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Effect of intraoperative radiotherapy combined with external beam radiotherapy following internal drainage for advanced pancreatic carcinoma

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World Journal of Gastroenterology 2004年第11期10卷 1669-1671页

作者： Hong-BingMa zheng-lidi Xi-JingWang Hua-FenKang Huai-CiDeng Ming-HuaBai DepartmentofOncology theSecondHospitalofXi'anJiaotongUniversityXi'an710004-ShaanxiProvinceChina DepartmentofRadiationOncology theFirstHospitalofXi'anJiaotongUniversityXi'an710068ShaanxiProvinceChina DepartmentofOncology theSecondHospitalofXi'anJiaotongUniversityXi'an710004-ShaanxiProvinceChina

AIM: To determine the survival of advanced pancreatic cancer patients treated with intraoperative radiotherapy (IORT) combined with external beam radiation therapy (EBRT) following internal drainage (cholecystojejunostomy or choledochojejunostomy). METHODS: Eighty-one patients with advanced pancreatic cancer who received IORT combined with EBRT following internal drainage (ID) between 1996 and 2001 were retrospectively analyzed. Among the 81 patients, 18 underwent ID+IORT, 25 ID+IORT+EBRT (meanwhile, given 5-Fu 300 mg/m^2 iv drip, 2f/w), 16 EBRT, 22 had undergone simple internal drainage. The IORT dose was 15-25Gy in a single fraction. The usual EBRT dose was 30-40Gy with a daily fraction of 1.8-2.0 Gy. RESULTS: The complete remission rate, partial remission rate of patients with backache and abdominal pain treated with ID+IORT were 55.5%, 33.3% respectively. Alleviation of pain was observed 2 or 3 wk after IORT. The median survival time (MST) of ID+IORT group was 10.7 mo. The pain remission rate of patients treated with ID+IORT+EBRT was 92%, and their MST was 12.2 mo. The MST of patients treated with EBRT and simple internal drainage was 5.1 mo and 7.0 mo, respectively. The survival curve of ID+IORT group and ID+IORT+EBRT group was significantly better than that of EBRT group (P<0.05). The difference between the ID+IORT+EBRT group and ID group was significant (P<0.05). CONCLUSION: IORT combined with EBRT following internal drainage can alleviate pain, improve quality of life and prolong survival time of patients with advanced pancreatic cancer.

关键词：外科手术放射线疗法胰腺癌晚期 IORT EBRT 物理治疗

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Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma

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World Journal of Gastroenterology 2005年第5期11卷 744-747页

作者： Hong-BingMa Hai-TaoHu zheng-lidi Zuo-RenWang Jing-SenShi Xi-JingWang YiLi DepartmentofCancerSurgery SecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina DepartmentofHumanAnatomy MedicalCollegeofXi'anJiaotongUniversityXi'an710068ShaanxiProvinceChina DepartmentofNeurology Xi'anCenterHospitalXi'an710003ShaanxiProvinceChina DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM: To investigate the role of cyclin D1, p16 and retinoblastoma in cancerous process of gallbladder carcinomas and to assess the relation between cyclin D1, p16, Rb and the biological characteristics of gallbladder carcinoma. METHODS: Forty-one gallbladder carcinoma, 7 gallbladder adenoma and 14 chronic cholecystitis specimens were immunohistochemically and histopathologically investigated for the relation of cyclin D1, p16 and Rb with Nevin staging and pathologic grading. RESULTS: The expression rates of abnormal cyclin Dl in gallbladder carcinoma (68.3%)and gallbladder adenoma (57.1%) were significantly higher than those in chronic cholecystitis (7.1%) (P<0.05). No significant difference was found both among the pathological grades G1, G2 and G3 and among Nevin stagings S1-S2, S3 and S4-S5 of gallbladder carcinoma. The positive rates of p16 (48.8%) and Rb (58.5%) in gallbladder carcinoma were significantly lower compared to those in adenoma (100.0%) and cholecystitis (100.0%) (P<0.05). The positive rates of p16 and Rb in Nevin stagings S1-S2 (80.0% and 90.0%) and S3 (46.2% and 61.5%) gallbladder carcinomas were significantly higher than those in S4-S5(33.3% and 38.8%) (P<0.05), and those in pathologic grades G1(54.5% and 81.8%) and G2 (50.0% and 62.5%) gallbladder carcinoma were significantly higher than those in G3 (28.6% and 35.7%) (P<0.05). The protein expression of p16 and Rb had a negative-correlation in gallbladder carcinoma (r= -0.2993, P<0.05), and this negative-correlation was correlated with Nevin staging (P<0.05). Moreover, the protein expression of p16 and cyclin Dl had a negative-correlation in gallbladder carcinoma (r = -0.9417, P<0.05). CONCLUSION: Cyclin Dl may play a role in the early stage of gallbladder carcinoma. Mutation of p16 and Rb genes might be correlated with progression of gallbladder carcinoma. Analysis of p16 and Rb can estimate the prognosis of gallbladder carcinoma. Expression of p16 and Rb may be correlated with Nevin staging and

