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Quantum Tunneling Radiation of Reissner-Nordstrom de Sitter Black Hole with a Global Monopole

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Communications in Theoretical Physics 2006年第3期45卷 457-460页

作者： JIANG Qing-Quan YANG Shu-zheng li hui-ling Institute of Theoretical Physics West China Normal University Nanchong 637002 China

Applying Parikh＇s quantum tunneling model, we study the quantum tunneling radiation of Reissne- Nordstrom de Sitter black hole with a global monopole. The result shows that the tunneling rates at the event horizon and the cosmic horizon are related to Bekenstein-Hawking entropy if we take the energy conservation into consideration, and the true radiate spectrum is not precisely thermal.

关键词： Reissner-Nordstrom de Sitter black hole global monopole energy conservation tunneling rate

Role of Epstein-Barr Virus Encoded Latent Membrane Protein 1 in the Carcinogenesis of Nasopharyngeal Carcinoma

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Cellular & Molecular Immunology 2007年第3期4卷 185-196页

作者： hui zheng lili li Duosha Hu Xiyun Deng Ya Cao Cancer Research Institute Xiangya School of Medicine Central South University Changsha Hunan China

Epstein-Barr virus （EBV）-encoded latent membrane protein 1 （LMPI） has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma （NPC）. Our studies focused on the role of LMP1 in NPC, and showed that LMP1 triggers the NF-κB, AP-1 and STAT signaling pathways. Strikingly, LMP1 was found to mediate the formation of a new heterodimer between c-Jun and JunB. Also, we have identified JAK/STAT and PI-PLC-PKC activation triggered by LMP1 through upregulating the expression of JAK3 and enhancing the phosphorylation of STATo The constitutive activation of these signaling cascades explains LMP1＇s ability to induce such a diverse array of morphological and phenotypic effects in cells and provides insight into how LMP1 may induce cell transformation, in which multihit targeted genes in the downstream play an essential role. All signaling cascades triggered by LMP1 ultimately lead to the disruption of the cell cycle： the acceleration of G1/S phase and the arrest of G2/M phase. We also found that LMP1 induced the expression of hTERT and promoted cell immortalization. Importantly, by intervening physical intracellular signal transduction pathways and disturbing the progression of the cell cycle, LMP1, an important oncoprotein encoded by EBV, is thought to be a key modulator in the pathogenesis of NPC. Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC. Cellular ＆ Molecular Immunology.

关键词： latent membrane protein 1 nasopharyngeal carcinoma signal transduction

Psathyrellins A-E,Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

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Natural Products and Bioprospecting 2021年第4期11卷 447-452页

作者： Han Wu hui-Xiang Yang zheng-hui li Tao Feng Ji-Kai liu Anhui Key Laboratory of Modern Chinese Materia Medica School of PharmacyAnhui University of Chinese MedicineHefei 230012People’s Republic of China School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan 430074People’s Republic of China

Five previously undescribed guanacastane diterpenoids,namely psathyrellins A-E(1-5),were obtained from cultures of the mushroom Psathyrella *** structures with absolute configurations were elucidated by extensive spec... 详细信息

关键词： Psathyrella candolleana Guanacastane diterpenoids Antibacterial activity

Prognostic impact of dissected lymph node count on patients with node-negative gastric cancer

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World Journal of Gastroenterology 2009年第31期15卷 3926-3930页

作者： Chang-Ming Huang Jian-Xian lin Chao-hui zheng Ping li Jian-Wei Xie Bi-Juan lin hui-Shan Lu Department of Ontology Affiliated Union Hospital Fujian Medical University No. 29 Xinquan Road Fuzhou 350001 Fujian Province China

AIM:To investigate the long-term effect of the number of resected lymph nodes (LNs) on the prognosis of patients with node-negative gastric ***: Clinical data of 211 patients with gastric cancer, without nodal involvement, were analyzed retrospectively after D2 radical operation. We analyzed the relationship between the number of resected LNs with the 5-year survival, the recurrence rate and the post-operative complication ***: The 5-year survival of the entire cohort was 82.2%. The total number of dissected LNs was one of the independent prognostic factors. Among patients with comparable depth of invasion, the larger the number of resected LNs, the better the survival (Plity to detect a significant survival difference among subgroups. Patients had a better long-term survival outcomes with LN counts ≥15 for pT1-2, ≥20 for pT3-4, and ≥15 for the entire cohort. The overall recurrence rate was 29.4% within 5 years after surgery. There was a statistically significant, negative correlation between the number of resected LNs and the recurrence rate (P>0.01). The post-operative complication rate was 10.9% and was not signif icantly correlated with the number of dissected LNs (P>0.05).CONCLUSION: For node-negative gastric cancer, sufficient number of dissected LNs is recommended during D2 lymphadenectomy, to improve the long-term survival and reduce the recurrence. Suitable increments of the dissected LN count would not increase the post-operative complication rate.

