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Recent Climate Trends on the Northern Slopes of the Tianshan Mountains, Xinjiang, China

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Journal of Mountain Science 2009年第3期6卷 255-265页

作者： ZHANG Hongfeng OUYANG Zhiyun zheng hua wang Xiaoke State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beifing 100085 China

In arid regions, mountains fulfill important ecological and economic functions for the surrounding lowlands. In the scenario of global warming, mountain ecosystems change rapidly, especially in the arid region of northwestern China. This paper provides an assessment of the changes in temperature and precipitation in the historical records of climate on the northern slopes of the eastern Tianshan Mountains. A Mann-Kendall nonparametric trend and Sen＇s tests are employed to analyze the interannual changes and innerannual variability in temperature and precipitatiofi in the regions of low to high altitude. The present study finds that the largest increases in annual temperature are observed at stations in the low altitude regions. The significant increasing trends in temperature tend to occur mainly in late winter and early spring at stations from middle to high altitude, but in summer and autumn at stations of low altitudes. The increasing trends in annual precipitation are found from the middle to high altitude areas, but decreasing trends are found in the low altitude areas. The significant increasing trends in precipitation occur mostly in winter and earlier spring at stations from the middle to high altitudes, while the increasing and decreasing trend coexists at stations of low altitude with most of the significant trend changes occurring in March, June and August.

关键词： Mountainous region Climate change Temperature Precipitation China

Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants

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Science China Chemistry 2020年第4期63卷 534-545页

作者： zheng-hua wang Can-Can Zhao Qiang-Zhe Zhang Chuan-Lin wang Hang Zhang De-Jun Ma Da-Wei wang Xin Wen Lu-Yuan Li Zhen Xi State Key Laboratory of Elemento-organic Chemistry Department of Chemical BiologyCollege of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300071China National Pesticide Engineering Research Center(Tianjin) Tianjin 300071China

Cyclic dinucleotides(CDNs) are known to activate stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence of different single nucleotide polymorphism(SNP) of human STING(hSTING) gene poses an obstacle to achieve broad-spectrum activation by CDNs. We reported here the design and synthesis of a total of 36 CDNs, representing all structural variations, that contain four bases(A, G, C, U) and two linkage directions(2′-5′-linked and 3′-5′-linked phosphodiester).Through systematic evaluation of IFN-β induction with a dual-luciferase reporter assay, we discovered that wild type hSTING and two isoforms(HAQ and AQ) showed strong response while hSTING-R232 H and R293 Q exhibited the relatively weak response to CDNs stimulation. For the first time, we found that the c[G(2′,5′)U(2′,5′)] showed excellent activity against all five hSTING variants even equivalent to the endogenous ligand c[G(2′,5′)A(3′,5′)]. Furthermore, we have also demonstrated that 3′-3′CDNs with two 3′-5′ phosphodiesters showed higher serum and hydrolase stability than 2′-2′ CDNs with two 2′-5′ phosphodiesters and 2′-3′ CDNs with one 2′-5′ and one 3′-5′ phosphodiester. It is very interesting to note that 2′-2′ CDNs has been found for the first time to show strong activity. These findings will stimulate our exploration for the new functional role of CDNs, and provide guidelines to design CDNs based hSTING targeted drugs.

关键词： cyclic dinucleotides(CDNs) stimulator of interferon genes(STING) pyrimidine CDNs interferonβ ecto-nucleotide pyrophosphatase/phosphodiesterase 1(ENPP1)

A new multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth

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Chinese Journal of Aeronautics 2025年第1期38卷 568-585页

作者： Xinghui HAN Yanhui wang Lin hua Wuhao ZhuaNG Fangyan zheng Wei FENG Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000China

Spiral bevel gears are critical transmission components,and are widely used in the aerospace *** paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel ***,the multi-DOF envelope forming principle of spiral bevel gears is ***,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement ***,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel ***,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their ***,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming *** simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods.

