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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng Wu Wen-Jia Chen Xin-Ning yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Signal molecule-mediated hepatic cell communication during liver regeneration

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World Journal of Gastroenterology 2009年第46期15卷 5776-5783页

作者： Zhen-yu zheng Shun-Yan weng Yan yu School of Agricultureand Biology Shanghai Jiao Tong University Shanghai 200240China

Liver regeneration is a complex and well-orchestrated process,during which hepatic cells are activated to produce large signal molecules in response to liver injury or mass *** signal molecules,in turn,set up the connections and cross-talk among liver cells to promote hepatic *** this review,we endeavor to summarize the network of signal molecules that mediates hepatic cell communication in the regulation of liver regeneration.

关键词： Signal molecule Hepatic cells Cellular cross-talk Signal communication Liver regeneration

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Influence of propagation direction on operation performance of rotating detonation combustor with turbine guide vane

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Defence Technology（防务技术） 2021年第5期17卷 1617-1624页

作者： Wan-li Wei yu-wen Wu Chun-sheng weng Quan zheng National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing210094China

Due to the pressure gain combustion characteristics,the rotating detonation combustor(RDC)can enhance thermodynamic cycle ***,the performance of gas-turbine engine can be further improved with this combustion *** the present study,the RDC operation performance with a turbine guide vane(TGV)is experimentally *** and air are used as propellants while hydrogen and air mass flow rate are about 16.1 g/s and 500 g/s and the equivalence ratio is about 1.0.A pre-detonator is used to ignite the ***-frequency dynamic pressure transducers and silicon pressure sensors are employed to measure pressure oscillations and static pressure in the combustion *** experimental results show that the steady propagation of rotating detonation wave(RDW)is observed in the combustion chamber and the mean propagation velocity is above 1650 m/s,reaching over 84%of theoretical Chapman-Jouguet detonation *** and counterclockwise propagation directions of RDW are *** clockwise propagation direction,the static pressure is about 15%higher in the combustor compared with counterclockwise propagation direction,but the RDW dominant frequency is *** the oblique shock wave propagates across the TGV,the pressure oscillations reduces *** addition,as the detonation products flow through the TGV,the static pressure drops up to 32%and 43%for clockwise and counterclockwise propagation process respectively.

关键词： Rotating detonation combustor Propagation direction Turbine guide vane Operation performance

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A NEW T_(c)FORMULA FOR SUPERCONDUCTORS

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Chinese Physics Letters 1984年第1期1卷 7-10页

作者： WU Hang-sheng weng zheng-yu Department of Physics University of Science and Technology of ChinaHefei

A formula of the critical temperature for superconductors with smallλis derived from the Eliashberg equation1.

关键词： equation superconductors critical

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Chiral metal phosphonates: assembly, structures and functions

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Science China Chemistry 2020年第5期63卷 619-636页

作者： Guo-Guo weng Li-Min zheng State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringCollaborative Innovation Centre of Advanced MicrostructuresNanjing UniversityNanjing 210023China

As an important class of inorganic-organic hybrid materials, metal phosphonates can exhibit versatile structures, interesting functions and high water and thermal stabilities. Despite a large number of metal phosphonates reported in the past two decades,the development of chiral metal phosphonates is still in its infancy. This review summarizes the current status in this topical field including the synthetic strategies, the crystal structures of chiral metal phosphonates reported thus far, and their physical and chemical properties. Future challenges in this promising field are also discussed.

关键词： chiral metal phosphonate structure property

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Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng Liao Sha Liao yu-Jiao Gao Xi Wang Li-Hong Guo Su zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin yuan Yi-Juan zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

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Effects of total pressures and equivalence ratios on kerosene/air rotating detonation engines using a paralleling CE/SE method

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Defence Technology（防务技术） 2021年第6期17卷 1805-1816页

作者： Fang Wang Chun-sheng weng yu-wen Wu Qiao-dong Bai Quan zheng Han Xu National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing210094China

In this paper,the kerosene/air rotating detonation engines(RDE)are numerically investigated,and the emphasis is laid on the effects of total pressures and equivalence ratios on the operation characteristics of RDE including the initiation,instabilities,and propulsive performance.A hybrid MPI t OpenMP parallel computing model is applied and it is proved to be able to obtain a more effective parallel performance on high performance computing(HPC)systems.A series of cases with the total pressure of 1 MPa,1.5 MPa,2 MPa,and the equivalence ratio of 0.9,1,1.4 are *** one hand,the total pressure shows a significant impact on the instabilities of rotating detonation *** instability phenomenon is observed in cases with low total pressure(1 MPa)and weakened with the increase of the total *** total pressure has a small impact on the detonation wave velocity and the specific *** the other hand,the equivalence ratio shows a negligible influence on the instabilities,while it affects the ignition process and accounts for the detonation velocity *** is more difficult to initiate rotating detonation waves directly in the lean fuel operation *** difference was observed in the thrust with different equivalence ratios of 0.9,1,and *** highest specific impulse was obtained in the lean fuel cases,which is around 2700 *** findings could provide insights into the understanding of the operation characteristics of kerosene/air RDE.

