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Quercetin inhibits truncated isoform of dopamine-and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer

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Food Science and Human Wellness 2024年第5期13卷 2653-2667页

作者： Han-Sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Chih-Hsiung wu You-Cheng Liao Jungshan Chang Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho Department of Biological Science&Technology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Institute of Biochemistry and Molecular Biology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Department of Surgery School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Department of Surgery Taipei Medical University HospitalTaipei 110TaiwanChina Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Institute of Food Sciences and Technology National Taiwan UniversityTaipei 106TaiwanChina

Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2(HER2)-positive(HER2+)breast cancer(BC).The truncated isoform of dopamine-and cAMPregulated phosphoprotein(t-DARPP)has been reported to be involved in trastuzumab therapy resistance and promoting tumor *** evaluate the t-DARPP expression in BC,paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+BC tumor *** established 2 patient-derived xenografts(PDX)mice models to test the efficacy of trastuzumab,named model 1(non-responder)and model 2(responder).t-DARPP and p95-HER2 protein-protein interactions were detected in PDX tumor tissue from non-responders using Förster resonance energy transfer ***,there is no response from the ***,mechanistic studies using transwell and western blot assays demonstrated that t-DARPP could upregulate epithelial-mesenchymal transition signaling proteins,enhance p95-HER2 expression and promote cell *** found that quercetin effectively reduced t-DARPP expression in HER2+BC *** t-DARPP ShRNA-suppressed cells,quercetin synergistically enhanced trastuzumab-induced apoptotic cell death and G2/M phase *** conclusion,the combination of quercetin and trastuzumab treatment by targeting t-DARPP in HER2+BC patients has the potential as a biomarker for mitigating drug resistance.

关键词： p95-Human epidermal growth factor receptor 2 (HER2) HER2-positive breast cancer Quercetin Trastuzumab resistance Truncated isoform of dopamine-and cAMPregulated phosphoprotein

Effects of Sodium Cyclohexyl Sulfamate on Growth and Development of Drosophila melanogaster

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Agricultural Biotechnology 2024年第4期13卷 65-69页

作者： Lei WEI Danni MA Guobao JIANG Jiayu wu Na FENG College of Life Science and Food Engineering Shaanxi Xueqian Normal UniversityXi'an 710100China

[Objectives]This study was conducted to investigate the effects of different concentrations of sodium cyclohexyl sulfamate on the growth and development of Drosophila melanogaster.[Methods]Different concentrations of sodium cyclohexyl sulfamate were added to the culture medium,and the effects of different concentrations of sodium cyclohexyl sulfamate on the development time and weight of *** in various life stages were statistically analyzed.[Results]High concentration of sodium cyclohexyl sulfamate delayed the time of pupation and eclosion of ***,which made *** lose *** number of male *** in the first generation was much larger than that of female individuals,which indicated that the effect of sodium cyclohexyl sulfamate on male *** was greater than that of female *** a word,high concentration of sodium cyclohexyl sulfamate significantly inhibited the growth and development of ***.[Conclusions]This study provides some reference data for the research perspective of food additives and the safe use of sodium cyclohexyl sulfamate.

关键词： Drosophila melanogaster Sodium cyclohexyl sulfamate Pupation Eclosion

Laryngeal leiomyoma:A case report and review of literature

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World Journal of Clinical Cases 2024年第18期12卷 3529-3533页

作者： Yu wu Jing-Man Li Tian-Jiao Zhang Xin Wang Department of Otolaryngology Head and Neck SurgeryThe First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Leiomyomas(LMs)are mesenchymal tumors that arise from smooth muscle *** most commonly arise in organs with an abundance of smooth muscle such as the uterus and gastrointestinal ***,LMs are rarely detected in the head and neck *** this study,we report a rare case of laryngeal LM(LLM)and summarized the clinical characteristics of reported LLMs to help clinicians better understand this rare disease and improve its diagnosis,treatment,and postoperative *** SUMMARY A 49-year-old man was admitted to our ENT outpatient clinic with a chief complaint of pharynx discomfort for 2 *** performed under topical anesthesia revealed a solitary,pink mass at the tubercle of *** via laryngeal endoscopy was performed under general anesthesia,and the lesion was excised *** immunohistochemical staining for desmin and smooth-muscle actin indicated a smooth muscle origin and the diagnosis was laryngeal *** surgery,the patient’s condition was stable,and he was discharged 2 d after *** the 1-year postoperative period,the patient’s condition remained stable without evidence of *** Surgical resection is the preferred treatment for LLMs,its early diagnosis and differential diagnosis have important clinical significance.

