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Endoscopic“calabash”ligation and resection for small gastric mesenchymal tumors

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World Journal of Gastrointestinal Endoscopy 2024年第10期16卷 545-556页

作者： Xi-Min Lin Yue-Ming Peng Hao-Tian Zeng Jia-Xing Yang zheng-lei xu Department of Gastroenterology The Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina Department of Nursing Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND Gastric mesenchymal tumors(GMT)are identified as soft tissue neoplasms that arise from mesenchymal stem cells within the gastrointestinal *** pri-marily encompass gastric stromal tumors(GST),gastric leiomyomas,and gastric *** most GMT are benign,there are still potential malignant changes,especially ***,early surgical intervention is the primary treat-ment for *** have designed a simple endoscopic“calabash”ligation and resection(ECLR)procedure to treat *** efficacy and safety need to be com-pared with those of traditional endoscopic techniques,such as endoscopic sub-mucosal excavation(ESE).AIM To assess the safety and effectiveness of ECLR in managing small GMT(sGMT)with a maximum diameter≤20 mm by comparing to *** This retrospective analysis involved patients who were hospitalized in our institution between November 2021 and March 2023,underwent endoscopic resection,and received a pathological diagnosis of *** with a tumor diameter≤20 mm were chosen and categorized into two cohorts:Study and control *** study group was composed of patients treated with ECLR,whereas the control group was composed of those treated with *** on general clinical characteristics(gender,age,tumor diameter,tumor growth direction,tumor pathological type,and risk grade),surgery-related information(complete tumor resection rate,operation duration,hospitalization duration,hospitalization cost,and surgical complications),and postoperative follow-up were collected for both *** aforementioned data were subsequently analyzed and *** Five hundred and eighty-nine individuals were included,with 297 cases in the control group and 292 in the study *** propensity score matching,the final analysis incorporated 260 subjects in each *** findings indicated that the study group exhibited shorter operation duration and lowered medical expenses relative to the control ***,the study group rep

关键词： Endoscopic“calabash”ligation and resection Endoscopic submucosal excavation Gastric mesenchymal tumors Gastric stromal tumors leiomyoma Schwannoma

Efficacy and safety of endoscopic resection in treatment of small gastric stromal tumors: A state-of-the-art review

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 462-471页

作者： Ze-Ming Chen Min-Si Peng Li-Sheng Wang zheng-lei xu Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina

Gastrointestinal stromal tumors can occur in any part of the gastrointestinal tract,but gastric stromal tumors(GSTs)are the most *** GSTs have the potential to become malignant,and these can be divided into four different grades by risk from low to high:Very low risk,low risk,medium risk,and high *** guidelines all recommend early complete excision of GSTs larger than 2 cm in ***,it is not clear whether small GSTs(sGSTs,i.e.,those smaller than 2 cm in diameter)should be treated as early as *** National Comprehensive Cancer Network recommends that endoscopic ultrasonographyguided(EUS-guided)fine-needle aspiration biopsy and imaging(computed tomography or magnetic-resonance imaging)be used to assess cancer risk for sGSTs detected by gastroscopy to determine *** EUS indicates a higher risk of tumor,surgical resection is *** are some questions on whether sGSTs also require early *** studies have shown that endoscopic treatment of GSTs with diameters of 2-5 cm is very *** here address whether endoscopic therapy is also suitable for *** this paper,we try to explain three questions:(1)Does sGST require treatment?(2)Is digestive endoscopy a safe and effective means of treating sGST?and(3)When sGSTs are at different sites and depths,which endoscopic treatment method is more suitable?

