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BL03HB: a Laue microdiffraction beamline for both protein crystallography and materials science at SSRF

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Nuclear Science and Techniques 2024年第7期35卷 68-78页

作者： Zhi-Jun Wang Si-Sheng Wang zheng-Huang Su Li Yu Yu-Zhu Wang bo Sun Wen Wen Xing-Yu Gao Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Science Beijing100049China

A Laue microdiffraction beamline(BL03HB) was constructed at the Shanghai Synchrotron Radiation Facility(SSRF).This beamline features two consecutive focusing points in two different sectors within its end station, the first dedicated to protein crystallography and the other tailored to materials science applications. Based on a superbend dipole magnet with a magnetic field of 2.29 T, a two-stage focusing design was implemented with two sets of Kirkpatrick-Baez mirrors to achieve a micro white beam as small as 4.2 μ m ×4.3 μ m at the first sector and 0.9 μ m ×1.3 μ m at the second sector in the standard beamline operation mode at SSRF. The X-ray microbeam in the two sectors can be easily switched between monochromatic and white beams by moving a four-bounce monochromator in or out of the light path, respectively. In the protein crystallography sector, white-beam Laue microdiffraction was demonstrated to successfully determine the structure of protein crystals from only a few images of diffraction data collected by a Pilatus 2 M area detector. In the materials science sector,the white-beam Laue diffraction was collected in a reflection geometry using another Pilatus 2 M area detector, which could map the microstructural distribution on the sample surface by scanning the samples. In general, the BL03HB beamline promotes the application of Laue microdiffraction in both protein crystallography and materials science. This paper presents a comprehensive overview of the BL03HB beamline, end station, and the first commission results.

关键词： Crystallography White-beam Laue microdiffraction Beamline Synchrotron

Three-stage niobium mineralization at Bayan Obo, China

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National Science Review 2024年第4期11卷 102-110页

作者： Yan Yu Yang Li Yu Liu Xiao-Xiao Ling Li-Guang Wu Li Yang lan Yang bo Yang Yong-Gang Zhao Xian-Hua Li State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Science University of Chinese Academy of Sciences Ministry of Education Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking University Mining Research Institute Baotou Iron and Steel(Group) Co.LTD State Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization

The Chinese Bayan Obo deposit is a world-class rare earth element(REE) deposit with considerable niobium(Nb) and iron(Fe) resources. A complete genetic understanding on all metals is fundamental for establishing genetic models at Bayan Obo. With extensive research being focused on REE enrichment, the timing and controls of Nb enrichment remain unresolved at Bayan Obo, which is mainly due to the challenges in dating, i.e. multistage thermal events, fine-grained minerals with complex textures and the rare occurrence of uranium-enriched minerals with mature dating methods. Based on robust geological and petrographic frameworks, here we conducted ion probe uranium-lead(U-Pb) dating of ferrocolumbite to unravel the timing, hence the genesis of Nb mineralization. Three types of hydrothermal ferrocolumbites—key Nb-bearing minerals—are identified based on their textures and mineral assemblages. They yield U-Pb ages of 1312 ± 47 Ma(n = 99), 438 ± 7 Ma(n = 93), and 268 ± 5 Ma(n = 19), respectively. In line with deposit geology, we tentatively link the first, second and third stage Nb mineralization to Mesoproterozoic carbonatite magmatism, ubiquitous early Paleozoic hydrothermal activity, and Permian granitic magmatism, respectively. While quantifying the contribution of metal endowment from each stage requires further investigation, our new dates highlight that multi-stage mineralization is critical for Nb enrichment at Bayan Obo, which may also have implications for the enrichment mechanism of Nb in REE deposits in general.

