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Correlation between gut microbiota and tumor immune microenvironment:A bibliometric and visualized study

World Journal of Clinical Oncology 2025年第2期16卷 110-129页

作者： zheng-jun hu hui-Rong Zhu Yong-Jie Jin Pan Liu Xiao-Wei Yu Yu-Ren Zhang Department of Oncology Shanghai Jiading District Hospital of Traditional Chinese MedicineShanghai 200000China Department of Oncology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200000China School of Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230000Anhui ProvinceChina

BACKGROUND In recent years,numerous reports have been published regarding the relationship between the gut microbiota and the tumor immune microenvironment(TIME).However,to date,no systematic study has been conducted on the relationship between gut microbiota and the TIME using bibliometric *** To describe the current global research status on the correlation between gut microbiota and the TIME,and to identify the most influential countries,research institutions,researchers,and research hotspots related to this *** We searched for all literature related to gut microbiota and TIME published from January 1,2014,to May 28,2024,in the Web of Science Core Collection *** then conducted a bibliometric analysis and created visual maps of the published literature on countries,institutions,authors,keywords,references,etc.,using CiteSpace(6.2R6),VOSviewer(1.6.20),and bibliometrics(based on R 4.3.2).RESULTS In total,491 documents were included,with a rapid increase in the number of publications starting in *** country with the highest number of publications was China,followed by the United *** has the highest number of citations in *** a centrality perspective,the United States has the highest influence in this *** institutions with the highest number of publications were Shanghai Jiao Tong University and Zhejiang ***,the institution with the most citations was the United States National Cancer *** authors,Professor Giorgio Trinchieri from the National Institutes of Health has the most local impact in this *** most cited author was Fan *** results of journal publications showed that the top three journals with the highest number of published papers were Frontiers in Immunology,Cancers,and Frontiers in *** three most frequently used keywords were gut microbiota,tumor microenvironment,and *** This study systematically elaborates on the research progress re

关键词： Gut microbiota Tumor immune microenvironment Bibliometric CiteSpace VOSviewer R-bibliometrics

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In Vivo Kinetics and Biodistribution of a Hantaan Virus DNA Vaccine after Intramuscular Injection in Mice

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Virologica Sinica 2010年第3期25卷 177-182页

作者： Si WANG Qing NIE Lan-yan zheng jun hu En-jie LUO Department of Medical microbiology and parasitology Preclinical Medical College China Medical University Shenyang 110001 China

To study the kinetics in vivo of a Hantaan virus DNA vaccine, we constructed a fusion DNA vaccine, pEGFP/S, by cloning the S segment of Hantavirus into the vector, pEGFP-C1, which encodes Green fluorescent protein EGFP. In this report, we provide evidence that pEGFP/S was distributed and persistently expressed for more than 60 days in several organs after inoculation. Our findings suggest that the persistent immune responses induced by a Hantaan virus DNA vaccine are likely due to the plasmid pEGFP/S deposited in vivo, which acts as a booster immunization.

关键词： Hantaan virus DNA vaccine Intramuscular injection Immunologic memory Nucleocapsid protein

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上下自体角膜缘干细胞移植治疗翼状胬肉的疗效比较

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国际眼科杂志 2015年第8期15卷 1472-1474页

作者：胡郑君李婷长江大学附属仙桃市第一人民医院眼科中国湖北省仙桃市433000

目的：比较取自上方与下方的带角膜缘干细胞的球结膜移植治疗翼状胬肉的疗效,以及术后球结膜瘢痕化对日后行青光眼滤过手术的影响。方法：对182例252眼初发翼状胬肉患者随机抽签法分成两组,A组85例110眼行翼状胬肉切除联合上方自体角膜... 详细信息

目的：比较取自上方与下方的带角膜缘干细胞的球结膜移植治疗翼状胬肉的疗效,以及术后球结膜瘢痕化对日后行青光眼滤过手术的影响。方法：对182例252眼初发翼状胬肉患者随机抽签法分成两组,A组85例110眼行翼状胬肉切除联合上方自体角膜缘干细胞移植,B组97例142眼翼状胬肉切除联合下方自体角膜缘干细胞植治疗翼状胬肉,术后1-12mo随访,观察两组的复发率和取自体角膜缘干细胞后球结膜瘢痕情况,以及对日后行青光眼滤过手术的影响。结果：随访1-12mo,A组和B组术后复发率相比较,差异无统计学意义（χ^2=0.015,P〉0.05）。A组取上方自体角膜缘干细胞后造成上方球结膜的瘢痕化;B组取下方自体角膜缘干细胞造成下方球结膜瘢痕化。因常规行青光眼滤过手术,通常选在正上方、鼻上或颞上方球结膜区,B组保留了上方健康的球结膜,为日后行青光眼滤过手术保留了手术区域。结论：上方与下方取自体角膜缘干细胞移植均能有效地治疗翼状胬肉,但下方取自体角膜缘干细胞移植能为日后行青光眼滤过手术保留手术区域。

关键词：上方与下方取自体角膜缘干细胞移植翼状胬肉青光眼滤过手术

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin zheng Zi-Yu Ye jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang Cao Yin-Long Xu Jia-Wei Chai Kai zheng jun-Jie Kong jun Liu Shun-Zhen zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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H型叶栅通道流计算网格的改进

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推进技术 2003年第5期24卷 436-439页

作者：周正贵胡骏南京航空航天大学能源与动力学院江苏南京210016

提出一种壁面正交、尾迹区网格节点分布逐渐均匀化叶栅通道网格生成方法。为了研究壁面处网格正交性对数值计算结果的影响,推导出壁面附近流动参数一阶导数离散误差与网格线交角的数学关系。采用N S方程分别对平板紊流附面层流和叶栅通... 详细信息

