRLY and SSYLGRN)were found in maca protein hydrolysates using in silico tools and molecular *** revealed prominent ACE inhibitory activity with an IC50 value of 5.01μM as a mixed-type ACE *** analysis of the structure-activity connection demonstrated that the arginine at N-terminal is the most likely active residue in RSRGVFF,and two phenylalanines at the C-terminal also contributed to its inhibitory ***,these results indicate that maca protein may be one of the substances that leads to antihypertensive *** provides a new perspective to understanding the ACE inhibitory activity of maca and offers valuable insights to enlighten the structure-activity relationship of ACEI peptides.

关键词： Maca protein ACE inhibitory peptide Molecular docking Enzyme kinetics Structure-activity relationship

Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease:implication of acrolein and TRPA1

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Translational Neurodegeneration 2021年第2期10卷 151-165页

作者： Liangqin Shi Yazhou lin Yucheng Jiao Seth AHerr Jonathan Tang Edmond Rogers zhengli Chen Riyi Shi College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075China Center for Paralysis Research&Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteIN 47907USA Laboratory of Animal Disease Model College of Veterinary MedicineSichuan Agricultural UniversityChengdu 625014China Department of Orthopedics Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityInstitute of Trauma and OrthopedicsShanghai 200025China Weldon School of Biomedical Engineering Purdue University West LafayetteWest LafayetteIN 47907USA

Background:The mechanisms underlying lesions of dopaminergic(DA)neurons,an essential pathology of Parkinson’s disease(PD),are largely unknown,although oxidative stress is recognized as a key *** have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in PD pathology,and that acrolein scavenger hydralazine can reduce the elevated acrolein,mitigate DA neuron death,and alleviate motor deficits in a 6-hydroxydopamine(6-OHDA)rat *** such,we hypothesize that a structurally distinct acrolein scavenger,dimercaprol(DP),can also offer neuroprotection and behavioral ***:DP was used to lower the elevated levels of acrolein in the basal ganglia of 6-OHDA *** acrolein levels and related pathologies were measured by *** and behavioral effects of 6-OHDA injections and DP treatment were examined using the open field test and rotarod *** was assessed using mechanical allodynia,cold hypersensitivity,and plantar ***,the effects of DP were assessed in vitro on SK-N-SH dopaminergic cells exposed to ***:DP reduced acrolein and reversed the upregulation of pain-sensing transient receptor potential ankyrin 1(TRPA1)channels in the substantia nigra,striatum,and *** also mitigated both motor and sensory deficits typical of *** addition,DP lowered acrolein and protected DA-like cells in ***’s ability to upregulate TRPA1 was also verified in vitro using cell ***:These results further elucidated the acrolein-mediated pathogenesis and reinforced the critical role of acrolein in PD while providing strong arguments for anti-acrolein treatments as a novel and feasible strategy to combat neurodegeneration in *** the extensive involvement of acrolein in various nervous system illnesses and beyond,anti-acrolein strategies may have wide applications and broad impacts on human health.

关键词： Oxidative stress Parkinson’s disease Neuroinflammation Acrolein TRPA1 Dimercaprol

Groups-dependent phosphines as the organic redox for point defects elimination in hybrid perovskite solar cells

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Journal of Energy Chemistry 2021年第3期30卷 23-29页

作者： zhengli Wu Miao Zhang Yifan Liu Yuxi Dou Yinjie Kong lin Gao Weitao Han Guijie Liang Xiao Li Zhang Fuzhi Huang Yi-Bing Cheng Jie Zhong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan 528200GuangdongChina Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053HubeiChina School of Materiale Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina Department of Materials Science and Engineering Monash UniversityVIC 3800Australia

Lead(Pb)^(0) and iodine(I)^(0) point defects generated during perovskite solar cell(PSC)fabrication and photoconversion form deep band energy levels as the carriers’recombination *** defects not only deteriorate device efficiency,but also facilitate chemical degradation with ion migration,resulting in restricted device ***,we present a novel type of phosphines as the point defects stabilizer for hybrid perovskite solar cells with enhanced *** phosphines with varied side groups of tributyl,trioctyl and triphenyl are exampled as the dopants in perovskite *** group dependent redox properties were observed in the perovskite film,dependent on their molecular weights and steric hinderances of *** partially oxidized tributyl phosphine(TBUP)with additional tributyl phosphine oxides(TBPO)is efficient in reduction of lead(Pb)^(0) and iodine(I)^(0) concentrations during the device fabrication and *** device with TBUP-TBPO pair showed enhanced power conversion efficiency(PCE)to 20.48% and maintain 91.7% of their initial PCEs after 500 h at 65℃ thermal ***,this work presents an efficient route of utilize the phosphine species to reduce point defects in the perovskite film,which promoting further development of novel phosphorous additives with defects stabilization,interface passivation and encapsulation for low-cost solution processed PSCs.

