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Subdiaphragmatic abscess caused by the recently identifi ed pathogen Cutibacterium modestum: a case report

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World Journal of Emergency Medicine 2024年第5期15卷 422-424页

作者： Lian Liang Ni Tan Mingbin Feng Xiaolin Xu Zuyong Li Xiaoxing Tan Tangchun Liu Nengtai Ouyang Yin Zhang zhengfei yang Department of Emergency Medicine Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Cellular&Molecular Diagnostics Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Biliary-Pancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Ultrasound Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Subdiaphragmatic abscess is uncommon in patients who undergo resection for hepatocellular *** identifi cation of pathogens and appropriate treatment can be challenging.[1]Herein,we present a case of subdiaphragmatic abscess caused by Cutibacterium modestum.A 66-year-old man was admitted to our hospital with fever,cough,and persistent,dull pain in the right upper quadrant for two *** patient’s medical history included liver cirrhosis,radical resection of hepatocellular carcinoma three months prior to admission,and type 2 diabetes *** examination revealed tachycardia with small moist rales in the right lower *** examination revealed an L-shaped,well-healed surgical incision in the right upper quadrant without intra-abdominal mass or tenderness.

关键词： admitted abscess tachycardia

肠-肺微生物群在免疫系统构建和调节中的重要作用

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中山大学学报（医学科学版） 2024年第2期45卷 171-179页

作者：张萌杨正飞中山大学孙逸仙纪念医院全科医学科广东广州510120 中山大学孙逸仙纪念医院急诊科广东广州510120

微生物与人体免疫系统的互动一直是生物医学研究的焦点。新一代测序发现不仅肠道,呼吸道也存在着微生物群,且肠-肺微生物群之间通过免疫细胞及其活性因子等形成了一个相互关联的网络。本综述旨在探讨肠道和肺部微生物群如何调节免疫应答... 详细信息

微生物与人体免疫系统的互动一直是生物医学研究的焦点。新一代测序发现不仅肠道,呼吸道也存在着微生物群,且肠-肺微生物群之间通过免疫细胞及其活性因子等形成了一个相互关联的网络。本综述旨在探讨肠道和肺部微生物群如何调节免疫应答,包括其在局部和全身免疫调节中的作用;同时,解析肠-肺轴之间的免疫联系,对深入理解微生物在免疫系统的作用及探索新的疾病诊疗策略具有重要临床意义。

关键词：肠道微生物呼吸道微生物肠-肺轴免疫系统免疫应答

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脓毒症中T细胞亚群变化诱导的免疫抑制

临床急诊杂志 2024年第3期25卷 153-158页

作者：张萌杨正飞中山大学孙逸仙纪念医院急诊科广州510120

脓毒症是由创伤、感染等引起的临床急危重综合征,其患病率和死亡率在全球范围内居高不下。随着对脓毒症病理生理机制研究的深入,免疫调节逐渐成为该领域研究热点,而T淋巴细胞是机体免疫状态的关键特征指标,其功能受损和数量锐减是导致... 详细信息

脓毒症是由创伤、感染等引起的临床急危重综合征,其患病率和死亡率在全球范围内居高不下。随着对脓毒症病理生理机制研究的深入,免疫调节逐渐成为该领域研究热点,而T淋巴细胞是机体免疫状态的关键特征指标,其功能受损和数量锐减是导致脓毒症患者后期免疫麻痹甚至死亡的重要因素。本文综述了CD8^(+)、CD4^(+)及调节性T细胞在脓毒症中的变化情况和致病机制,同时分析了各类T细胞抑制性免疫检查点在脓毒症中的分子作用机制,最后阐述了脓毒症免疫治疗的相关研究进展,以期为脓毒症临床监测和治疗提供新的研究靶点和思路。

关键词：脓毒症免疫抑制 T淋巴细胞抑制性免疫检查点免疫治疗

新PCI生物测量仪的重复性、再现性和一致性

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中山大学学报（医学科学版） 2024年第3期45卷 484-492页

作者：陈烁烁杨正菲黎紫璇叶桂彤杨晓王梦怡中山大学中山眼科中心眼科学国家重点实验室广东广州510060 暨南大学附属深圳爱尔眼科医院广东深圳518051

【目的】评估基于部分相干干涉测量原理的新型眼生物测量仪Myopia Master用于测量眼轴、角膜曲率的重复性和再现性,比较其与IOL Master 500的一致性。【方法】同一名操作者随机先后顺序使用新型眼球生物测量仪Myopia Master和IOL Master... 详细信息

