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Histone H4K8hib modification promotes gene expression and regulates rice immunity

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Molecular Plant 2025年第1期18卷 9-13页

作者： Qiutao Xu Xuan ma Xuelu Wei zhengting Chen Yuhang Duan Yuliang Ju Zhaoyun Wang Jing Chen Lu zheng Xiaolin Chen Junbin Huang Jisen Zhang Xiaoyang Chen State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of AgricultureGuangxi UniversityNanning 530004China College of Agriculture Ningxia UniversityYinchuan 750021China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070China Anhui Province Key Laboratory of Crop Integrated Pest management Anhui Agricultural UniversityHefei 230036China

Dear Editor,Histones undergo various post-translational modifications essential for transcription,DNA replication,repair,and other cellular processes(Li et al.,2018).While histone methylation and acetylation are well studied,emerging short-chain lysine acylations,such as crotonylation,succinylation,lactylation,acetoacetylation,and 2-hydroxyisobutyrylation(Khib)(Li et al.,2018;Lu et al.,2018;zheng et al.,2021;Gao et al.,2023),are expanding the field of epigenetic *** these short-chain acylations,Khib has garnered recent attention as an evolutionarily conserved modification on histone proteins,extensively characterized in yeast and animals,where it plays a role in glucose response and virus infection(Huang et al.,2017;Zhao et al.,2022).In plants,H4K8hib has been identified on histones,but its functions and the enzymes involved in its removal remain *** this study,we analyzed the H4K8hib modification profile in rice,exploring its role in the rice immune response and identifying the enzymes responsible for its removal.

关键词： immunity modification expanding

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地表粗糙度影响风力机输出功率的实验研究

华中科技大学学报(自然科学版) 2025年第1期53卷 79-85页

作者：马高生王鹏锜李德顺郑权兰州理工大学能源与动力工程学院甘肃省风力发电工程技术创新中心

利用尖劈和粗糙元组合构建四种符合不同风廓线指数的边界层．在轮毂高度处来流平均风速、湍流积分尺度和风速脉动功率谱相同的前提下，考察不同的风速廓线对风力机功率频谱的影响．结果表明：风力机输出功率频谱与来流的湍流频谱在频域... 详细信息

利用尖劈和粗糙元组合构建四种符合不同风廓线指数的边界层．在轮毂高度处来流平均风速、湍流积分尺度和风速脉动功率谱相同的前提下，考察不同的风速廓线对风力机功率频谱的影响．结果表明：风力机输出功率频谱与来流的湍流频谱在频域上表现为三个对应的区域，分别为湍流谱中以大尺度湍流结构为代表的低频区域、代表湍流能量耗散的中间区和以小尺度和微尺度漩涡为代表的高频区．不同的地表粗糙度下，对应于中间区域的风力机输出功率频谱表现衰减的斜率不同；相同的地表粗糙度下，衰减程度与湍流积分尺度、风速等因素无关，两个量的频谱特征呈现出一种非线性关系，衰减斜率有随地表粗糙度增加而增大的趋势．不同风廓线指数下风力机输出功率有较大差别，来流中的能量差异是造成输出功率变化的重要原因．

关键词：地表粗糙度风力机功率频谱湍流频谱风洞实验

基于铝土矿的矿物复合材料的制备及其在川宣地1井深部卤水提锂中的应用

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岩石矿物学杂志 2025年第1期44卷 181-193页

作者：钱程郑绵平张永生中国地质科学院矿产资源研究所自然资源部盐湖资源与环境重点实验室北京100037 中国地质科学院自然资源部深地科学与探测技术实验室北京100037 中国地质科学院矿产资源研究所自然资源部成矿作用与资源评价重点实验室北京100037

以天然铝土矿为原料,制备了以LiCl·2 Al(OH)_(3)·n H_(2)O为核心成分的铝土矿基矿物复合材料(bauxite-based mineral composites,BMC),并用于川宣地1井深部卤水中锂的分离和富集,并探讨了模拟溶液和真实卤水中BMC对Li^(+)的吸附和解... 详细信息