关键词： Leiomyoma Larynx Smooth tumor Endoscopic surgery Case report

基于EEMD-WPT的温室环境数据优化处理研究

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华南农业大学学报 2024年第3期45卷 397-407页

作者：吴伟斌杨柳吴维浩吴贤楠沈梓颖张方任罗远强华南农业大学工程学院广东广州510642 南方农业机械与装备关键技术教育部重点研究室/国家柑橘产业体系机械化研究室/广东省山地果园机械创新工程技术研究中心广东广州510642

【目的】解决温室系统中的数据采集传感器容易受到多种环境因素的干扰,从而导致数据中存在噪声的问题。【方法】提出一种集合经验模态分解(Ensemble empirical mode decomposition,EEMD)与小波包自适应阈值(Wavelet packet adaptive thr... 详细信息

【目的】解决温室系统中的数据采集传感器容易受到多种环境因素的干扰,从而导致数据中存在噪声的问题。【方法】提出一种集合经验模态分解(Ensemble empirical mode decomposition,EEMD)与小波包自适应阈值(Wavelet packet adaptive threshold,WPT)算法联合的数据降噪处理方法,并采用卡尔曼滤波与自适应加权平均算法对降噪后的数据进行融合。【结果】将EEMD-WPT算法应用于含噪温、湿度数据的降噪处理,相较于降噪前的数据,信噪比提升了73.08%。该算法相较于传统WPT算法具有更好的降噪效果,处理后的数据信噪比提升了40.31%,均方根误差降低了84.75%。【结论】该算法能解决数据跳动、冗余和丢失等问题,并为温室控制系统提供了有效的参数,具有较大的实际应用价值。

关键词： EEMD 小波包自适应阈值降噪温室数据融合

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Review of artificial intelligence applications in astronomical data processing

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Astronomical Techniques and Instruments 2024年第1期1卷 1-15页

作者： Hailong Zhang Jie Wang Yazhou Zhang Xu Du Han wu Ting Zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China

Artificial Intelligence(AI)is an interdisciplinary research field with widespread *** aims at developing theoretical,methodological,technological,and applied systems that simulate,enhance,and assist human ***,notable accomplishments of artificial intelligence technology have been achieved in astronomical data processing,establishing this technology as central to numerous astronomical research areas such as radio astronomy,stellar and galactic(Milky Way)studies,exoplanets surveys,cosmology,and solar *** article systematically reviews representative applications of artificial intelligence technology to astronomical data processing,with comprehensive description of specific cases:pulsar candidate identification,fast radio burst detection,gravitational wave detection,spectral classification,and radio frequency interference ***,it discusses possible future applications to provide perspectives for astronomical research in the artificial intelligence era.

关键词： Astronomical techniques Astronomical methods Astroinformatics

A new ChatGPT-empowered,easy-to-use machine learning paradigm for environmental science

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Eco-Environment & Health 2024年第2期3卷 131-136页

作者： Haoyuan An Xiangyu Li Yuming Huang Weichao Wang Yuehan wu Lin Liu Weibo Ling Wei Li Hanzhu Zhao Dawei Lu Qian Liu Guibin Jiang State Key Laboratory of Environmental Chemistry and Toxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Biomedical Engineering Institute School of Control Science and EngineeringShandong UniversityJinan 250061China

The quantity and complexity of environmental data show exponential growth in recent ***-quality big data analysis is critical for performing a sophisticated characterization of the complex network of environmental *** learning(ML)has been employed as a powerful tool for decoupling the complexities of environmental big data based on its remarkable fitting ***,due to the knowledge gap across different subjects,ML concepts and algorithms have not been well-popularized among researchers in environmental *** this context,we introduce a new research paradigm—“ChatGPT t ML t Environment”,providing an unprecedented chance for environmental researchers to reduce the difficulty of using ML *** instance,each step involved in applying ML models to environmental sustainability,including data preparation,model selection and construction,model training and evaluation,and hyper-parameter optimization,can be easily performed with guidance from *** also discuss the challenges and limitations of using this research paradigm in the field of environmental ***,we highlight the importance of“secondary training”for future application of“ChatGPT t ML t Environment”.

