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Impaired pericyte-Müller glia interaction via PDGFRβsuppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1800-1808页

作者： Wei xu Li-Jin Cui xiao-Ying Yang xiao-Yuan Cui Jian Guo Guo-Xing xu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350212Fujian ProvinceChina Fujian Institute of Ophthalmology Fuzhou 350001Fujian ProvinceChina

AIM:To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptorβ(PDGFRβ)signaling pathway in retinal pericytes on photoreceptor loss and Müller glial ***:Sprague-Dawley rats were exposed to intense light to induce retinal *** antibody against PDGFRβwere deployed to block the signaling pathway in retinal pericytes through intravitreal *** histology and Müller glial reaction were assessed following light *** vitro,normal and PDGFRβ-blocked retinal pericytes were cocultured with Müller cell line(rMC-1)to examine morphological and protein expression changes upon supplementation with light-injured supernatants of homogenized retinas(SHRs).RESULTS:PDGFRβblockage 24h prior to intense light exposure resulted in a significant exacerbation of photoreceptor *** upregulation of GFAP and p-STAT3,observed after intense light exposure,was significantly inhibited in the PDGFRβblockage *** ther upregulation of cytokines monocyte chemoattractant protein 1(MCP-1)and interleukin-1β(IL-1β)was also observed following PDGFRβ*** the in vitro coculture system,the addition of light-injured SHRs induced pericyte deformation and upregulation of proliferating cell nuclear antigen(PCNA)expression,while Müller cells exhibited neuron-like morphology and expressed ***,PDGFRβblockage in retinal pericytes abolished these cellular responses to light-induced damage,consistent with the in vivo PDGFRβblockage ***:Pericyte-Müller glia interaction plays a potential role in the endogenous repair process of retinal *** of this interaction exacerbates photoreceptor degeneration in light-induced retinal injury.

关键词： pericyte Müller glia light-induced retinal injury platelet-derived growth factor receptorβ signal pathway

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Simulation of the L-valve in the circulating fluidized bed with a coarse-grained discrete particle method

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Particuology 2024年第7期90卷 266-280页

作者： Ruixiang Tang zheng Zou Ji xu Junwu Wang Qingshan Zhu Hongzhong Li State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesP.O.Box 353Beijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing100190China

Stable and controllable solid flow is essential in circulating fluidized bed (CFB) systems. The L-valve is a typical non-mechanical valve that can provide flexible solid feeding. The investigation of the solid circulation rate and the hydrodynamic characteristics of the L-valve is crucial to its design and operation. The gas-solid flow in the L-valve of a full-loop CFB is studied with the coarse-grained discrete particle method (EMMS-DPM). Good agreements on the solid circulation rate and the pressure drop through the L-valve are achieved between the simulated and experimental data. The solid circulation rate increases linearly with the aeration velocity until the stable particle circulation of the CFB is destroyed. The flow patterns in the horizontal section of L-valve are gas-solid slug flow above the stationary solid layer and the moving solid layer, respectively. The effects of L-valve geometric parameters on the solid flow characteristics are also investigated. The results indicate that reducing the diameter and length of the horizontal section of L-valve can improve the solid transport efficiency, especially at low aeration velocity. Besides, the solid conveying capacity and flow stability are improved when the sharp bend of L-valve is modified to be a gradual bend.

关键词： L-valve Circulating fluidized bed Full loop Discrete particle method Gas-solid flow

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Genetic engineering drives the breakthrough of pig models in liver disease research

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Liver Research 2024年第3期8卷 131-140页

作者： Chenhao xu Xixi Fang xiao xu xuyong Wei Zhejiang University School of Medicine HangzhouZhejiangChina Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People’s HospitalHangzhouZhejiangChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province HangzhouZhejiangChina Hangzhou Normal University HangzhouZhejiangChina School of Clinical Medicine Hangzhou Medical CollegeHangzhouZhejiangChina NHC Key Laboratory of Combined Multi-organ Transplantation HangzhouZhejiangChina Institute of Translational Medicine Zhejiang UniversityHangzhouZhejiangChina

Compared with the widely used rodents,pigs are anatomically,physiologically,and genetically more similar to humans,making them high-quality models for the study of liver ***,we review the latest research progress on pigs as a model of human liver disease,including methods for establishing them and their advantages in studying cystic fibrosis liver disease,acute liver failure,liver regeneration,non-alcoholic fatty liver disease,liver tumors,and *** also emphasize the importance of genetic engineering techniques,mainly the CRISPR/Cas9 system,which has greatly enhanced the utility of porcine models as a tool for substantially advancing liver disease *** engineering is expected to propel the pig as one of the irreplaceable animal models for future biomedical research.

