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Hemorrhagic transformation in patients with large-artery atherosclerotic stroke is associated with the gut microbiota and lipopolysaccharide

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Neural Regeneration Research 2024年第7期19卷 1532-1540页

作者： Qin Huang Minping Wei Xianjing Feng Yunfang Luo Yunhai liu Jian Xia Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Peking University People’s HospitalBeijingChina Clinical Research Center for Cerebrovascular Disease of Hunan Province Central South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Hemorrhagic transformation is a major complication of large-artery atheroscle rotic stroke(a major ischemic stro ke subtype)that wo rsens outcomes and increases *** of the gut microbiota is an important feature of stroke,and some specific bacteria and bacterial metabolites may contribute to hemorrhagic transformation *** aimed to investigate the relationship between the gut microbiota and hemorrhagic transformation in largearte ry atheroscle rotic stro *** observational retrospective study was *** May 2020 to September 2021,blood and fecal samples were obtained upon admission from 32 patients with first-ever acute ischemic stroke and not undergoing intravenous thrombolysis or endovascular thrombectomy,as well as 16 healthy *** with stro ke who developed hemorrhagic transfo rmation(n=15)were compared to those who did not develop hemorrhagic transformation(n=17)and with healthy *** gut microbiota was assessed through 16S ribosomal ribonucleic acid *** also examined key components of the lipopolysaccharide pathway:lipopolysaccharide,lipopolysaccharide-binding protein,and soluble *** observed that bacterial diversity was decreased in both the hemorrhagic transformation and non-hemorrhagic transfo rmation group compared with the healthy *** patients with ischemic stro ke who developed hemorrhagic transfo rmation exhibited altered gut micro biota composition,in particular an increase in the relative abundance and dive rsity of members belonging to the Enterobacteriaceae *** lipopolysaccharide and lipopolysaccharide-binding protein levels were higher in the hemorrhagic transformation group compared with the non-hemorrhagic transfo rmation ***,lipopolysaccharide-binding protein,and soluble CD14 concentrations were associated with increased abundance of Enterobacte ***,the role of the gut microbiota in hemorrhagic transformation was evaluated using

关键词： gut microbiota hemorrhagic transformation inflammation lipopolysaccharide stroke

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Discharge evolution law of debris flow based on a sharp bend physical modeling test

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Journal of Mountain Science 2024年第6期21卷 1904-1915页

作者： LU Ming SUN Hao liu Jinfeng Abrar HUSSAIN SHANG Yuqi FU Hang Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China

For the basins with debris flow development,its channel terrain exhibits a tortuous shape,which significantly restricts the movement of debris flows and leads to severe erosion effects on the concave ***,this study aims to analyze the shear force of debris flows within the bend *** established the relationship between the shear force and bend curvature through laboratory *** the long-term erosion by debris flows,the curvature radius of bends gradually increases,however,when this increasing trend reaches an equilibrium state with the intensity of debris flow discharge,there will be no significant change in curvature *** general,the activity pattern and discharges of debris flows would remain relatively ***,we can infer the magnitude of debris flow discharges from the terrain parameters of the bend channel.

关键词： Debris flow discharge Erosion effect Bend channel Curvature radius

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Spatiotemporal Evolution of Urban Heat Islands and Optimization of Spatial Network Construction in the Central Urban Area of Fuzhou City, China

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Chinese Geographical Science 2024年第5期34卷 917-930页

作者： ZHAO Qiuyue YU Kunyong GENG Jianwei LIN Jiqing AI Jingwen liu Jian College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China University Key Lab for Geomatics Technology and Optimize Resources Utilization in Fujian Province Fujian Agriculture and Forestry UniversityFuzhou 350002China