关键词： Machine learning Environmental application ChatGPT Secondary training

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis ina Temporal Manner

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Research 2024年第1期2023卷 33-48页

作者： Fangqian Wang Yuxiao Ye Zengjie Zhang Wangsiyuan Teng Hangxiang Sun Xupeng Chai Xingzhi Zhou Jiayu Chen Haochen Mou Yinwang Eloy Xiaoqiang Jin Liang Chen Zhenxuan Shao Yan wu Yue Shen An Liu Peng Lin Jianwei Wang Xiaohua Yu Zhaoming Ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejang University School of MedicineHangzhou CityZhejiang ProvincePR China Orthopedics Research Institute of Zhejang University Hangzhou CityZhejiang ProvincePR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou CityZhejiang ProvincePR China School of Material Science and Engineering University of New South WalesSydney 2052Australia

Platelet-derived growth factor-BB(PDGF-BB)/platelet-derived growth factor receptor-β(PDGFR-β)pathway is conventionally considered as an important pathway to promote osteogenesis;however,recent study suggested its role during osteogenesis to be *** the differential functions of this pathway during 3 stages of bone healing,we hypothesized that temporal inhibition of PDGF-BB/PDGFR-βpathway could shift the proliferation/differentiation balance of skeletal stem and progenitor cells,toward osteogenic lineage,which leads to improved bone *** first validated that inhibition of PDGFR-βat late stage of osteogenic induction effectively enhanced differentiation toward *** effect was also replicated invivo by showing accelerated bone formation when block PDGFR-βpathway at late stage of critical bone defect healing mediated using ***,we found that such PDGFR-βinhibitor-initiated bone healing was also effective in the absence of scaffold implantation when administrated ***,timely inhibition of PDGFR-βblocked extracellular regulated protein kinase 1/2 pathway,which shift proliferation/differentiation balance of skeletal stem and progenitor cell to osteogenic lineage by upregulating osteogenesis-related products of Smad to induce *** study offered updated understanding of the use of PDGFR-βpathway and provides new insight routes of action and novel therapeutic methods in the field of bone repair.

关键词： healing sized implantation

Assessment of Meteorological Threats to the Coordinated Search and Rescue of Unmanned/Manned Aircraft

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Meteorological and Environmental Research 2024年第1期15卷 27-29,37页

作者： Fei YAN Chuan LI Xiaoyi FU Kefeng wu Yuying LI Civil Aviation Flight University of China Guanghan 618307China Nanjing University of Aeronautics and Astronautics Nanjing 211106China

The architecture and working principle of coordinated search and rescue system of unmanned/manned aircraft,which is composed of manned/unmanned aircraft and manned aircraft,were first introduced,and they can cooperate with each other to complete a search and rescue ***,a threat assessment method based on meteorological data was proposed,and potential meteorological threats,such as storms and rainfall,can be predicted by collecting and analyzing meteorological ***,an experiment was carried out to evaluate the performance of the proposed method in different *** experimental results show that the coordinated search and rescue system of unmanned/manned aircraft can be used to effectively assess meteorological threats and provide accurate search and rescue guidance.

关键词： Unmanned/manned aircraft Coordinated search and rescue Assessment of meteorological threats Meteorological data

Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology

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Chinese Chemical Letters 2024年第5期35卷 13-16页

作者： Weiwei He Hongbo Zhang Xudong Lin Lili Zhu Tingting Zheng Hao Pei Yang Tian Min Zhang Guoyue Shi Lei wu Jianlong Zhao Gulinuer wumaier Shengqing Li Yufang Xu Honglin Li Xuhong Qian Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China Department of Pulmonary and Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

This review explores the concept of life-on-a-chip,which involves the creation of miniaturized biological systems,such as organs,tissues,and model organisms,on microscale platforms called microfluidic *** chips consist of intricately etched channels,wells,and chambers that enable precise control and observation of fluids,cells,and biochemical reactions,facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli,drugs,or disease *** review highlights the application of a novel technology,“Beyond Limit Manufacturing”(BLM),in the development of sophisticated three-dimensional cell models and model organism ***-on-a-chip and organ-on-a-chip(OoC)are among the thriving developments in the field of microfluidics,allowing for the reconstruction of living microenvironments and implementation of multiple *** review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions,emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.

关键词： Beyond Limit Manufacturing Model-organism-on-a-chip Organ-on-a-chip