关键词： Gallbladder carcinoma Cyclin Dl p16 protein Retinoblastoma protein Tumor metastasis

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Construction of targeted plasmid vector pcDNA3.1-Egr.1p-p16 and its expression in pancreatic cancer JF305 cells induced by radiation in vitro

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World Journal of Gastroenterology 2007年第31期13卷 4214-4218页

作者： Hong-Bing Ma Xi-JingWang HuaFen Kang Ming-Hua Bai zheng-lidi Jie Ma Hui Xia zheng Li Jie LiU Cong-Mei Wu Department of Oncology TheSecondAffiliated HospitalMedicalcollegeofXi’an Jiaotong UniversityXi’an710004ShaanxiProvinceChina Medical Department Xi’an Central HospitalXi’an710003ShaanxiProvinceChina National Laboratory of Molecular Oncology Cancer InstituteHospitalChineseAcademyofMedicalSciencesandPekingUnionMedicalCollegeBeijing100021China ResearchCencerofReproductiveMedicine MedicalcollegeofShantouUniversityShantou515031GuangdongProvinceChina

To construct pcDNA3.1-Egr.1p-p16 recombinant plasmid and investigate the expression of p16 in pancreatic cancer JF305 cells induced by radiation and the feasibility of gene radiotherapy for pancreatic carcinoma.

关键词： pcDNA3.1-Egr. 1p-p16 Reconstructionplasmid, X-ray radiation

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不同基质养分条件下凤眼蓝入侵对两种沉水植物生长的影响

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福建师范大学学报（自然科学版） 2023年第4期39卷 38-45页

作者：郑立地王奇周建福建省林业科学研究院福建福州350012 福建师范大学地理科学学院福建福州350007 福建泉州湾湿地生态系统国家定位观测研究站福建泉州362000 国家林业和草原局林草调查规划院北京100714 北京农学院生物与资源环境学院北京102206 农业农村部华北都市农业重点实验室北京102206

为探讨基质养分对沉水植物和入侵性浮水植物凤眼蓝种间关系的影响.选取金鱼藻、狐尾藻为研究对象,进行温室控制实验.研究结果显示:(1)基质养分显著增加了两种沉水植物的生物量、总茎长和茎节数,凤眼蓝的侵入均显著降低了两种植物的各项... 详细信息

为探讨基质养分对沉水植物和入侵性浮水植物凤眼蓝种间关系的影响.选取金鱼藻、狐尾藻为研究对象,进行温室控制实验.研究结果显示:(1)基质养分显著增加了两种沉水植物的生物量、总茎长和茎节数,凤眼蓝的侵入均显著降低了两种植物的各项生长数据;(2)基质养分变化和凤眼蓝两种处理的交互作用对金鱼藻影响不显著,对狐尾藻分支数的生长指标影响显著;(3)基质养分增加对两种沉水植物与凤眼蓝的相对作用指数(RII)影响较小.研究表明凤眼蓝的入侵均降低了两种沉水植物的竞争强度,基质养分的变化改变了植物的种间关系,且改变的趋势不同.

