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Morphological and serum hyaluronic acid, laminin and type Ⅳ collagen changes in dimethylnitrosamine-induced hepatic fibrosis of rats

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World Journal of Gastroenterology 2005年第48期11卷 7620-7624页

作者： Chun-Hui Li Dong-Ming Piao Wen-Xie Xu zheng-ri yin Jing-Shun Jin Zhe-Shi Shen Department of Pathology Affiliated Hospital of Yanbian University College of Medicine Yanji 133000 Jilin Province China Department of Physiology College of Medicine Shanghai Jiaotong University Shanghai 200030 China Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China

AIM： To study the morphological and serum hyaluronic acid （HA）, laminin （LN）, and type IV collagen changes in hepatic fibrosis of rats induced by dimethylnitrosamine （DMN）.METHODS： The rat model of liver fibrosis was induced by DMN. Serum HA, type IV collagen, and LN were measured by ELISA. The liver/weight index and morphological changes were examined under electron microscope on d 7, 14, 21, and 28 by immunohistochemical alpha smooth muscle actin α-SMA staining as well as Sirius-red and HE ***： The levels of serum HA, type IV collagen and LN significantly increased from d 7 to d 28 （P = 0.043）. The liver/weight index increased on d 7 and decreased on d 28. In the model group, the rat liver stained with lie and Sirius-red showed evident hemorrhage and necrosis in the central vein of hepatic 10 Iobules on d 7. Thin fibrotic septa were formed joining central areas of the liver on d 14. The number of α-SMA positive cells was markedly increased in the model group. Transitional hepatic stellate cells were observed under electron microscope. All rats in the model group showed micronodular fibrosis in the hepatic parenchyma and a network of α-SMA positive cells. Typical myofibroblasts were embedded in the core of a fibrous septum. Compared to the control group, the area-density percentage of collagen fibrosis and pathologic grading were significantly different in the model group （P〈0.05） on different d （7, 14, and 28）. The area-density percentage of collagen fibrosis in hepatic tissue had a positive correlation with the levels of serum HA, LN, and type IV ***： The morphological and serum HA, type IV collagen, and LN are changed in DMN-induced liver fibrosis in rats.

关键词： Rat Hepatic fibrosis DMN Morphologicalchange Serum Experimental studies

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Experimental observation of spontaneous symmetry breaking in a quantum phase transition

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 34-39页

作者： Wen Ning ri-Hua zheng Jia-Hao Lu Fan Wu Zhen-Biao Yang Shi-Biao zheng Fujian Key Laboratory of Quantum Information and Quantum Optics College of Physics and Information EngineeringFuzhou UniversityFuzhou 350108China Hefei National Laboratory Hefei 230088China

Spontaneous symmetry breaking(SSB)plays a central role in understanding a large variety of phenomena associated with phase transitions,such as superfluid and *** far,the transition from a symmetric vacuum to a macroscopically ordered phase has been substantially *** process bridging these two distinct phases is critical to understanding how a classical world emerges from a quantum phase transition,but so far remains unexplored in *** here report an experimental demonstration of such a process with a quantum Rabi model engineered with a superconducting *** move the system from the normal phase to the superradiant phase featuring two symmetry-breaking field components,one of which is observed to emerge as the classical *** results demonstrate that the environment-induced decoherence plays a critical role in the SSB.

关键词： quantum phase transition Rabi model spontaneous symmetry breaking superconducting circuit Schrodinger cat states

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Effect of an Airbag-selective Portal Vein Blood Arrester on the Liver after Hepatectomy:A New Technique for Selective Clamping of the Portal Vein

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Current Medical Science 2024年第2期44卷 380-390页

