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Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-Zhu Lu Qian-Qian Guo Chang-Jun lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

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Phosphine-Relayed Aldehyde-Olefination and Aza-Wittig Reaction with 2,2,2-Trifluorodiazoethane

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Chinese Journal of Chemistry 2018年第8期36卷 723-730页

作者： Fa-Guang Zhang Ning lv Yan zheng Jun-An Ma Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic Sciences and Tianjin Collaborative Innovation Center of Chemical Science & Engineering Tianjin University Tianjin 300072 China

Phosphine-relayed olefination and aza-Wittig reactions of readily available aldehydes with 2,2,2-trifluorodiazoethane （CF3CHN2） have been realized. This protocol enables the facile construction of a series of triflu... 详细信息

关键词： diazo compounds olefination Wittig reactions 2,2,2-trifluorodiazoethane phosphine

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Integral Sliding Mode Control of a Marine Surface Vehicle with Accurate Tracking Performance

Integral Sliding Mode Control of a Marine Surface Vehicle wi...

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第36届中国控制会议

作者： Shuailin lv Ning Wang Zhongjiu zheng Marine Engineering College Dalian Maritime University

ISBN: (纸本)9781538629185

In this paper,an integral sliding mode based tracking control(ISMTC) scheme is proposed for a marine surface vehicle(MSV) in order to achieve accurate tracking *** features of the ISMTC scheme are as follows:(1)The integral sliding mode(ISM) technique is employed to realize accurate tracking performance,whereby a finite-time unknown observer is designed and integrated into the ISMTC scheme so as to improve the robustness of the overall closed-loop system;(2)It is shown that complicated unknowns including uncertainties and external disturbances can be exactly reconstructed in a short time by using the ISMTC scheme;(3) Fast convergence rate and accurate tracking performance can be realized pertaining to the ISMTC scheme for trajectory tracking control of an *** studies are ulteriorly conducted to verify the feasibility and remarkable performance of the proposed ISMTC scheme.

关键词： Finite-time stability Integral sliding mode(ISM) Finite-time unknown observer(FUO) Trajectory tracking control Marine surface vehicle(MSV)

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A Human Active Lower Limb Model for Chinese Pedestrian Safety Evaluation

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Journal of Bionic Engineering 2021年第4期18卷 872-886页

作者： Fuhao Mo Dian Luo zheng Tan Bo Shang Xiaojiang lv Donghua Zhou State Key Laboratory of Advanced Design and Manufacture for Vehicle Body Hunan UniversityHunan 410082China School of Mechanical Engineerings Hunan University of Science and Technology Xiangtan 411201China Pan Asia Technical Automotive Center Co. LtdShanghai 201201China Zhejiang Key Laboratory of Automobile Safety Technology Geely Automobile Research InstituteNingbo 315336China Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformAcademy of Forensic ScienceMinistry of JusticeShanghai 200063China

A subsystem impactor test for pedestrian lower limb injury evaluation has been brought in China New Car Assessment Protocol(CNCAP).Concerning large anthropometric differences of the people from different countries,the present study aims to establish and validate a finite element lower limb model representing 50th Chinese male size for pedestrian safety research,then compare its biomechanical responses with the general models currently in wide use in the world for pedestrian safety *** the vehicle-pedestrian impact loading environment,the previously developed lower limb model with three-dimensional muscles was adjusted and validated through the related ***,the biomechanical responses of the validated model were compared with the Total Human Model for Safety(THUMS)and Advanced Pedestrian Legform Impactor(aPLI)models by combing with four typical *** results showed that both consistency and significant differences of biomechanical responses existed between the present model and the other two *** injury measurements of the thigh region of the present model showed extremely large differences with the other two models,while the tibia and Medial Collateral Ligament(MCL)injury measurements show similar ***,it can be concluded that directly using the aPLI or THUMS models for Chinese pedestrian safety evaluation is not robust concerning both kinematic responses and injury measurements.