关键词： Animal model Liver disease Genetic engineering CRISPR/Cas9 Xenogeneic liver transplantation Pig

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Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction:Efficient photodegradation of organic pollutant and toxicity evaluation

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Journal of Materials Science & Technology 2024年第3期170卷 200-211页

作者： Yanyan Zhao xu Fan Hongxing zheng Enzhou Liu Jun Fan xuejun Wang College of Biology Pharmacy and Food Engineering Shangluo UniversityShangluo 726000China QinLing-Bashan Mountains Bioresources Comprehensive Development C.I.C. Shaanxi University of TechnologyHanzhong 723001China School of Chemical Engineering Northwest UniversityXi’an 710069China

Constructing of heterojunction was identified as a feasible way to improve photocatalytic activity of *** this work,a n-p type Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was successfully prepared for organic pollutants *** Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction exhibited much higher pho-tocatalytic activity towards Rhodamine B(92.24%,expose to visible light for 60 min),norfloxacin(81.73%,expose to visible light for 90 min)and levofloxacin(87.46%,expose to visible light for 90 min)than pure Bi_(2)WO_(6)and pure AgInS_(2).Toxicity analysis indicated the low environmental toxicity of Rhodamine B degradation intermediates for Rye seeds and Sudangrass seeds germination and *** study displayed that AgInS_(2)and Bi_(2)WO_(6)work as the primary photocatalyst to form·O_(2)−and ·OH,*** improved photocatalytic activity of the Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was due to the im-proved light response range and intensified carrier separation ***,a S-scheme charge transfer mechanism including multiple charge transfer channels was *** work could provide an effective strategy for organic pollutants degradation in wastewater.

关键词： Photocatalysis S-scheme heterojunction AgInS_(2) Bi_(2)WO_(6) Toxicity experiments

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Anemoside B4 inhibits SARS-CoV-2 replication in vitro and in vivo

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Chinese Herbal Medicines 2024年第1期16卷 106-112页

作者： Mingyue xiao Ronghua Luo Qinghua Liang Honglv Jiang Yanli Liu Guoqiang xu Hongwei Gao Yongtang zheng Qiongming xu Shilin Yang College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Soochow UniversitySuzhou 215123China College of Pharmacy Guangxi University of Chinese MedicineNanning 530000China

Objective: Anemoside B4(AB4), the most abundant triterpenoidal saponin isolated from Pulsatilla chinensis, inhibited influenza virus FM1 or Klebsiella pneumoniae-induced pneumonia. However, the anti-SARS-CoV-2 effect of AB4 has not been unraveled. Therefore, this study aimed to determine the antiviral activity and potential mechanism of AB4 in inhibiting human coronavirus SARS-CoV-2 in vivo and in ***: The cytotoxicity of AB4 was evaluated using the Cell Counting Kit-8(CCK8) assay. SARS-CoV-2 infected HEK293T, HPAEpiC, and Vero E6 cells were used for in vitro assays. The antiviral effect of AB4 in vivo was evaluated by SARS-CoV-2-infected hACE2-IRES-luc transgenic mouse model. Furthermore,label-free quantitative proteomics and bioinformatic analysis were performed to explore the potential antiviral mechanism of action of AB4. Type Ⅰ IFN signaling-associated proteins were assessed using Western blotting or immumohistochemical ***: The data showed that AB4 reduced the propagation of SARS-CoV-2 along with the decreased Nucleocapsid protein(N), Spike protein(S), and 3C-like protease(3CLpro) in HEK293T cells. In vivo antiviral activity data revealed that AB4 inhibited viral replication and relieved pneumonia in a SARS-CoV-2 infected mouse model. We further disclosed that the antiviral activity of AB4 was associated with the enhanced interferon(IFN)-β response via the activation of retinoic acid-inducible gene Ⅰ(RIG-1) like receptor(RLP) pathways. Additionally, label-free quantitative proteomic analyses discovered that 17 proteins were significantly altered by AB4 in the SARS-CoV-2 coronavirus infections cells. These proteins mainly clustered in RNA ***: Our results indicated that AB4 inhibited SARS-CoV-2 replication through the RLR pathways and moderated the RNA metabolism, suggesting that it would be a potential lead compound for the development of anti-SARS-CoV-2 drugs.