以天然铝土矿为原料,制备了以LiCl·2 Al(OH)_(3)·n H_(2)O为核心成分的铝土矿基矿物复合材料(bauxite-based mineral composites,BMC),并用于川宣地1井深部卤水中锂的分离和富集,并探讨了模拟溶液和真实卤水中BMC对Li^(+)的吸附和解吸性能。模拟Li^(+)溶液吸附结果表明,拟二级动力学模型和Langmuir模型能较好地描述吸附过程,且298 K时Li^(+)饱和容量为2.78 mg/g。川宣地1井深部卤水中Li^(+)分离和富集研究结果表明,BMC用量1.0 g/25 mL时,卤水中Li^(+)的吸附率达到86.38%,在Na^(+)、K^(+)、Ca^(2+)和Mg^(2+)等竞争离子存在的情况下,对Li^(+)具有良好的选择性吸附,经过5次吸附和再生后,吸附容量下降了10.64%。洗脱液经过离子交换树脂除杂后,采用Na_(2)CO_(3)沉淀的方式对洗脱液中Li^(+)进行富集,Li_(2)CO_(3)产率最高可达80%以上,且制备的Li_(2)CO_(3)与商用分析纯Li_(2)CO_(3)具备相当的品质,表明铝土矿基矿物复合材料在卤水提取Li^(+)方面具备一定的应用潜力。

关键词：铝土矿矿物复合材料卤水提锂

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中成药治疗慢性阻塞性肺疾病稳定期的网状Meta分析

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中国中药杂志 2025年第1期50卷 248-266页

作者：张媛媛张梦真马千千周继红广州中医药大学广东广州510000 广州中医药大学第七临床医学院广东深圳518000

基于网状Meta分析,比较不同中成药治疗慢性阻塞性肺疾病稳定期的临床疗效及安全性。计算机检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、EMbase、Cochrane Library数据... 详细信息

基于网状Meta分析,比较不同中成药治疗慢性阻塞性肺疾病稳定期的临床疗效及安全性。计算机检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、EMbase、Cochrane Library数据库收录的中成药治疗慢性阻塞性肺疾病稳定期的随机对照试验(RCT)。检索时间为建库至2024年2月。根据Cochrane偏倚风险评估工具对纳入文献进行质量评价,采用Revman 5.4、State 16.0软件绘制偏倚风险,并进行网状Meta分析。最终纳入113篇RCTs,总样本量8265例,涉及14种中成药。网状Meta分析显示,(1)改善肺功能第1秒用力呼气量占用力肺活量百分比(FEV1/FVC)方面,累计概率排名曲线下面积(SUCRA)排名前3的干预措施为金水宝胶囊+常规西医、玉屏风散+常规西医、三子止咳胶囊+常规西医;(2)提高临床疗效方面,SUCRA排名前3的干预措施为益肺胶囊+常规西医、玉屏风颗粒+常规西医、补肺活血胶囊+常规西医;(3)改善肺功能第1秒用力呼气量占预计值百分比(FEV1%pred)方面,SUCRA排名前3的干预措施为金水宝胶囊+常规西医、补肺颗粒+常规西医、百令胶囊+常规西医;(4)提高6 min步行试验(6MWT)方面,SUCRA排名前3的干预措施为金水宝胶囊+常规西医、百令胶囊+常规西医、健脾益肺口服液+常规西医;(5)降低慢性阻塞性肺疾病评估测试评分(CAT)方面,SUCRA排名前3的干预措施为补肺颗粒+常规西医、益肺胶囊+常规西医、益肺活血颗粒+常规西医;(6)减少慢性阻塞性肺疾病急性加重期(AECOPD)1年内发作次数方面,SUCRA排名前3的干预措施为玉屏风胶囊+常规西医、玉屏风散+常规西医、健脾益肺口服液+常规西医;(7)安全性方面,28篇报告了不良反应,主要涉及消化系统、循环系统和神经系统。结果表明,不同中成药联合常医西医治疗可有效改善FEV1/FVC、FEV1%pred,提高临床疗效和6MWT,降低CAT,减少AECOPD 1年内发作次数。但由于纳入文献的局限性,缺乏不同干预措施之间的直接比较,结果还需进一步验证。

