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Long noncoding RNA TARL promotes antibacterial activity and prevents bacterial escape in Miichthys miiuy through suppression of TAK1 downregulation

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Science China(Life Sciences) 2023年第6期66卷 1340-1357页

作者： Weiwei zheng Xing lv Shiying Xin Yuena Sun Tianjun Xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266237China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Shanghai Ocean UniversityMinistry of EducationShanghai201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China

Noncoding RNA(ncRNA)is an important regulatory factor that plays a major role in innate ***,most studies on ncRNA have focused on mammals,resulting in a knowledge gap on nc RNA in lower vertebrates such as teleost *** this study,we identified a new long noncoding RNA(lncRNA),termed TAK1-related lnc RNA(TARL),which can play a positive role in the antibacterial immunity of Miichthys miiuy to Vibrio anguillarum and *** also found a novel micro RNA miR-2188-3p that could target TAK1 and inhibit the host antibacterial response and promote bacterial *** further found that the antibacterial effect inhibited by miR-2188-3p could be reversed with ***,*** and *** are the two most susceptible Gram-negative pathogens of aquaculture fish,and the economic losses caused by these two bacteria are immeasurable every *** study is the first to report on the ability of lnc RNA to prevent the escape of *** and *** in fish through the competing endogenous RNA(ceRNA)*** results not only elucidate the ce RNA mechanism of the lncRNA in antibacterial immune responses but also provide new insights into the impact of lnc RNA on host immunity and bacterial escape.

关键词： lncRNA microRNA ceRNA innate immunity antibacterial

端氨基含量对PA 6非等温结晶动力学的影响

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合成纤维工业 2024年第1期47卷 48-55页

作者：陈亮郑文戴钧明吕汪洋海阳科技(江苏)研究院有限公司江苏泰州225300 浙江省现代纺织技术创新中心浙江绍兴312000 浙江理工大学纺织纤维材料与加工技术国家地方联合工程实验室浙江杭州310018

为探究端氨基含量对聚酰胺6(PA 6)非等温结晶动力学的影响,以端氨基含量分别为57.5,70.7,83.4 mmol/kg的PA 6(相对黏度均为2.8)为研究对象,使用热重分析仪测试PA 6的热稳定性,利用差示扫描量热仪研究不同冷却速率(∅)下PA 6的非等温结晶... 详细信息

为探究端氨基含量对聚酰胺6(PA 6)非等温结晶动力学的影响,以端氨基含量分别为57.5,70.7,83.4 mmol/kg的PA 6(相对黏度均为2.8)为研究对象,使用热重分析仪测试PA 6的热稳定性,利用差示扫描量热仪研究不同冷却速率(∅)下PA 6的非等温结晶过程,通过Jeziorny法和莫志深法修正的Avrami方程对PA 6的非等温结晶动力学进行分析,并运用Kissinger方程计算PA 6的非等温结晶活化能(△E)。结果表明:不同端氨基含量PA 6均具有较高的热稳定性,且随着端氨基含量增加,热稳定性逐渐提高;随着∅的增大,不同端氨基含量PA 6的结晶区间均有向低温区移动的趋势;PA 6晶体以二维片状和三维球晶共存的方式进行生长,且端氨基含量较高的PA 6更倾向于以三维球晶的形式进行生长,端氨基含量的增加对PA 6的结晶过程具有促进作用;莫志深法修正的Avrami方程能很好地描述结晶过程,单位时间内PA 6的结晶度与∅成正比;随着端氨基含量的增加,PA 6非等温结晶活化能增大,结晶过程释放的热量增加,分子链的运动能力增强,结晶速率更大,结晶能力更强。

关键词：聚酰胺6 端氨基含量冷却速率非等温结晶动力学结晶活化能

A Novel Low Air Pressure-Assisted Approach for the Construction of Cells-Decellularized Tendon Scaffold Complex

