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Aerodynamic/stealth design of S-duct inlet based on discrete adjoint method

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 725-746页

作者： Jun DENG Ke ZHAO Lin ZHOU Wei ZHANG Bowen SHU Jiangtao HUANG zhenghong GAO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Aerospace Technology Institute of China Aerodynamic Research and Development CenterMianyang 621000Sichuan ProvinceChina

It is a major challenge for the airframe-inlet design of modern combat aircrafts,as the flow and electromagnetic wave propagation in the inlet of stealth aircraft are very *** this study,an aerodynamic/stealth optimization design method for an S-duct inlet is *** upwind scheme is introduced to the aerodynamic adjoint equation to resolve the shock wave and flow *** multilevel fast multipole algorithm(MLFMA)is utilized for the stealth adjoint equation.A dorsal S-duct inlet of flying wing layout is optimized to improve the aerodynamic and stealth *** the aerodynamic and stealth characteristics of the inlet are effectively ***,the optimization results are analyzed,and it shows that the main contradiction between aerodynamic characteristics and stealth characteristics is the centerline and crosssectional *** S-duct is smoothed,and the cross-sectional area is increased to improve the aerodynamic characteristics,while it is completely opposite for the stealth *** radar cross section(RCS)is reduced by phase cancelation for low frequency *** method is suitable for the aerodynamic/stealth design of the aircraft airframe-inlet system.

关键词： S-duct inlet aerodynamic/stealth optimization design discrete adjoint upwind scheme multilevel fast multipole algorithm(MLFMA)

Long-term exposure to aryl hydrocarbon receptor agonist neburon induces reproductive toxicity in male zebrafish(Danio rerio)

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Journal of Environmental Sciences 2024年第8期142卷 193-203页

作者： Fucong Zhang Chen Tang Yue Zhu Qian Wang Xin Huang Chunyan Yang Chengyong He zhenghong Zuo Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems School of Life SciencesXiamen UniversityXiamen 361102China

Neburon is a phenylurea herbicide that is widely used worldwide,but its toxicity is poorly *** our previous study,we found that neburon has strong aryl hydrocarbon receptor(AhR)agonist activity,but whether it causes reproductive toxicity is not *** the present study,zebrafish were conducted as a model organism to evaluate whether environmental concentrations of neburon(0.1,1 and 10μg/L)induce reproductive disorder in *** exposure to neburon for 150 days from embryo to adult,that the average spawning egg number in high concentration group was 106.40,which was significantly lower than 193.00in control *** result was mainly due to the abnormal male reproductive behavior caused by abnormal transcription of genes associated with reproductive behavior in the brain,such as *** proportions of spermatozoa in the medium and high concentration groups were 82.40%and 83.84%,respectively,which were significantly lower than 89.45%in control *** result was mainly caused by hormonal disturbances and an increased proportion of apoptotic *** hormonal disruption was due to the significant changes in the transcription levels of key genes in the hypothalamus-pituitary-gonadal axis following neburon *** treatment also significantly activated the AhR signaling pathway,causing oxidative stress damage and eventually leading to a significant increase in apoptosis in the exposed ***,these data filled the currently more vacant profile of neburon toxicity and might provide information to assess the ecotoxicity of neburon on male reproduction at environmentally relevant concentrations.

关键词： Zebrafish Neburon Male reproductive toxicity HPG axis AhR agonist

Black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

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Journal of Environmental Sciences 2024年第3期137卷 53-64页

作者： Chao Shen Xiaoyan Ding Jinpeng Ruan Fengkai Ruan Weiping Hu Jiyi Huang Chengyong He Yi Yu zhenghong Zuo Department of Nephrology State Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesFujian Clinical Research Center for Chronic Glomerular DiseaseThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China