关键词：中成药慢性阻塞性肺疾病稳定期随机对照试验网状Meta分析

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VOCs Emission Retrieval in Industrial Parks Based on the ADMS Model

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1340-1349页

作者： Yan, Ou Wang, Ti-Jian Ruan, Zhao-Yuan ma, Gen-Hui Sheng, Xiang-Yu Wang, Yu-zheng School of the Environment Nanjing University Nanjing210023 China School of Atmosphere Science Nanjing University Nanjing210023 China Limited Company Beijing100012 China Cambridge Environmental Research Consultants Ltd. United Kingdom Jiangsu Boshi Environmental Industry Research Institute Limited Company Nanjing211111 China

To estimate the emission strength of volatile organic compounds(VOCs)from enterprises at an industrial park scale,this study established a VOC source estimation method based on small-scale air quality modeling(ADMS)and mobile monitoring data. First,hourly meteorological data was used to identify the enterprises along the vehicle path based on wind direction. The impact of enterprise emissions on the concentration at the mobile monitoring points was calculated using ADMS. Simulation results were compared with observed values to quantify the VOC source strengths of different enterprises. Further inversion experiments were conducted based on mobile monitoring data from Shenyang Economic Development Zone from July 28th to August 10th,resulting in the hourly emission strengths of the top ten enterprises. In this study,two time periods,from 10:00 to 11:00 on July 28th and from 10:00 to 11:00 on July 29th,exhibited higher emissions from enterprises,primarily from those related to furniture manufacturing. Additionally,emissions from VOCs exceeded 100 g·s-1 in three of the enterprises. Validation of the model tracing results was conducted based on observational data and the results indicated a good correlation between simulated and observed values. The source apportionment method established in this study provides a novel approach for quantifying emission strength of VOCs in industrial parks, offering a scientific basis for precise control of atmospheric pollution emissions in industrial park areas. © 2025 Science Press. All rights reserved.

关键词： Air quality

A Simplified Computational Model of Mushroom Body for Tethered Bees' Abdominal Swing Behavior Induced by Optic Flow

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Chinese Journal of Electronics 2021年第2期30卷 296-302页

作者： zheng Nenggan ma qian WANG Xuefei ZHAO Lei GONG Zhefeng Qiushi Academy for Advanced Studies Zhejiang University College of Computer Science and Technology Zhejiang University Department of Neurobiology Zhejiang University School of Medicine Zhejiang Lab

Understanding sensorimotor neural circuits plays an important role in the study of behavioral mechanisms. By virtue of a relatively simple brain structure and sophisticated locomotion behaviors, insects are selected as comparative research subjects to discover the basic principles of neural science. Specific abdominal swing behaviors of tethered bees induced by optomotor response are realized. To model functionality of mushroom body in the optic-flow induced swing behaviors, a simplified 3-layer Spiking neural network(SNN) is proposed. Spike response model is used as the single neuron model in the proposed SNN, which is trained by supervised learning method. The computational model can accurately simulate and predict the bees’ abdominal swing behaviors exhibiting ipsilateral direction and proportional frequencies with optic flow stimulus.

关键词： image sequences optic flow stimulus tethered bees induced neurophysiology SNN neural science brain specific abdominal swing biomechanics mobile robots comparative research subjects neurocontrollers single neuron model simplified computational model neural network neural nets learning (artificial intelligence) behavioral mechanisms mushroom body optomotor response sophisticated locomotion behaviors optic-flow induced swing behaviors spike response model sensorimotor neural circuits relatively simple brain structure

Using air curtains to reduce short-range infection risk in consulting ward: A numerical investigation

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Building Simulation 2021年第2期14卷 325-335页

作者： Jin Ye Hua qian Jianchao ma Rong Zhou Xiaohong zheng School of Energy and Environment Southeast UniversityNanjing210096China Engineering Research Center of BEEE Ministry of Education of ChinaNanjing210096China First Affiliated Hospital of Guangzhou Medical University Guangzhou510000China Guangzhou Angel Biosafety Co. LtdGuangzhou510000China Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology Nanjing210096China

