检索结果-南通市图书馆

Low Grip Strength and Increased Mortality Hazard among Middle-Aged and Older Chinese Adults with Chronic Diseases

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2023年第3期36卷 213-221页

作者： XIE Kai Hong HAN Xiao zheng wei jun ZHUANG Su Fang School of Nursing Zhejiang Chinese Medical UniversityHangzhou 311400ZhejiangChina School of health humanities Peking UniversityBeijing 100000China School of Public Health Zhejiang Chinese Medical UniversityHangzhou 311400ZhejiangChina Office of Disciplinary Inspection and Supervision The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 311006ZhejiangChina

Objective This study aims to evaluate the association between lower grip strength and mortality *** We selected 10,280 adults aged 45 to 96 years old from the China Health and Retirement Longitudinal Study and used multivariate Cox proportional hazard models to assess the association of grip strength with mortality *** addition,we explored the possibility of a nonlinear relationship using a 4-knot restricted spline *** We found that elevated grip strength was associated with lower mortality up to a certain *** baseline quartile values of grip strength were 30,37,and 44 kg for males and 25,30,and35 kg for *** adjusting for confounders,with category 1 as the reference group,the adjusted HRs were 0.58(0.42-0.79)in males and 0.70(0.48-0.99)in females(category 4).We also found a linear association between grip strength values and all-cause death risk(males,P=0.274;females,P=0.883)using restricted spline *** males with a grip strength<37 kg and females with a grip strength<30 kg,grip strength and death were negatively *** Grip strength below a sex-specific threshold is inversely associated with mortality hazard among middle-aged and older Chinese adults with chronic diseases.

关键词： Grip strength Death Chronic disease

Shared p-cycles design for dual link failure restorability in optical WDM networks

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2007年第3期14卷 74-78页

作者： XIE zheng-cheng XING jun-wei WU Li JI Yue-feng Key Laboratory of Optical Communications and Lightwave Technologies Beijing University of Posts and Telecommunications Beijing 100876 China

Pre-configured cycles （p-cycles） can attain high capacity efficiency and fast protection switching times in wavelength division multiplexing （WDM） networks. This article proposes the weighted straddling link algorithm（WSLA） for generating a subset of all cycles that can guarantee 100% restorability in case of dual link failure, and give an integer linear programming（1LP） formulation that solves the shared p-cycles design problem minimizing the total spare capacities. Numerical result shows that our method can achieve 100% dual link failure restorability with acceptable spare capacity. The larger standard deviation of demand set and the larger node degree network, the better the shared p-cycles scheme performs.

关键词： dual link failure p-cycles WDM

Influence of Post-annealing in N2 on Structure and Electrochemical Characteristics of LiNi0.5Mn1.5O4

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2013年第2期29卷 329-332页

作者： HE Shi-ci ZHANG Qian LIU wei-wei FANG Guo-qing SATO Yuichi zheng jun-wei LI De-cheng Institute of Chemical Power Sources Soochow University Suzhou 215006 P. R. China Department of Applied Chemistry Faculty of Engineering Kanagawa University Yokohama 221-8686 Japan

LiNi0.5Mn1.504 prepared by a spray drying method was re-treated in N2 at 500, 600 and 700℃, respec- tively. Their structural and electrochemical properties were studied by means of Fourier transform infrared（FTIR）, X-ray diffraction（XRD）, and charge-discharge tests. The space group of the ***.504 transforms from P4332 to Fd3m at an annealing temperature of 700℃. The electrochemical characteristics of the treated samples are closely related to the annealing temperature. The sample treated in N2 at 500℃ shows both an improved rate capability and cyclic performance at a high temperature compared with the as-prepared sample, while the sample treated in N2 at 700℃ shows dramatically decrease in its reversible capacity.

关键词： Li-ion battery Cathode material LiNio.sMnl.504 Structural and electrochemical property

Microvascular decompression for a patient with oculomotor palsy caused by posterior cerebral artery compression:A case report and literature review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第20期10卷 7138-7146页

作者： Jian Zhang zheng-jun wei Hang Wang Yan-Bing Yu Hong-Tao Sun Tianjin Key Laboratory of Neurotrauma Repair Institute of Traumatic Brain Injury and NeuroscienceCharacteristic Medical Center of Chinese People’s Armed Police ForceTianjin 300162China Department of Neurosurgery China-Japan Friendship HospitalBeijing 100069China

BACKGROUND Aneurysm compression,diabetes,and traumatic brain injury are well-known causative factors of oculomotor nerve palsy(ONP),while cases of ONP induced by neurovascular conflicts have rarely been reported in the medical ***,we report a typical case of ONP caused by right posterior cerebral artery(PCA)compression to increase neurosurgeons’awareness of the disease and reduce misdiagnosis and *** SUMMARY A 54-year-old man without a known medical history presented with right ONP for the past 5 *** patient presented to the hospital with right ptosis,diplopia,anisocoria(rt 5 mm,lt 2.5 mm),loss of duction in all directions,abduction,and light impaired pupillary *** resonance angiography and computed tomography venography examinations showed no phlebangioma,aneurysm,or intracranial *** conducting oral glucose tolerance and prostigmin tests,diabetes and myasthenia gravis were *** nerve magnetic resonance imaging showed that the right PCA loop was in direct contact with the cisternal segment of the right oculomotor nerve(ON).Microvascular decompression(MVD)of the culprit vessel from the ON through a right subtemporal craniotomy was carried out,and the ONP symptoms were significantly relieved after 3 *** Vascular compression of the ON is a rare pathogeny of ONP that may be refractory to drug therapy and ophthalmic strabismus *** is an effective treatment for ONP induced by neurovascular compression.