关键词： lower limb injury biomechanics human body modeling pedestrian safety finite element analysis

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Investigation on micro-mechanism of palm oil as natural ester insulating oil for overheating thermal fault analysis of transformers

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High Voltage 2022年第4期7卷 812-824页

作者： Hanbo zheng Xufan Li Yongji Feng Hang Yang Weijie lv Guangxi Key Laboratory of Intelligent Control and Maintenance of Power Equipment Guangxi UniversityNanningChina

In order to explore the pyrolysis mechanism of palm oil as the natural ester insulating liquid from the molecular aspect,the ReaxFF reactive force field was used to simulate the pyrolysis process of palm ***,the molecular models of the four main molecules of palm oil-tripalmitin,trilinolein,triolein,and tristearin-are constructed via density functional theory(DFT).Secondly,the vibrational frequencies of the four molecules are calculated,so as to calculate the infrared(IR)***,molecular dynamics(MD)simulations employing the ReaxFF method are performed to simulate the pyrolysis reaction of the palm oil system under different temperatures,so as to observe the generation pathways of major products used in the dissolved gas analysis(DGA)in the transformer thermal fault ***,hydrogen bonds in the pyrolysis process are *** is found that the number of hydrogen bonds gradually increased with the increase of pyrolysis time and pyrolysis *** reveals why the life of the insulating paper immersed with natural esters is prolonged,and why the breakdown voltage is reduced slowly in the actual experiment from another *** study can provide theoretical guidance and effective reference for the thermal fault analysis of an insulating liquid using palm oil as raw material.

关键词： fault pyrolysis mechanism

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Flotation behaviors of chalcopyrite and galena using ferrate(Ⅵ) as a depressant

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International Journal of Mining Science and Technology 2023年第1期33卷 93-103页

作者： Yongxing zheng Yusong Huang Panjin Hu Xianhui Qiu Jinfang lv Lingyun Bao State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China Faculty of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

This paper investigated the effects of potassium ferrate(PF)on the flotation performances of chalcopyrite and *** flotation results showed that PF obviously depressed galena,but had little effects on the floatability of chalcopyrite within pH range of 4.0–*** potential tests showed that the addition of PF induced the formation of more amounts of hydrophilic species on the surface of galena under an alkaline *** grade O-isopropyl-N-ethyl thionocarbamate(IPETC)chemically adsorbed on the surface of the PF-treated chalcopyrite and galena after its *** angle measurements showed that with the addition of PF,the contact angle of the galena surface significantly decreased compared with the chalcopyrite *** electrochemical impedance spectroscopy(LEIS)tests showed that the addition of PF increased the impedance of the galena surface.X-ray photoelectron spectroscopy(XPS)analyses revealed that the formation of hydrophilic species,namely lead sulfite,lead hydroxide and ferric hydroxide,on the galena surface,decreased its floatability in the presence of PF,while the formation of hydrophobic species,namely copper disulfide and elemental sulfur,on the chalcopyrite surface,maintained its ***,a descriptive model for the reaction of PF with chalcopyrite and galena was proposed.

关键词： Flotation Chalcopyrite Galena Potassium ferrate

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A universal elliptical disc(UED)model to represent natural rock fractures

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International Journal of Mining Science and Technology 2022年第2期32卷 261-270页

作者： Jun zheng Jichao Guo Jiongchao Wang Honglei Sun Jianhui Deng Qing lv Department of Civil Engineering Zhejiang UniversityHangzhou 310058China Center for Balance Architecture Zhejiang UniversityHangzhou 310007China College of Civil Engineering Zhejiang University of TechnologyHangzhou 310023China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource&HydropowerSichuan UniversityChengdu 610065China

Since natural fractures are often non-equidimensional,the circular disc model still has great *** contrast,the elliptical disc model is more applicable to representing natural fractures,especially for slender *** paper developed a universal elliptical disc(UED)model by incorporating the center point,size,and azimuth of fractures as ***,with respect to the azimuth of elliptical fractures in three-dimensional(3D)space,we proposed a paradigm to construct its probability density function(PDF)by coupling the orientation and rotation angle of long axis based on three coordinate *** illustrate the construction process of the PDF of the fracture azimuth,we took the orientation following the Fisher distribution and the rotation angle following Von Mises distribution as an example.A rock slope is used to show the use of the developed UED model,and the 3D DFNs for the slope rock mass are generated by Monte Carlo *** addition,the DFNs for the rock mass are also generated based on the existing circular disc model and non-universal elliptical disc *** comparison results from the three models clearly illustrate the superiority of the UED model over the existing circular and non-universal elliptical disc models.