关键词： Multi-DOF envelope forming Spiral bevel gear Back taper tooth Metal flow Process design

Promoting Vasa Vasorum Neovascularization of Vein Grafts Extenuates Hypoxia of the Wall and Its Subsequent Influence on Intimal Hyperplasia

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Chinese Medical Journal 2017年第11期130卷 1327-1332页

作者： Rong-Jiang Zou zheng-hua wang Chen-Xi wang Song Xue Department of Cardiovascular Surgery Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Background： The autologous saphenous vein is the most common conduit for coronary artery bypass grafting, but the vein graft disease will occur. This study used Matrigel basement membrane matrix with many different growth factors to promote vasa vasorum neovascularization and extenuate the hypoxia to improve remodeling. Methods： This study observed the hypoxia and thickness of the vein grafts at different times. Normal veins and vein grafts with 15 min ofischemia one day postoperatively were harvested in the neck of rabbits. Paired vein grafts with 15 min ischemia bilaterally （control vs. Matrigel basement membrane matrix） were performed and harvested at 2, 6, and 12 weeks postoperatively. The rabbits were randomly divided into four postoperative groups （six rabbits in each group）： Group 1, one day postoperatively; Group 2, 2 weeks postoperatively; Group 3, 6 weeks postoperatively; and Group 4, 12 weeks postoperatively. The dimensions of vessel wall were captured, and the mean thicknesses of intima, media, and adventitia were measured. The hypoxia-inducible factor （HIF）- 1α and HIF-2ot labeling indices ofintima, media, and adventitia were also measured. Results： In Group 1, the labeling index of HIF-1α was high in the normal vein and decreased significantly in the vein grail one day postoperatively （intima： 80 4- 3% vs. 12 4- 1%, P = 0.01 ; media： 67 ±5% vs. 11 ± 1%, P = 0.01 ; adventitia： 40 ± 10% vs. 7 ±2%, P = 0.03）. The labeling index of HIF-2α had similar trend as HIF-1α （intima： 80 ± 10% vs. 10 ± 5%, P = 0.02; media： 60± 14% vs. 12 ± 2%, P = 0.01 ; adventitia： 45±20% vs. 10±4%, P = 0.03）. Compared with the control vein gratrol vein grafts with Matrigel basement membrane matrix had lower labeling indices of HIF-1α and HIF-2α in media and adventitia at Group 2 （HIF-1α： 34 ± 5% vs. 20 ±4%, P = 0.04 for media： 23 ± 3% vs. 11 ± 2%, P = 0.03 for adventitia; HIF-2α： 37 ± 6% vs. 21 ± 4%, P = 0.03 for media; 24 ±4% vs. 13 ± 2%, P = 0.04 for adventitia） and Group 3 （HIF

关键词： Hypoxiaz Hypoxia-inducible Factor lntimal Hyperplasia Vein Graft

Vapreotide-modified nanomicelle as a targeted nanocarrier for delivering paclitaxel to the tumors with overexpression of somatostatin receptors

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Journal of Chinese Pharmaceutical Sciences 2015年第8期24卷 501-513页

作者： Wenjie Hou hua zheng Jiancheng wang Department of Pharmaceutics School of PharmaceuticaI Sciences Peking University Health Science Center Beijing 100191 China

Somatostatin receptors （SSTRs） were widely expressed in many tumor cells. As a somatostatin analogue, vapreotide （VAP） can be exploited as a modifier for targeting tumor therapy based on its high affinity to SSTR. In this study, we conjugated α-NH2 of exocyclic n-phenylalanine （D-Phe） of vapreotide to N-hydroxysuccinimidyl-PEG2000-DSPE （NHS-PEG-DSPE）, and the resulted DSPE-PEG-VAP was used as a targeting component to construct the targeted micelles for delivering paclitaxel （VAP-M-PTX） through a thin-film hydration method. Similar particle size, zeta potential, drug encapsulation efficiencies, drug release behaviors and hemolysis effects were observed between the targeted micelles （VAP-M-PTX） and the non-targeted micelles （M-PTX）. In MCF-7 cells, significantly higher intracellular fluorescence intensity （1.5-fold） was determined by flow cytometry after incubation of coumarin-6 loaded targeted micelles （VAP-M-Cou） for 3 h compared with non-targeted mieelles （M-Cou）, and similar finding was observed confocal microscopy. Furthermore, in comparison with non-targeted formulations, higher antitumor efficacy and higher drug accumulation were found in MCF-7 tumors in nude mice after intravenous injection of the targeted micelles. In conclusion, we believed that the vapreotide-modified nanomicelles could be a promising targeted nanocarrier for delivering anticancer drugs to the tumors with overexpression of somatostatin receptors.

关键词： Somatostatinreceptor Vapreotide Targeted nanomicelle Paclitaxel Tumor therapy

Towards few-shot mixed-type dialogue generation

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Science China(Information Sciences) 2025年第2期68卷 120-133页

作者： Zeming LIU Haifeng wang Zeyang LEI zheng-Yu NIU hua WU Wanxiang CHE Research Center for Social Computing and Information Retrieval Baidu Inc.

