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Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism

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World Journal of Gastroenterology 2022年第43期28卷 6131-6156页

作者： Zi-Li Ai Xian Zhang Wei Ge You-Bao Zhong Hai-Yan Wang zheng-yun zuo Duan-Yong Liu Department of Postgraduate Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Department of Proctology Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330006Jiangxi ProvinceChina Laboratory Animal Research Center for Science and Technology Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Formula-Pattern Research Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina

BACKGROUND Studies have shown that a high-fat diet(HFD) can alter gut microbiota(GM)homeostasis and participate in lipid metabolism disorders associated with ***, regulating the construction of GM with the balance of lipid metabolism has become essential for treating obesity. Salvia miltiorrhiza extract(Sal), a common traditional Chinese medicine, has been proven effective against atherosclerosis, hyperlipidemia, obesity, and other dyslipidemia-related *** To investigate the anti-obesity effects of Sal in rats with HFD-induced obesity, and explore the underlying mechanism by focusing on GM and lipid *** Obesity was induced in rats with an HFD for 7 wk, and Sal(0.675 g/1.35 g/2.70g/kg/d) was administered to treat obese rats for 8 wk. The therapeutic effect was evaluated by body weight, body fat index, waistline, and serum lipid level. Lipid factors(cAMP, PKA, and HSL) in liver and fat homogenates were analyzed by ELISA. The effect of Sal on GM and lipid metabolism was assessed by 16S rRNAbased microbiota analysis and untargeted lipidomic analysis(LC-MS/MS),*** Sal treatment markedly reduced weight, body fat index, serum triglycerides(TG), total cholesterol(TC), low-density lipoprotein, glucose, free fatty acid, hepatic lipid accumulation, and adipocyte vacuolation, and increased serum high-density lipoprotein(HDL-C) in rats with HFD-induced obesity. These effects were associated with increased concentrations of lipid factors such as c AMP, PKA, and HSL in the liver and adipose tissues, enhanced gut integrity, and improved lipid metabolism. GM analysis revealed that Sal could reverse HFD-induced dysbacteriosis by promoting the abundance of Actinobacteriota and Proteobacteria, and decreasing the growth of Firmicutes and Desulfobacterita. Furthermore, LC-MS/MS analysis indicated that Sal decreased TGs(TG18:2/18:2/20:4, TG16:0/18:2/22:6), DGs(DG14:0/22:6, DG22:6/22:6), CL(18:2/18:1/18:1/20:0), and increased ceramides

关键词： Salvia miltiorrhiza extract Obesity Gut microbiota Lipid metabolism High fat diet

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen zuo-Tang Liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

黄秋葵果实发育过程中细胞壁组成成分、糖代谢及相关酶活性的变化

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江苏农业学报 2023年第5期39卷 1217-1224页

作者：陈瑶瑶严良文刘建汀刘智成余洁郑作芸朱海生龙岩市农业科学研究所福建龙岩364000 福建省蔬菜遗传育种重点实验室福建福州350013 龙岩市新罗区农业局福建龙岩364000

以黄秋葵(Abelmoschus esculentus L.)卡里巴和油绿一号果实为试验材料,测定果实发育过程中细胞壁组成成分、糖分积累及相关酶活性的变化,并对纤维素含量与纤维素代谢酶活性进行了相关性分析。结果表明:两个品种黄秋葵果实的适宜采收期... 详细信息

以黄秋葵(Abelmoschus esculentus L.)卡里巴和油绿一号果实为试验材料,测定果实发育过程中细胞壁组成成分、糖分积累及相关酶活性的变化,并对纤维素含量与纤维素代谢酶活性进行了相关性分析。结果表明:两个品种黄秋葵果实的适宜采收期为花后6~7 d,在果实发育过程中木质素和半纤维素含量均先上升后下降,纤维素含量不断上升,纤维素合酶(CesA)和纤维素酶(Kor)活性不断上升,蔗糖合酶(SS-I)、内切葡聚糖酶(Cx)和外切葡聚糖酶(C1)活性先升高后降低,β-葡萄糖苷酶(β-GC)活性不断降低。卡里巴果实中木质素、半纤维素、纤维素含量和纤维素代谢相关酶活性均高于油绿一号。相关性分析结果表明,CesA和Kor酶活性与纤维素含量呈显著正相关,β-GC酶活性与纤维素含量呈极显著负相关。糖分含量测定结果显示,两个品种果实中的蔗糖含量均呈上升趋势,果糖与葡萄糖的含量均在花后6 d达到峰值,果实中蔗糖磷酸合成酶(SPS)和蔗糖转化酶(SAI、BAI、NI)活性的峰值期均出现在果实老化前。综上所述,纤维素含量不断增加是影响黄秋葵果实老化的主要因素,CesA、Kor和β-GC为参与纤维素代谢的关键酶类,蔗糖代谢酶参与了黄秋葵果实的成熟老化过程。