作者： Ce-xiong FU Xiao-ri QIN Jin-song CHEN Jie ZHONG Yu-xu XIE Bi-dan LI Qing-qing FU Fang LI Jin-fang zheng Department of Hepatobiliary and Pancreatic Surgery Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China University of South China Hengyang 421001China Department of Gastroenterology Gastroenterology Endoscopy CenterHainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 57031lChina Center of Clinical Laboratory Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China Department of Radiology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Objective:A novel technique was explored using an airbag-selective portal vein blood arrester that circumvents the need for an intraoperative assessment of anatomical variations in patients with complex intrahepatic space-occupying ***:Rabbits undergoing hepatectomy were randomly assigned to 4 groups:intermittent portal triad clamping(PTC),intermittent portal vein clamping(PVC),intermittent portal vein blocker with an airbag-selective portal vein blood arrester(APC),and without portal blood occlusion(control).Hepatic ischemia and reperfusion injury were assessed by measuring the 7-day survival rate,blood loss,liver function,hepatic pathology,hepatic inflammatory cytokine infiltration,hepatic malondialdehyde levels,and proliferating cell nuclear antigen ***:Liver damage was substantially reduced in the APC and PVC *** APC animals exhibited transaminase levels similar to or less oxidative stress damage and inflammatory hepatocellular injury compared to those exhibited by the PVC *** was significantly higher in the control group than in the other *** APC group had less bleeding than the PVC group because of the avoidance of portal vein skeletonization during ***,more operative time was saved in the APC group than in the PVC ***,the total 7-day survival rate in the APC group was higher than that in the PTC ***:Airbag-selective portal vein blood arresters may help protect against hepatic ischemia and reperfusion injury in rabbits undergoing partial *** technique may also help prevent liver damage in patients requiring hepatectomy.

关键词： hepatectomy portal vein hepatic damage selective clamping

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Relationship between atrial natriuretic peptide-immunoreactive cells and microvessels in rat gastric mucosa

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Acta Pharmacologica Sinica 2006年第2期27卷 205-211页

作者： Chun-hui LI~(2,3) Zong-wei YANG~3 zheng-ri yin~3 zheng JIN~3 De-gang XING~3 Lian-hua PIAO~3 Yong-chul KIM~4 Wen-xie XU~(2,5) ~2College of Life Science and Biotechnology.Shanghai Jiaotong University,Shanghai 200240,China:~3Department of Physiology.Yanbian University College of Medicine.Yanji 133000.China ~4Department of Physiology,Chungbuk National University,College of Medicine.Cheongju.Chungbuk 361-763,Korea College of Life Science and Biotechnology Shanghai Jiaotong University Shanghai China Department of Physiology Yanbian University College of Medicine Yanji China Department of Physiology Chungbuk National University College of Medicine Cheongju Korea

Aim:To investigate the ultrastructural localization of atrial natriuretic peptide(ANP)-synthesizing cells and the relationship between ANP-synthesizing cellsand microvessels in rat gastric ***:Immunohistochemistry tech-niques and postembedding immunoelectron microscopy techniques were used tovalidate the findings regarding the expression of ANP-synthesizing cells and theultrastructural localization of ANP-synthesizing cells in the gastric ***-tochemistry techniques and the tannic acid-ferric chloride method(TA-Fe stain-ing method)were used to reveal microvessel density and the distribution of ANP-synthesizing cells in different regions of the ***:Cells expressingANP were localized and ANP-synthesizing cells were identified as enterochroma-ffin(EC)cells in the gastric ***-synthesizing cells existed in differentregions of the *** percentage ANP-synthesizing cells in the mucosawas greatest in the fundus(46.7%e5.3%),intermediate in the antrum(40.1%±4.5%),and least in the body(21.6%±3.6%).There was a positive relationshipbetween the percentage of ANP-synthesizing cells and the density of microvesselsin the antral mucosa,but not in the fundus or body ***:ANP issynthesized by EC cells in rat gastric mucosa,and ANP-synthesizing cells aremost dense in the gastric *** may act not only as a regional autocrineand/or paracrine regulator,but also as an endocrine regulatory peptide in thegastrointestinal tract.

