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Tumor burden score and alpha-fetoprotein level predict prognosis of patients with unresectable hepatocellular carcinoma treated with tyrosine kinase inhibitor and anti-PD-1 antibody

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iLIVER 2024年第3期3卷 22-31页

作者： Shichuan Tang Tingfeng Huang Cong Luo Jun Fu Kailing Zhang Qingjing Chen Jie Kong Jianxi Zhang zhenghong sun Yongkang Diao Kongying Lin Yongyi Zeng Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350025China Department of Hepatopancreatobiliary Surgery Wanyuan Central HospitalWanyuan 636350China Department of Hepatopancreatobiliary Surgery Zizhong County People's HospitalZizhong 641200China Department of Gastroenterology Wenjiang District People's HospitalChengdu 611100China Department of Hepatobiliary Heze Municipal HospitalHeze 274000China Department of Hepatobiliary Surgery Xiamen Hospital of Traditional Chinese MedicineXiamen 361000China Department of General Surgery Guizhou Maotai HospitalZunyi 564500China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNavy Medical University(Second Military Medical University)Shanghai 200082China The Liver Disease Research Center of Fujian Province Fuzhou 350025China

Background:Tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies in combination provide survival benefits for patients with unresectable hepatocellular carcinoma(uHCC).However,the tool used to determine which patients likely benefit most from this treatment strategy has not been *** sought to develop a prognostic scoring system based on tumor burden score(TBS)and alpha-fetoprotein(AFP)to predict the long-term prognosis of uHCC treated with TKIs and anti-PD-1 ***:Data on patients with uHCC treated with TKIs and anti-PD-1 antibodies from multiple centers were *** prognostic accuracy of TBS,AFP,Barcelona Clinic Liver Cancer(BCLC),and CTA(Combined TBS and AFP)for 2-year progression-free survival(PFS)and overall survival(OS)was ***:Overall,278 patients with uHCC treated with TKIs and anti-PD-1 antibodies were enrolled,including 48 BCLC-B and 230 BCLC-C HCC ***(AUC?0.721 and 0.683)outperformed TBS(AUC?0.680 and 0.621),AFP(AUC?0.606 and 0.594),and BCLC staging(AUC?0.551 and 0.555)in predicting PFS and *** 2-year PFS and OS for low CTA(low TBS/low AFP)were 65.7%and 94.4%,respectively,which were significantly higher than 21.6%and 44.9%(p<0.001 and p?0.002),respectively,for intermediate CTA(low TBS/high AFP or high TBS/low AFP)and 8.7%and 12.1%(both p<0.001),respectively,for high CTA(high TBS/high AFP).Multivariable Cox regression analysis indicated that CTA grading was an independent prognostic factor for PFS and OS(referent:low CTA;intermediate CTA,HR 2.87 and 7.17;high CTA,HR 5.52 and 10.31,respectively).Conclusions:CTA grading is an accurate tool for stratifying the prognosis of uHCC treated with TKIs and anti-PD-1 antibodies and may help determine which patients may benefit more from this treatment strategy.

关键词： Hepatocellular carcinoma Tyrosine kinase inhibitor Anti-PD-1 antibody Tumor burden score Alpha-fetoprotein

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食品安全问题和食品检测的发展及优化

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现代食品 2019年第24期4卷 125-127页

作者：孙正宏王娟宝鸡市食品药品检验检测中心

食品安全问题直接影响着人们的生命健康。目前,食品安全问题越来越多,为了及时发现食品中潜在的安全隐患,为餐饮服务食品安全工作提供支持,相关部门需注重食品检测工作。本文主要分析了食品安全存在的问题、食品检测的发展及优化措施。

关键词：食品安全食品检测发展优化

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基于国产数控机床机电匹配性研究

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制造技术与机床 2013年第9期 57-58页

作者：童国荣孙正宏朱宏杰王战勇汉川数控机床股份公司陕西汉中723003

国家数控机床专项"汉川机床采用国产数控系统加工大型机床零件应用示范工程"之科研任务"国产数控机床机电匹配性研究"。其实质是数控机床进给系统的转矩匹配和惯量匹配问题之研究。数控机床进给系统的惯量匹配严重地影响着数控机床的性... 详细信息

国家数控机床专项"汉川机床采用国产数控系统加工大型机床零件应用示范工程"之科研任务"国产数控机床机电匹配性研究"。其实质是数控机床进给系统的转矩匹配和惯量匹配问题之研究。数控机床进给系统的惯量匹配严重地影响着数控机床的性能、功能以及精度保持性、性能稳定性,文章对此进行了分析研究。