关键词： Kerosene/air rotating detonation waves Total pressure Equivalence ratio Instabilities MPItOpenMP

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Hot Deformation Behavior of a New 9%Cr Heat Resistant Steel G115

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Journal of Iron and Steel Research International 2013年第9期20卷 73-79页

作者： YAN Peng LIU zheng-dong LIU Wei BAO Han-sheng weng yu-qing Key Laboratory of Advanced Material of Ministry of Eclucation of China School of Materials Science and EngineeringTsinghua University Institute for Special Steels China Iron and Steel Research Institute

The hot deformation behavior of a new heat resistant steel Gl15 designed for 650 ℃ ultra-supercritical （USC） power plants was experimentally studied. Hot compression test was carried out in the temperature range of 900-1 200 ℃ and the strain rate range of 0.1-20 s i by using Gleeble 3800 thermal-mechanical simulator, and the corresponding flow curves were obtained. Experimental results show that the flow stress increases with the decrease of deformation temperature and the increase of strain rate. The hot deformation activation energy of G115 steel was determined to be 494 kJ/mol and the constitutive equation was also obtained. For convenience of the practical applica-tion, a good approximate equation was obtained for calculating the peak stress values of Gl15 steel under different deformation conditions. At the strain value of 0.9, natural logarithm of the critical Zener Hollomon parameter Zc of Gl15 steel was determined to be in the scope of 49.67 and 50.65, above which there will be no dynamic recrystalliza-tion （DRX）. And natural logarithm of the critical Zener-Hollomon parameter Zc of Gl15 steel was determined to be in the scopes of 45.58 and 46.27, below which full DRX may occur. Then, the status diagram of dynamic micro structures of G115 steel was established. In addition, the strain rate sensitivity of Gl15 steel is not constant during the test temperature range and it increases linearly from 900 to 1 200 ℃. Therefore, hot deformation at higher tem- peratures would obtain better workability.

关键词： heat resistant steel G115 hot deformation dynamic recrystallization constitutive equation Zener Hol-lomon parameter

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De novo transcriptome analysis of Spodoptera exigua multiple nucleopolyhedrovirus(SeMNPV) genes in latently infected Se301 cells

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Virologica Sinica 2016年第5期31卷 425-436页

作者： zheng Fang Jingxu Shao Qingbei weng School of Life Sciences Guizhou Normal University

Cells of the P8-Se301-C1 strain are Spodoptera exigua cell clones that each harbor a partial version of the S. exigua multiple nucleopolyhedrovirus （SeMNPV） genome and which are resistant to homologous SeMNPV infections. The cells produce no viral progeny, suggesting that the infection is a latent-like viral infection. To investigate the SeMNPV genes harbored in the P8-Se301-C1 cells, the de novo transcriptomes of P8-Se301-Cl cells and S. exigua Se301 cells were analyzed and compared. A total of 54,569,296 reads were obtained from the P8-Se301-C1 cells that yielded 112,565 final unigenes with a mean length of 1,093 nt. A total of 56,865,504 reads were obtained from the Se301 cells that yielded 102,996 final unigenes with a mean length of 1,082 nt. Ten SeMNPV gene transcripts （se5, se7, se8, se12, se43, se45, se89, se90, se124, and se126） were detected in the P8-Se301-C1 cells by RNA-Seq but not in the Se301 cells, which was verified by RT- PCR. 5＇/3＇ RACE analyses showed that the 3＇- or 5＇-end sequences of the viral transcripts are aligned to the host gene sequences in P8-Se301-C1 cells, suggesting that the SeMNPV genes may integrate into and be transcribed with the host genes in the P8-Se301-C1 cells. Furthermore, six additional viral gene transcripts, sell, se42, se44, se88, se91, and se127 （incorporated into chimeric fusion transcripts in the P8-Se301-C1 cells）, were detected in the RACE analyses. Taken together, sixteen SeMNPV transcripts were identified in the P8-Se301-C1 cell strain. This study provides information to develop the understanding of baculovirus latent infections and superinfection exclusion.

关键词： RNA-Seq SeMNPV baculovirus latent infection Spodoptera exigua

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