As an ultrasmall derivative of black phosphorus(BP)sheets,BP quantum dots(BP-QDs)have been effectively used in many ***,information on the cardiotoxicity induced by BP-QDs remains *** aimed to evaluate BP-QD-induced cardiac toxicity in *** examination of heart tissue sections was *** sequencing,real-time quantitative PCR(RT–qPCR),western blotting,and enzyme-linked immunosorbent assay(ELISA)assays were used to detect the m RNA and/or protein expression of proinfammatory cytokines,nuclear factor kappa B(NF-κB),phosphatidylinositol3 kinase-protein kinase B(PI3K-AKT),peroxisome proliferator-activated receptor gamma(PPARγ),and glucose/lipid metabolism pathway-related *** found that heart weight and heart/body weight index(HBI)were significantly reduced in mice after intragastric administration of 0.1 or 1 mg/kg BP-QDs for 28 *** addition,obvious infammatory cell infiltration and increased cardiomyocyte diameter were observed in the BP-QD-treated *** expression of proinfammatory cytokines and genes related to the NF-κB signaling pathway further confirmed that BP-QD exposure induced infammatory *** addition,BP-QD treatment also affected the PI3K-AKT,PPARγ,thermogenesis,oxidative phosphorylation,and cardiac muscle contraction signaling *** expression of genes related to glucose/lipid metabolism signaling pathways was dramatically affected by BP-QD exposure,and the effect was primarily mediated by the PPAR signaling *** study provides new insights into the toxicity of BP-QDs to human health.

关键词： BP-QDs Cardiac toxicity Infammatory responses NF-κB signaling pathway PPARγsignaling pathway Glucose/lipid metabolism

Insights and reviews on battery lifetime prediction from research to practice

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Journal of Energy Chemistry 2024年第7期94卷 716-739页

作者： Xudong Qu Dapai Shi Jingyuan Zhao Manh-Kien Tran zhenghong Wang Michael Fowler Yubo Lian Andrew FBurke Hubei Longzhong Laboratory Hubei University of Arts and ScienceXiangyang 441000HubeiChina Institute of Transportation Studies University of California DavisDavisCA 95616USA Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada BYD Automotive Engineering Research Institute Shenzhen 518118GuangdongChina

The rising demand for energy storage solutions,especially in the electric vehicle and renewable energy sectors,highlights the importance of accurately predicting battery health to enhance their longevity and *** article comprehensively examines various methods used to forecast battery health,including physics-based models,empirical models,and equivalent circuit models,among *** delves into the promise of data-driven prognostics,utilizing both conventional machine learning and cuttingedge deep neural network *** advantages and limitations of hybrid models are thoroughly analyzed,with a focus on the benefits of integrating diverse data sources to improve prognostic *** practical case studies,the article showcases the effectiveness and flexibility of these *** also critically addresses the challenges encountered in applying battery health prognostics in realworld scenarios,such as issues of scalability,complexity,and data *** these challenges,the article underscores the emerging opportunities brought about by recent technological,academic,and research *** include the development of digital twin models for batteries,the use of data-centric AI and standardized benchmarking,the potential integration of blockchain technology for enhanced data security and transparency,and the synergy between edge and cloud computing to boost data analysis and *** primary goal of this article is to enrich the understanding of current battery health prognostic techniques and to inspire further research aimed at overcoming existing hurdles and tapping into new *** concludes with a visionary perspective on future research directions and potential developments in this evolving field,encouraging both researchers and practitioners to explore innovative solutions.

关键词： Batteries Lifetime Health Machine learning Deep learning Field Real world

Combination of High Yield Strength and Improved Ductility of 21Cr Lean Duplex Stainless Steel by Tailoring Cold Deformation and Low-Temperature Short-Term Aging

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 695-702页

作者： zhenghong Liu Zhigang Wu Ying Han Xiaolei Song Guoqing Zu Weiwei Zhu Xu Ran Key Laboratory of Advanced Structural Materials Ministry of EducationChangchun University of TechnologyChangchun130012China School of Materials Science and Engineering Changchun University of TechnologyChangchun130012China Jilin Province Key Laboratory of Advanced Materials Processing and Application for Rail Transit Changchun University of TechnologyChangchun130012China

