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Carney complex: Two case reports and review of literature

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World Journal of Clinical Cases 2018年第14期6卷 800-806页

作者： Shuang Li Lian Duan Feng-Dan Wang Lin Lu zheng-yu jin Department of Radiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiology Peking Union Medical College Hospital Department of Endocrinology Peking Union Medical College Hospital

Lian Duan, Lin Lu, Carney complex （CNC） is an extremely rare genetic syndrome of pigmented skin lesions, endocrine hyper-function and myxoma. Given its diverse clinical mani-festations, CNC is often misdiagnosed. Recognition of some special clinical manifestations and imaging features may help with the diagnosis. Early diagnosis of CNC would alert ongoing surveillance of tumors and complications; the prognosis of CNC may thus be improved by early treatment. Herein, we report two cases of CNC with bone lesions.

关键词： Carney complex Osteochondromyxoma Primary pigmented nodular adrenocortical disease Computed tomography Magnetic resonance imaging Case report

Radiomics approaches in gastric cancer: a frontier in clinical decision making

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Chinese Medical Journal 2019年第16期132卷 1983-1989页

作者： yue Wang zheng-yu jin Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Objective: To review the application of radiomics in gastric cancer and its challenges as well as future prospects. Data sources: A research for relevant studies were performed in PubMed with the terms of “radiomics,”“texture analysis,” and “gastric cancer.” The search was updated until February 28th, 2019. Study selection: All original articles regarding the investigation of texture analysis or radiomics in gastric cancer were retrieved. Only papers written in English were included. Results: A total of 17 original articles were selected in final. It is shown that radiomics has yielded moderate to excellent performance in a spectrum of respects including differential diagnosis, assessment of histological differential degree, evaluation of tumor stage, prediction of response to therapy, and prognosis in gastric cancer. Yet, a number of challenges are facing both radiomics itself and its application in gastric cancer. Conclusions: Radiomics holds great potential in facilitating decision-making in gastric cancer. With the standardization of work-flow and advancement of machine learning methods, radiomics is expected to make great breakthroughs in precision medicine of gastric cancer.

关键词： Gastric cancer Radiology Radiomics

Effects of Saline Administration, Abdominal Compression, and Prolongation of Acquisition Delay on Image Quality Improvement of CT Urography

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Chinese Medical Sciences Journal 2012年第4期27卷 201-206页

作者： Hao Sun Hua-dan Xue Wei Liu Xuan Wang yu Chen zheng-yu jin Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective To retrospectively evaluate the effects of saline administration following contrast material injection, abdominal compression and two delay phase acquisition on image quality improvement of computed tomographic urography (CTU). Methods Medical records and informed consents of patients were obtained. In totally 122 patients (50 men, 72 women), two delay phase images with CTU were performed. Scans began simultaneously with a contrast bolus injection of 100 mL (300 mgI/mL) followed by a saline bolus injection of 100 mL at a rate of 5 mL/s. Two delay phase images were taken at 400 and 550 seconds for each patient. Examinations were taken by using abdominal compression or not. The distention and opacification of the urinary tract were evaluated by two interpreters together on transverse images and post-processing images. Effects of four techniques (saline administration and abdominal compression, saline administration only, compression only, and neither saline administration nor compression) and two delay phase acquisition on image quality improvement were analysed by using ANOVA and Chi-square test. Results Saline administration improved opacification (P<0.05) and increased overall image quality (P<0.01) of the intrarenal collecting system and proximal ureter. Abdominal compression (P<0.05) and delayed phase image acquisition of 550 seconds (P<0.01) all improved distention of the intrarenal collecting system and proximal ureter but did not improve opacification. No statistically significant effects on the distal ureter were found. However, there were more visualized distal ureteral segments with the longer imaging delay. Conclusion Saline administration, abdominal compression and longer imaging delays are all effective in improving image quality of 64-detector row CTU.

关键词： computed tomographic urography image quality

Clinical Value of Dual-energy CT in Detection of Pancreatic Adenocarcinoma: Investigation of the Best Pancreatic Tumor Contrast to Noise Ratio

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Chinese Medical Sciences Journal 2012年第4期27卷 207-212页