Building an agent capable of conducting both open-domain and task-oriented dialogues, known as mixed-type dialogues, has been an enduring challenge for the AI community. Previous approaches have focused on constructing largescale human-annotated datasets for training models. However, annotating these datasets is expensive and hinders the practical application of these models. This paper identifies a novel challenge, few-shot mixed-type dialogue generation. To address this challenge, we first present a pre-trained dialogue generation framework with modular-based architecture and prompttuning component. Additionally, we collect a mixed-type dialogue dataset that combines persona-chat with conversational recommendation or task-oriented dialogues within a single dialogue session. Specifically, the modular-based architecture allows us to easily incorporate more supervised signals and human-annotated information, thereby facilitating the learning of sessionlevel dialogue logic. We pre-train this dialogue generation framework using multiple external datasets and then fine-tune it on the mixed-type dialogue dataset we collected. Experimental results demonstrate that the three key designs — modular-based architecture, prompt-tuning component, and model pre-training — significantly enhance the performance of this framework compared to state-of-the-art baselines.

关键词： mixed-type dialogue dialogue generation PLATO-prompt Mixed-FS few-shot

Clinical and immunopathological features of patients with lupus hepatitis

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Chinese Medical Journal 2013年第2期126卷 260-266页

作者： zheng Ru-hua wang Jin-hui wang Shu-bing CHEN Jie GUAN Wei-ming CHEN Min-hu Department of Gastroenterology and Hepatology First AffiliatedHospital of Sun Yat-sen University Guangzhou Guangdong510080 China

Background Lupus hepatitis is yet to be characterized based on its clinical features and is often difficult to differentially diagnose from other liver diseases. We aimed to elucidate clinical, histopathological and immunopathological features of lupus hepatitis and to evaluate primarily the effectiveness of liver immunopathological manifestations on differential diagnosis of lupus hepatitis from other liver diseases. Methods A retrospective study was performed to analyze clinical features of lupus hepatitis in 47 patients out of 504 inpatients with systemic lupus erythematosus （SLE） in First Affiliated Hospital of Sun Yat-sen University, China from May 2006 to July 2009, and to evaluate the association between lupus hepatitis and SLE activity. Additionally, liver histopathological changes by hematoxylin and eosin （HE） staining and immunopathological changes by direct immunofluorescence test in 10 lupus hepatitis cases were analyzed and compared to those in 16 patients with other liver diseases in a prospective study. Results Of 504 SLE patients, 47 patients （9.3%） were diagnosed to have lupus hepatitis. The prevalence of lupus hepatitis in patients with active SLE was higher than that in those with inactive SLE （11.8% vs. 3.2%, P 〈0.05）. The incidence of hematological abnormalities in patients with lupus hepatitis was higher than that in those without lupus hepatitis （40.4% vs. 21.7%, P 〈0.05）, such as leucocytes count （2.92x109/L vs. 5.48x109/L）, platelets count （151x109/L vs. 190x109/L）, serum C3 and C4 （0.34 g/L vs. 0.53 g/L; 0.06 g/L vs. 0.09 g/L）（P 〈0.05）; 45 of 47 （95.7%） lupus hepatitis patients showed 1 upper limit of normal （ULN）〈serum ALT level 〈5 ULN. The liver histopathological features in patients with lupus hepatitis were miscellaneous and non-specific, similar to those in other liver diseases, but liver immunopathological features showed positive intense deposits of complement lq in 7/10 patients with lupus hepatitis and negative complement lq depo

关键词： lupus,liver injury immunopathology

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing Xuyun hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong zheng He wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Preface to Special Issue on Flexible and Smart Electronics for Sensors 4.0

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Journal of Semiconductors 2025年第1期46卷 2-3页

作者： Zhuoran wang Yang Li Qilin hua School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China School of Integrated Circuits Shandong UniversityJinan 250101China

The evolution of information technology has propelled the advancement of sensors into a new era,referred to as Sensors 4.0^([1]).This era is characterized by the integration of key technological developments,including the internet of things(IoT),Industry 4.0,big data,artificial intelligence(AI),robotics,and digital *** innovations necessitate that sensors become increasingly interconnected and *** concept of"everything is connected"demands that sensors undertake a broader and more complex range of tasks,a challenge that conventional,bulky devices are ill-equipped to address.

关键词： Smart artificial equipped