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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song zheng-zhi wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Chaihu-Shugan-San exerts an antidepressive effect by downregulating miR-124 and releasing inhibition of the MAPK14 and Gria3 signaling pathways

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Neural Regeneration Research 2018年第5期13卷 837-845页

作者： Qiong Liu Ning-Ning Sun zheng-zhi wu Da-Hua Fan Mei-Qun Cao Department of Cardiovascular Medicine Xiang Ya Hospital of Central South University Changsha Hunan Province China Shenzhen Institute of Geriatrics Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University Shenzhen Guangdong Province China The Eighth Affiliated Hospital of Sun Yat-sen University Shenzhen Guangdong Province China Chinese and Wsetern Integrative Medicine Shcool of Medicine Jinan University Guangzhou Guangdong Province China.

Dysregulation of mi R-124 has been reported to be involved in the pathophysiology of depression. Chaihu-Shugan-San, a traditional Chinese medicine, has antidepressive activity; however, the underlying mechanisms remain unclear. In this study, to generate a rodent model of depression, rats were subjected to a combination of solitary confinement and chronic unpredictable mild stress for 28 days. Rats were intragastrically administered Chaihu-Shugan-San（2.835 m L/kg/d） for 4 weeks, once a day. Real-time reverse-transcription quantitative polymerase chain reaction, mi RNA microarray, western blot assay and transmission electron microscopy demonstrated that ChaihuShugan-San downregulated mi R-124 expression and upregulated the m RNA and protein levels of mitogen-activated protein kinase 14（MAPK14） and glutamate receptor subunit 3（Gria3）. Chaihu-Shugan-San also promoted synapse formation in the hippocampus. The open field test, sucrose consumption test and forced swimming test were used to assess depression-like behavior. After intragastric administration of Chaihu-Shugan-San, sucrose consumption increased, while the depressive behaviors were substantially reduced. Together, these findings suggest that Chaihu-Shugan-San exerts an antidepressant-like effect by downregulating mi R-124 expression and by releasing the inhibition of the MAPK14 and Gria3 signaling pathways.

关键词： nerve regeneration traditional Chinese medicine Chaihu-Shugan-San depression open-field test sucrose consumption test forced swimming test miR-124 neural plasticity MAPK14 Gria3 neural regeneration

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NUMERICAL AND EXPERIMENTAL STUDY ON LIQUID-SOLID FLOW IN A HYDROCYCLONE

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Journal of Hydrodynamics 2009年第3期21卷 408-414页

作者： WANG Li-yang zheng zhi-chu wu Ying-xiang GUO Jun ZHANG Jun TANG Chi Laboratory of Applied Fluid Dynamics Division of Engineering Sciences Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

Hydrocyclones are widely used in industry, of which the geometrical design using CFD techniques is gaining more popularity in recent years. In this study, the Euler-Euler approach and the Reynolds stress model are applied to simulate the liquid-solid flowfield in a hydrocyclone. The methodology is validated by a good agreement between experimental data and numerical results. Within the research range, the simulation indicates that the liquid-solid separation mainly occurs in the conical segment, and increasing conical height or decreasing cylindrical height helps to improve the grade efficiencies of solid particles. Based on these results, two of the same hydrocyclones are designed and installed in series to establish a liquid-solid separation system. Many experiments are then conducted under different conditions, in which the effects of the water cut and the second hydrocyclone on the separation are investigated. The results also confirm that smaller solid particles are more susceptible to the inlet conditions, and the second hydrocyclone plays a more important role as the water cut reduces.

关键词： hydrocyclone liquid-solid flow model efficiency

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Effectiveness of surgical resection for complicated liver cancer and its influencing factors: A retrospective study

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World Journal of Clinical Cases 2020年第4期8卷 736-742页

作者： Jian Yu zhi-zheng wu Teng Li Ying Xu Yu-Cheng Zhao Bo-Lun Zhang Hu Tian Department of General Surgery Shandong Provincial Qianfoshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of General Surgery the First Affiliated Hospital of Shandong First Medical UniversityTaian 271016Shandong ProvinceChina Department of Hepatological Surgery Shandong Provincial Qianfoshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina

BACKGROUND Surgical resection is the preferred method for patients with complex liver *** the tumor is in a special position, the surgery is highly risky, postoperative complications can easily occur, and the prognosis is not *** To investigate the effectiveness of surgical resection for complex liver cancer and its influencing *** Fifty-seven patients who had complicated liver cancer and underwent surgical resection at our hospital from August 2015 to August 2016 were enrolled in this study. All patients were followed for three years, and their postoperative complications, survival, and factors that impacted their survival were *** The total incidence of postoperative complications was 45.61%, and the incidence of pleural effusion was the highest at 28.07%. There were no correlations between the 2-year and 3-year survival rates and sex, age, and Hbs Ag of the patients(P >0.05). In terms of pathological parameters, the 2-year and 3-year survival rates were significantly different according to the presence of a tumor capsule, degree of liver cirrhosis, satellite or focal lesions, hepatic vein thrombosis, portal vein tumor thrombus, and intraoperative blood loss(P < 0.05).CONCLUSIONThe effectiveness of surgical resection for complex hepatocellular carcinoma may be affected by factors such as the presence of a tumor capsule, cirrhosis degree,satellite or focal lesions, hepatic vein embolization, portal vein tumor thrombus,and intraoperative blood loss. Therefore, these factors should be controlled and prevented during surgery to help improve patient survival after surgery.

关键词： Complicated liver cancer Surgical resection Survival rate Complications

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Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2023年第1期18卷 226-232页

作者： Lin Wang Bi-Qiang Zhou Ying-Hong Li Qian-Qian Jiang Wei-Hong Cong Ke-Ji Chen Xiao-Min Wen zheng-zhi wu The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhen Institute of GeriatricsShenzhenGuangdong ProvinceChina The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhenGuangdong ProvinceChina China Academy of Chinese Medical Sciences Xiyuan HospitalBeijingChina School of Chinese Medicine Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that berberine has neuroprotective effects against Alzheimer’s disease,including antagonizing tau phosphorylation,and inhibiting acetylcholinesterase activity and neural cell ***,its low bioavailability and adverse reactions with conventional administration limit its clinical *** this study,we prepared berberine nanoliposomes using liposomes characterized by low toxicity,high entrapment efficiency,and biodegradability,and modified them with ***-modified berberine nanoliposomes had uniform particle size and high entrapment *** used the lactoferrin-modified berberine nanoliposomes to treat a mouse model of Alzheimer’s disease established by injection of amyloid-beta 1-42 into the lateral ***-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus,reduced tau over-phosphorylation in the cerebral cortex,and improved mouse *** findings suggest that modification with lactoferrin can enhance the neuroprotective effects of berberine nanoliposomes in Alzheimer’s disease.

关键词： acetylcholinesterase Alzheimer’s disease apoptosis berberine brain targeting lactoferrin nanoliposomes neuroprotective effects Tau phosphorylation

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Diagnostic model of saliva protein finger print analysis of patients with gastric cancer

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World Journal of Gastroenterology 2009年第7期15卷 865-870页

作者： zheng-zhi wu Ji-Guo Wang Xiao-Li Zhang Southern Medical University Guangzhou 510515 Guangdong Province China Affiliated Shenzhen Hospital of Southern Medical University 3002 West Sungang Road Shenzhen 518035 Guangdong Province China

AIM:To explore the method for early diagnosis of gastric cancer by screening the expression spectrum of saliva protein in gastric cancer patients using mass spectrometry for ***:Proportional peptide mass fingerprints were obtained by analysis based on proteomics matrix-assisted laser desorption ionization time-of-flight/mass spectrometry.A diagnosis model was established using weak cation exchange magnetic beads to test saliva specimens from gastric cancer patients and healthy ***:Significant differences were observed in the mass to charge ratio(m/z) peaks of four proteins(1472.78 Da,2936.49 Da,6556.81 Da and 7081.17 Da) between gastric cancer patients and healthy ***:The finger print mass spectrum of saliva protein in patients with gastric cancer can be established using gastric cancer proteomics.A diagnostic model for distinguishing protein expression mass spectra of gastric cancer from non-gastric-cancer saliva can be established according to the different expression of proteins 1472.78 Da,2936.49 Da,6556.81 Da and 7081.17 *** method for early diagnosis of gastric cancer is of certain value for screening special biological markers.

关键词： Saliva Protein finger print model Gastriccancer Matrix-assisted laser desorption ionization-time-of-flight/mass spectrometry Weak cationexchange Magnetic bead Proteomics

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Effects of estrogen on collagen gel contraction by human retinal glial cells

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Chinese Medical Journal 2012年第22期125卷 4098-4103页

作者： QIU Qing-hua CHEN zhi-Yi YIN Li-li zheng zhi wu Xing-wei Shanghai Jiao Tong Univ Dept Ophthalmol Peoples Hosp 1 Shanghai 200080 Peoples R China Shanghai Heping Eye Hosp Shanghai 200437 Peoples R China

Background There are definite gender differences in patients with macular holes. Menopausal women over 50 years are most affected. We aimed to observe the effect of estrogen on collagen gel contraction by cultured human retinal glial cells. It is speculated that estrogen could strengthen the tensile stress of the macula by maintaining the correct morphology and contraction. Methods Estrogen was used to determine its effects on collagen gel contraction, and its function was measured using morphological changes in cells. Human retinal glial cells were cultured in collagen solution. The cells were then exposed to collagen gels and the degree of contraction of the gel was determined. Results Estrogen at differing concentrations had no effect on the growth of human retinal glial cells. However, after exposed to collagen gel block, less contraction was noted in the estrogen-treated group than in the control group. Conclusions Estrogen can inhibit collagen gel contraction by glial cells. These results suggest a mechanism for macular hole formation, which is observed in menopausal females.