关键词：数控机床转矩匹配惯量匹配

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三辊研磨剥离鳞片石墨制备低碳含碳耐火材料用微/纳米石墨薄片

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稀有金属材料与工程 2020年第2期49卷 682-687页

作者：黄军同刘明强孙正红侯小龙李喜宝陈智胡智辉马金婷冯志军南昌航空大学江西南昌330063

对三辊研磨剥离技术在低碳含碳耐火材料中的应用进行理论分析的基础上,以鳞片石墨(FG)为原料、酚醛树脂(PF)作为研磨介质,采用三辊研磨机差速剥离得到微/纳米石墨薄片(GNP),研究了剥离次数对剥离产物结构和形貌的影响。以乙醇为溶剂,对F... 详细信息

对三辊研磨剥离技术在低碳含碳耐火材料中的应用进行理论分析的基础上,以鳞片石墨(FG)为原料、酚醛树脂(PF)作为研磨介质,采用三辊研磨机差速剥离得到微/纳米石墨薄片(GNP),研究了剥离次数对剥离产物结构和形貌的影响。以乙醇为溶剂,对FG经三辊研磨剥离得到的产物进行浸泡、超声清洗以排除PF后再干燥,并对产物进行了XRD、SEM、TEM和粒度分析等表征。研究发现,尺寸~150微米级、厚度为几微米级FG在剥离过程中厚度不断减薄,尺寸也有所减小,当剥离次数逐渐增加到8次甚至16次时,剥离得到了尺寸为10~30μm、厚度达30~100 nm的GNP。相关技术能够应用到低碳、超低碳耐火材料工业以降低碳含量,以及推广到航空工业树脂基碳纤维复合材料中以改善树脂界面结合强度。

关键词：鳞片石墨三辊研磨微/纳石墨片酚醛树脂低碳含碳耐火材料

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不同干燥方式对香菇品质的影响

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农产品加工 2017年第1期 115-117,120页

作者：赵旭博孙正宏田阳曹丽西北农林科技大学食品科学与工程学院陕西咸阳712100 宝鸡市食品药品检验检测中心陕西宝鸡721013 宝鸡市产品质量监督检验所陕西宝鸡721013

香菇最早栽培在中国,距今已有800多年的历史,是亚洲地区主要食用菌。我国是世界香菇生产第一大国,日本排第2位,韩国居第3位。香菇含有较高的水分、多糖、维生素等一些营养元素,但存在不易进行运输、贮藏及加工等问题,因此干燥是在此之... 详细信息

香菇最早栽培在中国,距今已有800多年的历史,是亚洲地区主要食用菌。我国是世界香菇生产第一大国,日本排第2位,韩国居第3位。香菇含有较高的水分、多糖、维生素等一些营养元素,但存在不易进行运输、贮藏及加工等问题,因此干燥是在此之前的必备工序之一。香菇作为我国最大的出口菇,干制效果关系着我国的出口效益。通过综述香菇的几种干燥方式,并列举了各自优缺点,结果显示热泵干燥是香菇及其他果蔬中最有前景的干燥方式。

关键词：香菇干燥方法品质分析

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Mechanism of unconventional aerodynamic characteristics of an elliptic airfoil

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Chinese Journal of Aeronautics 2015年第3期28卷 687-694页

作者： sun Wei Gao zhenghong Du Yiming Xu Fang School of Aeronautics Northwestern Polytechnical University

Abstract The aerodynamic characteristics of elliptic airfoil are quite different from the case of con ventional airfoil for Reynolds number varying from about 104 to 106. In order to reveal the funda mental mechanism, the unsteady flow around a stationary two-dimensional elliptic airfoil with 16% relative thickness has been simulated using unsteady Reynolds-averaged NavieStokes equations and the 7 Reot transition turbulence model at different angles of attack for flow Reynolds number of 5 x 10^5. The aerodynamic coefficients and the pressure distribution obtained by computation are in good agreement with experimental data, which indicates that the numerical method works well. Through this study, the mechanism of the unconventional aerodynamic characteristics of airfoil is analyzed and discussed based on the computational predictions coupled with the wind tunnel results. It is considered that the boundary layer transition at the leading edge and the unsteady flow separation vortices at the trailing edge are the causes of the case. Furthermore, a valuable insight into the physics of how the flow behavior affects the elliptic airfoil＇s aerodynamics is provided.