Proper matching of cold-rolled deformation and low-temperature short-term aging can simultaneously enhance the strength and ductility of the lean duplex stainless steel. To investigate this, the microstructure evolution of cold-rolled and aging steels was observed by using scanning electron microscopy, transmission electron microscopy and electron backscattered diffraction. Additionally, the phase volume fraction was measured using X-ray diffraction. In this study, it was observed that the elongation of 21Cr lean duplex stainless steel significantly increased to 16.7% after undergoing moderate cold deformation (~ 40% reduction) and subsequent aging treatment at 550 ℃ for 30 min. Remarkably, the material still maintained a high yield strength of 1045 MPa. Such an excellent mechanical property was attributed to a unique microstructure combination of fine α'-martensite, twins, coarsened austenite resulting from partial martensite reverse transformation, and two-phase fine layered structure. The result of this study may open up new horizons for the alloy development in order to overcome the low ductility of cold-rolled high-strength lean duplex stainless steel.

关键词： Lean duplex stainless steel Cold rolling Aging Microstructure Mechanical properties Use our pre-submission checklist

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

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Bone Research 2024年第2期12卷 421-437页

作者： Hongzhen Chen Xuekun Fu Xiaohao Wu Junyi Zhao Fang Qiu zhenghong Wang Zhuqian Wang Xinxin Chen Duoli Xie Jie Huang Junyu Fan Xu Yang Yi Song Jie Li Dongyi He Guozhi Xiao Aiping Lu Chao Liang Department of Systems Biology School of Life SciencesSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Institute of Integrated Bioinfomedicine and Translational Science(IBTS) School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Division of Immunology and Rheumatology Stanford UniversityStanfordCA 94305USA VA Palo Alto Health Care System Palo AltoCA 94304USA Institute of Plant and Food Science Department of BiologySouthern University of Science and TechnologyShenzhen 518055China Department of Rheumatology Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Computational Biology St.Jude Children’s Research HospitalMemphisTNUSA Department of Laboratory Medicine Peking University Shenzhen HospitalShenzhenChina Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou 510006China Shanghai University of Traditional Chinese Medicine Shanghai 200032China State Key Laboratory of Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of Lifeomics100850 BeijingChina

Rheumatoid arthritis(RA)is an autoimmune *** studies hold an opinion that gut microbiota is environmentally acquired and associated with RA ***,accumulating evidence demonstrates that genetics also shape the gut *** is known that some strains of inbred laboratory mice are highly susceptible to collagen-induced arthritis(CIA),while the others are resistant to ***,we show that transplantation of fecal microbiota of CIA-resistant C57BL/6J mice to CIA-susceptible DBA/1J mice confer CIA resistance in DBA/1J mice.C57BL/6J mice and healthy human individuals have enriched *** than DBA/1J mice and RA *** of *** prevents CIA in DBA/1J *** identify that *** mainly produces propionate and C57BL/6J mice and healthy human individuals have higher level of ***-like synoviocytes(FLSs)in RA are activated to undergo tumor-like *** disrupts HDAC3-FOXK1 interaction to increase acetylation of FOXK1,resulting in reduced FOXK1 stability,blocked interferon signaling and deactivation of *** treat CIA mice with propionate and show that propionate attenuates ***,a combination of propionate with anti-TNF etanercept synergistically relieves *** results suggest that *** or propionate could be an alternative or complementary approach to the current therapies.

关键词： HDAC3 cytes interferon

无参数自适应罚函数的高效代理模型优化设计方法

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北京航空航天大学学报 2024年第4期50卷 1262-1272页

作者：张伟高正红王超夏露西北工业大学航空学院西安710072 西北工业大学翼型、叶栅空气动力学国家级重点实验室西安710072 北京电子工程总体研究所北京100854

在飞行器气动外形优化设计中,复杂约束条件导致设计空间可行域呈现不连续的特征,且理想解大多靠近约束边界,传统高效代理模型方法难以适用。研究了参考点对优化设计的影响,提出了一种考虑约束的参考点选择机制;对于最优解靠近边界的问题... 详细信息