关键词： Stomach neoplasms Lymph nodes Gastrectomy Lymphadenectomy Prognosis

Ten new aurovertins from cultures of the basidiomycete Albatrellus confluens

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Natural Products and Bioprospecting 2013年第1期3卷 8-13页

作者： Hua GUO Tao FENG zheng-hui li Ji-Kai liU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China School of Chemistry and life Science Anshan Normal CollegeAnshan 114005China University of Chinese Academy of Sciences Beijing 100049China

Aurovertins J-S(1-10),together with four known metabolites,aurovertins B,C,E,and I(11-14),were isolated from cultures of the basidiomycete Albatrellus *** structures of compounds 1-10 were elucidated on the basis of e... 详细信息

关键词： Albatrellus confluens aurovertins cytotoxic activities

Twelve new compounds from the basidiomycete Boreostereum vibrans

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Natural Products and Bioprospecting 2012年第5期2卷 200-205页

作者： Jian-Hai DING Tao FENG zheng-hui li liang li Ji-Kai liU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China School of Chemical Science and Technology Yunnan UniversityKunming 650091China Graduate University of Chinese Academy of Sciences Beijing 100049China

Seven cadinane sesquiterpenoids,named boreovibrins A-G(1-7),three dihydrobenzofurans(8-10),and two lactones(11 and 12),together with one known compound(13),were isolated from cultures of the basidiomycete Boreostereum *** new structures were elucidated by means of spectroscopic *** 5,6,and 11 showed weak inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases(11β-HSD).

关键词： cadinane sesquiterpenoid boreovibrin dihydrobenzofuran lactone Boreostereum vibrans

Five new polyketides from the basidiomycete Craterellus odoratus

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Natural Products and Bioprospecting 2012年第4期2卷 170-173页

作者： Hua GUO Tao FENG zheng-hui li Ji-Kai liU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China School of Chemistry and life Science Anshan Normal CollegeAnshan 114005China Graduate University of Chinese Academy of Sciences Beijing 100049China

Five new polyketides,craterellones A-E(1-5),were isolated from cultures of basidiomycete Craterellus odoratus,together with five known compounds(6-10).Structures of 1-5 were elucidated on the basis of extensive spectroscopic *** compounds were evaluated for their inhibitory activities against one isozyme of 11β-hydroxysteroid dehydrogenase(11β-HSD1)and cytotoxic activities on five tumor cell *** 10 exhibited significant cytotoxicity against HL-60,SMMC-7721,A-549,MCF-7,and SW-480,with IC50 values of 0.50,0.69,0.64,1.10,0.54μM,respectively.

关键词： Craterellus odoratus craterellones polyketides

Furan Derivatives and Polyketides from the Fungus Irpex lacteus

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Natural Products and Bioprospecting 2021年第2期11卷 215-222页

作者： Meng Wang zheng‑hui li Masahiko Isaka Ji‑Kai liu Tao Feng School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan 430074People’s Republic of China National Center for Genetic Engineering and Biotechnology(BIOTEC) 113 Thailand Science ParkPathumthani 12120Thailand

Eight new furan derivatives,irpexins A‒H(1‒8),two new polyketides,irpexins I and J(9 and 10),together with nine known compounds were isolated from the fermentation of Irpex *** structures and absolute configurations were elucidated on the basis of extensive spectroscopic methods and Mosher ester *** compounds shows no cytotoxicity to human MCF-7 and Hela cancer cell lines at the concentration of 10μM.

关键词： Irpex lacteus Furan derivatives Polyketides

The fracture network model of Shen 229 block buried hill:A case study from liaohe Basin,China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1904-1910页

作者： XING Yu-zhong FAN Tai-liang zheng li-hui Energy Sources Department China University of Geosciences. Beijing 100083 China Exploration ＆ Exploitation Research Institute of liaohe Oil Field Company Petrochina. Panjin 124010. China

High oil production from the Proterozoic formation of Shen 229 block in Damingtun Depression, liaohe Basin, China, indicates the presence of natural fractured reservoir whose production potential is dominated by the structural fracture. A con- sistent structural model and good knowledge of the fracture systems are therefore of key importance in reducing risk in the de- velopment strategies. So data from cores and image logs have been collected to account for the basic characteristics of fracture, and then the analyzed results were integrated with the structural model in order to restrict the fracture network development during the structural evolvement. The structural evolution of the Proterozoic reservoir with time forms the basis for understanding the de- velopment of the 3D fracture system. Seismic interpretation and formation correlation were used to build a 3D geological model. The fault blocks that compose the Proterozoic formation reservoir were subsequently restored to their pre-deformation. From here, the structures were kinematically modeled to simulate the structural evolution of the reservoirs. At each time step, the dilatational and cumulative strain was calculated throughout the modelling history. The total strain which records the total spatial variation in the reservoir due to its structural history, together with core data, well data and the lithology distribution, was used to simulate geologically realistic discrete fracture networks. The benefit of this technique over traditional curvature analysis is that the structural evolution is taken into account, a factor that mostly dominates fracture formation.

关键词： Buried hill Fracture network In-situ stress Structural fracture