关键词： estrogen human retinal glial cells three-dimensional culture

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EFFECT OF Zr ON DUCTILITY OF CAST Ni_3 Al-BASE ALLOYS

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Acta Metallurgica Sinica(English Letters) 1992年第6期5卷 409-413页

作者： zheng zhi wu Weiwen GUO Jianting ZHU Yaoxiao Institute of Metal Research,Academia Sinica,Shenyang,China Institute of Metal Research,Academia Sinica,Shenyang 110015,China Inst of Metal Research Acad Sinica Shenyang China

Many compressive and tensile tests showed that the room temperature ductility of boron-free Ni_3Al alloy may be markedly improved by a moderate addition of *** ductility of the stoichiometric Ni_3Al and even slightly enriched with Al,may be improved fairly between 400 —600℃,which behaves much better if Zr is added together with ***,the high tem- perature ductility of Ni_3Al alloys containing Cr may be significantly increased by Zr which segregates slightly along grain ***,the toughening mechanism of Zr alloying seems to be different from that of B addition.

关键词： Ni_3Al Zr toughening ductility brittleness

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Simulating Greedy Propagation of P2P Worms

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Journal of Electronic Science and Technology 2010年第4期8卷 307-311页

作者： Guo-zheng wu zhi-Guang Qin School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu 610054 China

Greedy propagation policy for unstructured P2P worms employs the neighboring node list of each node in peer-to-peer （P2P） network to speed up the propagation of P2P worms. After describing the technique background of P2P worms, the algorithm of greedy propagation is addressed. Simulating design for this novel propagation policy is also described. Then, the effects of the greedy propagation policy on spreading speed, convergence speed, and attacking traffic in static P2P worms are simulated and discussed. The primary experimental results show that the greedy propagation is harmful and can bring severe damages to P2P network.

关键词： Greedy propagation Internet worms peer-to-peer network peer-to-peer worms worms propagating.

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Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai Ⅰ extract and effects of guide drug borneol on pharmacokinetics

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Chinese Herbal Medicines 2020年第1期12卷 79-87页

作者： Shao-yu Liang Yong-chang Zeng Qian-qian Jiang Jun-hong wu zheng-zhi wu The First Affiliated Hospital of Shenzhen University Shenzhen 518035China Shenzhen Institute of Geriatrics Shenzhen 518020China

Objective:To investigate the in vivo pharmacokinetic characteristics of 17 bioactive components including ginsenoside Rg1,Rb1,Rd,berberine,epiberberine,jatrorrhizine,palmatine,columbamine,coptisine,evodiamine,dehydroevodiamine,rutaecarpine,limonin,hyperin,curcumin,demethoxycurcumin and bisdemethoxycurcumin in rat plasma after oral administration of Xintiantai I extract powder(XI)and Xintiantai I without guide drug borneol extract powder(XI without borneol),and study the compatibility effects of guide drug borneol on the ***:A UHPLC-MS/MS method was established and fully validated for the comparative pharmacokinetics of 17 bioactive *** pharmacokinetics parameters of 17 bioactive components after oral administration of XI and XI without borneol were calculated by the software of DAS 3.0 and ***:The specificity,linearity,lower limit of quantification(LLOQ),precision,accuracy,extraction recovery rates,matrix effects,and stability of the UHPLC-MS/MS assay were good within the acceptance criteria from FDA *** drug borneol can significantly increase AUC of G-Rd,palmatine,hyperin,curcumin,demethoxycurcumin,bisdemethoxycurcumin and Cmaxof 16 bioactive components except for dehydroevodiamine(P<0.05),decrease Tmaxof G-Rd,berberine,columbamin,coptisine,limonin and MRT of 17 bioactive components in XI group(P<0.05).Conclusion:Guide drug borneol enhanced the absorption of G-Rd,palmatine,hyperin,curcumin,demethoxycurcumin and bisdemethoxycurcumin.

关键词： borneol comparative pharmacokinetics multi-bioactive components UHPLC-MS/M XintiantaiⅠ

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