关键词： Microvascular decompression Oculomotor nerve palsy Oculomotor nerve Magnetic resonance imaging Posterior cerebral artery Neurovascular conflict Case report

Deformation characteristics and thresholds of the Tanjiawan landslide in the Three Gorges Reservoir Area,China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2022年第5期19卷 1370-1385页

作者： ZHANG Fu-ling DENG Mao-lin YI Qing-lin LU Shu-qiang zheng wei-jun HUANG Hai-feng ZHU Xing Hubei Geological Disaster Prevention and Control Engineering Technology Research Center China Three Gorges UniversityYichang 443002China College of Civil Engineering&Architecture China Three Gorges UniversityYichang 443002China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China Natural Resources and Planning Bureau ofZigui County Yichang 443002China

Since the first impoundment of the Three Gorges Reservoir(TGR)in China in 2003,more than 5000 landslides including potential landslides were *** this paper,a deep-seated active landslide in TGR area was *** years’monitoring data and field investigations from 2006 to 2020 were used to analyze the deformation characteristics,influencing factors,and meteohydrological *** landslide showed a none-overall periodic movement pattern featuring acceleration during long-duration rainfall and rapid transition to constant creep after rainfall *** secondary sliding masses,No.1 and No.2,were defined via field *** reservoir has no impact on the deformation whereas long-duration-low-intensity rainfall is the main *** present,the cumulative displacements of the main sliding mass range from 0.9 to 3.2 m,and the deformation during the rainy season is gradually *** boundary of this landslide was formed,and the boundary of No.2 sliding mass became *** probability of the failure of sliding mass No.2 is very high under the conditions of continuous *** 15-day antecedent rainfall combined with 4-day cumulative rainfall could be the rainfall threshold which could be associated with the groundwater level S1 of 294 m above sea level for forecasting large deformation of Tanjiawan landslide.

关键词： Three Gorges Reservoir Deformation characteristics Deep-seated landslide Rainfall threshold Groundwater threshold

基于白化变换及曲率特征的3维物体识别及姿态计算

在线全文

学校读者我要写书评

暂无评论

清华大学学报（自然科学版） 2016年第10期56卷 1025-1030页

作者：郑军魏海永清华大学机械工程系先进成形制造教育部重点实验室北京100084

为解决3维物体识别及姿态计算问题,提出了一种基于白化变换和改进U弦长曲率特征的图像识别及姿态计算方法。该方法首先提取物体的2维形状特征,然后使用白化变换对模板物体图像轮廓和目标物体图像轮廓进行处理,使处理后的轮廓点集仅存在... 详细信息

为解决3维物体识别及姿态计算问题,提出了一种基于白化变换和改进U弦长曲率特征的图像识别及姿态计算方法。该方法首先提取物体的2维形状特征,然后使用白化变换对模板物体图像轮廓和目标物体图像轮廓进行处理,使处理后的轮廓点集仅存在旋转关系;根据改进后的U弦长曲率方法,求取两轮廓的曲率,并进行匹配。实验结果表明:该方法具备较好的仿射不变性,其识别速度达到58ms/帧(CPU:2.3GHz;内存:4GB),识别率在无遮挡情况下达到了100%,姿态检测精度达到了1.5°。

关键词：物体识别仿射不变白化变换曲率姿态计算

Moxifloxacin:cardiovascular effects in conscious,jacketed cynomolgus monkeys following oral (nasogastric intubation) administration

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2013年第3期 595-596页

作者： HU Miao-miao XING Guo-zhen Matthew SKINNER YU Hong WANG Shao-dong ZHAO Li zheng wei-jun REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park MacclesfieldUK

OBJECTIVE Moxifloxacin is a fluoroquinolone with a broad spectrum of antibacterial *** aim of this study was to investigate the cardiovascular effects of moxifloxacin,administered to conscious,jacketed cynomolgus monkeys as single oral *** was a validation study performed to assess the new DSI Jacketed External Telemetry(JET) system recently installed at *** There were 6 animals(3 males and 3 females) in two *** of the same gender were group-housed in the same *** received 4 doses of vehicle control(3 fe-males) or vehicle control followed by moxifloxacin(3 males) with single ascending doses at 15,45 and 135 mg·*** animals had at least 3 to 4 dose-free days between each dose *** JET system(Data Science International,US),including two receivers and 6 devices,was used for continuous ECG data and body temperature(surface) collection for approximately 1 h before,until 24 h after each *** Administration of moxifloxacin to group-housed conscious male primates was associated with a dose-dependent prolongation of QTc interval(increase of 9 and 16% vs timematched vehicle data after 45 and 135 mg·kg-1,respectively).In female monkeys,administered multiple doses of vehicle,QTc was comparable across consecutive dosing *** results demonstrate the usefulness of the JET system in conscious monkeys for evaluating the cardiovascular effects of drugs under normal physiological conditions.