关键词： niobium mineralization U-Pb dating ferrocolumbite Bayan Obo

Risk factors for recurrence of common bile duct stones after surgical treatment and effect of ursodeoxycholic acid intervention

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 103-112页

作者： Wei-Hong Yuan zheng Zhang Qi Pan bo-Neng Mao Tao Yuan Department of Gastroenterology Yixing People’s HospitalYixing 214200Jiangsu ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an accurate diagnostic method for choledocholithiasis and treatment option for stone ***,ursodeoxycholic acid(UDCA)can dissolve cholesterol stones and prevent their development and reappearance by lowering the cholesterol concen-tration in *** these treatment options,there are still patients who experience stone *** clinical data of 100 patients with choledochal stones who were hospitalized at the Yixing People’s Hospital and underwent ERCP for successful stone extraction between June 2020 and December 2022 were retrospectively *** to the post-ERCP treatment plan,100 patients were classified into UDCA(n=47)and control(n=53)*** aimed to assess the clinical efficacy and rate of relapse in the two patient *** then collected information(basic demographic data,clinical characteristics,and serum biochemical indicators)and determined the factors contributing to relapse using logistic regression *** secondary goal was to determine the effects of UDCA on liver function after *** to the control group,the UDCA group demonstrated a higher clinical effectiveness rate of 92.45%vs 78.72%(Planine aminotransferase,alkaline phosphatase,and aspartate aminotransferase,between the two groups before *** treatment,all liver function indices were significantly *** the control vs UDCA groups,the UDCA group exhibited significantly lower levels of all indices(55.39±6.53 vs 77.31±8.52,32.10±4.62 vs 45.39±5.69,142.32±14.21 vs 189.63±16.87,112.52±14.25 vs 149.36±15.36,122.61±16.00 vs 171.33±22.09,96.98±10.44 vs 121.35±11.57,respectively,all P<0.05).The stone recurrence rate was lower in the UDCA group(13.21%)in contrast with the control group(44.68%).Periampullary divertic

关键词： Endoscopic retrograde cholangiopancreatography Recurrence Ursodeoxycholic acid Common bile duct stones Clinical effective rate Risk factors

Effect of Ti Particles on the Microstructure and Mechanical Properties of AZ91 Magnesium Matrix Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 513-524页

作者： Lu Xiao Ting-Ting Liu Yue Chu bo Song Jie Zhao Xian-Hua Chen Kai-Hong zheng Fu-Sheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China lntelligent Manufacturing and Automobile School Chongqing College of Electronic EngineeringChongqing 401331China School of Materials and Energy Southwest UniversityChongqing 400715China Science and Technology Research Institute of CNNC 404 Co.LTD Gansu 735100China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

Spherical micro-Ti particle(TiP)-reinforced AZ91 magnesium alloy composites were fabricated by semi-solid stirring assisted ultrasonic vibration,which were then subjected to hot *** microstructure results showed that the addition of Ti particles refined the grain size and decreased the texture intensity of the as-extruded AZ91 *** Al3Ti phase with a thickness of 100 nm formed at the Ti/Mg interface,which had a non-coherent relationship with the magnesium *** as-extruded 1 vol.%TiP/AZ91 composite exhibited the best comprehensive mechanical properties,with yield strength,ultimate tensile strength,and elongation at break of 366 MPa,456 MPa,and 14.6%,respectively,which were significantly higher than those of the AZ91 ***,the addition of Ti particles can improve the strength and ductility of the AZ91 alloy,demonstrating the value of magnesium matrix composites for commercial applications.

关键词： Magnesium matrix composites Ti particles Interface Mechanical properties

Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-Xiu Yuan Qi-Gui Cai Zhen-Yang Zhang Jian-Zhong Zhou Cai-Yun lan Jiang-bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of *** To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database *** up to December 2022 comparing nCRT and nCT in patients with EC were *** The analysis revealed significant differences between nCRT and nCT in terms of disease-free *** results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than ***,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for ***,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis

Joint Effects of Multipollutant Mixtures on Mortality in Chengdu,China

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Biomedical and Environmental Sciences 2024年第1期37卷 112-116页

作者： ZHANG Ying TIAN Qi Qi HU Wen Dong ZHANG Shao bo WANG Shi Gong zheng Can Jun Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225SichuanChina Yunnan R&D Institute of Natural Disaster on Chengdu University of Information Technology Kunming 650034YunnanChina Chengdu Plain Urban Meteorology and Environment Sichuan Provincial Field Scientific Observation and Research Station Chengdu 610225SichuanChina Chinese Center for Disease Control and Prevention National Institute for Communicable Disease Control and PreventionBeijing 102206China

Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant ***,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.

