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Effectiveness and safety of human umbilical cord-mesenchymal stem cells for treating type 2 diabetes mellitus

World Journal of Diabetes 2022年第10期13卷 877-887页

作者： Xiao-Fen Lian Dong-Hui Lu Hong-Li Liu Yan-Jing Liu Xiu-Qun Han Yang Yang Yuan Lin Qing-Xiang Zeng zheng-jie huang Feng Xie Cai-Hao huang Hong-Mei Wu Ai-Mei Long Ling-Ping Deng Fan Zhang Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Research&Development Zhejiang MaiDa Gene Tech Co.LtdZhoushan 316000Zhejiang ProvinceChina Department of Endocrinology Huizhou Central People's HospitalHuizhou 516000Guangdong ProvinceChina Department of Endocrinology Longgang District Central Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina

BACKGROUND Progressive pancreaticβ-cell dysfunction is a fundamental part of the pathology of type 2 diabetes mellitus(T2DM).Cellular therapies offer novel opportunities for the treatment of T2DM to improve the function of isletβ-*** To evaluate the effectiveness and safety of human umbilical cord-mesenchymal stem cell(hUC-MSC)infusion in T2DM *** Sixteen patients were enrolled and received 1×10^(6) cells/kg per week for 3 wk as intravenous hUC-MSC *** effectiveness was evaluated by assessing fasting blood glucose,C-peptide,normal glycosylated hemoglobin A1c(HbA1c),insulin resistance index(homeostatic model assessment for insulin resistance),and isletβ-cell function(homeostasis model assessment ofβ-cell function).The dosage of hypoglycemic agents and safety were evaluated by monitoring the occurrence of any adverse events(AEs).RESULTS During the entire intervention period,the fasting plasma glucose level was significantly reduced[baseline:9.3400(8.3575,11.7725),day 14±3:6.5200(5.2200,8.6900);P<0.01].The HbA1c level was significantly reduced on day 84±3[baseline:7.8000(7.5250,8.6750),day 84±3:7.150(6.600,7.925);P<0.01].The patients’isletβ-cell function was significantly improved on day 28±3 of intervention[baseline:29.90(16.43,37.40),day 28±3:40.97(19.27,56.36);P<0.01].The dosage of hypoglycemic agents was reduced in all patients,of whom 6(50%)had a decrement of more than 50%and 1(6.25%)discontinued the hypoglycemic *** patients had transient fever,which occurred within 24 h after the second or third *** patient(2.08%)had asymptomatic nocturnal hypoglycemia after infusion on day 28±*** liver damage or other side effects were *** The results of this study suggest that hUC-MSC infusion can improve glycemia,restore isletβ-cell function,and reduce the dosage of hypoglycemic agents without serious ***,hUC-MSC infusion may be a novel option for the treatment of T2DM.

关键词： Type 2 diabetes Human umbilical cord mesenchymal stem cells Blood glucose Homeostasis model assessment ofβ-cell function Hypoglycemic agents

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： jie Wang Wei Wang Xuheng Chen Junfang Bao Qiuyue Hao Heng zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua Pan Hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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数据要素赋能新质生产力:内在机理、现实障碍与法治进路

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上海经济研究 2024年第5期 37-52页

作者：许中缘郑煌杰中南大学法学院 410083

新质生产力注重以创新驱动发展,用科技创新塑造发展新动能,已然成为数字经济发展与社会进步的核心驱动力。数据要素与新质生产力具有深度耦合与相互塑造之关联,前者通过自身特性与其他生产要素融合,发挥出乘数效应,并作用于生产、流通... 详细信息

新质生产力注重以创新驱动发展,用科技创新塑造发展新动能,已然成为数字经济发展与社会进步的核心驱动力。数据要素与新质生产力具有深度耦合与相互塑造之关联,前者通过自身特性与其他生产要素融合,发挥出乘数效应,并作用于生产、流通、消费、分配环节,催生新质劳动资料、孕育新质劳动对象、培育新质劳动力,从而促进新质生产力形成。然而,当前数据要素面临着规则不完善、市场不成熟、监管不到位、安全不足够之现实障碍,难以充分发挥出其赋能效应。鉴此,亟需在法治框架下,健全数据要素确权、定价、交易规则,确保数据合法流通与利用;推进数据要素基础设施发展,构建全国性数据交易市场;革新传统市场规制法,加强数据要素市场监督建设;构建数据控制者义务体系,优化数据流通利用保障机制,以加快完善数据要素基础制度,赋能新质生产力发展。

关键词：新质生产力数据要素数据确权数据治理数据利用

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赋能新质生产力:数据要素市场化的法律配置

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理论与改革 2024年第6期 63-80页

作者：许中缘郑煌杰中南大学法学院

党的二十届三中全会进一步强调了加快培育新质生产力,并指出构建全国一体化技术和数据市场,推进要素市场化改革。数据要素与新质生产力具有深度耦合与相互塑造之关联,数据产权理论、交易成本理论、信息共享理论亦为数据要素市场化奠定... 详细信息