Air curtains is promising in reducing the short-range infection risk in *** quantitatively evaluate its performance,this paper explores air curtains equipped on normal consulting desk to avoid doctor’s direct exposure to the patient exhaled pollutants.A numerical investigation is conducted to evaluate the effects of supply air velocity and angle on cutting off *** results show that the average mass fraction of exhaled pollutants decreases significantly(70%–90%)in the consulting ward,indicating satisfying performance of air *** supply air velocity is demonstrated to be conducive in forming full air curtains,whereas an excessively high supply air velocity may be of adverse effects by entraining exhaled ***,the supply air angle is also critical due to its coupling with supply air *** is found that larger angle(0°–40°)is better where velocity is less than 3 m/s,otherwise a small angle(20°)is preferable where velocity is larger than 3 m/*** flow could be well suppressed at the supply air angle 20°but moves over air curtains at 40°.This study can provide effective and intuitive guidance in applying air curtains in consulting wards.

关键词： air curtains consulting ward cutting off performance numerical investigation

Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

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Science China Life Sciences 2025年

作者： Xiaonan Wang Ning Zhou Xuejiao J.Gao Zijing Zhu Minmin Sun qian Wang Haolin Cao Xuetong Wu Caiyu Zhou Qingkang zheng Ye Yuan Yuan Liu Lei Chen Jing Jiang Pengcheng Bu Lizeng Gao CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences School of Life Sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2S_n, n≥2）, not organic polysulfides. Studies on the mechanism of action（MoA） show that H2S_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（NADP+）. However, low H2S_nyield makes garlic derivatives hard to be a reliable donor of H2S_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3S4that generates H2S_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2S_nmicroreactor（GAPSR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPSR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

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Interfacial regulation induced rate capability and cycling stability of poly(perylene diimide) organic electrode

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materials Reports: Energy 2025年第1期5卷 53-60页

作者： Fu, Xijie Liu, Xinxin Sun, Yue Feng, Xiangming Li, Cuiping ma, Zi-Feng zheng, Jinyun Chen, Weihua College of Chemistry Zhengzhou University Zhengzhou450001 China Shaoxing Research Institute of Renewable Energy and Molecular Engineering Shanghai Jiao Tong University Shaoxing312000 China

Organic electrodes are considered competitive candidates for the next-generation high-performance energy storage devices owing to their advantages of structural flexibility and abundant resources. However, solubility and low electronic conductivity have been major obstacles to the practical application. To address these challenges, the structural design and interfacial regulation of organic electrodes are crucial to the performance enhancement. Herein, we report on a π-conjugated polymer cathode material of poly(3,4,9,10-perylenetetracarboxylic diimide) (PPI) for metal ion batteries, and the performance optimization is achieved by matching suitable conductive carbons and liquid electrolytes. Ultimately, the carbon nanotubes (CNTs) with weight content of 25% and 1 M NaPF6 in ethylene carbonate/diethyl carbonate electrolyte are introduced to assemble the batteries, and the discharge specific capacity, cycling stability and rate performance are enhanced effectively. The PPI-CNT||Na battery displays high specific capacities of 146.4 and 117 mah g−1 at current densities of 0.1 C and 5 C, respectively. Furthermore, PPI-CNT||Na battery demonstrates excellent long-term cycling stability of 5000 cycles with low 0.007 mah g−1 capacity decay per cycle at 1C due to the thin and uniform cathode electrolyte interphase. Moreover, the PPI-CNT||Na battery presents good cycling stability at high temperatures of 60 °C, and retains a capacity of 132.5 mah g−1 after 300 cycles with a high capacity retention rate of 96.9%. Besides, PPI-CNT displays good electrochemical performance and compatibility in lithium-ion and potassium-ion batteries. This work provides an alternative optimization strategy for organic electrodes applied in long-lifetime metal ion batteries. © 2024 The Authors

关键词： Sodium-ion batteries