关键词： anemoside B4 interferon RNA metabolism quantitative proteomics SARS-CoV-2

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Effect of Pre-strain on Microstructure and Stamping Performance of High-strength Low-alloy Steel

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 774-780页

作者：刘坡 WEN Zhicheng LIU zheng 许峰 School of Mechanical Engineering Guilin University of Aerospace TechnologyGuilin 541004China School of Automotive Engineer-ing Changshu Institute of TechnologyChangshu 215500China

In this study,pre-strain ranging from 0 to 0.12 was applied through uniaxial tension on high-strength low-alloy(HSLA)specimens with four kinds of grain *** of pre-strain and grain size on me-chanical property was investigated through tensile *** of the pre-strained and tensile tested samples were analyzed,*** 30.8°v-bending and following flattening,as well as Erichson cupping tests,were performed on the pre-strained *** show the elongation ratio of grain and dislocation density increases with *** platform is removed when pre-strain is larger than 0.06 while yielding plateau period decreases with pre-strain less than 0.06 due to reduction of pinning *** 30.8°v-bending and the following flattening tests are successfully accomplished on all the pre-strained samples with different grain *** in grain size,along with increase in pre-strain,causes increase in strength and decrease in elongation rate as well as cupping ***-strain causes very slight effect on bending ability,much less than that on mechanical property and cupping test *** impact of the pre-strain and grain size on HSLA steel deformability is inconspicuous.

关键词： strain hardening dislocation texture bending erichson cupping test

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Atomically dispersed Mn-N_(x) catalysts derived from Mn-hexamine coordination frameworks for oxygen reduction reaction

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Carbon Energy 2024年第5期6卷 114-126页

作者： Guoyu Zhong Liuyong Zou xiao Chi Zhen Meng Zehong Chen Tingzhen Li Yongfa Huang xiaobo Fu Wenbo Liao Shaona zheng Yongjun xu Feng Peng Xinwen Peng Guangdong Provincial Key Laboratory of Distributed Energy Systems School of Chemical Engineering and Energy TechnologyDongguan University of TechnologyDongguanChina State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhouChina Department of Chemistry Centre for Advanced 2D Materials(CA2DM)National University of SingaporeSingaporeSingapore School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhouChina

Metal-organic frameworks recently have been burgeoning and used as precursors to obtain various metal-nitrogen-carbon catalysts for oxygen reduction reaction(ORR).Although rarely studied,Mn-N-C is a promising catalyst for ORR due to its weak Fenton reaction activity and strong graphitization ***,we developed a facile strategy for anchoring the atomically dispersed nitrogen-coordinated single Mn sites on carbon nanosheets(MnNCS)from an Mn-hexamine coordination *** atomically dispersed Mn-N_(4) sites were dispersed on ultrathin carbon nanosheets with a hierarchically porous *** optimized MnNCS displayed an excellent ORR performance in half-cells(0.89 V *** hydrogen electrode(RHE)in base and 0.76 V *** in acid in half-wave potential)and Zn-air batteries(233 mW cm^(−2)in peak power density),along with significantly enhanced *** functional theory calculations further corroborated that the Mn-N_(4)-C(12)site has favorable adsorption of*OH as the rate-determining *** findings demonstrate that the metal-hexamine coordination framework can be used as a model system for the rational design of highly active atomic metal catalysts for energy applications.

关键词： carbon nanosheets electrocatalyst metal-organic frameworks Mn-N_(4) oxygen reduction reaction Zn-air batteries

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Thermal and hydrological processes in permafrost slope wetlands affect thermosyphon embankment stability

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Advances in Climate Change Research 2024年第4期15卷 680-694页

作者： Bo-Wen TAI Qing-Bai WU xiao-Ming xu State Key Laboratory of Frozen Soil Engineering Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