关键词： Redox Perovskite solar cells Phosphine organics Lead defect Stability

Contents of chemical elements in stomach during prenatal development:different age-dependent dynamical changes and their significance

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World Journal of Gastroenterology 2003年第5期9卷 1063-1066页

作者： Shao-FanHou Hai-RongLi Li-ZhenWang De-ZhuLi lin-ShengYang Chong-zhengli InstituteofGeographicalSciencesandNaturalResourcesResearch CASBeijing100101China BeijingUniversityofChineseMedicinePharmacyHuguosiHospital Beijing100035China

AIM: To observe dynamic of different chemical elements in stomach tissue during fetal ***: To determine contents of the 21 chemical elements in each stomach samples from fetus aging four to ten months. The content values were compared to those from adult tissue samples, and the values for each month group were also analyzed for dynamic ***: Three representations were found regarding the relationship between contents of the elements and ages of the fetus, including the positive correlative (K), reversely correlative (Na, Ca, P, Al, Cu, Zn, Fe, Mn, Cr, Sr, Li, Cd, Ba,Se ) and irrelevant groups (Mg, Co, Ni, V, Pb, Ti).CONCLUSION: The chemical elements' contents in stomach tissues were found to change dynamically with the stomach weights. The age-dependent representations for different chemical elements during the prenatal development may be of some significance for assessing development of fetal stomach and some chemical elements. The data may be helpful for the nutritional balance of fetus and mothers during prenatal development and even the perinatal stages.

关键词：胎儿胃组织化学因素生理功能胃动力学临床意义

Identification of Immunogenic Determinants of the Spike Protein of SARS-like Coronavirus

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Virologica Sinica 2013年第2期28卷 92-96页

作者： Peng Zhou Zhenggang Han lin-Fa Wang zhengli Shi Center for Emerging Infectious Diseases Wuhan Institute of Virology Chinese Academy of Sciences (CAS) CSIRO Livestock Industries Australian Animal Health Laboratory Institut fur Biochemie Universitat Zu Lubeck Program in Emerging Infectious Diseases Duke-NUS Graduate Medical School

Bat SARS-Iike coronavirus （SL-CoV） has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike （S） proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have been reports studying the overall immunogenicity of SsL, knowledge on the precise location of immunodominant determinants for SSL is still lacking. In this study, using a series of truncated expressed SsL fragments and SsL specific mouse sera, we identified two immunogenic determinants for SSL. Importantly, one of the two regions seems to be located in a region not shared by known immunogenic determinants of the SSARS. This finding will be of potential use in future monitoring of SL-CoV infection in bats and spillover animals and in development of more effective vaccine to cover broad protection against this new group of coronaviruses.

关键词： Bat SL-CoV Immune Vaccine

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芳烃三氟甲基断裂单碳氟键的反应研究进展

有机化学 2021年第12期41卷 4554-4564页

作者：安辛妮冯璋黄林杨义刘正立四川轻化工大学化学与环境工程学院四川自贡643000 重庆大学药学院重庆401331

芳烃三氟甲基化合物价廉易得,通过对其C(sp^(3))-F键进行选择性切断是合成含偕二氟基团医药中间体的重要途径.然而,该转化中面临着巨大挑战,如C(sp^(3))-F键难以活化,以及如何实现选择性脱单氟键等问题.近年来该领域发展迅速,取得了一... 详细信息

芳烃三氟甲基化合物价廉易得,通过对其C(sp^(3))-F键进行选择性切断是合成含偕二氟基团医药中间体的重要途径.然而,该转化中面临着巨大挑战,如C(sp^(3))-F键难以活化,以及如何实现选择性脱单氟键等问题.近年来该领域发展迅速,取得了一系列重要的研究成果.如通过对三氟甲基的转化,开发出了构建偕二氟烷基基团的简洁而高效的方法,其中涉及二氟烷基自由基或二氟甲基碳阳离子中间体.根据ArCF3选择性切断单C(sp^(3))-F键的策略进行分类,对该领域最新研究进展进行了概述.

关键词：选择性碳氟键切断芳烃三氟甲基二氟烷基自由基

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药盒体的冲压成形模拟及其关键模具设计

热加工工艺 2011年第7期40卷 181-182页

作者：吕琳王正立吕华聪重庆理工大学材料科学与工程学院重庆400054

针对药盒体零件的成形难点,对该零件的相关工艺参数进行了分析与计算,设计了需三次拉深、反拉深、再冲孔、翻孔、整形、切边的工艺。通过对拉深工艺进行计算机数值模拟,优化了工艺参数。最后设计了反拉深模具,能够实现药盒体的冲压成形。

关键词：药盒体冲压成形关键模具

基于转录组学解析铜驯化缓解高温胁迫对大黄鱼的氧化损伤

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海洋渔业 2023年第5期45卷 559-569页

作者：谢正丽宋炜吉群曾霖中国水产科学研究院渔业机械仪器研究所上海200090 中国水产科学研究院东海水产研究所上海200090 蚌埠学院食品与生物工程学院安徽蚌埠233030

为探讨铜驯化对高温胁迫下大黄鱼(Larimichthys crocea)氧化损伤和基因表达水平的影响,将体质量为(48.92±3.62)g的大黄鱼暴露在铜离子浓度为0和10μg·L^(-1)的水体中14 d,再暴露在温度为32℃的水体中24 h。结果显示,高温胁迫显著增加... 详细信息