关键词： Aerodynamic characteristicsBoundary layer transition Elliptic aerofoil section Flow separation Numerical analysis

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Discovery of a ~1.37 Ga Granite in the Eastern Part of the Northern Margin of the North China Craton and its Geological Significance

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Acta Geologica Sinica(English Edition) 2020年第2期94卷 563-564页

作者： WEN Kai sun Guosheng LIU zhenghong XU Zhongyuan LI Pengchuan College of Earth Sciences Jilin UniversityChangchun 130061JilinChina

Diabase sills with baddeleyite/zircon U-Pb ages of-1.32 Ga have been found in many areas of the North China Craton(NCC)(Peng,2015).Some researchers have proposed that this magmatic event should be related to the breakup of the Columbia supercontinent.A few studies have reported this period of granitoids only to be present in the Shangdu,*** Sonid Zuoqi areas(Zhang et al.,2012;sun *** et al..2018).This study concerns the first discovery of a-1.37 Ga granite in the southern Jilin Province,in the eastern part of the northern margin of the *** has great significance for the study of the breakup of the Colombia supercontinent,the magmatism of the NCC,and the relationship between the supercontinent and other continents during this period.

关键词： Eastern continent Craton

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关于林格曼测烟黑度计测量方法的讨论

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计量与测试技术 2022年第8期49卷 13-14,18页

作者：周宇雷霆徐建陈柄洪杨国林孙正洪成都市计量检定测试院贵阳新天光电科技有限公司

本文针对目前不同方法在林格曼测烟黑度计黑度值的测量过程中存在的问题进行了讨论,为统一林格曼测烟黑度计校准方法提供了方向。

关键词：林格曼测烟黑度计黑度值校准方法

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Modulation of the DNA repair system and ATR-p53 mediated apoptosis is relevant for tributyltin-induced genotoxic effects in human hepatoma G2 cells

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Journal of Environmental Sciences 2015年第1期27卷 108-114页

作者： Bowen Li Lingbin sun Jiali Cai Chonggang Wang Mengmeng Wang Huiling Qiu zhenghong Zuo State Key Laboratory of Cellular Stress Biology School of Life Sciences Xiamen University Department of Gynaecology The Affiliated Chenggong Hospital of Xiamen University

The toxic effects of tributyltin（TBT） have been extensively documented in several types of cells, but the molecular mechanisms related to the genotoxic effects of TBT have still not been fully elucidated. Our study showed that exposure of human hepatoma G2 cells to 1–4 μmol/L TBT for 3 hr caused severe DNA damage in a concentration-dependent manner. Moreover, the expression levels of key DNA damage sensor genes such as the replication factor C, proliferating cell nuclear antigen and poly（ADP-ribose）polymerase-1 were inhabited in a concentration-dependent manner. We further demonstrated that TBT induced cell apoptosis via the p53-mediated pathway, which was most likely activated by the ataxia telangiectasia mutated and rad-3 related（ATR）protein kinase. The results also showed that cytochrome c, caspase-3, caspase-8,caspase-9, and the B-cell lymphoma 2 were involved in this process. Taken together, we demonstrated for the first time that the inhibition of the DNA repair system might be more responsible for TBT-induced genotoxic effects in cells. Then the generated DNA damage induced by TBT initiated ATR-p53-mediated apoptosis.

关键词： Tributyltin DNA damage DNA repair Rad-3 related(ATR) protein kinase Apoptosis

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Cloning and Characterization of the Phytoene Desaturase(pds) Gene-a Key Enzyme for Carotenoids Synthesis in Dunaliella(Chlorophyta)

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Journal of Ocean University of China 2008年第3期7卷 311-318页

作者： sun Guohua SUI zhenghong ZHANG Xuecheng Marine Fisheries Research Institute of Shandong Province Yantai 264006 P. R. China Lab of Algae Biotechnology College of Marine Life Sciences Ocean University of China Qingdao 266003 P. R. China

The unicellular green alga Dunaliella is outstanding for its ability of massive accumulation of carotenoids. To elucidate the carotenoids synthesis pathway in this alga,phytoene desaturase(pds) gene cDNA together with its DNA sequences were isolated and their structures and functions analyzed. The full-length pds cDNA of 2290 bp(GenBank Accession No. DQ243892) was de-duced from RACE results,including untranslated 21 bp 5'-and 520 bp 3'-flanking regions and an open reading frame of 582 amino acids,coding a protein of 64.196 kDa. The DNA sequence of 2908 bp(GenBank Accession No. DQ845248) including five introns was obtained. The fifth intron was uncompleted and complex,including two bases' perfect repeats(GT) 10 and large different-sized repeats within the last 400 bp. The Southern blot hybridization result demonstrated that this gene occurred as a single copy in this species,and the quantitative RT-PCR result showed that the transcription of this gene was constitutive. The evolutional significance of pds was discussed.

关键词： carotenoids cDNA Dunaliella salina phytoene desaturase

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