关键词： Gastrointestinal stromal tumors Small gastric stromal tumors Malignant High risk factors Endoscopy Treatment

Endoloop ligation after endoscopic mucosal resection using a transparent cap: A novel method to treat small rectal carcinoid tumors

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World Journal of Gastroenterology 2019年第10期25卷 1259-1265页

作者： Ding-Guo Zhang Su Luo Feng Xiong zheng-lei xu Ying-xue Li Jun Yao Li-Sheng Wang Department of Gastroenterology Shenzhen People’s HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan University

BACKGROUND Local endoscopic resection is an effective method for the treatment of small rectal carcinoid tumors, but remnant tumor at the margin after resection remains to be an *** To evaluate the efficacy and safety of resection of small rectal carcinoid tumors by endoloop ligation after cap-endoscopic mucosal resection(LC-EMR) using a transparent *** Thirty-four patients with rectal carcinoid tumors of less than 10 mm in diameter were treated by LC-EMR(n = 22) or endoscopic submucosal dissection(ESD)(n =12) between January 2016 and December 2017. Demographic data, complete resection rates, pathologically complete resection rates, operation duration, and postoperative complications were collected. All cases were followed for 6 to 30 *** A total of 22 LC-EMR cases and 12 ESD cases were enrolled. The average age was48.18 ± 12.31 and 46.17 ± 12.57 years old, and the tumor size was 7.23 ± 1.63 mm and 7.50 ± 1.38 mm, respectively, for the LC-EMR and ESD groups. Resection time in the ESD group was longer than that in the LC-EMR group(15.67 ± 2.15 min vs 5.91 ± 0.87 min; P < 0.001). All lesions were completely resected at one time. No perforation or delayed bleeding was observed in either *** complete resection(P-CR) rate was 86.36%(19/22) and 91.67%(11/12) in the LC-EMR and ESD groups(P = 0.646), respectively. Two of the three cases with a positive margin in the LC-EMR group received transanal endoscopic microsurgery(TEM) and tumor cells were not identified in the postoperative specimens. The other case with a positive margin chose follow-up without further operation. One case with remnant tumor after ESD received further local ligation treatment. Neither local recurrence nor lymph node metastasis was found during the follow-up *** LC-EMR appears to be an efficient and simple method for the treatment of small rectal carcinoid tumors, which can effectively avoid margin remnant tumors.

关键词： Rectal carcinoid Endoscopic submucosal dissection Endoscopic mucosal resection Ligation

Correction to“Efficacy and safety of endoscopic resection in treatment of small gastric stromal tumors:A state-of-the-art review”

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World Journal of Gastrointestinal Oncology 2022年第5期14卷 1065-1066页

作者： Ze-Ming Chen Min-Si Peng Li-Sheng Wang zheng-lei xu Department of Gastroenterology The Second Clinical Medical College Jinan University (Shenzhen People's Hospital) Shenzhen 518000 Guangdong Province China. Department of Gastroenterology The Second Clinical Medical College Jinan University (Shenzhen People's Hospital) Shenzhen 518000 Guangdong Province China. 78249073@***.

TO THE EDITOR Correction:The name of our institution"Department of Gastroenterology,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,Shenzhen 518000,Guangdong Province,China"[1]should be changed to"Department of Gastroenterology,The Second Clinical Medical College,Jinan University(Shenzhen People's Hospital),Shenzhen 518000,Guangdong Province,China".

关键词： treatment Guangdong Jinan

DCVAE-adv:A Universal Adversarial Example Generation Method for White and Black Box Attacks

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Tsinghua Science and Technology 2024年第2期29卷 430-446页

作者： lei xu Junhai Zhai College of Mathematics and Information Science Hebei UniversityBaoding 071002China

Deep neural network(DNN)has strong representation learning ability,but it is vulnerable and easy to be fooled by adversarial *** order to handle the vulnerability of DNN,many methods have been *** general idea of existing methods is to reduce the chance of DNN models being fooled by observing some designed adversarial examples,which are generated by adding perturbations to the original *** this paper,we propose a novel adversarial example generation method,called *** from the existing methods,DCVAE-adv constructs adversarial examples by mixing both explicit and implicit perturbations without using original ***,the proposed method can be applied to both white box and black box *** addition,in the inference stage,the adversarial examples can be generated without loading the original images into memory,which greatly reduces the memory *** compared DCVAE-adv with three most advanced adversarial attack algorithms:FGSM,AdvGAN,and AdvGAN++.The experimental results demonstrate that DCVAE-adv is superior to these state-of-the-art methods in terms of attack success rate and transfer ability for targeted *** code is available at https://***/xzforeverlove/DCVAE-adv.