为探讨铜驯化对高温胁迫下大黄鱼(Larimichthys crocea)氧化损伤和基因表达水平的影响,将体质量为(48.92±3.62)g的大黄鱼暴露在铜离子浓度为0和10μg·L^(-1)的水体中14 d,再暴露在温度为32℃的水体中24 h。结果显示,高温胁迫显著增加了大黄鱼肝脏中活性氧(ROS)和脂质过氧化物(LPO)含量(P<0.05)。铜驯化对常温下ROS和LPO含量不产生影响,而显著降低了高温胁迫下大黄鱼ROS和LPO含量(P<0.05),表明铜驯化缓解了高温胁迫对大黄鱼的氧化损伤。从高温胁迫组vs对照组、铜驯化组vs对照组和(铜驯化+高温胁迫)组vs高温胁迫组中分别筛选到828个、2311个和1084个差异基因。GO和KEGG分析发现,差异基因主要富集在与TCA循环、氧化磷酸化、谷胱甘肽代谢、内质网蛋白加工、吞噬体和MAPK信号通路等相关功能上。聚类分析表明,高温胁迫下调了TCA循环、氧化磷酸化、谷胱甘肽代谢、吞噬体和MAPK信号等通路中的大部分基因表达,上调了内质网蛋白加工通路中的大部分基因表达,而铜驯化则对高温胁迫下大黄鱼的这些基因表达调控产生了拮抗效应,表明铜驯化通过改善有氧代谢、抗氧化、自噬和凋亡来提高大黄鱼的高温胁迫耐受性。研究结果可为深入研究铜污染物对大黄鱼高温胁迫耐受性的影响及其分子机制提供基础资料。

关键词：大黄鱼高温胁迫铜污染物转录组信号通路

基于多线程C/S模型的财经网络传输系统设计

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计算机工程与应用 2003年第18期39卷 184-186页

作者：林峰周正利上海交通大学电子工程系上海200030

财经网络传输系统中,要求能够实时并行地处理多种不同数据类型的传输。应用Windows2000多线程编程方法,结合C/S(客户机/服务器)模型,把不同类型数据流的传输创建成多个线程,采用相应的同步共享操作以协调它们的执行,实现了系统的要求,... 详细信息

财经网络传输系统中,要求能够实时并行地处理多种不同数据类型的传输。应用Windows2000多线程编程方法,结合C/S(客户机/服务器)模型,把不同类型数据流的传输创建成多个线程,采用相应的同步共享操作以协调它们的执行,实现了系统的要求,保证了网络传输系统的高效率和高可靠性。

关键词：多线程客户机/服务器 TCP/IP 监听

基于转录组解析铜驯化对低温胁迫下大黄鱼氧化损伤的影响

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中国水产科学 2022年第10期29卷 1425-1436页

作者：曾霖王永红宋炜谢正丽张惠蚌埠学院食品与生物工程学院浙江海洋大学国家海洋设施养殖工程技术研究中心中国水产科学研究院东海水产研究所中国水产科学研究院渔业机械仪器研究所

为探讨铜驯化对低温胁迫下大黄鱼(Larimichthyscrocea)氧化损伤和基因表达水平的影响,本研究将体重为(48.92±3.62) g的大黄鱼暴露在铜浓度为0和10μg/L的水体中14 d,再暴露在温度为8℃的水体中24 h。结果显示,低温胁迫显著增加了活性氧... 详细信息

为探讨铜驯化对低温胁迫下大黄鱼(Larimichthyscrocea)氧化损伤和基因表达水平的影响,本研究将体重为(48.92±3.62) g的大黄鱼暴露在铜浓度为0和10μg/L的水体中14 d,再暴露在温度为8℃的水体中24 h。结果显示,低温胁迫显著增加了活性氧(ROS)和脂质过氧化物(LPO)含量。尽管铜驯化对ROS和LPO含量不产生影响,但铜驯化显著增加了低温胁迫下大黄鱼ROS和LPO含量,表明铜驯化加剧了低温胁迫对大黄鱼的氧化损伤。从铜驯化相对对照组、低温胁迫相对对照组和铜驯化+低温胁迫相对低温胁迫中分别筛选到2288个、1425个和1382个差异基因。GO和KEGG分析发现差异基因主要富集在与脂肪酸代谢、糖类有氧代谢、谷胱甘肽代谢、内质网应激、自噬和凋亡等相关的通路中。聚类分析表明,低温胁迫上调了不饱和脂肪酸合成、内质网应激、自噬和凋亡等相关通路中的大部分基因表达,而铜驯化则对低温胁迫下大黄鱼的这些基因表达调控产生了拮抗效应,表明铜驯化通过抑制不饱和脂肪酸合成、内质网应激、自噬和凋亡来降低大黄鱼的低温胁迫耐受性。研究结果为深入研究铜污染物对大黄鱼低温胁迫耐受性的影响及其分子机制提供科学依据。

关键词：大黄鱼低温胁迫铜污染物转录组信号通路