作者： Yong-lan He Da-ming Zhang Hua-dan Xue zheng-yu jin Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective To quantitatively compare and determine the best pancreatic tumor contrast to noise ratio (CNR) in different dual-energy derived datasets. Methods In this retrospective, single center study, 16 patients (9 male, 7 female, average age 59.4±13.2 years) with pathologically diagnosed pancreatic cancer were enrolled. All patients received an abdominal scan using a dual source CT scanner 7 to 31 days before biopsy or surgery. After injection of iodine contrast agent, arterial and pancreatic parenchyma phase were scanned consequently, using a dual-energy scan mode (100 kVp/230 mAs and Sn 140 kVp/178 mAs) in the pancreatic parenchyma phase. A series of derived dual-energy datasets were evaluated including non-liner blending (non-linear blending width 0-500 HU; blending center -500 to 500 HU), mono-energetic (40-190 keV), 100 kVp and 140 kVp. On each datasets, mean CT values of the pancreatic parenchyma and tumor, as well as standard deviation CT values of subcutaneous fat and psoas muscle were measured. Regions of interest of cutaneous fat and major psoas muscle of 100 kVp and 140 kVp images were calculated. Best CNR of subcutaneous fat (CNR F ) and CNR of the major psoas muscle (CNR M ) of non-liner blending and mono-energetic datasets were calculated with the optimal mono-energetic keV setting and the optimal blending center/width setting for the best CNR. One Way ANOVA test was used for comparison of best CNR between different dual-energy derived datasets. Results The best CNR F (4.48±1.29) was obtained from the non-liner blending datasets at blending center -16.6±103.9 HU and blending width 12.3±10.6 HU. The best CNR F (3.28±0.97) was obtained from the mono-energetic datasets at 73.3±4.3 keV. CNR F in the 100 kVp and 140 kVp were 3.02±0.91 and 1.56±0.56 respectively. Using fat as the noise background, all of these images series showed significant differences (P<0.01) except best CNR F of mono-energetic image sets vs. CNR F of 100 kVp image (P=0.460). Similar r

关键词： pancreatic adenocarcinoma dual-energy contrast to noise ratio non-linear blending

CFD SIMULATION OF FLUID CATALYTIC CRACKING IN DOWNER REACTORS

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China Particuology 2006年第3期4卷 160-166页

作者： Fei Liu Fei Wei yu zheng Yong jin Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University Beijing 100084 P.R. China

A mathematical model has been developed for the simulation of gas-particle flow and fluid catalytic cracking in downer reactors. The model takes into account both cracking reaction and flow behavior through a four-lump reaction kinetics coupled with two-phase turbulent flow. The prediction results show that the relatively large change of gas velocity affects directly the axial distribution of solids velocity and void fraction, which significantly interact with the chemical reaction. Furthermore, model simulations are carried out to determine the effects of such parameters on product yields, as bed diameter, reaction temperature and the ratio of catalyst to oil, which are helpful for optimizing the yields of desired products. The model equations are coded and solved on CFX4.4.

关键词： downer fluid catalytic cracking (FCC) lumping kinetic model computational fluid dynamics (CFD)

EXPERIMENTAL STUDY OF INFLAMMATORY AND METASTATIC LYMPH NODES WITH DIFFUSION WEIGHTED IMAGING ON ANIMAL MODEL: COMPARISON WITH CONVENTIONAL METHODS

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Chinese Medical Sciences Journal 2008年第3期23卷 166-171页

作者： Hua-dan Xue Shuo Li Hong-yi Sun zheng-yu jin Fei Sun Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 General Electric Medical Solution Shanghai 200336

Objective To investigate the feasibility of magnetic resonance （MR） diffusion weighted imaging （DWI） in discriminating inflammatory from VX2 carcinoma metastatic lymph nodes in rabbit model. Methods Twenty New Zealand white rabbits were randomly divided into 2 groups. Complete Freund＇s adjuvant was injected into the bilateral dorsal footpads to set up ipsilateral lymphadenitis model （n = 10）, and the other 10 rabbits received a subcutaneous implantation of VX2 tumor cell suspension （1.5×10^7 cells/mL） in both thighs to set up metastatic lymph node model. MR imaging scan covering the popliteal fossa and lilac fossa including short time inversion recovery echo-planar imaging DWI （STIR-EPI-DWI）, Tl-weighted imaging （T1WI） and T2-weighted imaging （T2WI） was performed 2 weeks after injection. T2WI signal intensity （SI）, DWI SI, long/short axial ratio （LSR） and apparent diffusion coefficient （ADC） values of the lymph nodes were evaluated in all cases. Right after MR imaging scan, popliteal and iliac fossa lymph nodes were collected for hematoxylin-eosin staining. Results Totally 33 lymph nodes larger than 5 turn, including 22 inflammatory and 11 metastatic ones, were successfully isolated and taken into pathological analysis. LSR showed no significant difference between the inflammatory and malignant lymph nodes （P 〉 0.05）. Both benign and malignant lymph nodes appeared iso-intense on TlWI and hyperintense on both T2WI and DWI images with an even lower TlWI and higher T2WI SI core at the hilum. Both T2WI and DWI SI showed no significant difference between two pathological groups （P 〉 0.01） in popliteal fossa. The mean ADC value of inflammatory nodes [（1.199±0.281） ×10^-3 mm^2/s] was significantly higher than that of metastatic nodes [（0.858 ± 0.090） ×10^-3 mm^2/s, P 〈 0.01]. On ADC map, a high ADC value central area could be seen in most of the lymph nodes no matter benign or malignant. ADC value gave out the largest area under curve （AUCADC = 0.955） compared with o

关键词： magnetic resonance diffusion weighted imaging lymph node

WHOLE BODY DIFFUSION WEIGHTED IMAGING:A NEW ERA OF ONCOLOGICAL RADIOLOGY

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Chinese Medical Sciences Journal 2008年第3期23卷 129-132页

作者： zheng-yu jin Hua-dan Xue Hua Tao Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 MR Modality General Electric Healthcare China Beijing 100176

Cancer has become the leading cause of mortality in the urban area of China. Whole body diffusion weigntea imaging （WB-DWI）, also known as virtual positron emission tomography, has gradually become accepted as an image tool in tumor localization, characterization, staging and monitoring response to therapy or tumor recurrence. Our article aimed to summarize the limited initial clinical use of WB-DWI in the referred area, and to analyze the most potential advantage of WB-DWI in therapeutic monitoring and tumor staging. WB-DWI as a highly sensitive, completely non-invasive, well-tolerated and low price technique has a promising furture in tumor assessment. Profound clinical study is necessary for its further application improvement.