关键词： atrial natriuretic factor enterochromaffin cells blood vessels gastric mucosa

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Constructing Lithium-Free Anode/Separator Interface via 3D Carbon Fabric Scaffold for Ultrasafe Lithium Metal Batteries

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Research 2024年第3期2023卷 359-368页

作者： Dongdong Li Shengchen Yang Zijian zheng Wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China Department of Materials Chemistry Huzhou University1 Xueshi RoadHuzhou 313000China Laboratory for Advanced Interfacial Materials and Devices School of Fashion and TextilesDepartment of Applied Biology and Chemical TechnologyResearch Institute for Intelligent Wearable Systems(RI-IWEAR)Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityHong Kong SAR 999077China

Metallic lithium represents a promising anode candidate to be utilized in future high-energy lithium ***,the undesirable dendrite growth and fragile solid-electrolyte interphase(SEI)pose critical challenge for pursuing further practical *** contrast to traditional approaches of using inert/lithiophilicity coating,here,we demonstrate a reverse strategy of introducing a highly conductive and lithophobic carbon fabric(CF)scaffold on lithium foil to guide a favorable nucleation site of lithium far away from the anode/separator *** CF scaffold with high conductivity can couple with inner electric field for achieving a uniform distribution of the lithium-ion flux,while the lithophobic feature offers the condition to guide the preferred deposition of lithium onto the underlying lithium foil,which greatly reduces the risk of dendrite-induced short ***,the SEI immersed in the CF scaffold is well supported by CF fibers and therefore exhibits extremely high stability during charge–discharge *** a result,the lithium/CF anodes show>2,000-h stable cycling at 0.5 mA cm−*** metal batteries equipped with our lithium/CF anode deliver a high capacity retention of~99.99%per cycle,i.e.,retain~97.3%capacity after 200 *** unique interface-regulation strategy is versatile for various conductive scaffolds(e.g.,ultrathin and ultralight conductive fabrics),exhibiting high superiority for highly safe lithium metal batteries.

关键词： lithium equipped versatile

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一维合成维度水基声子晶体

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物理学报 2024年第10期73卷 221-226页

作者：胡晨阳梁家洛郑日翌陆久阳邓伟胤黄学勤刘正猷华南理工大学物理与光电学院广州510640 武汉大学物理科学与技术学院人工微纳结构教育部重点实验室武汉430072

水下声学在水下通信、水下定位和导航等方面具有广泛的应用.借助拓扑物理的概念,研究水基声子晶体中的拓扑态为水下声波的创新性调控提供了一种全新的手段,既有基础研究价值,又有重要的应用前景.本文设计了一种一维的双层铁栅水基声子晶... 详细信息

水下声学在水下通信、水下定位和导航等方面具有广泛的应用.借助拓扑物理的概念,研究水基声子晶体中的拓扑态为水下声波的创新性调控提供了一种全新的手段,既有基础研究价值,又有重要的应用前景.本文设计了一种一维的双层铁栅水基声子晶体,通过把层间的相对横向平移量等效成一个合成维度,实现了合成二维狄拉克点.相对平移量的改变导致二重简并能带打开带隙.伴随着带隙的打开、闭合以及再次打开,能带发生翻转,也就是发生拓扑相变,从一种能谷相变化到另一种能谷相.在不同能谷相声子晶体构成的界面处,能谷陈数保证界面态的确定性存在.数值仿真与实验测量结果吻合良好,都展示了不同能谷相声子晶体的体能带以及它们之间的界面态色散.本文提出的水基声子晶体结构简单,借助合成维度的概念,为在低维实空间体系中研究高维体系拓扑特性提供了一种有效的途经,有望为拓扑功能性水声器件的设计提供新思路.此外,可以把实空间体系拓展到二维甚至是三维,并引入更多的合成维度,用于研究更高维度体系的拓扑态及其输运特性.