关键词： Discrete fracture networks Rock mass Discontinuity Elliptical disc model Fisher distribution Monte Carlo simulation

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A new estimation method and an anisotropy index for the deformation modulus of jointed rock masses

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 153-168页

作者： Bohu Zhang Junyan Mu Jun zheng Qing lv Jianhui Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500China Department of Civil Engineering Zhejiang UniversityHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The deformation modulus of a rock mass is an important parameter to describe its mechanical *** this study,an analytical method is developed to determine the deformation modulus of jointed rock masses,which considers the mechanical properties of intact rocks and joints based on the superposition *** to incorporating the variations in the orientations and sizes of joint sets,the proposed method is applicable to the rock mass with persistent and parallel joints as well as that with nonpersistent and nonparallel *** addition,an anisotropy index AIdmfor the deformation modulus is defined to quantitatively describe the anisotropy of rock *** range of AIdmis from 0 to 1,and the more anisotropic the rock mass is,the larger the value of AIdmwill *** evaluate the proposed method,20 groups of numerical experiments are conducted with the universal distinct element code(UDEC).For each experimental group,the deformation modulus in 24 directions are obtained by UDEC(numerical value)and the proposed method(predicted value),and then the mean error rates are *** that the mean error rate is the mean value of the error rates of the deformation modulus in 24 directions,where for each direction,the error rate is equal to the ratio of numerical value minus predicted value to the numerical *** results show that(i)for different experimental groups,the mean error rates vary between 5.06%and 22.03%;(ii)the error rates for the discrete fracture networks(DFNs)with two sets of joints are at the same level as those with one set of joints;and(iii)therefore,the proposed method for estimating the deformation modulus of jointed rock masses is valid.

关键词： Deformation modulus Analytical method Anisotropy index Jointed rock masses Mechanical behavior Discrete fracture network(DFN)

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数字人推动智慧图书馆创新发展:技术、优势与实现路径

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新世纪图书馆 2024年第9期 61-67页

作者：郑聪柏雪吕艳娥陈茫桂林理工大学图书馆广西桂林541000 桂林理工大学商学院广西桂林541000

数字人作为元宇宙的重要元素和入口,在智慧图书馆与元宇宙融合发展的背景下,为智慧图书馆创新发展提供了新的切入点。论文通过梳理数字人概念、起源、分类,以及建模、驱动、对话等核心技术,总结出数字人具有超越真人局限、IP打造和多人... 详细信息

数字人作为元宇宙的重要元素和入口,在智慧图书馆与元宇宙融合发展的背景下,为智慧图书馆创新发展提供了新的切入点。论文通过梳理数字人概念、起源、分类,以及建模、驱动、对话等核心技术,总结出数字人具有超越真人局限、IP打造和多人协同、定制化服务、全时段工作、自动创作等应用优势,探讨其在智慧图书馆建设领域的潜在应用场景,从而推进智慧图书馆建设的理论创新、管理创新、服务创新。此外,论文还从成本控制、自然人权力保障、读者自控能力影响等方面对数字人在智慧图书馆应用的潜在风险进行了分析。

关键词：数字人智慧图书馆创新发展

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河流水质自动监测站取水平台优化设置技术要点与案例

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四川环境 2024年第4期43卷 119-124页

作者：肖克彦傅宇宋伟吕倩茹郑丙辉郑奇四川省凉山州西昌生态环境监测站四川西昌615000 中国环境科学研究院湖泊水污染治理与生态修复国家工程实验室北京100012 上海市浦东新区水文水资源管理事务中心上海200129

水质自动站是获取水环境质量数据的重要手段。国家相关标准对于水质自动站站址选择做了原则性的规定,但是自动站取水口受河道冲淤,人类活动的影响,可能影响监测结果的代表性和准确性。本文介绍了自然河流水质自动站取水平台优化设置的... 详细信息

水质自动站是获取水环境质量数据的重要手段。国家相关标准对于水质自动站站址选择做了原则性的规定,但是自动站取水口受河道冲淤,人类活动的影响,可能影响监测结果的代表性和准确性。本文介绍了自然河流水质自动站取水平台优化设置的技术要点:自然河流水质自动站站址选择尽可能选择顺直或尽可能不受冲淤影响的河段、取水平台位置的99%水位保证率下水深不小于1m、流速不小于断面平均流速的30%。以阿七大桥水质自动站为例,分析了取水平台受下游电站运行和河道冲淤对取水平台获环境的影响,明晰了获取水样代表性不足的原因,提出阿七大桥断面取水口位置优化建议。

关键词：河流水质自动站取水平台位置优化阿七大桥

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