Although accelerated urbanization has led to economic prosperity,it has also resulted in urban heat island ***,identifying methods of using limited urban spaces to alleviate heat islands has become an urgent *** this study,we assessed the spatiotemporal evolution of urban heat islands within the central urban area of Fuzhou City,China from 2010 to *** assessment was based on a morphological spatial pattern analysis(MSPA)model and an urban thermal environment spatial network constructed us-ing the minimum cumulative resistance(MCR)*** measures for the spatial network were proposed to provide a theor-etical basis for alleviating urban heat *** results show that the heat island area within the study area gradually increased while that of urban cold island area gradually *** core area was the largest of the urban heat island patch landscape elements with a significant impact on other landscape elements,and represented an important factor underlying urban heat island network *** thermal environment network revealed a total of 197 thermal environment corridors and 93 heat island *** locations were then optimized according to the current land use,which maximized the potential of 1599.83 *** based on current land use led to an increase in climate resilience,with effective measures showing reduction in thermal environment spatial network structure and function,contributing to the mitigation of urban heat *** findings support the use of current land use patterns during urban heat island mitigation measure planning,thus providing an important reference basis for alleviating urban heat island effects.

关键词： urban heat island spatiotemporal analysis circuit theory post optimization evaluation climate mitigation Fuzhou City,China

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Regioselective and asymmetric allylic alkylation of vinyl epoxides for the construction of allylic alcohols via synergistic catalysis

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Science China Chemistry 2024年第2期67卷 542-550页

作者： Min Chen Longqing Yang Yuzhen Li Yinhe Qu Guihua Pan Xiaoming Feng Xiaohua liu Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu610064China

A highly efficient asymmetric allylic alkylation of cyclic and acyclic carbon nucleophiles with vinyl epoxides has been developed,which exhibits good functional group compatibility,high atomic and step *** protocol utilizes a strategy of synergistic catalysis with a chiral N,N'-dioxide/Ni~Ⅱ complex and an achiral Pd~0 catalyst,generating a series of multisubstituted allylic alcohols with a quaternary carbon stereocenter in high yield and excellent regio-,Z/E-and enantioselectivity under mild *** transformations of the product demonstrate the potential utility of this protocol in the synthesis of allyl alcohol derivatives and natural product *** studies revealed that the N,N′-dioxide/metal complexes play an important role in controlling the Z/E-and *** density functional theory(DFT) calculations further demonstrated that multiple C–H···π interactions between the aromatic rings of the two substrates and the amide moiety in the ligand stabilized the dominant transition state.

关键词： asymmetric allylic alkylation synergistic catalysis vinyl epoxides allyl alcohol multiple weak interactions

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Aluminum exposure impairs oocyte quality via subcellular structure disruption and DNA damage-related apoptosis in mice

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Journal of Environmental Sciences 2024年第5期139卷 308-319页

作者： Hongge Li Jingcai liu Weihua Nong Mengying Shen Sheng Dou Shaochen Sun Junli Wang The Affiliated Hospital of Youjiang Medical University for Nationalities Guangxi 533000China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of Medical Laboratory Youjiang Medical University for NationalitiesGuangxi 533000China Industrial College of Biomedicine and Health Industry Youjiang Medical University for NationalitiesGuangxi 533000China Reproductive Medicine Guangxi Medical and Health Key Discipline Construction ProjectThe Affiliated Hospital of Youjiang Medical University for NationalitiesGuangxi 533000China

Aluminum(Al)can lead to an exposure of creature in varieties ways for its universality,and it could disturb normal physiological metabolism,with the damage to multisystem including *** the oocyte quality is critical for female reproduction,we inspected the toxicity of Al on mouse oocyte *** constructed in vitro exposure mouse model,and we found that 5 mmol/L Al had adverse effects on oocyte maturation by impairing organelle and *** spindle and misaligned chromosomes which might be considered to be caused by elevated levels of acetylation,as well as abnormal distribution of actin dynamics could hinder normal meiosis of *** dysfunction indicated that Al affected proteins synthesis,transport and digestion,which would further damage oocyte *** order to explore the mechanism of Al toxicity,our further investigation demonstrated that Al caused mitochondrial dysfunction and imbalance calcium homeostasis,resulting in limited energy ***,high level of reactive oxygen species,DNA damage and apoptosis caused by oxidative stress were also the manifestation of Al toxicity on *** conclusion,our study provided the evidence that Al exposure affected oocyte quality through its effects on spindle organization,actin dynamics,organelle function and the induction of DNA damage-related apoptosis with mouse model.

