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Computers, Materials & Continua 2024年第6期79卷 4237-4257页

作者： Weiwei Zhang Jiaqiang Li Chao Wang Meng Li Zhi rao College of Computer Science and Technology Zhengzhou University of Light IndustryZhengzhou450001China Technology Research and Development Center Jilin Tobacco Industry Company LimitedChangchun130031China College of Tobacco Science and Engineering Zhengzhou University of Light IndustryZhengzhou450001China Raw Material Department Hongyun Honghe Tobacco(Group)CompanyKunming650202China

In practical engineering,multi-objective optimization often encounters situations where multiple Pareto sets(PS)in the decision space correspond to the same Pareto front(PF)in the objective space,known as Multi-Modal Multi-Objective Optimization Problems(MMOP).Locating multiple equivalent global PSs poses a significant challenge in real-world applications,especially considering the existence of local *** identifying and locating both global and local PSs is a major *** tackle this issue,we introduce an immune-inspired reproduction strategy designed to produce more offspring in less crowded,promising regions and regulate the number of offspring in areas that have been thoroughly *** approach achieves a balanced trade-off between exploration and ***,we present an interval allocation strategy that adaptively assigns fitness levels to each *** strategy ensures a broader survival margin for solutions in their initial stages and progressively amplifies the differences in individual fitness values as the population matures,thus fostering better population ***,we incorporate a multi-population mechanism that precisely manages each subpopulation through the interval allocation strategy,ensuring the preservation of both global and local *** results on 21 test problems,encompassing both global and local PSs,are compared with eight state-of-the-art multimodal multi-objective optimization *** results demonstrate the effectiveness of our proposed algorithm in simultaneously identifying global Pareto sets and locally high-quality PSs.

关键词： Multimodal multi-objective optimization problem local PSs immune-inspired reproduction

Dynamic feedforward control for Mach number in wind tunnel

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Dynamic feedforward control for Mach number in wind tunnel

Detection of a temporal salient object benefits from visual stimulus-specific adaptation in avian midbrain inhibitory nucleus

第40届中国控制会议

作者： Wenshan Yu Ming Zhang zhengzhou rao Zhi Wei Gang Liu College of Intelligent System National University of Defense Technology High Speed Aerodynamic Institute China Aerodynamics Research and Development

To meet the measurement accuracy of drag coefficient required for the large commercial aircraft aerodynamic tests,it is imperative to improve the control accuracy of Mach *** this paper,the Mach number control strategy based on dynamic feedforward control is ***,the theory and stability of the dynamic feedforward control are ***,the Mach number control model consisting of an electro-hydraulic servo,a static pressure control and perturbation subsystems is ***,the dynamic feedforward controller is obtained by using the approximate order-reduced ***,through simulation analysis,the perturbation model is verified,and then the control effects of dynamic feedforward control and feedback control are *** simulation results indicate that the control accuracy of Mach number is greatly improved.

关键词： Intermittent TWT Flow Field Control Perturbation Dynamic Feedforward Control Simulation

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Integrative Zoology 2024年第2期19卷 288-306页

作者： Jiangtao WANG Xiaoping rao Shuman HUANG Zhizhong WANG Xiaoke NIU Minjie ZHU Songwei WANG Li SHI Department of Automation Zhengzhou University School of Electrical EngineeringZhengzhouChina State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanChina Department of Automation Tsinghua UniversityBeijingChina

Food and predators are the most noteworthy objects for the basic survival of wild animals,and both are often deviant in both spatial and temporal domains and quickly attract an animal’s *** stimulus-specific adaptation(SSA)is considered a potential neural basis of salient sound detection in the temporal domain,related research on visual SSA is limited and its relationship with temporal saliency is *** avian nucleus isthmi pars magnocellularis(Imc),which is central to midbrain selective attention network,is an ideal site to investigate the neural correlate of visual SSA and detection of a salient object in the time ***,the constant order paradigm was applied to explore the visual SSA in the Imc of *** results showed that the firing rates of Imc neurons gradually decrease with repetitions of motion in the same direction,but recover when a motion in a deviant direction is presented,implying visual SSA to the direction of a moving ***,enhanced response for an object moving in other directions that were not presented ever in the paradigm is also *** verify the neural mechanism underlying these phenomena,we introduced a neural computation model involving a recoverable synaptic change with a“center-surround”pattern to reproduce the visual SSA and temporal saliency for the moving *** results suggest that the Imc produces visual SSA to motion direction,allowing temporal salient object detection,which may facilitate the detection of the sudden appearance of a predator.