关键词： deep neural network adversarial examples white box attack black box attack robustness

Effect of aluminum phosphate gel on prevention of early rebleeding after ligation of esophageal variceal hemorrhage

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1651-1659页

作者： Zhu-Liang Zhang Min-Si Peng Ze-Ming Chen Ting Long Li-Sheng Wang zheng-lei xu The Second Clinical Medical College of Jinan University Shenzhen 518000Guangdong ProvinceChina Department of Gastroenterology Shenzhen People's HospitalShenzhen 518020Guangdong ProvinceChina Department of Pathology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina

BACKGROUND Liver cirrhosis is the main cause of portal *** leading cause of death in patients with liver cirrhosis is its most common complication,esophageal variceal bleeding(EVB).Endoscopic variceal ligation(EVL)is recommended by many guidelines to treat EVB and prevent rebleeding;however,esophageal ulcers occur after *** healing of ulcers and unhealed ulcers lead to high rebleeding and mortality ***,the prevention of early postoperative rebleeding is of great significance in improving the quality of life and prognosis of *** To evaluate the efficacy of aluminum phosphate gel(APG)plus a proton pump inhibitor(PPI)in the prevention of early rebleeding after EVL in patients with *** The medical records of 792 patients who were diagnosed with EVB and in whom bleeding was successfully stopped by EVL at Shenzhen People’s Hospital,Guangdong Province,China from January 2015 to December 2020 were *** to the study inclusion and exclusion criteria,401 cases were included in a PPI-monotherapy group(PPI group),and 377 cases were included in a PPI and APG combination therapy(PPI+APG)*** compared the incidence rates of early rebleeding and other complications within 6 wk after treatment between the two *** two-sample t-test,Wilcoxon rank-sum test,and chisquared test were adopted for statistical *** No significant differences in age,sex,model for end-stage liver disease score,coagulation function,serum albumin level,or hemoglobin level were found between the two *** incidence of early rebleeding in the PPI+APG group(9/337;2.39%)was significantly lower than that in the PPI group(30/401;7.48%)(P=0.001).Causes of early rebleeding in the PPI group were esophageal ulcer(3.99%,16/401)and esophageal varices(3.49%,14/401),while those in the PPI+APG group were also esophageal ulcers(5/377;1.33%)and esophageal varices(4/377;1.06%);such causes were significantly less frequent in the PPI+APG gr

关键词： Esophageal variceal bleeding Esophageal variceal ligation Proton pump inhibitor Endoscopic variceal ligation Aluminum phosphate gel

Precipitating thermally reinforcement phase in aluminum alloys for enhanced strength at 400℃

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Journal of Materials Science & Technology 2024年第5期172卷 71-82页

作者： Xiang Su Yuan lei Yang Chen Hongjie Qu Zhixiang Qi Gong zheng xu Liu Henggao Xiang Guang Chen National Key Laboratory of Advanced Casting Technologies MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials TechnologyEngineering Research Center of Materials Behavior and DesignMinistry of EducationNanjing University of Science and TechnologyNanjing 210094China School of Aviation and Mechanical Engineering Changzhou Institute of TechnologyChangzhou 213032China