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Current Medical Science 2022年第3期42卷 569-576页

作者： Xin HUANG zheng-tao lv Peng CHENG An-min CHEN Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective The goal of this study was to develop a decellularized tendon scaffold(DTS)and repopulate it with adipose-derived stem cells(ADSCs)assisted by low air pressure(LP).Methods The porcine superficial flexor tendons were processed into the DTSs using a combination of physical,chemical,and enzymatic *** effectiveness of decellularization was verified by histological analysis and DNA *** properties of the DTSs were evaluated by quantitative analysis of biochemical characterization,porosimetry,in vitro biocompatibility assessment,and biomechanical ***,the ADSCs-DTS complexes were constructed via cell injection assisted by LP or under atmospheric *** differences in cell distribution,biomechanical properties,and the total DNA content were compared by histological analysis,biomechanical testing,and DNA quantification,*** Histological analysis confirmed that no cells or condensed nuclear materials were retained within the DTSs with widened interfibrillar *** decellularization treatment resulted in a significant decrease in the content of DNA and glycosaminoglycans,and a significant increase in the *** DTSs were cytocompatible in vitro and did not show reduced collagen content and inferior biomechanical properties compared with the fresh-frozen *** assistance of LP promoted the broader distribution of cells into the adjacent interfibrillar space and cell proliferation in *** biomechanical properties of the scaffolds were not significantly affected by the recellularization *** A novel LP-assisted approach for the construction of cells-DTS complex was established,which could be a methodological foundation for further bioreactor and in vitro studies.

关键词： tendon decellularization adipose-derived stem cells recellularization low air pressure tissue engineering

Ti-Al反应扩散机制及动力学研究进展(下)

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稀有金属材料与工程 2024年第6期53卷 2067-2082页

作者：张建宇陈亚宇杨国强吕征刘宏基马鹏辉曾洪涛李河宗河北工程大学机械与装备工程学院河北邯郸056038 河北工程大学河北省智能工业装备技术重点实验室河北邯郸056038 河北工程大学材料科学与工程学院河北邯郸056038

通过Ti和Al制备的Ti-Al系金属间化合物及复合材料由于具有优异的物理、化学和力学性能,在航空航天、汽车以及其它领域具有良好的应用前景。这些材料包括TiAl_(3)、γ-TiAl和α_(2)-Ti_(3)Al等金属间化合物,以及Ti/Al、Ti/α_(2)-Ti_(3)A... 详细信息

通过Ti和Al制备的Ti-Al系金属间化合物及复合材料由于具有优异的物理、化学和力学性能,在航空航天、汽车以及其它领域具有良好的应用前景。这些材料包括TiAl_(3)、γ-TiAl和α_(2)-Ti_(3)Al等金属间化合物,以及Ti/Al、Ti/α_(2)-Ti_(3)Al、Ti/γ-TiAl、Ti/TiAl_(3)、Ti/TiAl_(3)/Al和Al/TiAl_(3)等金属-金属或金属-金属间化合物复合材料。在上述材料的制备过程中,会涉及到各种Ti-Al反应扩散过程。因此,对Ti-Al反应扩散机理及动力学的深入理解,有助于合理高效地制备Ti-Al系金属间化合物及复合材料。目前对Ti-Al反应扩散机理及动力学的研究非常广泛,但很多结论仍存在争议。本文(下)部分系统综述了Ti-Al反应扩散动力学的研究现状,并对其未来的研究方向进行了展望。

关键词： Ti-Al 反应扩散动力学固相反应固-液反应

DAO to HANOI via DeSci: AI Paradigm Shifts from AlphaGo to ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2023年第4期10卷 877-897页

作者： Qinghai Miao Wenbo zheng Yisheng lv Min Huang Wenwen Ding Fei-Yue Wang School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China School of Computer Science and Artificial Intelligence Wuhan University of TechnologyWuhan 430070China Institute of Automation Chinese Academy of SciencesBeijing 100190China Institute of System Engineering Macao University of Science and TechnologyMacaoChina