关键词：水基声子晶体合成维度狄拉克点界面态

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生涯建构箱庭对高校学生生涯适应力的干预效果

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中国临床心理学杂志 2024年第2期32卷 480-484,462页

作者：姚璇琛郑晴张日昇北京师范大学发展心理研究院北京100875

目的:探究生涯建构箱庭对于高校学生生涯适应力的干预效果及咨询过程中的重要因素。方法:12名来访者随机分为实验组和等待组,实验组进行每周1次共4次的生涯建构箱庭咨询,等待组无干预。在结束对照后,对等待组进行同样流程的干预。用生... 详细信息

目的:探究生涯建构箱庭对于高校学生生涯适应力的干预效果及咨询过程中的重要因素。方法:12名来访者随机分为实验组和等待组,实验组进行每周1次共4次的生涯建构箱庭咨询,等待组无干预。在结束对照后,对等待组进行同样流程的干预。用生涯适应力量表和学生生涯建构问卷评价干预效果,并在干预后进行质性访谈。结果:在组间比较中,实验组生涯适应力量表、学生生涯建构问卷后测得分显著高于等待组;组内比较中,将实验组与接受干预后的等待组数据合并分析,接受干预后的量表得分都显著高于干预前,且干预后一个月的回访量表得分与干预后无显著差异。共12名来访者完成质性访谈,质性分析结果显示生涯建构箱庭对高校学生有帮助的内容为思考与探索、领悟与整合、计划与行动。结论:生涯建构箱庭能够有效提高高校学生的生涯适应力,帮助其解决生涯问题。

关键词：生涯建构咨询箱庭疗法生涯适应力干预研究

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公共草场自主治理实现机制——基于SES框架的案例分析

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草地学报 2024年第4期32卷 1021-1033页

作者：乌日汗李平张苏日塔拉图钱政成王强中国农业科学院草原研究所内蒙古呼和浩特010010

随着牧区社会-生态系统破碎化问题的凸显,公共草场自主治理引起了学术界关注。然而,中国现行草地承包制度下,自主治理制度的可行性及其实现机制仍有待系统研究。本文连续三年跟踪调查了内蒙古一片公共草场,应用SES框架解构了案例地复杂... 详细信息

随着牧区社会-生态系统破碎化问题的凸显,公共草场自主治理引起了学术界关注。然而,中国现行草地承包制度下,自主治理制度的可行性及其实现机制仍有待系统研究。本文连续三年跟踪调查了内蒙古一片公共草场,应用SES框架解构了案例地复杂系统,并依据案例地情形构建了关联博弈模型,解析了公共草场自主治理制度下牧户互动机制。结果表明:草地资源的可持续利用关乎牧户长期生产成本。为了节约长期生产成本,牧区社区制定了公共草场自主治理制度。制度实施过程中,依据牧草长势和牲畜膘情形成了动态的草畜平衡规则,可操作的惩罚制度和地方政府弹性干预促进了自主治理制度的良好运作。同时,牧户之间的放牧博弈和社会交往博弈相互关联,使得自主治理制度以较低成本自我实施。该制度的有效实施有助于提高草地资源使用的公平性,也有利于牧户之间、牧户与地方政府之间信任的增长,提高生产互惠性和生产效率。因此,应探索建立自主治理和承包制度并存的多样化草地资源管理体系。

关键词：自主治理 SES框架关联博弈草地资源管理

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不同施氮水平下硅肥对谷子抗倒伏能力、产量和品质的影响

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植物营养与肥料学报 2024年第4期30卷 641-654页

作者：温银元郭之瑶郑志强胡奇林赵娟董淑琦原向阳温日宇尹美强山西农业大学农学院山西太谷030801 甘肃省平凉市农业科学院甘肃平凉744000 山西省吕梁市乡村振兴局山西吕梁033000

[目的]倒伏严重影响谷子产量和品质。探究不同施氮水平下硅肥提高谷子茎秆强度、产量及品质的作用,为谷子高产高效施肥提供技术方案。[方法]以晋谷21和张杂13为供试谷子品种,在山西太谷进行大田试验。在常规施氮量N_(1)(180 kg/hm^(2))... 详细信息