关键词： adaptation attention model pigeon saliency

Sequential neoadjuvant chemotherapy using pegylated liposomal doxorubicin and cyclophosphamide followed by taxanes with complete trastuzumab and pertuzumab treatment for HER2-positive breast cancer: A phase Ⅱ single-arm study

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Chinese Journal of Cancer Research 2024年第1期36卷 55-65页

作者： Yaping Yang Liang Jin Yudong Li Nanyan rao Chang Gong Shunrong Li Jiannan Wu Jinghua Zhao Linxiaoxiao Ding Fengxia Gan Jun Zhang Ruifa Feng Zhenzhen Liu Qiang Liu Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationGuangzhou 510120China Department of Thyroid and Breast Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China Breast and Thyroid Surgery Guilin Medical College Second Affiliated HospitalGuilin 541199China Department of Breast Disease Henan Breast Cancer Centerthe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008China

Objective: Despite cardiotoxicity overlap, the trastuzumab/pertuzumab and anthracycline combination remains crucial due to significant benefits. Pegylated liposomal doxorubicin(PLD), a less cardiotoxic anthracycline, was evaluated for efficacy and cardiac safety when combined with cyclophosphamide and followed by taxanes with trastuzumab/pertuzumab in human epidermal growth factor receptor-2(HER2)-positive early breast cancer(BC).Methods: In this multicenter, phase II study, patients with confirmed HER2-positive early BC received four cycles of PLD(30-35 mg/m^(2)) and cyclophosphamide(600 mg/m^(2)), followed by four cycles of taxanes(docetaxel,90-100 mg/m^(2) or nab-paclitaxel, 260 mg/m^(2)), concomitant with eight cycles of trastuzumab(8 mg/kg loading dose,then 6 mg/kg) and pertuzumab(840 mg loading dose, then 420 mg) every 3 weeks. The primary endpoint was total pathological complete response(tp CR, yp T0/is yp N0). Secondary endpoints included breast p CR(bp CR),objective response rate(ORR), disease control rate, rate of breast-conserving surgery(BCS), and safety(with a focus on cardiotoxicity).Results: Between May 27, 2020 and May 11, 2022, 78 patients were treated with surgery, 42(53.8%) of whom had BCS. After neoadjuvant therapy, 47 [60.3%, 95% confidence interval(95% CI), 48.5%-71.2%] patients achieved tp CR, and 49(62.8%) achieved bp CR. ORRs were 76.9%(95% CI, 66.0%-85.7%) and 93.6%(95% CI,85.7%-97.9%) after 4-cycle and 8-cycle neoadjuvant therapy, respectively. Nine(11.5%) patients experienced asymptomatic left ventricular ejection fraction(LVEF) reductions of ≥10% from baseline, all with a minimum value of >55%. No treatment-related abnormal cardiac function changes were observed in mean N-terminal pro-BNP(NT-pro BNP), troponin I, or high-sensitivity ***: This dual HER2-blockade with sequential polychemotherapy showed promising activity with rapid tumor regression in HER2-positive BC. Importantly, this regimen showed an acceptable safety

关键词： Breast cancer HER2-positive breast cancer dual HER2 blockade neoadjuvant therapy sequential therapy

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2.4m跨声速风洞双转轴控制系统

兵工自动化 2011年第10期30卷 79-80页

作者：饶正周郁文山马永一中国空气动力研究与发展中心高速所四川绵阳622661

由于原双转轴控制系统无法满足风洞试验使用要求,重新研制出采用"工控机+手操器+运动控制卡"控制方案的双转轴机构控制系统。新系统由独立型运动控制卡、伺服驱动器、上位计算机、智能远程手操器构成。分别介绍了控制系统硬件总体方案... 详细信息

由于原双转轴控制系统无法满足风洞试验使用要求,重新研制出采用"工控机+手操器+运动控制卡"控制方案的双转轴机构控制系统。新系统由独立型运动控制卡、伺服驱动器、上位计算机、智能远程手操器构成。分别介绍了控制系统硬件总体方案和双转轴控制系统软件设计。新研制系统可分别在控制间通过上位PC机和在风洞试验段现场通过智能手操器进行精确控制,并已投入风洞型号试验近2年。实际应用结果表明:新系统达到了控制精度要求,在操作便利性及可靠性方面有较大的提升。

关键词：风洞双转轴机构交流伺服电机伺服驱动器智能手操器

基于知识规则的2.4m风洞控制开车参数自动生成专家系统

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兵工自动化 2015年第6期34卷 94-96页

作者：饶正周马永一杨兴锐中国空气动力研究与发展中心高速所四川绵阳622661

针对2.4m风洞控制开车参数往往取决于人工经验、难以准确给定控制参数的问题,开发一种基于知识规则的控制开车参数自动生成专家系统。首先简要介绍了2.4m风洞核心控制系统和专家系统的基本架构,然后详细介绍了开车参数自动生成专家系统... 详细信息