关键词：黄秋葵果实发育细胞壁组成成分糖代谢糖代谢酶活性

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An Effective Cloud Workflow Scheduling Approach Combining PSO and Idle Time Slot-Aware Rules

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IEEE/CAA Journal of Automatica Sinica 2021年第5期8卷 1079-1094页

作者： yun Wang Xingquan zuo the School of Computing Science Beijing University of Posts and TelecommunicationsBeijing 100876China the School of Information Engineering Nanchang Institute of TechnologyNanchang 330099China the Key Laboratory of Trustworthy Distributed Computing and Service(BUPT) Ministry of EducationBeijing 100876China

Workflow scheduling is a key issue and remains a challenging problem in cloud *** with the large number of virtual machine(VM)types offered by cloud providers,cloud users need to choose the most appropriate VM type for each *** task scheduling sequences exist in a workflow *** task scheduling sequences have a significant impact on the scheduling *** is not easy to determine the most appropriate set of VM types for tasks and the best task scheduling ***,the idle time slots on VM instances should be used fully to increase resources'utilization and save the execution cost of a *** paper considers these three aspects simultaneously and proposes a cloud workflow scheduling approach which combines particle swarm optimization(PSO)and idle time slot-aware rules,to minimize the execution cost of a workflow application under a deadline constraint.A new particle encoding is devised to represent the VM type required by each task and the scheduling sequence of *** idle time slot-aware decoding procedure is proposed to decode a particle into a scheduling *** handle tasks'invalid priorities caused by the randomness of PSO,a repair method is used to repair those priorities to produce valid task scheduling *** proposed approach is compared with state-of-the-art cloud workflow scheduling *** show that the proposed approach outperforms the comparative algorithms in terms of both of the execution cost and the success rate in meeting the deadline.

关键词： Cloud computing idle time slot particle swarm optimization task scheduling sequence workflow scheduling

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豆浆菌肥在茶树栽培中的应用效果

福建农业学报 2014年第2期29卷 194-196页

作者：苏秋芹李春维郑作芸张桃英福建省龙岩市农业科学研究所福建龙岩364000

为研究豆浆菌肥在茶树栽培中的应用效果，进行茶树上施用豆浆菌肥试验，结果表明：与喷清水的对照相比，豆浆菌肥施用处理，能增加茶树冠面单位面积的茶芽数量26.7％，提高茶叶经济产量26.24，提早开采期3～5d，延长采摘期10d左右。同... 详细信息

为研究豆浆菌肥在茶树栽培中的应用效果，进行茶树上施用豆浆菌肥试验，结果表明：与喷清水的对照相比，豆浆菌肥施用处理，能增加茶树冠面单位面积的茶芽数量26.7％，提高茶叶经济产量26.24，提早开采期3～5d，延长采摘期10d左右。同时茶芽持嫩性增强，茶树常见病害的发病率降低，茶叶感官品质与生化品质得到改善。豆浆菌肥在茶树栽培中应用效果良好，表现出较好的应用前景。

关键词：豆浆菌肥乌龙茶栽培

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li zuo Han Guo Zi-Fei Xu Ying Zeng yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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硅铝溶胶混合黏结剂的稳定性及其催化性能的研究

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石化技术与应用 2017年第1期35卷 28-31页

作者：张涛丁伟许鹏郑云锋左少卿高雄厚兰州交通大学化学与生物工程学院甘肃兰州730070 中国石油兰州化工研究中心甘肃兰州730060 中国石油石油化工研究院北京100083

以酸性硅溶胶、碱性硅溶胶为原材料,考察了6种不同酸碱性质的硅溶胶与铝溶胶按硅铝比(质量比)1∶1混合后的凝胶情况和稳定性,并分别以铝溶胶、酸性硅溶胶与铝溶胶、碱性硅溶胶与铝溶胶为黏结剂制备催化裂化(FCC)催化剂,对其孔结构、酸... 详细信息

以酸性硅溶胶、碱性硅溶胶为原材料,考察了6种不同酸碱性质的硅溶胶与铝溶胶按硅铝比(质量比)1∶1混合后的凝胶情况和稳定性,并分别以铝溶胶、酸性硅溶胶与铝溶胶、碱性硅溶胶与铝溶胶为黏结剂制备催化裂化(FCC)催化剂,对其孔结构、酸性及酸量进行分析,考察了引入部分硅溶胶的FCC催化剂在性能上的变化。结果表明:硅溶胶与铝溶胶混合凝胶程度及稳定性受硅铝溶胶的浓度及p H值等因素的影响。酸性硅溶胶与铝溶胶不能直接混合,但可以用蒸馏水先稀释再混合,则不发生凝胶;碱性硅溶胶不能与铝溶胶直接混合,可调节碱性硅溶胶p H值为1~7;硅、铝混合溶胶催化剂与铝溶胶催化剂比较,孔体积和B酸、L酸的酸量减小,比表面积增加。

关键词：硅溶胶铝溶胶黏结剂催化裂化催化剂

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management