From AlphaGo to ChatGPT,the field of AI has launched a series of remarkable achievements in recent ***,comparing,and summarizing these achievements at the paradigm level is important for future AI innovation,but has not received sufficient *** this paper,we give an overview and perspective on machine learning ***,we propose a paradigm taxonomy with three levels and seven dimensions from a knowledge ***,we give an overview on three basic and twelve extended learning paradigms,such as Ensemble Learning,Transfer Learning,etc.,with figures in unified *** further analyze three advanced paradigms,i.e.,AlphaGo,AlphaFold and ***,to enable more efficient and effective scientific discovery,we propose to build a new ecosystem that drives AI paradigm shifts through the decentralized science(DeSci)movement based on decentralized autonomous organization(DAO).To this end,we design the Hanoi framework,which integrates human factors,parallel intelligence based on a combination of artificial systems and the natural world,and the DAO to inspire AI innovations.

关键词： ChatGPT decentralized science(DeSci) decentralized autonomous organization(DAO) machine learning paradigm shift

Dynamics of the Eukaryotic Microbial Community at the Breeding Sites of the Large Yellow Croaker Pseudosciaena crocea in the Southern East China Sea

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Journal of Ocean University of China 2022年第3期21卷 789-800页

作者： ZHOU Shouheng zheng Shizhan lv Tianying YANG Wen LUKWAMBE Betina NICHOLAUS Regan LI Chenghua zheng Zhongming School of Marine Sciences Ningbo UniversityNingbo315211China Department of Aquculture Technology School of Aquatic Sciences and Fisheries TechnologyUniversity of Dar es SalaamDar es Salaam999132Tanzania Department of Natural Sciences Mbeya University of Science and TechnologyMbeya999068Tanzania

Clarifying eukaryotic microbial spatial distribution patterns and their determinants is an important idea in ecological ***,information on the distribution patterns of eukaryotic microbial community structures(EMCSs)within oceans remains *** this study,surface water samples from the southern East China Sea(SECS)were collected to investigate the spatiotemporal variation in EMCSs by using 18S rRNA high-throughput sequencing technology and the impact of this variation on Pseudosciaena crocea during the breeding *** results indicated that the distribution patterns of the eukaryotic microbial community structure were different among the Sansha Bay,Mindong and Wentai reserves and the offshore East China *** addition,there were notable potential effects of EMCSs on fishery *** variation partitioning analysis showed the environmental and spatial factors caused 53.4%of the variation in the EMCSs,indicating that spatially structured environmental factors were the key determinants of the EMCSs spatial heterogeneity in the SECS and may have contributed to the general distribution of *** addition,all the environmental factors were the main factors driving the distribution of eukaryotic microbes except for total ***,it was noted some phytoplankton such as Poterioochromonas and Rhizophydium of fungi in Sansha Bay can effectively prevent Cyanobacteria *** are natural high-quality baits for juvenile fish distributed in Sansha Bay,Mindong and Wentai *** study provides a part of the insight into potential eukaryotic community distributions in large water bodies and how they are affected by environmental factors.

关键词： southern East China Sea 18S rRNA gene sequencing variation partitioning analysis eukaryotic microbes

Recent advances of mixed-transition-metal-substituted polyoxometalates

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Science China Chemistry 2022年第8期65卷 1515-1525页

作者： Zhimin Wang Xing Xin Mo Zhang zheng Li Hongjin lv Guo-Yu Yang MOE Key Laboratory of Cluster Science Beijing Key Laboratory of Photoelectroic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488China

Polyoxometalates(POMs)have been emerging as one of the most widely-studied interdisciplinary research fields of inorganic chemistry due to their structural diversities and versatile physicochemical *** incorporation of transition metals into lacunary POM ligands can lead to the formation of various transition-metal-substituted POMs(TMSPs)with wide potential applications in research areas including medicine,magnetism,functional materials,catalysis,and energy *** this review,we summarized the recent advances of mixed-transition-metal-substituted POMs(Mixed TMSPs)with respect to their synthetic strategies,structural diversities,and relevant ***,a comprehensive outlook of this research area was also prospected.

