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Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma

Current Medical Science 2024年第5期44卷 890-901页

作者： Bi-qiong ZHANG Feng-qing WANG Jie YIN xiao-tan YU zheng-xi hu Liang-hu GU Qing-yi TONG Yong-hui ZHANG hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult lymphohematopoietic *** the limitations of current therapies,there is a pressing need to develop new and effective drugs for DLBCL *** A series of pyrrolidone derivatives were synthesized,and their antitumor activities were assessed,particularly against DLBCL cell ***-activity relationship(SAR)analysis was conducted to identify key structural components essential for *** most promising compound,referred to as compound 7,was selected for further mechanistic *** expression levels of relevant mRNA and protein were detected by RT-qPCR and Western blotting,and the expression of mitochondrial membrane potential and ROS was detected using flow cytometry for further assessment of cell cycle arrest and *** The compound 7 exhibited good antitumor activity among the synthesized derivatives,specifically in DLBCL cell *** analysis highlighted the critical role ofα,β-unsaturated ketones in the antitumor efficacy of these ***,compound 7 was found to induce significant DNA damage,trigger an inflammatory response,cause mitochondrial dysfunction,and disrupt cell cycle progression,ultimately leading to apoptosis of DLBCL *** The compound 7 has good antitumor activity and can induce multiple cellular mechanisms leading to cancer cell *** findings warrant further investigation of the compound 7 as a potential therapeutic agent for DLBCL.

关键词： pyrrolidone analogs Michael acceptor DNA damage mitochondrial dysfunction apoptosis

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Defect Engineering with Rational Dopants Modulation for High‑Temperature Energy Harvesting in Lead‑Free Piezoceramics

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Nano-Micro Letters 2025年第3期17卷 87-101页

作者： Kaibiao xi Jianzhe Guo Mupeng zheng Mankang Zhu Yudong Hou Key Laboratory of Advanced Functional Materials Ministry of EducationCollege of Materials Science and EngineeringBeijing University of TechnologyBeijing 100124People’s Republic of China

High temperature piezoelectric energy harvester(HTPEH)is an important solution to replace chemical battery to achieve independent power supply of HT wireless ***,simultaneously excellent performances,including high figure of merit(FOM),insulation resistivity(ρ)and depolarization temperature(Td)are indispensable but hard to achieve in lead-free piezoceramics,especially operating at 250°C has not been reported ***,well-balanced performances are achieved in BiFeO3–BaTiO3 ceramics via innovative defect engineering with respect to delicate manganese *** to the synergistic effect of enhancing electrostrictive coefficient by polarization configuration optimization,regulating iron ion oxidation state by high valence manganese ion and stabilizing domain orientation by defect dipole,comprehensive excellent electrical performances(Td=340°C,ρ250°C>10^(7)Ωcm and FOM_(250°C)=4905×10^(–15)m^(2)N^(−1))are realized at the solid solubility limit of manganese *** HT-PEHs assembled using the rationally designed piezoceramic can allow for fast charging of commercial electrolytic capacitor at 250°C with high energy conversion efficiency(η=11.43%).These characteristics demonstrate that defect engineering tailored BF-BT can satisfy high-end HT-PEHs requirements,paving a new way in developing selfpowered wireless sensors working in HT environments.

关键词： Lead-free piezoceramic Defect engineering Dopants modulation High-temperature Piezoelectric energy harvester

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Two New Compounds from Schisandra propinqua ***

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Natural Products and Bioprospecting 2017年第3期7卷 257-262页

作者： Miao Liu zheng-xi hu Yuan-Qing Luo Min Zhou Wei-Guang Wang xiao-Nian Li Xue Du Jian-xin Pu Han-Dong Sun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People’s Republic of China

Schisanpropinoic acid(1),a new bergamotane sesquiterpenoid,and schisanpropinin(2),a new tetrahydrofuran lignan with a rare epoxyethane unit,were identified from the stems and leaves of Schisandra propinqua *** structures were determined based on comprehensive spectroscopic and mass spectrometric *** absolute configuration of 1 was determined by X-ray *** 1 and 2 were tested for their cytotoxic activity against five human tumor cell lines.

关键词： Schisandra propinqua var.propinqua Bergamotane-type sesquiterpenoid Lignan Absolute configuration Cytotoxicity

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen zheng Song Dinggang Fan Bing hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng zheng Wang Ruisong Zhu Ruijie Liu Jiang Ma Lina hu Weihua Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

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Triterpenoids from Whole Plants of Phyllanthus urinaria

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Chinese Herbal Medicines 2017年第2期9卷 193-196页

作者： Ye Wu Shuang-shuang xie zheng-xi hu Zhao-di Wu Yi Guo Jin-wen Zhang Jian-ping Wang Yong-bo Xue Yong-hui Zhang Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and Technology

Objective To study the chemical constituents of whole plant of Phyllanthus urinaria and their biological *** The chemical constituents were isolated and purified by repeated column chromatography over silica gel,Rp-C18（reverse phase）,MCI,and Sephadex LH-20,as well as semi-preparative *** spectroscopic analyses were used for the structure *** this case,the inhibitory rate of NO production of the isolated triterpenoids was *** Seven triterpenoids,identified as28-norlup-20（29）-ene-3,17β-diol（1）,betulin（2）,β-betulinic acid（3）,3-oxofriedelan-28-oic acid（4）,oleanolic acid（5）,3R-E-coumaroyltaraxerol（6）,and 3R-Zcoumaroyltaraxerol（7）,were isolated and identified from the whole plants of *** 1-5 exerted inhibitory effects against NO production in LPS-induced RAW264.7 mouse macrophages with the inhibitory rate of NO production ranging from 4.0%to 27.8%at the concentration of 25 μmol/*** To the best of our knowledge,this is the first report of compounds 1-4,6,and 7 from the family *** 1-5 exhibited inhibitory effects against NO production in LPS-induced RAW264.7 mouse macrophages.