To ensure the long-term service performance of infrastructure such as railways,highways,airports and oil pipelines built on permafrost slope wetland sites,it is imperative to systematically uncover the long-term heat-water changes of soil in slope wetlands environment under climate *** specifically,considering valuable field data from 2001 to 2019,the long-term heat and water changes in active layers of the slope wetland site along the Qinghai-Xizang Railway(QXR)are illustrated,the effect of thermosyphon measures in protecting the permafrost environment is evaluated,and the influences of climate warming and hydrological effects on the stability of slope wetland embankments are systematically *** permafrost at the slope wetland site is rapidly degrading,demonstrating a reduction in active layer thickness of>3.7 cm per year and a permafrost temperature warming of>0.006℃ per *** thermosiphon embankment developed by QXR has a specific cooling period;thus,to mitigate the long-term impacts of climate warming on the thermal stability of permafrost foundation,it is essential to implement strengthening measures for the thermosiphon embankment,such as adding a crushed-rock layer or sunshade board on the slope of thermosiphon embankment to creating a composite cooling ***-term seasonal groundwater seepage intensifies frost damage to the slope wetland embankment,while long-term seasonal supra-permafrost water and groundwater seepage exacerbates uneven transverse deformation of slope wetland ***-term climate warming and slope effects have altered the surface water and groundwater hydrological processes of slope wetlands,potentially leading to an increased occurrence of slope embankment *** results are crucial for improving our understanding of heat and water variation processes in the active layer of slope wetland sites located in permafrost regions and ensuring long-term service safety for the QXR.

关键词： Heat and water process Active layer Slope wetland Permafrost environment Thermosyphon embankment

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Existence of long-range magnetic order in Heisenberg spin nanoribbons with edge modification

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Communications in Theoretical Physics 2024年第7期76卷 134-144页

作者： Da-cheng Ma Ling-yi Cui Chu-xiao Sun xiao-dan Chi zheng-Nan XianYu An Du College of Science Northeastern UniversityShenyang 110819China Department of Basic Science Dalian Naval AcademyDalian 116018China Department of Physics College of SciencesShenyang University of Chemical TechnologyShenyang 110142China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityChina Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of EducationChina

Long-range magnetic order appears on a side decorated Heisenberg spin nanoribbon at nonzero temperature,although no spontaneous magnetization exists in a one-or two-dimensional isotropic Heisenberg model at any nonzero temperature according to the Mermin-Wagner *** use of the spin Green's function method,we calculated the magnetizations of Heisenberg nanoribbons decorated by side spins with single-ion anisotropy and found that the system exhibits a nonzero transition temperature,whether the decorated edge spins of the system link together or separate from each *** the width of the nanoribbon achieves infinite limit,the transition temperatures of the system tend to the same finite constant eventually whether one edge or both edges are decorated by side spins in the *** results reveal that the magnetism of a low-dimensional spin system is different from that of a threedimensional spin *** the single-ion anisotropy of edge spins in a Heisenberg spin nanoribbon can be modulated by an electric field experimentally,various useful long-range magnetic orders of the system can be *** work can provide a detailed theoretical basis for designing and fabricating next-generation low-dimensional magnetic random-access memory.

关键词： Nanoribbon magnetic anisotropy long-range magnetic order Heisenberg model transition temperature

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Effects of stigma on the quality of lifein patients with epilepsy

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Acta Epileptologica 2024年第2期7卷 110-118页

作者： Chunmei Hu Yuping Zhao zheng xiao Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityNO.1 Youyi Rd.ChongqingYuzhong District 400016China Department of Neurology The People’s Hospital of NanchuanChongqing 408400China

Background This study was aimed to evaluate the stigma and quality of life(QoL)in adult patients with epilepsy(PWEs)and explore the relationship between stigma and *** Two hundred and ninety-eight PWEs admitted to the Epilepsy Center of the First Affiliated Hospitalof Chongqing Medical University during September 2020 and March 2021 were enrolled in this *** participantscompleted self-reported questionnaires including the Stigma Scale for Epilepsy and the Quality of Life in EpilepsyInventory-31(QOLIE-31).Results A total of 146(49%)PWEs reported an experience of *** total score of QOLIE-31 and the individualscores of seven subscales(worry about new seizures,emotion,well-being,energy and fatigue,cognitive impairment,medication effect,and social function)were significantly decreased in these patients(P<0.001).Multivariate stepwiselinear regression analysis showed that the annual household income per capita,the number of antiseizure medica-tions and stigma had statistically significant effects on QoL(P<0.05).Among them,stigma had the most significantnegative *** Nearly half of PWEs have experienced ***,lower household income per capita,and polyp-harmacy treatment are associated with poorer *** has the most obvious negative impact.

关键词： Perceived stigma Epilepsy Quality of life

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