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Chemical Research in Chinese Universities 2013年第1期29卷 139-143页

作者： LAN Hai-nan WANG Yue-xi zheng ming-zhu HAN Wei-wei zheng Xin College of Animal Science and Technology Jilin Agricultural University Changchun 130118 P. R. China Key Laboratory for Molecular Enzymology and Engineering Ministry of Education Jilin University Changchun 130012 P. R. China

The G protein coupled receptor（GPCR）, one of the members in the superfamily, which consists of thousands of integral membrane proteins, exerts a wide variety of physiological functions and responses to a large portion of the drug targets. The 3D structure of somatostatin receptor I（SSTR1） was modeled and refined by means of homology modeling and molecular dynamics simulation. This model was assessed by Verify-3D and Vadar, which confirmed the reliability of the refined model. The interaction between the inhibitor cysteamine, somatostatin（SST） and SSTR1 was investigated by a molecular docking program, Affinity. The binding module not only showed the crucial residues involved in the interaction, but also provided important information about the interaction between SSTR1 on the one hand and ligands on the other, which might be the significant evidence for the structure-based design.

关键词： Somatostatin receptor 1 Homology modeling Docking

Changes of moisture distribution and migration in fresh ear corn during storage

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Journal of Integrative Agriculture 2019年第11期18卷 2644-2651页

作者： WANG Hao LIU Jing-sheng MIN Wei-hong zheng ming-zhu LI Hao College of Food Science and Engineering/The National Engineering Laboratory on Wheat and Corn Further Processing Jilin Agricultural University

Understanding of moisture changes in fresh ear corn(Zea mays L.)during storage is imperative for maintaining fresh corn *** changes of moisture distribution and migration in fresh ear corn during storage were investigated using low-field nuclear magnetic resonance(NMR)and magnetic resonance imaging(MRI).Water loss was greater than water migration in fresh ear corn within the first hour of storage;thereafter,water loss was weaker than water *** the extension of storage time,the signal intensity of MRI in different parts of sliced fresh corn with cob showed a downward trend,and the rate of signal intensity reduction was higher in the peripheral area than at the central part of sliced fresh corn with *** relative proportion of bound water increased with a concomitant drop in that of free water,when the total water content reduced in fresh ear corn under *** conclusion,NMR and MRI are useful and non-destructive tools for real-time monitoring of moisture distribution,migration,and loss in fresh ear corn during storage to assess its *** results can be used for future design of the preserving and processing conditions for fresh ear corn.

关键词： fresh ear corn NMR MRI moisture distribution moisture migration

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Prognostic significance of the preoperative hemoglobin to albumin ratio for the short-term survival of gastric cancer patients

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 580-593页

作者： Ce-Gui Hu Bai-E Hu Jin-Feng zhu zheng-ming zhu Chao Huang Department of Gastrointestinal Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Hemoglobin and albumin are associated with the prognosis of gastric cancer(GC)patients. However, the prognostic value of the hemoglobin to albumin ratio(HAR) for the short-term survival of GC patients with D2 radical resection has not been *** To investigate the significance of the HAR in evaluating the short-term survival of GC patients after D2 radical resection and to construct a nomogram to predict the prognosis in GC patients after surgery, thus providing a reference for the development of postoperative individualized treatment and follow-up *** Cox regression and Kaplan-Meier analysis was used for prognostic *** regression was used to analyze the relationships between HAR and the clinicopathological characteristics of the GC patients. A prognostic nomogram model for the short-term survival of GC patients was constructed by R *** HAR was an independent risk factor for the short-term survival of GC *** patients with a low HAR had a poor prognosis(P < 0.001). Low HAR was markedly related to high stage [odds ratio(OR) = 0.45 for Ⅱ vs Ⅰ;OR = 0.48 for Ⅲ vs Ⅰ], T classification(OR = 0.52 for T4 vs T1) and large tumor size(OR = 0.51 for ≥4 cm vs < 4 cm)(all P < 0.05). The nomogram model was based on HAR, age,CA19-9, CA125 and stage, and the C-index was *** Preoperative low HAR was associated with short-term survival in GC *** prognostic nomogram model can accurately predict the short-term survival of GC patients with D2 radical resection.

关键词： Gastric cancer Hemoglobin to albumin ratio Short-term survival Prognosis Nomogram

Identification of key genes controlling cancer stem cell characteristics in gastric cancer

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World Journal of Gastrointestinal Surgery 2020年第11期12卷 442-459页