在飞行器气动外形优化设计中,复杂约束条件导致设计空间可行域呈现不连续的特征,且理想解大多靠近约束边界,传统高效代理模型方法难以适用。研究了参考点对优化设计的影响,提出了一种考虑约束的参考点选择机制;对于最优解靠近边界的问题,罚函数法更加有效,但惩罚因子的设置对于罚函数方法影响很大,不合适的惩罚因子反而会损害优化效率,分析了优化过程中罚函数方法对惩罚因子的要求,提出了一种无参数自适应罚函数的代理模优化设计方法,引入基于样本分析的惩罚项,结合归一化目标值和约束值,在优化过程中动态调整惩罚因子,使优化能够尽可能地聚焦于可行域内,迅速收敛到最优解,实现样本的高效配置。通过带约束的函数算例和翼型优化算例证实,所提方法可以大幅提高飞行器气动外形优化设计效率。

关键词：优化设计代理模型参考点气动设计自适应罚函数

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捐赠母乳的临床应用及人乳库发展

中华临床营养杂志 2024年第3期32卷 180-185页

作者：李巾宇李正红中国医学科学院北京协和医学院北京协和医院儿科北京100730 疑难重症及罕见病国家重点实验室北京100730

生命早期1000 d是婴幼儿体格发育和智力发育的关键阶段,是预防成年期慢性疾病的窗口期。这一阶段的营养支持对婴幼儿生长发育和终身健康至关重要。母乳具有独特的营养和免疫活性,是此阶段最理想的食物来源。母乳喂养对儿童健康的短期及... 详细信息

生命早期1000 d是婴幼儿体格发育和智力发育的关键阶段,是预防成年期慢性疾病的窗口期。这一阶段的营养支持对婴幼儿生长发育和终身健康至关重要。母乳具有独特的营养和免疫活性,是此阶段最理想的食物来源。母乳喂养对儿童健康的短期及长期益处已被广泛报道。对于无法获得足够亲母母乳的新生儿,捐赠母乳是提供营养的首选和最佳选择,捐赠母乳对降低新生儿疾病的发病率、死亡率和新生儿监护病房医疗费用有一定作用。处理捐赠母乳的专业机构是人乳库,随着全球人乳库的发展,我国人乳库的建设也在飞速发展。截至2021年,我国已发布关于医疗机构人乳库运营和管理的相关官方标准,也有关于人乳库单位成本或成本分析的相关数据。人乳库的建设对捐赠母乳的临床应用起到了保障、规范和促进作用。目前,我国人乳库建设亟须解决的问题是运营资金不足和捐赠者及捐乳乳量不稳定。为给捐赠母乳和人乳库的发展提供更多的循证医学基础,仍需在捐赠母乳的应用价值、捐赠母乳灭菌方式及资金来源拓展、人乳库运营及成本优化等多方面进一步探索研究。

关键词：母乳母乳喂养捐赠母乳人乳库

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马方综合征临床表型变异机制的研究进展

中华胸心血管外科杂志 2024年第3期40卷 167-171页

作者：李正红胡馗贵州省人民医院心外科贵阳550002 遵义医科大学遵义563000

马方综合征(Marfan syndrome, MFS)是一种由基因突变引起的常染色体显性遗传性结缔组织病, 其致病机制尚未完全阐明。由于MFS临床表型复杂多变且无法预测, 使得轻症或非典型患者的诊断变得困难, 极易出现误诊或漏诊, 延误诊疗。因此, ... 详细信息

马方综合征(Marfan syndrome, MFS)是一种由基因突变引起的常染色体显性遗传性结缔组织病, 其致病机制尚未完全阐明。由于MFS临床表型复杂多变且无法预测, 使得轻症或非典型患者的诊断变得困难, 极易出现误诊或漏诊, 延误诊疗。因此, 明确引起MFS表型变异的机制对轻症及非典型患者诊断、表型的预测、预后的评估具有重要意义。本文针对马方综合征临床表型变异的机制及其研究进展进行综述, 以期指导临床诊疗工作。

关键词：马方综合征临床表型 MFS 变异机制