关键词： moxifloxacin cardiovascular effects

A validation safety pharmacology study of the central nervous system,employing a functional observational battery in female cynomolgus monkey

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2013年第3期 579-580页

作者： HU Li-ping zheng wei-jun ZHANG Long-sheng CHEN Xiao-qiang LI Liang-shun LI Ming YU Hong REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica

The objective of this study was to establish and validate a functional observational battery(FOB) at the Center for Drug Safety Evaluation & Research(CDSER) that provides a basic neurological and behavioral assessment in cynomolgus *** female cynomolgus monkeys were assigned to this study and were administered the vehicle and substances〔chlorpromazine,(+)-MK-801 or caffeine〕in 4 separated days(a 7-d wash-out period between each drug treatment).On each dosing day,4 animals were staggered for dosing.A FOB was performed and recorded by two independent observers for each animal at designated time *** between two observers were evaluated and actions were taken to minimize the subjective *** administration of 5 mg·kg-1 chlorpromazine resulted in sedative effect between 0.5 and 3 h post dose and decreased body temperature at 1 h post *** administration of(+) MK-801(0.1,0.5,1.25 and 2.5 mg·kg-1) resulted in suppressed behavior(low arousal,infrequent vocalization,hypoactive,etc),autonomic responses(salivation,decreased respiration and rectal temperature,etc) and sensorimotor / neuromuscular alternations(unsteady,un-coordinated,lack of auditory response,tremor and convulsion,etc) at all doses,and monkeys becoming unconscious and /or pupil dilation at high dose levels(1.25 and 2.5 mg·kg-1).The observations were mainly recorded between 0.5 and 3 h post *** resulted in stimulant behavioral changes(high arousal,hyperactivity and /or intermittent circling behavior) in one monkey at a dose of 30 mg·kg-1(between 0.5 and 4.5 h post dose) or one of two monkeys at a dose of 45 mg·kg-1(between 0.5 and 1 h post dose).At higher doses(one monkey dosed at 45 mg·kg-1 and one at 60 mg·kg-1),caffeine resulted in decreased arousal and hypoactive between 0.5 and 3 h post *** alteration caused by caffeine was evidenced by vomiting /retching seen in the 45 mg·kg-1 monkey at 0.5 h post dose and in the 60 mg·kg-1 monkey between 0.5 and 3 h pos

关键词： saftey evaluation pharmacology monkey

Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal damage

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2013年第3期 492-493页

作者： YU Hong Sonya GALES zheng wei-jun QIN Qiu-ping Dale THURMAN HU Li-ping QIAO jun-wen REN Jin CHEN Ya-fei Russell BIALECKI Lew KINTER Nigel BARRASS Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park MacclesfieldUK Global Safety Assessment AstraZeneca R&D BostonMAUSA

OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney *** Study #1,11 monkeys(2-3 /sex /group) were given vehicle or imipenem(180 mg·kg-1,iv infusion once daily for 7 d) and urine was collected on days xxxxx for biomarker *** Study #2,24 monkeys(3 /sex /group) were given of vehicle or imipenem(45,90 or 180 mg·kg-1,iv infusion once daily for 7 d).The following endpoints were assessed in both studies: clinical observations,body weight,food consumption,haematology,coagulation,blood chemistry,urine analysis,imipenem concentration /toxicokinetics (TK) and gross and microscopic *** Study #1: Imipenem causes minor body weight loss,increased urea and creatinine,and decreased phosphate in *** total protein and bilirubin were observed in the *** effects were progressive and most pronounced at days 7 and *** and relative kidney weights were increased in both *** histopathological findings were present in kidneys of the dosed monkeys,consisting of minimal to moderate tubular necrosis /degeneration /*** biomarkers(α-1 and β-2 microglobulin,clusterin,Tamm-Horsfall protein and vascular endothelial growth factor) increased progressively and significantly from day 2 onward and preceded notable changes in urinalysis or plasma chemistry on day 7 or 8,*** #2: There were similar findings to Study #1 in the 180 mg·kg-1 imipenem treatment *** total bilirubin and decreased of phosphate in plasma and an increase of urinary urobilinogen /ketones were observed in a dose related *** to imipenem 〔Cmax and AUC(0-3 h) 〕increased in proportion from 45-90 mg·kg-1 but more than in proportion from 90-180 mg·*** The no observed adverse effect level(NOAEL) for the imipenem induced kidney injury was identified as 90 mg·*** increases of five urinary biomark

关键词： imipenem toxicity biomarkers renal damage