关键词： Aluminum Oocyte Cytoskeleton Organelle DNA damage

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A Deep Learning Approach for Forecasting Thunderstorm Gusts in the Beijing–Tianjin–Hebei Region

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Advances in Atmospheric Sciences 2024年第7期41卷 1342-1363页

作者： Yunqing liu Lu YANG Mingxuan CHEN Linye SONG Lei HAN Jingfeng XU Faculty of Information Science and Engineering Ocean University of ChinaQingdao 266100China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China

Thunderstorm gusts are a common form of severe convective weather in the warm season in North China,and it is of great importance to correctly forecast *** present,the forecasting of thunderstorm gusts is mainly based on traditional subjective methods,which fails to achieve high-resolution and high-frequency gridded forecasts based on multiple observation *** this paper,we propose a deep learning method called Thunderstorm Gusts TransU-net(TGTransUnet)to forecast thunderstorm gusts in North China based on multi-source gridded product data from the Institute of Urban Meteorology(IUM)with a lead time of 1 to 6 *** determine the specific range of thunderstorm gusts,we combine three meteorological variables:radar reflectivity factor,lightning location,and 1-h maximum instantaneous wind speed from automatic weather stations(AWSs),and obtain a reasonable ground truth of thunderstorm ***,we transform the forecasting problem into an image-to-image problem in deep learning under the TG-TransUnet architecture,which is based on convolutional neural networks and a *** analysis and forecast data of the enriched multi-source gridded comprehensive forecasting system for the period 2021–23 are then used as training,validation,and testing ***,the performance of TG-TransUnet is compared with other *** results show that TG-TransUnet has the best prediction results at 1–6 *** IUM is currently using this model to support the forecasting of thunderstorm gusts in North China.

关键词： thunderstorm gusts deep learning weather forecasting convolutional neural network transformer

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A new TiO_(2) nanorods/MoTe_(2) quantum dots/Al_(2)O_(3) composite photocatalyst for efficient photoelectrochemical water splitting under simulated sunlight

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Frontiers of Materials Science 2024年第2期18卷 61-74页

作者： Jie Meng Hongmei liu Sainan Zhang Baogui Ye Min Feng Daoai Wang School of Chemistry and Chemical Engineering Lanzhou Jiaotong UniversityLanzhou 730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Qingdao Centerof Resource Chemistry and New Materials Qingdao 266100China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 265503China

The solar-to-hydrogen conversion using the photoelectrochemical(PEC)method is a practical approach to producing clean ***,it relies on the availability of photocatalyst *** this work,a novel photocatalyst comprising molybdenum telluride quantum dots(MoTe_(2) QDs)-modified titanium dioxide nanorods(TiO_(2) NRs)was prepared for the enhancement of the PEC water splitting performance after combination with a Al_(2)O_(3) layer using the atomic layer deposition(ALD)***_(2) QDs were initially prepared,and then they were loaded onto TiO_(2) NRs using a warm water bath-based heating *** a layer of Al_(2)O_(3) was deposited onto resulted TiO_(2) NRs/MoTe_(2) QDs,the composite TiO_(2) NRs/MoTe_(2) QDs/Al_(2)O_(3) was finally *** simulated sunlight(100 mW·cm^(-2)),such a composite exhibited a maximum photocurrent density of 2.25 mA·cm^(-2) at 1.23 V(versus RHE)and an incident photon-to-electron conversion efficiency of 69.88%at 380 nm,which are 4.33 and 6.66 times those of pure TiO_(2) NRs,***,the composite photocatalyst fabricated in this work may have promising application in the field of PEC water splitting,solarcells andotherphotocatalyticdevices.