关键词：生物入侵湿地生态种间竞争相对作用指数

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黄河三角洲潮汐区和生态恢复区湿地土壤特征和重金属分布

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湿地科学 2015年第5期13卷 535-542页

作者：郑立地肖蓉姚新颖马梓文张明祥白军红北京林业大学自然保护区学院北京100083 北京师范大学环境学院北京100875

以黄河三角洲国家级自然保护区内的潮汐区天然湿地和生态恢复区湿地为研究区,采集两区域内芦苇(Phragmites australis)盐沼、盐地碱蓬(Suaeda salsa)盐沼和裸地的上层土壤(0~30 cm深度),测定其含水率、p H、电导率、有机碳含量和微生物... 详细信息

以黄河三角洲国家级自然保护区内的潮汐区天然湿地和生态恢复区湿地为研究区,采集两区域内芦苇(Phragmites australis)盐沼、盐地碱蓬(Suaeda salsa)盐沼和裸地的上层土壤(0~30 cm深度),测定其含水率、p H、电导率、有机碳含量和微生物生物量碳、氮含量,并测定重金属Cd、Cr、Cu、Ni、Pb和Zn的含量。结果表明,在生态恢复区,土壤p H显著低于潮汐区;芦苇盐沼和裸地土壤电导率低于潮汐区,其中,芦苇盐沼土壤电导率差异显著(n=18,p<0.05);芦苇盐沼和盐地碱蓬盐沼土壤含水率和有机碳含量高于潮汐区,有机碳含量显著高于潮汐区(n=18,p<0.05);生态恢复区土壤中的微生物生物量碳含量显著高于潮汐区(n=18,p<0.05),而微生物量氮含量只在芦苇盐沼土壤中显著高于潮汐区。生态恢复区芦苇盐沼和裸地土壤中的重金属含量总体低于潮汐区,其中,芦苇盐沼土壤中Cd、Cr含量和裸地土壤中Cu含量显著低于潮汐区(n=18,p<0.05);生态恢复区盐地碱蓬盐沼土壤中重金属含量总体高于潮汐区,其中Cr、Cu、Ni和Zn含量显著高于潮汐区(n=18,p<0.05)。利用潜在生态风险指数法,评价土壤重金属污染情况,重金属Cd为研究区重金属污染风险的主要贡献因子,生态恢复区土壤生态风险指数低于潮汐区天然湿地土壤。相关性分析表明,在碱性高的土壤中,有机成分显著减少(n=18,p<0.05),重金属含量下降;Cr、Cu、Ni、Pb和Zn含量之间显著相关(n=18,p<0.01),说明这些重金属元素在黄河三角洲土壤中具有同源性,而Cd与Cu、Pb含量之间不相关,说明Cd与Cu、Pb具有不同的来源。

关键词：土壤特性重金属分布盐沼潮汐区恢复区黄河三角洲

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功率自行车运动对慢性期膝骨性关节炎的疗效

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当代医学 2019年第20期25卷 32-34页

作者：郑丽娣叶羽翀蔡霞英毕研贞福建医科大学附属闽东医院康复医学科

目的探讨功率自行车运动对慢性期膝骨性关节炎(KOA)的临床疗效。方法KOA患者56例,随机分为运动组(28例)和对照组(28例)。两组均给予药物、伸屈膝训练、膝关节松动术、中频、超短波等常规康复治疗,运动组在常规康复治疗的基础上给予8周... 详细信息

目的探讨功率自行车运动对慢性期膝骨性关节炎(KOA)的临床疗效。方法KOA患者56例,随机分为运动组(28例)和对照组(28例)。两组均给予药物、伸屈膝训练、膝关节松动术、中频、超短波等常规康复治疗,运动组在常规康复治疗的基础上给予8周功率自行车运动。结果两组患者经常规康复治疗后西大略湖与麦克马斯特骨性关节炎指数(WOMAC)中的疼痛、僵硬、生理功能3项评分较治疗前均有明显下降(P<0.05或P<0.01),6min步行距离较治疗前均有明显增加(P<0.01),且运动组WOMAC中3项评分更低于对照组(P<0.05),6min步行距离更高于对照组(P<0.05),复发率也显著低于对照组(P<0.05)。结论功率自行车运动对慢性期膝骨性关节炎具有显著疗效。

关键词：膝骨性关节炎有氧运动功率自行车

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng zheng Wang Zhou Ying Mo Biao zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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Luminescence: a new perspective for investigating perovskite precursors

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Science China Materials 2025年第01期 312-313页

作者： Haofeng zheng Shaocong Hou School of Electrical Engineering and Automation Wuhan University Wuhan University Shenzhen Research Institute

In the past two decades, perovskite materials have made significant progress in optoelectronic semiconductors, emerging as formidable candidates for the next generation of commercial solar cells, light-emitting diodes (LEDs), and *** the fundamental solution chemistry and photophysics in solution-processed perovskite devices is crucial for comprehending to achieve highly efficient optoelectronic devices.

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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