关键词： biological activity Euphorbiaceae Phyllanthus urinaria triterpenoids

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑xia Su Jia‑Min hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Reverse modulation of defect density of Ce-MOF-808 by solventassisted ligand exchange for dicyclopentadiene hydrogenation

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Science China Chemistry 2025年

作者： Danfeng Zhao Fajie hu Rushuo Li xinmeng Xu Zhaokun Wang Zuoshuai xi Jun Tong xiubing huang Ge Wang Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule & Structure Construction School of Materials Science and Engineering University of Science and Technology Beijing

Defect engineering is a pivotal strategy for tailoring the electronic structure and physicochemical properties of catalysts, yet the straightforward manipulation of defect density in porous materials presents a current challenge. In this work, we achieved precise control over the coordination unsaturated site（CUS） content and pore architecture of Ce-MOF-808 by employing 2-fluorobenzoic acid（2-FBA） as a modifier. Leveraging the p Kadisparities among three ligands（1,3,5-tricarboxylic benzoic acid,formic acid, and 2-FBA）, we preserved the spn topology of Ce-MOF within an aqueous system, while realizing partial substitution of the auxiliary ligands and saturation of the CUS. The amount of 2-FBA was negatively correlated with the number of ligand defects, and the consequent decrease in Ce3+content and the increase in the number of ligand linkages also induced crystal structure transformation. The modulation of the defect structure was correlated with the catalytic performance of dicyclopentadiene（DCPD） hydrogenation reaction, in which Ce-MMF0.15, constructed by the modulation of 0.15 mol amount of 2-fluorobenzoic acid, exhibited an optimal ligand defect density and micro-mesoporous structure, enabling almost complete conversion of DCPD at 100 ℃ and 2 MPa. This article also elucidates the correlation between the regulation of defect density and the accessibility of frustrated Lewis pair（FLP） active sites, guiding the application of novel porous intrinsic FLP materials in hydrogenation catalysis.

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基于STM32低功耗磁弹性传感器检测系统的设计

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生物医学工程学杂志 2016年第5期33卷 972-978页

作者：唐詠罗洪艳陈曦郑小林胡宁苏添进李川廖彦剑重庆大学生物工程学院生物流变科学与技术教育部重点实验室重庆市医疗电子工程技术研究中心重庆400044

具有无线、无源、低成本、高灵敏度等特点的磁弹性传感器已在各个领域得到了广泛的应用研究,然而现有的检测装置通常体积较庞大、功耗高、便携性差,限制了该类传感器的应用范围。对此,本文设计了一套基于STM32的便携式、低功耗共振型磁... 详细信息

具有无线、无源、低成本、高灵敏度等特点的磁弹性传感器已在各个领域得到了广泛的应用研究,然而现有的检测装置通常体积较庞大、功耗高、便携性差,限制了该类传感器的应用范围。对此,本文设计了一套基于STM32的便携式、低功耗共振型磁弹性传感器检测系统。系统以扫频法为检测基础,以STM32为控制核心,永磁铁作为偏置磁场激励,集成交流激励信号单元、信号检测与采集单元,并利用SD卡存储测量数据,采用锂电池供电。实验结果表明:检测系统可使磁弹性传感器在不同介质、不同浓度中完成共振频率的测量,频率分辨率可达1Hz;测量不同尺寸的磁弹性传感器,所得传感器共振频率比为0.933 8,与理论值0.942 3接近;另外,与传统的阻抗分析仪搭建的组合式检测系统和现行的集成式检测系统相比,本系统工作时功耗为0.68 W,休眠时功耗仅为2.20mW。由此可见,本系统不仅能够代替原有的阻抗分析仪等组合式检测系统,而且能够大大提升现行集成式检测系统的功耗控制,兼具高集成度、便携式以及可用于长期监测等优点。

关键词：磁弹性传感器扫频法共振频率便携式低功耗

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SARS流行病传染动力学研究

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生物化学与生物物理进展 2004年第2期31卷 167-171页

作者：李铮陈曦滕虎修志龙孙丽华冯恩民大连理工大学环境与生命学院生物科学与工程系大连116024 大连理工大学应用数学系大连116024

Logistic确定型增长模型可被用来描述严重急性呼吸道综合症 (SARS)的流行规律 ,通过对部分国家、地区及中国内地部分省市的数据进行拟合 ,及其对拟合结果的分析 ,揭示了各个地区SARS传染力不均匀的现象 ,以及在控制措施上的差异所带来... 详细信息

Logistic确定型增长模型可被用来描述严重急性呼吸道综合症 (SARS)的流行规律 ,通过对部分国家、地区及中国内地部分省市的数据进行拟合 ,及其对拟合结果的分析 ,揭示了各个地区SARS传染力不均匀的现象 ,以及在控制措施上的差异所带来的不同效果 .同时 ,还对超级传播现象 (SSEs)

关键词：严重急性呼吸道综合症传染动力学超级传播现象 Logistic模型 SARS

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