【目的】评估基于部分相干干涉测量原理的新型眼生物测量仪Myopia Master用于测量眼轴、角膜曲率的重复性和再现性,比较其与IOL Master 500的一致性。【方法】同一名操作者随机先后顺序使用新型眼球生物测量仪Myopia Master和IOL Master 500采集屈光不正儿童右眼数据,以评估两仪器间一致性。其中部分儿童接受了My-opia Master重复性、再现性评估。数据包括眼轴(AL)、平坦角膜曲率(Kf)、陡峭角膜曲率(Ks)、平均角膜曲率(Km)、J0、J45。【结果】136人纳入一致性研究,其中58人纳入重复性和再现性研究。Myopia Master在AL测量中显示出高重复性、再现性(重复性Sw=0.02 mm,ICC=0.999;再现性Sw=0.04 mm,ICC=0.998),在角膜曲率测量显示中等的重复性[Sw范围:(0.04~0.12)D,ICC:(0.861~0.991)]和再现性[Sw范围:(0.06~0.20)D,ICC范围:(0.835~0.992)]。Myo-pia Master与IOL Master 500测量平均差异为AL(-0.01±0.04)mm、Kf(-0.09±0.15)D、Ks(-0.47±0.40)D、Km(-0.28±0.23)D、J0(0.18±0.20)D和J45(-0.01±0.12)D。【结论】在儿童近视筛查中AL和角膜曲率测量中显示出高重复性和再现性,但临床上AL和角膜曲率在Myopia Master和IOL Master 500之间不可互换使用。

关键词：部分相干干涉眼轴长度角膜曲率重复性再现性一致性

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粮食中玉米赤霉烯酮含量测定的前处理方法优化

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粮食科技与经济 2024年第2期49卷 101-104页

作者：唐陵辉杨振飞永州市食品质量安全监督检测检验中心湖南永州425000

优化GB 5009.209—2016高效液相色谱法前处理过程,建立新的粮食中玉米赤霉烯酮含量的高效液相色谱测定方法。样品经乙腈-水(V_(乙腈):V_(水)=4∶1)调速振荡器提取,免疫亲和柱富集净化,甲醇洗脱后,直接用水稀释定量至2.00 mL,采用C_(18)... 详细信息

优化GB 5009.209—2016高效液相色谱法前处理过程,建立新的粮食中玉米赤霉烯酮含量的高效液相色谱测定方法。样品经乙腈-水(V_(乙腈):V_(水)=4∶1)调速振荡器提取,免疫亲和柱富集净化,甲醇洗脱后,直接用水稀释定量至2.00 mL,采用C_(18)反相色谱柱(150 mm×4.6 mm,5.0μm),在10~500 ng/mL的质量浓度范围内线性关系良好,其相关系数R^(2)为0.999,检出限(LOD)和定量限(LOQ)分别为3.8μg/kg、12.8μg/kg,3个浓度水平加标回收率为94.3%~106.3%,精密度为0.8%~6.1%,连续4天的基质加标回收率为96.7%~104.8%,日间精密度为0.8%~4.3%,高效液相色谱可以很好地对粮食中玉米赤霉烯酮进行快速准确定量分析。经验证该方法与国标方法检测结果无显著性差异。与国标相比,尤其是本方法通过去除氮吹、省去流动相复溶步骤可实现快速、简便、批量检测,提高了工作效率。

关键词：粮食玉米赤霉烯酮高效液相色谱免疫亲和柱前处理

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混合式教学在食品生物技术课程中的探索

食品工业 2024年第1期45卷 154-157页

作者：朱江煜燕志杨正飞尹永祺方维明扬州大学食品科学与工程学院扬州225000 江苏省苏州技师学院苏州215000

随着信息技术的快速发展和教育模式的变革,混合式教学模式在高等教育中得到广泛的应用。以食品生物技术课程为例,探讨混合式教学模式在该课程中的应用效果和影响因素。混合式教学模式能够提高学生的学习成绩、学习动机和学习满意度。然... 详细信息

随着信息技术的快速发展和教育模式的变革,混合式教学模式在高等教育中得到广泛的应用。以食品生物技术课程为例,探讨混合式教学模式在该课程中的应用效果和影响因素。混合式教学模式能够提高学生的学习成绩、学习动机和学习满意度。然而,混合式教学模式在实践操作和实验训练方面仍存在一定的挑战,需要进一步改进和优化。文章对混合式教学在食品生物技术课程中的应用提出改进和优化的建议,为教育教学实践提供一定的参考和借鉴。

关键词：混合式教学食品生物技术学习成绩学习动机学习满意度

Instantaneous preparation of gold-carbon dot nanocomposites for on-site SERS identification of pathogens in diverse interfaces

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Photonics Research 2024年第6期12卷 1303-1312页