关键词： polyoxometalates lacunary POM ligands mixed-transition-metal substitution structural diversity catalysis

Effect of SiO_(2) nano film deposited on copper and aluminium electrodes on the power frequency breakdown voltage of SF_(6) gas

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High Voltage 2023年第4期8卷 791-798页

作者： Yu zheng Shengle Gong Lei Liu Zhihui Xiang Yichen lv Jianhui Yu Wenjun Zhou School of Electrical Engineering and Automation Wuhan UniversityWuhanChina State Key Laboratory of HVDC Transmissions Technology China Southern Power GridGuangzhouChina

In order to reveal the effect of insulating nano film on the insulation strength of SF_(6) gas gap,SiO_(2) nano film was deposited on the electrode surface by the plasma-enhanced chemical vapour deposition *** power frequency breakdown characteristics of SF_(6) gas under Cu and Al electrodes were obtained before and after *** results showed that when the Cu electrode was coated,the breakdown voltage was up to at most 11.5% higher than that of an uncoated Cu electrode in the pressure range of 0.2-0.5 *** the Al electrode was coated,the breakdown voltage of SF_(6) gas was lower than that of an uncoated one in the pressure range of 0.2-0.5 *** breakdown voltage of SF_(6) gas under the Cu electrode was slightly lower than that under the Al electrode,but the breakdown voltages under the coated Cu electrode were significantly higher than that under the coated Al *** SEM tests,it was found that the surface roughness of the electrode decreases after coating,but particles were formed on the surface of the Al *** content of metal fluoride formed on the coated Al electrode under multiple breakdowns was significantly higher than that on the coated Cu *** research results could provide references for improving insulation performance of GIS equipment.

关键词： coating electrode film

Highly Active Electrocatalyst Derived from ZIF-8 Decorated with Iron(III) and Cobalt(III) Porphyrin Toward Efficient Oxygen Reduction in Both Alkaline and Acidic Media

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Chemical Research in Chinese Universities 2022年第4期38卷 961-967页

作者： zheng Ruonan ZHAI Zihui QIU Chenxi GAO Rui lv Yang SONG Yujiang State Key Laboratory of Fine Chemicals&Dalian Key Laboratory of Core Materials and Units for Hydrogen Energy and Fuel Cells School of Chemical EngineeringDalian University of TechnologyDalian116024P.R.China

Zeolite imidazole frameworks 8(ZIF-8)and modified ones after pyrolysis are highly promising toward oxygen reduction reaction(ORR).Especially,the compositional modification of ZIF-8 is crucial to the enhancement of ORR performance,yet limited to the substitution of skeletal Zn(II)with other cations or simple physical adsorption of ***,we report the decoration of ZIF-8 with ORR active hemin(FeP)and Co(III)protoporphyrin(CoP)via the coordination between the peripheral carboxylic group of FeP and CoP with skeletal Zn(II).This allows well control over the quantity of loaded FeP and CoP,critical to the synthesis of advanced *** pyrolysis of FeP and CoP co-decorated ZIF-8 leads to highly active ORR electrocatalysts with a half-wave potential(E1/2)of 0.913 V(***)in 0.1 mol/L KOH *** an E1/2 of 0.803 V(***)in 0.1 mol/L HClO4 ***,our electrocatalyst shows much more improved and comparable durability in alkaline and acidic media,respectively,during 3000 cycles of cyclic voltammetry(CV)scanning relative to commercial Pt/C.

关键词： Non-noble metal electrocatalyst ZIF-8 Porphyrin Oxygen reduction reaction(ORR)