作者： Chao Huang Ce-Gui Hu Zhi-Kun Ning Jun Huang zheng-ming zhu Department of Gastrointestinal Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Self-renewal of gastric cancer stem cells(GCSCs)is considered to be the underlying cause of the metastasis,drug resistance,and recurrence of gastric cancer(GC).AIM To characterize the expression of stem cell-related genes in *** RNA sequencing results and clinical data for gastric adenoma and adenocarcinoma samples were obtained from The Cancer Genome Atlas database,and the results of the GC mRNA expression-based stemness index(mRNAsi)were *** gene coexpression network analysis was then used to find modules of interest and their key *** analysis of key genes was performed using the online tool Kaplan-Meier Plotter,and the online database Oncomine was used to assess the expression of key genes in *** mRNAsi was significantly upregulated in GC tissues compared to normal gastric tissues(P<0.0001).A total of 16 modules were obtained from the gene coexpression network;the brown module was most positively correlated with *** key genes(BUB1,BUB1 B,NCAPH,KIF14,RACGAP1,RAD54 L,TPX2,KIF15,KIF18 B,CENPF,TTK,KIF4 A,SGOL2,PLK4,XRCC2,a n d C1 orf112)were identified in the brown *** functional and pathway enrichment analyses showed that the key genes were significantly enriched in the spindle cellular component,the sister chromatid segregation biological process,the motor activity molecular function,and the cell cycle and homologous recombination *** analysis and Oncomine analysis revealed that the prognosis of patients with GC and the expression of three genes(RAD54 L,TPX2,and XRCC2)were consistently *** Sixteen key genes are primarily associated with stem cell self-renewal and cell proliferation ***54 L,TPX2,and XRCC2 are the most likely therapeutic targets for inhibiting the stemness characteristics of GC cells.

关键词： Gastric cancer Cancer stem cell Key gene The Cancer Genome Atlas database Weighted gene coexpression network analysis mRNA expression-based stemness index

The Molecular Structure and Potential Energy Function for Ne-HF System

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原子与分子物理学报 1999年第3期16卷 36-41页

作者： HUANG zheng a, RAN ming b, zhu zheng he b (a. Department of Applied Physics Southwest Jiaotong University, Chengdu 610031, China b. Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610065, China) Department of Applied Physics Southwest Jiaotong University Chengdu 610031 China Department of Chemistry Sichuan Normal University Chengd 610066 China Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China

１ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｉｎｆｌｕｅｎｃｅｏｆｒａｒｅ－ｇａｓａｔｏｍｓｔｏｔｈｅｖｉｂｒａｔｉｏｎａｌｐｏｐｕｌａｔｉｏｎｏｆＨＦｉｓｉｍｐｏｒｔａｎｔｔｏｔｈｅｃｈｅｍｉｃａｌｏｖｅｒｔｏｎｅＨＦｌａｓｅ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｉｎｆｌｕｅｎｃｅｏｆｒａｒｅ－ｇａｓａｔｏｍｓｔｏｔｈｅｖｉｂｒａｔｉｏｎａｌｐｏｐｕｌａｔｉｏｎｏｆＨＦｉｓｉｍｐｏｒｔａｎｔｔｏｔｈｅｃｈｅｍｉｃａｌｏｖｅｒｔｏｎｅＨＦｌａｓｅｒｓ．Ｉｎｐｒｅｓｅｎｔｐａｐｅｒ...

关键词： Ne-HF ab initio Many-body expansion theory Analytical potential energy function

Expression of c-erbB-2 proto-oncogene in extrahepatic cholangiocarcinoma and its clinical significance

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Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 412-415页

作者： Jun zheng and Yao-ming zhu Department of General Surgery,First College of Clinical Medical Science of China Three Gorges University(Yichang Central People’s Hospital),Yichang 443003,China Department of General Surgery First College of Clinical Medical Science of China Three Gorges University (Yichang Central People's Hospital) Yichang 443003 China. zhengjun1995@***

BACKGROUND:Many investigators have indicated that overexpression and amplification of the human proto-oncogene c-erbB-2 is an independent prognostic factor for primary tumors. We studied expression of c-erbB-2 protein in tissues from extrahepatic cholangiocarcinoma,tissues peripheral to the carcinoma and normal bile ducts,and discussed the occurrence and development of extrahepatic cholangiocarcinoma. Another aim was to explore possible application of the c-erbB-2 gene for clinical diagnosis,pathological differentiation and treatment of extrahepatic cholangiocarcinomas. METHODS:The c-erbB-2 expression levels from 75 samples of extrahepatic cholangiocarcinoma,48 samples of tissues peripheral to the carcinoma and 9 samples from normal bile ducts were assayed by immunohistochemical streptavidinbiotin complex(SABC). RESULTS:The rates of c-erbB-2 expression in extrahepatic cholangiocarcinomas,tissues peripheral to the carcinomas,and normal bile ducts were 80%(60/75),56%(27/48),and 0%(0/9),respectively. In the extrahepatic cholangiocarcinomas,the expression of c-erbB-2 was directly proportional to the malignant grade and tumor metastasis. The expression rate of c-erbB-2 in tumors with nerve infiltration was significantly higher than in those without nerve infiltration. The expression rates of c-erbB-2 in tumors with histological grade Ⅲ/Ⅳ were significantly higher than in those with histological grade Ⅰ. The expression of c-erbB-2 was not correlated with the size or position of tumors,blood vessel infiltration or patients’ sex or age.-,CONCLUSIONS:c-erbB-2 was only expressed in extrahepatic cholangiocarcinomas and tissues peripheral to the carcinomas but not in normal bile ducts,indicating that c-erbB-2 may play an important role in the occurrence and development of extrahepatic cholangiocarcinoma. The fact that the expression level of c-erbB-2 was highly correlated with differentiation grade and metastasis of the tumor suggests potential clinical importance of c-erbB-2 a