党的二十届三中全会进一步强调了加快培育新质生产力,并指出构建全国一体化技术和数据市场,推进要素市场化改革。数据要素与新质生产力具有深度耦合与相互塑造之关联,数据产权理论、交易成本理论、信息共享理论亦为数据要素市场化奠定了理论基础。在此基础上,数据要素方能凭借自身质性与其他生产要素相融合,从而催生新质劳动力、滋养新质劳动资料、塑造新质劳动对象,成为新质生产力的重要样态。然而,当前数据要素市场化面临着产权制度不健全、交易机制不完善、安全体系不完备之现实困境,阻碍了新质生产力的高质量发展。有鉴于此,亟须在审视域外先进经验与实践之上,以习近平关于新质生产力的重要论述为指导,构建中国式数据要素市场制度,即提升数据要素供给能力,搭建高质量数据交易平台,以加强市场基础建设;明确数据要素产权收益分配,探索多元交易模式,构建科学定价机制,推进统一市场体系建设,强化市场监管力度,以完善市场运行机制;推动数据要素市场法治化建设,加快数据安全技术研发与创新,以优化市场安全体系,赋能新质生产力发展。

关键词：新质生产力数据要素市场化数据产权数据治理数据安全《数据二十条》

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赋能新质生产力:数据要素资产化的法律配置

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湖北大学学报（哲学社会科学版） 2024年第5期51卷 136-146,F0003页

作者：许中缘郑煌杰中南大学法学院湖南长沙410083

数据要素资产化是数据要素市场形成的前提。数据要素具备虚拟替代性、多元共享性、跨界融合性,其转变为数据资产的关键在于,能被拥有或控制、很可能带来经济利益以及能够得到可靠计量。在此基础上,数据资产可以培养新质劳动力、孕育新... 详细信息

数据要素资产化是数据要素市场形成的前提。数据要素具备虚拟替代性、多元共享性、跨界融合性,其转变为数据资产的关键在于,能被拥有或控制、很可能带来经济利益以及能够得到可靠计量。在此基础上,数据资产可以培养新质劳动力、孕育新质劳动对象、催生新质劳动资料,成为新质生产力的重要质态。当前数据要素在资产化进程中,面临着权属界定不明确、安全保障不充足、会计确认不清晰、合规审查不完备之现实困境,阻碍数据资产乘积效应的发挥。故而,应立足于实际,以习近平总书记关于新质生产力的重要论述为指导,从“赋权”向“行为”转变,调整数据资产权益分配模式;完善数据资产保护体系,优化隐私数据评估机制;细化数据资产的价值计量与列示披露标准;基于数据来源与利用层面,改进数据资产合规审查机制。以此确保数据要素资产化在国家经济转型中发挥正向驱动作用,有效推动新质生产力的形成与发展。

关键词：新质生产力数据要素数据资产数据安全数据合规

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng jie Shen Jinxing Lu Chuqiang huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

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个人敏感信息处理规则的省思与完善

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山东青年政治学院学报 2023年第1期39卷 55-61页

作者：郑煌杰上海政法学院法律学院上海201701

当前我国《个人信息保护法》中个人敏感信息的处理规则,在适用过程中存在着一定的局限性:一是法律规定的模糊性;二是法定范围的狭隘性;三是界定标准的宽泛性。鉴于此,可以引用场景理论来完善个人敏感信息的处理规则。以场景理论下个人... 详细信息

当前我国《个人信息保护法》中个人敏感信息的处理规则,在适用过程中存在着一定的局限性:一是法律规定的模糊性;二是法定范围的狭隘性;三是界定标准的宽泛性。鉴于此,可以引用场景理论来完善个人敏感信息的处理规则。以场景理论下个人信息的五要件即信息主体、信息使用者、信息使用目的、信息特性、第三方主体来动态界定个人敏感信息的内涵范围。利用场景理论明确个人敏感信息与个人一般信息相互转化的边界,同时结合特定生活场景目的来确定个人敏感信息的适用范围,进而维持个人信息权益与社会公共利益之间的平衡。

关键词：《个人信息保护法》个人敏感信息场景要件场景目的

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元宇宙空间著作权扩张问题研究——以公共领域保留为视角

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山东青年政治学院学报 2022年第4期38卷 51-57页

作者：郑煌杰上海政法学院法律学院上海201701

元宇宙是运用区块链、人工智能、大数据等数字技术创造出的虚拟空间,其本质是对现实世界生活的映射。在元宇宙内创作的作品,其著作权在应用维度、客体维度、权利维度得到了扩张。著作权的无序扩张将会导致公共领域的式微,造成著作权私... 详细信息

元宇宙是运用区块链、人工智能、大数据等数字技术创造出的虚拟空间,其本质是对现实世界生活的映射。在元宇宙内创作的作品,其著作权在应用维度、客体维度、权利维度得到了扩张。著作权的无序扩张将会导致公共领域的式微,造成著作权私人利益与公共利益的严重失衡。当前,我国《著作权法》没有直接使用公共领域的概念,但在相关制度中都间接体现了公共领域的价值。为了应对元宇宙下著作权多维度的扩张,亟需厘清公共领域的内涵属性,并基于此从“引入公共领域规定”“完善公共领域制度”“优化合理利用条款”来限制著作权的扩张,进而维持著作权法律制度的动态平衡。

关键词：虚拟空间公共领域私人利益公共利益

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Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang Jianfeng zheng Guoyu Wang Yifei Gao Yatao Yang Jia Li Xiaojin Han Yan Cui Zhanggen huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Photoelectrocatalysis Z-scheme C–C coupling Ethanol

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