关键词： magnetic resonance imaging whole body imaging diffusion

Evaluation of Normal Adrenal Gland Volume by 64-slice CT

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Chinese Medical Sciences Journal 2012年第4期27卷 220-224页

作者： Xuan Wang zheng-yu jin Hua-dan Xue Wei Liu Hao Sun yu Chen Kai Xu Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective To measure volume and other parameters of normal adrenal glands in Chinese adults with 64-slice multidetector CT, to evaluate the relationship of volume result with age, sex and body size, and to explore the correlations between adrenal volume and other measurements. Methods This study was based on 125 acquired contrast-enhanced upper abdominal CT scans performed with a 64-slice CT. The final study group consisted of 81 patients (49 males, 32 females). Portal venous phase images were studied for the measurements. Both the reconstruction interval and thickness were 1.5 mm. Each adrenal gland was outlined manually with computer-assistant technology to calculate its volume. The maximal sectional area, length, width and thickness of each adrenal gland were also measured. Results The mean age of total population was 47.9±13.0 (range: 20-76) years. The left, right, and total adrenal gland volumes were 4.23±0.74 (range: 2.85-5.83) cm 3 , 4.26±0.86 (2.59-6.56) cm 3 , and 8.50±1.40 (5.80-11.39) cm 3 , respectively. These volumes increased with weight (r=0.381, 0.389, and 0.437 respectively, all P0.05), nor did volume change significantly with age (r=-0.033, -0.014, and -0.026, all P>0.05). Nearly all descriptors of bilateral adrenal glands correlated with ipsilateral volume except thickness (r=-0.027, P=0.814) and width (r=0.166, P=0.138) in the left side. Among these parameters, length had a stronger correlation with volume than others in the both left (r=0.412, P<0.001) and right (r=0.516, P<0.001) adrenal glands. Conclusion Our study has defined the volume distribution and other parameters of normal adrenal glands in Chinese adu

关键词： adrenal gland volumetry volume determination computed tomography

Determinants of Detection of Stones and Calcifications in the Hepatobiliary System on Virtual Nonenhanced Dual-energy CT

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Chinese Medical Sciences Journal 2016年第2期31卷 76-82页

作者： Da-ming Zhang Xuan Wang Hua-dan Xue zheng-yu jin Hao Sun yu Chen Yong-lan He Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective To retrospectively determine the features of stones and calcifications in hepatobiliary system on virtual nonenhanced (VNE) dual-energy computed tomography (CT), and to evaluate the possibility of VNE images in diagnosis for those lesions. Methods A total of 128 gall stones and calcifications of the liver found in 110 patients were examined with triple phase abdominal CT scan from July 2007 to December 2011, in which true nonenhanced (TNE) phase and arterial phase were performed with single-energy CT (120 kVp) and portal venous phase was performed with dual-energy CT (100 kVp and 140 kVp). VNE images were generated from the portal venous phase dual-energy CT data sets by using commercially VNC software. The mean CT values for the stone, liver, bile and paraspinal muscle, mean lesion density and size in area dimension, contrast-to-noise ratio (CNR) of lesion to the liver or bile, and image noise were assessed and compared between VNE and TNE images. The effective dose and size-specific dose estimate (SSDE) were also calculated. Results The mean CT values of the lesions measured on VNE images declined significantly compared with those measured on TNE images (164.51±102.13vs. 290.72±197.80 HU,P<0.001), so did the lesion-to-liver CNR (10.80±11.82vs.18.81±17.06,P<0.001) and the lesion-to-bile CNR (17.24±14.41 vs. 21.32±17.31,P<0.001). There was no significant difference in size of lesions area between VNE and TNE images (0.69±0.88vs.0.72±0.85 cm2,P=0.062). Compared to the 128 lesions found in TNE images, VNE images showed the same density in 30 (23.4%) lesions, lighter density in 88 (68.8%) lesions, while failed to show 10 (7.8%) lesions, and showed the same size in 61 (47.7%) lesions and smaller size in 57 (44.5%) lesions. The CT cutoff values of lesion and size were 229.21 HU and 0.15 cm2, respectively. The total effective dose for triple phase scan protocol with TNE images was 19.51±7.03 mSv, and the SSDE was 39.84±11.10 mGy. The effective dose for dual

关键词： virtual non-enhanced stone calcification hepatobiliary system dual-energy computed tomography