关键词： cholangiocarcinoma c-erbB-2 gene expression

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蚕蛹蛋白肽的制备及其运动饮料研制

食品科学 2009年第14期30卷 318-320页

作者：陈静郑明珠王浩吉林农业大学军事体育教研部吉林长春130118 吉林农业大学食品科学与工程学院吉林长春130118 吉林农业大学研究生学院吉林长春130118

以超临界提取油脂后的蚕蛹蛋白粉为原料,采用碱性蛋白酶水解制备蚕蛹蛋白肽,通过正交试验确定了蚕蛹蛋白肽酶解的最佳工艺条件为:酶解温度55℃,酶解时间2.5h,固液比1:7(m/m),pH8,酶用量7%([E]/[S]),此条件下水解度29.97%。并进行缓解体... 详细信息

以超临界提取油脂后的蚕蛹蛋白粉为原料,采用碱性蛋白酶水解制备蚕蛹蛋白肽,通过正交试验确定了蚕蛹蛋白肽酶解的最佳工艺条件为:酶解温度55℃,酶解时间2.5h,固液比1:7(m/m),pH8,酶用量7%([E]/[S]),此条件下水解度29.97%。并进行缓解体力疲劳功能的蚕蛹蛋白肽运动饮料的研制,得到最佳工艺为:蛋白肽与水比例1:5(V/V),蔗糖量6%,柠檬酸量0.15%。

关键词：蚕蛹蛋白肽缓解体力疲劳运动饮料

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响应面法优化长白山野菊花挥发油的提取工艺及成分分析

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食品与发酵工业 2016年第7期42卷 181-187页

作者：宋丽郑明珠王立江吉林农业大学小麦和玉米深加工国家工程实验室吉林长春130118 吉林农业科技学院食品工程学院吉林吉林132101

采用索式提取法对长白山野菊花挥发油进行提取,在单因素试验的基础上,以挥发油得率为指标,利用响应面法优化长白山野菊花挥发油提取工艺条件,确定最佳提取工艺条件。在抽提温度50.17℃,料液比1∶40(g∶m L),提取时间9.44 h的条件下,长... 详细信息

采用索式提取法对长白山野菊花挥发油进行提取,在单因素试验的基础上,以挥发油得率为指标,利用响应面法优化长白山野菊花挥发油提取工艺条件,确定最佳提取工艺条件。在抽提温度50.17℃,料液比1∶40(g∶m L),提取时间9.44 h的条件下,长白山野菊花挥发油得率可达4.953 62%,提取率达到95%以上。应用GC-MS测定挥发油中的主要成分有α-香树精、桉叶油素、乙酸龙脑酯、1,4-桉叶素、β–倍半水芹烯、(+)–雪松醇、红没药醇、右旋樟脑、异龙脑、石竹素以及(-)-α-柏木烯,均为倍半萜类化合物及其含氧衍生物,其中α-香树精含量为9.02%,也是长白山野菊花挥发油中特有的成分之一。

关键词：长白山野菊花挥发油索式提取法成分分析气相色谱质谱

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke Jiang Zhi Chen Ji Yu Chen zheng Shan Huang ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

阿卡波糖联合二甲双胍治疗2型糖尿病的临床疗效分析

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中外医药研究 2022年第5期1卷 39-41页

作者：郑明珠广东省梅州市妇幼保健计划生育服务中心广东梅州514000

目的:分析阿卡波糖联合二甲双胍治疗2型糖尿病的临床疗效。方法:选取2019年1月-2021年2月广东省梅州市妇幼保健计划生育服务中心收治的2型糖尿病患者60例为观察对象。根据随机数表法分为观察组和对照组,各30例。对照组给予阿卡波糖治疗... 详细信息

目的:分析阿卡波糖联合二甲双胍治疗2型糖尿病的临床疗效。方法:选取2019年1月-2021年2月广东省梅州市妇幼保健计划生育服务中心收治的2型糖尿病患者60例为观察对象。根据随机数表法分为观察组和对照组,各30例。对照组给予阿卡波糖治疗,观察组给予阿卡波糖联合二甲双胍治疗。比较两组患者焦虑情绪情况、血糖水平、胰岛功能指标、不良反应发生率。结果:治疗后,两组患者SAS评分均降低,观察组低于对照组,差异有统计学意义(P0.05)。结论:阿卡波糖联合二甲双胍治疗2型糖尿病可满足治疗需求,改善焦虑情绪,可调整患者血糖水平。

关键词：阿卡波糖二甲双胍 2型糖尿病心理状态血糖