提出一种壁面正交、尾迹区网格节点分布逐渐均匀化叶栅通道网格生成方法。为了研究壁面处网格正交性对数值计算结果的影响,推导出壁面附近流动参数一阶导数离散误差与网格线交角的数学关系。采用N S方程分别对平板紊流附面层流和叶栅通道流进行计算分析。结果表明:壁面处网格正交性对附面层内流动计算预测精度影响较大,而对势流区流动影响很小;尾迹区切向网格节点逐渐均匀化分布能更准确计算尾迹区流动。

关键词：压气机叶栅流流场仿真数值计算网格生成

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白内障超声乳化联合房角分离术治疗周边虹膜切除术后合并白内障

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国际眼科杂志 2015年第12期15卷 2099-2101页

作者：胡郑君胡红梅李婷长江大学附属仙桃市第一人民医院眼科中国湖北省仙桃市433000

目的:探讨白内障超声乳化联合房角分离术与单纯白内障超声乳化治疗周边虹膜切除术后合并白内障的临床疗效。方法:周边虹膜切除术后合并白内障患者69例85眼,随机分抽签法分为两组,观察组38例45眼,行白内障超声乳化联合人工晶状体植入联... 详细信息

目的:探讨白内障超声乳化联合房角分离术与单纯白内障超声乳化治疗周边虹膜切除术后合并白内障的临床疗效。方法:周边虹膜切除术后合并白内障患者69例85眼,随机分抽签法分为两组,观察组38例45眼,行白内障超声乳化联合人工晶状体植入联合房角分离术,对照组31例40眼行白内障超声乳化联合人工晶状体植入术,术后随访12mo,比较两组手术前后眼压、视力、中央前房深度及房角的变化。结果:术后1wk,观察组与对照组平均眼压分别为10.36±2.85、12.09±3.75mm Hg,均较术前降低,与术前比较差异有统计学意义(P0.05)。观察组与对照组中央前房平均深度分别为3.57±0.32、3.44±0.35mm,均较术前明显增加,与术前相比较差异有统计学意义(P0.05)。术后2mo,观察组房角粘连范围<90°共42眼(93.33%),高于对照组的31眼(77.50%),两者相比较差异有统计学意义(P<0.05)。结论:白内障超声乳化联合房角分离术治疗周边虹膜切除术后合并白内障,可以有效开放粘连的房角,控制眼压并提高视力,是一种安全有效的治疗方法。

关键词：白内障超声乳化房角分离周边虹膜切除术

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玻璃体腔Bevacizumab注射后联合二联术治疗新生血管性青光眼

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国际眼科杂志 2015年第5期15卷 892-894页

作者：胡郑君胡红梅张亮中国湖北省仙桃市第一人民医院眼科 433000

目的：观察玻璃体腔bevacizumab注射后联合二联术治疗新生血管性青光眼（ neovascular glaucoma, NVG ）的临床疗效。方法：NVG 患者25例25眼,行玻璃体腔内注射bevacizumab 1.0mg（0.05mL）,待虹膜新生血管消退,其中5眼行前房穿刺放... 详细信息

目的：观察玻璃体腔bevacizumab注射后联合二联术治疗新生血管性青光眼（ neovascular glaucoma, NVG ）的临床疗效。方法：NVG 患者25例25眼,行玻璃体腔内注射bevacizumab 1.0mg（0.05mL）,待虹膜新生血管消退,其中5眼行前房穿刺放液辅助控制眼压,2 wk后均接受小梁切除＋白内障超声乳化术（有9眼植入人工晶状体）。术后观察患者的眼压、视力、角膜、新生血管的变化及并发症,并随访12 mo。结果：患者25眼注射bevacizumab后,有20眼于3-5 d虹膜新生血管消退,另有5眼于7d后虹膜新血管消退,控制眼压后,测角膜内皮细胞计数1629±226个/mm2,小梁切除＋白内障超声乳化术后均未发生角膜内皮失代偿；随访12mo,20眼眼压控制在正常范围,2眼用1种抗青光眼药后眼压可控制在正常范围,3眼用抗青光眼药后眼压34-38 mmHg。9眼植入人工晶状体后,视力有提高。结论：玻璃体腔注射bevacizumab可以短期有效清除虹膜和前房角新生血管,降低眼压,并减少术中、术后出血风险,联合小梁切除＋白内障超声乳化术可有效治疗新生血管性青光眼。

关键词：新生血管性青光眼玻璃体腔注射bevacizumab 小梁切除+白内障超声乳化术

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen zheng Song Dinggang Fan Bing hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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烧结终点的优化控制

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自动化与仪表 2013年第4期28卷 29-32页

作者：刘增环郑军虎董军河北工程大学信息与电气工程学院邯郸056038 新兴铸管股份有限公司武安056300

为使烧结终点更稳定、适宜,在分析烧结过程热状态的基础上,利用风箱废气温度曲线与以台车长度为横轴所形成的面积(Areat)为基础,通过控制Areat值的大小实现烧结终点(BTP)预报策略,并提取料层同一断面的风箱废气温度,利用最小二乘法拟合... 详细信息

为使烧结终点更稳定、适宜,在分析烧结过程热状态的基础上,利用风箱废气温度曲线与以台车长度为横轴所形成的面积(Areat)为基础,通过控制Areat值的大小实现烧结终点(BTP)预报策略,并提取料层同一断面的风箱废气温度,利用最小二乘法拟合曲线。开发了基于Areat的烧结终点模糊控制系统。运行结果表明,烧结终点稳定性及烧结矿质量都有所提高。

关键词：废气温度面积烘结终点模糊控制正常拐点

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