关键词： MoTe_(2)quantum dot TiO_(2)nanorod Al_(2)O_(3) atomic layer deposition photoelectrochemistry

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Storm Liquefaction Deposits:A Possibility of Time Reversal in Sedimentary Strata of an Estuarial Coastal Area

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Journal of Ocean University of China 2024年第4期23卷 961-969页

作者： XU Guohui REN Yupeng HU Guanghai liu Zhiqin SUN Yongfu LIN Lin Key Laboratory of Marine Environment and Ecology Ministry of EducationOcean University of ChinaQingdao 266100China Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationOcean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourceQingdao 266061China National Deep Sea Center Qingdao 266237China

In the sedimentary strata dating of estuarial coastal areas,it is often found that there is phenomenon of time-reversal in *** seabed sediments could be liquefied under storm waves.A laboratory wave flume experiment demonstrated that storm-induced liquefaction deposits are formed by the oscillations of liquefied *** this paper,the particle size distribution and ^(210)Pb_(ex) specific activity of the sediment samples from the liquefaction disturbed zone and adjacent stable zone of the Yellow River Delta were *** stratigraphic divisions based on storm liquefaction deposit sequence can effectively explain the vertical changes in particle size and ^(210)Pb_(ex) specific *** to the differentiation of particles during the storm induced liquefaction,coarse and fine particles regrouped,which could explain the phenomenon of time-reversal in dating data.

关键词： ^(210)Pb_(ex)specific activity liquefaction deposition reversal sediment

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Review on current development of polybenzimidazole membrane for lithium battery

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Journal of Energy Chemistry 2024年第4期91卷 579-608页

作者： Yonggui Deng Arshad Hussain Waseem Raza Xingke Cai Dongqing liu Jun Shen College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060GuangdongChina Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management(IRC-HTCM) King Fahd University of Petroleum&MineralsKFUPM Box 504031261 DhahranSaudi Arabia Institute for Advanced Study Shenzhen UniversityShenzhen 518060GuangdongChina

With the rapid development of portable technology,lithium batteries have emerged as potential candidates for high-performance energy storage systems owing to their high energy density and cycling *** the key components of a lithium battery system,the separator plays a critical role as it directly influences the battery performance benchmark(cycling performance and safety).However,traditional polyolefin separators(polypropylene/polyethylene)are unable to meet the demands of highperformance and safer battery systems due to their poor electrolyte compatibility,thermal runaways,and ultimate growth of *** contrast,membranes fabricated using polybenzimidazole(PBI)exhibit excellent electrolyte wettability and outstanding thermal dimensional stability,thus holding great potential as separators for high-performance and high-safety *** this paper,we present a comprehensive review of the general requirements for separators,synthesis technology for separators,and research trends focusing PBI membranes in lithium batteries to alleviate the current commercial challenges faced by conventional polyolefin *** addition,we discuss the future development direction for PBI battery separators by considering various factors such as production cost,ecological footprint,preparation technology,and battery component *** exploring these perspectives,we aim to promote the continued application and exploration of PBI-based materials to advance lithium battery technology.

关键词： Lithium batteries Separators Porous separators Polybenzimidazole Membrane

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面向两个细则考核的风-储场站日前-日内两阶段功率优化上报策略

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电工技术学报 2024年第1期39卷 135-153页

作者：吴浩天柯德平刘念璋方珂郑景文武汉大学电气与自动化学院武汉430072 国网江苏省电力有限公司南京供电公司南京210019 国网湖北省电力有限公司电力科学研究院武汉430077

针对两个细则考核风功率上报准确率的问题,提出一种可有效降低风-储场站风险考核电量的日前-日内两阶段功率优化上报策略。首先,提出面向两个细则的风-储场站日前-日内功率协同上报框架;然后,以期望考核电量最小化为目标,建立计及储能... 详细信息

针对两个细则考核风功率上报准确率的问题,提出一种可有效降低风-储场站风险考核电量的日前-日内两阶段功率优化上报策略。首先,提出面向两个细则的风-储场站日前-日内功率协同上报框架;然后,以期望考核电量最小化为目标,建立计及储能调节的日前-日内两阶段风-储功率优化上报模型,模型中,日前、日内风功率场景集通过基于预测误差分箱的Cornish-Fisher级数与Cholesky分解法生成;最后,针对模型的多重非线性特征与不同时间尺度的求解效率要求,制定基于小步长线性化迭代的求解算法。算例仿真结果表明,相较其余上报策略与求解算法,该文提出的日前-日内协同上报策略及相应算法有效地提升了上报准确率及求解性能。

关键词：两个细则风功率上报日前-日内协同优化时间相关性储能调节

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