[目的]倒伏严重影响谷子产量和品质。探究不同施氮水平下硅肥提高谷子茎秆强度、产量及品质的作用,为谷子高产高效施肥提供技术方案。[方法]以晋谷21和张杂13为供试谷子品种,在山西太谷进行大田试验。在常规施氮量N_(1)(180 kg/hm^(2))和高施氮量N_(2)(450 kg/hm^(2))下,分别设置不施硅、施用硅酸钠(Si_(1),SiO_(2) 68.85 kg/hm^(2))和硅钙肥(Si_(2),SiO_(2) 67.2 kg/hm^(2)),共6个处理。在谷子成熟期测量其株高、抗倒伏能力相关指标、光合特性、产量和品质相关指标,并观察茎秆横切面显微结构。[结果]N_(1)水平下,施用硅肥降低了谷子基节长度,增加了茎粗、茎秆抗折力和穿刺力,晋谷21和张杂13两品种前五基节的节间长度分别降低了4.1%~30.1%和9.5%~11.5%,茎粗分别增加5.3%~19.4%和13.0%~34.1%;晋谷21抗倒性在N_(1)-Si_(1)处理较强,第一、第二基节抗倒伏指数较N_(1)-Si_0处理分别增加37.4%和35.8%,张杂13在N_(1)-Si_(2)处理时较强,第一、第二基节抗倒伏指数较N_(1)-Si_0处理分别增加136.0%和94.7%。N_(2)水平下,施用硅肥后晋谷21和张杂13前五基节的节间长度分别降低了9.6%~30.3%和10.6%~14.9%,茎粗分别增加了9.56%~23.9%和16.2%~31.0%,茎秆扁平度降低。硅钙肥对谷子茎秆强度影响大于硅酸钠,N_(2)-Si_(2)处理晋谷21的第二基节抗折力、穿刺力和抗倒伏指数比N_(2)-Si_0分别增加97.9%、77.6%和83.3%,张杂13的第一基节抗折力、穿刺力和抗倒伏指数比N_(2)-Si_0分别增加74.0%、66.8%和128%。施硅后谷子茎秆中机械组织增厚,维管束数量增多且排列均匀,向茎秆中心延伸,且在N_(2)水平下,硅钙肥作用效果优于硅酸钠。硅可促进谷子穗码发育,增加穗粗、穗粒数和千粒重,在高氮水平下硅钙肥处理使晋谷21和张杂13的产量分别增加23.8%和24.0%。施用硅肥能够提高谷子脂肪、蛋白质和氨基酸含量,在高氮水平下可以降低谷子直链淀粉/支链淀粉值。[结论]在高氮条件下,施用硅钙肥使谷子前五基节长度降低,茎粗增加,机械强度增加,进而提高抗倒伏能力;施用硅肥还可增加光合速率和蒸腾速率,促进物质积累和运输,增加产量,改善品质。

关键词：谷子硅酸钙硅酸钠施氮量基部茎秆性状机械强度抗倒伏指数产量品质

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信息化时代下高校计算机科学与技术专业教学改革探索

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湖北开放职业学院学报 2024年第3期37卷 164-165,168页

作者：郑日美北海职业学院广西北海536000

计算机技术的不断发展和创新,计算机科学与技术已经渗透到了各个行业和领域,为社会进步和企业发展创造了巨大的机会和条件。在数字化转型的加速推进下,企业需要更多满足市场需求的技术和人才,同时也对高校计算机科学与技术应用型人才培... 详细信息

计算机技术的不断发展和创新,计算机科学与技术已经渗透到了各个行业和领域,为社会进步和企业发展创造了巨大的机会和条件。在数字化转型的加速推进下,企业需要更多满足市场需求的技术和人才,同时也对高校计算机科学与技术应用型人才培养提出更高要求,以适应不断发展的技术和市场趋势。针对当前计算机科学与技术应用人才培养存在的问题,应从人才培养方案、课程体系建设、完善教学方法、加强教师培训等方面着手,更好地满足社会和行业对高素质计算机专业人才的需求。

关键词：应用型高校计算机科学与技术教学

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