针对2.4m风洞控制开车参数往往取决于人工经验、难以准确给定控制参数的问题,开发一种基于知识规则的控制开车参数自动生成专家系统。首先简要介绍了2.4m风洞核心控制系统和专家系统的基本架构,然后详细介绍了开车参数自动生成专家系统的设计方法。采用C++Builder语言开发了一套软件,实现了2.4m风动主要控制执行机构预置位置参数的自动生成。实际的应用结果表明:该系统具有适应能力强、覆盖范围广、可靠性高等特点。

关键词：风洞控制开车参数自动生成专家系统

Application of Sargassum fusiforme(Harv.)*** in Cigarettes

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Agricultural Biotechnology 2024年第1期13卷 49-50,65页

作者： Juanjuan LI Jing SHAN Xianyan rao Lina MA Weichuan WANG Mingyue ZHAO Youchi HU China Tobacco Guangdong Industrial Co. Ltd.Guangzhou 510385China zhengzhou Tobacco Research Institute of CNTC Zhengzhou 450001China

[Objectives]This study was conducted to investigate the application of Sargassum fusiforme(Harv.)*** cigarettes.[Methods]Tobacco-specific nitrosamines in the smoke of cigarettes added with ethanol extract of *** were determined,and the compounds related to the aroma of *** were identified by flavor-smelling experiment.[Results]With the addition of the ethanol extract of ***,the decrease in the total amount of four tobacco-specific nitrosamines in mainstream cigarette smoke reached 16.42%.The results of the flavor-smelling experiment showed that the aroma of *** might be related to(R)-5,6,7,7A-tetrahydro-4,4,7A-trimethyl-2(4H)-benzofuranone,glycerol,ethyl palmitate,methyl palmitate,ethyl linoleate,methyl(Z,Z,Z)-9,12,15-octadecatrienoate,ethyl(Z,Z,Z)-9,12,15-octadecatrienoate,phytol,and tetradecanoic acid.[Conclusions]The ethanol extract of *** has the potential function of reducing the content of tobacco-specific nitrosamines in smoke and improving the taste of cigarettes.

关键词： Sargassum fusiforme(Harv.)Setch. Tobacco-specific nitrosamines(TSNAs) Flavor smelling

城市老人子代照料者的压力过程机制与社会支持效果——非正式支持与正式支持的双调节作用

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郑州大学学报（哲学社会科学版） 2024年第2期57卷 54-62,143页

作者：李放饶丹沈苏燕南京农业大学公共管理学院江苏南京210095

基于压力过程与社会支持缓冲理论,运用8省份1541份调研数据和结构方程模型,探究非正式支持与正式支持在城市老人子代照料者的客观压力源与主观照料压力之间的调节作用,并从血缘关系和女性视角分别对比不同子代的人群差异。研究发现:老... 详细信息

基于压力过程与社会支持缓冲理论,运用8省份1541份调研数据和结构方程模型,探究非正式支持与正式支持在城市老人子代照料者的客观压力源与主观照料压力之间的调节作用,并从血缘关系和女性视角分别对比不同子代的人群差异。研究发现:老人照料需求、子女照料强度和压力评价之间具有显著的正向关系,社会支持在子女照料强度与照料压力之间存在负向调节作用,且非正式支持的调节作用大于正式支持。在不同子代群体中,儿子更得益于正式支持的作用,女儿和儿媳等女性照料者则更加依赖于非正式支持的调节。未来应从家庭整体视角建立完善的照料需求评估制度,通过树立照料者性别平等意识,提高已有政策利用度和替代性服务获得性等方式缓解照料压力。

关键词：家庭照料者压力源照料压力非正式支持正式支持

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软件逆向工程技术在2.4m风洞核心控制程序研制中的应用

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兵工自动化 2016年第9期35卷 54-56,61页

作者：饶正周易凡金志伟杨兴锐中国空气动力研究与发展中心高速所四川绵阳622661

为解决2.4 m风洞核心控制程序中存在几个没有源代码的C语言执行模块严重制约系统平台升级的问题,采用软件逆向工程技术研制新的替代模块。介绍了模块重新研制的步骤方法、软件调试方案等,给出程序改造后的实际控制曲线。试验数据结果表... 详细信息

为解决2.4 m风洞核心控制程序中存在几个没有源代码的C语言执行模块严重制约系统平台升级的问题,采用软件逆向工程技术研制新的替代模块。介绍了模块重新研制的步骤方法、软件调试方案等,给出程序改造后的实际控制曲线。试验数据结果表明:风洞流场和模型姿态控制精度达到或优于原来系统的指标,并已投入风洞试验实际应用,证明软件研制是成功的。

关键词：风洞控制软件逆向工程控制程序研制