Heat-resistant aluminum alloys are widely used in aerospace and automotive fields for manufacturing hot components due to their advantages in lightweight design and energy ***,the high-temperature strength of existing cast aluminum alloys is always limited to about 100 MPa at 350℃due to coarsening and transformation of strengthening ***,we reveal that the yield strength and ultimate tensile strength of the T6 state Al-8.4Cu-2.3Ce-1.0Mn-0.5Ni-0.2Zr alloy at 400◦C increase by 34%and 44%after re-aging at 300℃for 100 h,and its thermal strength exhibits distinguished ad-vantage over traditional heat-resistant aluminum *** enhanced elevated-temperature strength is attributed to the reprecipitation of the Ni-bearing T-Al_(20)Cu_(2)Mn_(3)phase,whose number density increases over one *** significant segregation of Ni,Ce,and Zr elements at the interfaces helps improve the thermal stability of the T *** thermostable T phase effectively strengthens the matrix by in-hibiting dislocation ***,a highly interconnected 3D intermetallic network along the grain boundaries can still remain after long-term re-aging at 300℃,which is conducive to imposing a drag on the grain boundaries at high *** finding offers a viable route for enhancing the elevated-temperature strength of heat-resistant aluminum alloys,which could provide expanded opportunities for higher-temperature applications.

关键词： Aluminum alloys Precipitation Thermally reinforcement phase Re-aging treatment High-temperature strength

Progress and prospect of Pt-based catalysts for electrocatalytic hydrogen oxidation reactions

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Nano Research 2024年第3期17卷 960-981页

作者： xu Zhang Ying Xie lei Wang Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

To achieve the goals of the peak carbon dioxide emissions and carbon neutral,the development and utilization of sustainable clean energy are extremely *** fuel cells are an important system for converting hydrogen energy into electrical ***,the slow hydrogen oxidation reaction(HOR)kinetics under alkaline conditions has limited its ***,elucidating the catalytic mechanism of HOR in acidic and alkaline media is of great significance for the construction of highly active and stable *** terms of practicality,Pt is still the primary choice for commercialization of fuel *** the above basis,we first introduced the hydrogen binding energy theory and bifunctional theory used to describe the HOR activity,as well as the pH *** that,the rational design strategies of Pt-based HOR catalysts were systematically classified and summarized from the perspective of activity *** addition,we further emphasized the importance of theoretical simulations and in situ characterization in revealing the HOR mechanism,which is crucial for the rational design of ***,the practical application of Pt-based HOR catalysts in fuel cells was also *** closing,the current challenges and future development directions of HOR catalysts were *** review will provide a deep understanding for exploring the mechanism of highly efficient HOR catalysts and the development of fuel cells.

关键词： Pt-based catalysts hydrogen oxidation reaction(HOR) electrocatalytic mechanism hydrogen binding energy theory bifunctional theory

An improved analysis method for assessing the nuclear-heating impact on the stability of toroidal field magnets in fusion reactors

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Nuclear Science and Techniques 2024年第6期35卷 163-176页

作者： Yu-Dong Lu Jin-Xing zheng xu-Feng Liu Huan Wu Jian Ge Kun xu Ming Li Hai-Yang Liu lei Zhu Fei Liu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

The superconducting magnet system of a fusion reactor plays a vital role in plasma confinement,a process that can be dis-rupted by various operational factors.A critical parameter for evaluating the temperature margin of superconducting magnets during normal operation is the nuclear heating caused by D-T *** study investigates the impact of nuclear heat-ing on a superconducting magnet system by employing an improved analysis method that combines neutronics and thermal *** the magnet system,toroidal field(TF)magnets are positioned closest to the plasma and bear the highest nuclear-heat load,making them prime candidates for evaluating the influence of nuclear heating on *** enhance the modeling accuracy and facilitate design modifications,a parametric TF model that incorporates heterogeneity is established to expedite the optimization design process and enhance the accuracy of the computations.A comparative analysis with a homogeneous TF model reveals that the heterogeneous model improves accuracy by over 12%.Considering factors such as heat load,magnetic-field strength,and cooling conditions,the cooling circuit facing the most severe conditions is selected to calculate the temperature of the *** selection streamlines the workload associated with thermal-hydraulic *** approach enables a more efficient and precise evaluation of the temperature margin of TF ***,it offers insights that can guide the optimization of both the structure and cooling strategy of superconducting magnet systems.

关键词： Superconducting magnet Nuclear heating Neutronics Thermal hydraulics