作者： YANXIAN GUO YE LIU CHAOCAI LUO YUE ZHANG yang LI FEI ZHOU ZHOUYI GUO zhengfei ZHUANG ZHIMING LIU School of Electronic Engineering and Intelligentization Dongguan University of TechnologyDongguan 523808China Department of Physics University of Science and Technology of ChinaHefei 230026China MOE Key Laboratory of Laser Life Science&Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Rapid detection of pathogens present on contaminated surfaces is crucial for food safety and public health due to the high morbidity and mortality of bacterial ***,a sensitive and efficient method for on-site identification of foodborne pathogens on anisotropic surfaces was developed by using an in situ instantaneously prepared surface-enhanced Raman scattering(SERS)*** achieve this,molybdenum-doped gallic acidderived carbon dots(MCDs)are utilized as the reductant for synthesizing Au@MCDs nanohybrids within just 3 s at ambient *** synergistic effect of the electromagnetic enhancement and charge transfer of Au@MCDs enables excellent SERS performance 10 times stronger than bare Au *** bioassay platform requires less than 5 min to complete the quantitative detection of foodborne pathogens on various microbial-contaminated interfaces with a sensitivity of 10 CFU/m *** innovative strategy breaks the long-standing limitations of SERS substrates in practical use,such as the time-consuming process,interference of residual surfactants,poor surface stability,and few application scenarios,providing a promising tool for widespread applications in biomedical research and clinical diagnostics.

关键词： temperature molybdenum consuming

Transcriptional landscapes of de novo root regeneration from detached Arabidopsis leaves revealed by time-lapse and single-cell RNA sequencing analyses

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Plant Communications 2022年第4期3卷 83-104页

作者： Wu Liu Yuyun Zhang Xing Fang Sorrel Tran Ning Zhai zhengfei yang Fu Guo Lyuqin Chen Jie Yu Madalene SIson Teng Zhang Lijun Sun Hongwu Bian Yijing Zhang Li yang Lin Xu National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of Sciences300 Fenglin RoadShanghai 200032China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing100049China Department of Plant Pathology University of GeorgiaAthensGA 30602USA College of Life Sciences Shanghai Normal UniversityShanghai 200234China Hainan Institute of Zhejiang University Yazhou Bay Science and Technology CitySanya 572025China School of Life Sciences Nantong UniversityNantongChina Institute of Genetic and Regenerative Biology Key Laboratory for Cell and Gene Engineering of Zhejiang ProvinceCollege of Life SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentDepartment of BiochemistryInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China These authors contributed equally to this article Department of Pharmacology and Chemical Biology UPMC Hillman Cancer CenterMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA

Detached Arabidopsis thaliana leaves can regenerate adventitious roots,providing a platformfor studying de novo root regeneration(DNRR).However,the comprehensive transcriptional framework of DNRR remains ***,we provide a high-resolution landscape of transcriptome reprogramming from wound response to root organogenesis in DNRR and show key factors involved in ***-lapse RNA sequencing(RNA-seq)of the entire leaf within 12 h of leaf detachment revealed rapid activation of jasmonate,ethylene,and reactive oxygen species(ROS)pathways in response *** analyses confirmed that ethylene andROSmay serve as wound signals to ***,time-lapse RNA-seq within 5 d of leaf detachment revealed the activation of genes involved in organogenesis,wound-induced regeneration,and resource allocation in the wounded region of detached leaves during adventitious *** studies showed that BLADE-ON-PETIOLE1/2,which control aboveground organs,PLETHORA3/5/7,which control root organogenesis,and ETHYLENE RESPONSE FACTOR115,which controlswound-induced regeneration,are involved in ***,single-cell RNA-seq data revealed gene expression patterns in thewounded region of detached leaves during adventitious ***,our study not only provides transcriptome tools but also reveals key factors involved in DNRR from detached Arabidopsis leaves.

关键词： single-cell RNA-seq time-lapse RNA-seq de novo root regeneration plant regeneration wounding Arabidopsis thaliana

Research Progress and Challenges on Persistent Organic Pollutants in Lakes

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Journal of Earth Science 2024年第2期35卷 729-736页

作者： Wei Guo Xiaoyu Ji zhengfei Yu Hongchen Jiang Xiangyu Guan School of Ocean Sciences China University of GeosciencesBeijing 100083China State Key Lab of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and *** in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,which are constrained and regulated by various physical,chemical and biological *** can affect ecological conditions,chemical properties of water and sedi ments,and biodiversity of the lake ***,it is important to study the sources,migration,transformation,environmental behavior and ecological impacts of POPs in lake *** re view summarizes research progress on detection technologies,diversity and origins,historical records,migration and transformation,distribution patterns,degradation and toxic effects of POPs in *** nally,future directions related to POPs in lakes were summarized.

关键词： persistent organic pollutants(POPs) lakes transformation degradation microbes environment geolgogy