关键词： mixtures monoxide consequences

CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency

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Genes & Diseases 2024年第5期11卷 48-50页

作者： Yue Ding zheng Ye bo Ding Songwei Feng Furong Du Xuejiao Ma Xiaoxuan Wang Yang Shen Department of Obstetrics and Gynaecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.Ltd.NanjingJiangsu 210042China

Recently,immune checkpoint inhibitors(ICIs)and poly(ADP-ribose)polymerase inhibitors(PARPi)have played a pivotal role in prolonging the recurrence-free survival of patients with ovarian cancer(OC).1,2 Although PARPi have revolutionized the treatment of OC,the absence of reliable predictive biomarkers limits the broad application of ICIs for patients with homologous recombination(HR)deficiency(HRD).3 CXC-chemokine ligand 13(CXCL13)is a cytokine constitutively secreted in the stromal cells of the B-cell region of secondary lymphoid tissue.4 It exclusively binds to the chemokine receptor CXCR5,which is abundantly expressed in subsets of mature circulating B lymphocytes,follicular helper T cells,and skin-derived dendritic cells,and governs the migration of these cells into secondary lymphoid organs in response to the CXCL13 gradient.5 In this study,we aimed to elucidate the role of CXCL13 in shaping the tumor immune microenvironment(TIME)in HR-deficient OC and to explore its relationship with the cGAS-STING signaling pathway.

关键词： CXCL13 cancer organs

The inhibitory effect of adenosine on tumor adaptive immunity and intervention strategies

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1951-1964页

作者： Longsheng Wang Jie Zhang Wenxin Zhang Mingming zheng Hongjie Guo Xiaohui Pan Wen Li bo Yang Ling Ding Zhejiang Province Key Laboratory of Anti-Cancer Drug Research Institute of Pharmacology and ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China The Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 310018China Nanhu Brain-Computer Interface Institute Hangzhou 311100China

Adenosine(Ado)is significantly elevated in the tumor microenvironment(TME)compared to normal *** binds to adenosine receptors(AdoRs),suppressing tumor antigen presentation and immune cell activation,thereby inhibiting tumor adaptive *** downregulates major histocompatibility complex II(MHC II)and co-stimulatory factors on dendritic cells(DCs)and macrophages,inhibiting antigen *** suppresses anti-tumor cytokine secretion and T cell activation by disrupting T cell receptor(TCR)binding and signal *** also inhibits chemokine secretion and KCa3.1 channel activity,impeding effector T cell trafficking and infiltration into the tumor ***,Ado diminishes T cell cytotoxicity against tumor cells by promoting immune-suppressive cytokine secretion,upregulating immune checkpoint proteins,and enhancing immune-suppressive cell *** Ado production in the TME can significantly enhance anti-tumor immune responses and improve the efficacy of other *** and clinical development of inhibitors targeting Ado generation or AdoRs is ***,this article will summarize and analyze the inhibitory effects and molecular mechanisms of Ado on tumor adaptive immunity,as well as provide an overview of the latest advancements in targeting Ado pathways in anti-tumor immune responses.

关键词： Adenosine Adenosine receptors Adenosine-generating enzymes Tumor microenvironment Immune suppression Immune escape Clinical treatment Targeting drugs

Strong Antiferromagnetic Exchange-Coupling Observed in Hydride-Bridged Dimeric Dysprosium(Ⅲ)Single-Molecule Magnet

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Chinese Journal of Chemistry 2024年第4期42卷 391-396页

作者： Qian-Cheng Luo Ke-Xin Yu Peng-bo Jin Ye-Ye Liu Yuan-Qi Zhai Yan-Zhen zheng Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentXi'an Key Laboratory of Electronic Devices and Materials ChemistrySchool of Chemistry and School of PhysicsXi'an Jiaotong University99 Yanxiang RoadXi'anShaanxi710054 China

One dihydride-bridged dimeric Dy(Ⅲ)guanidinate complex,formulated as[{(Me_(3)Si)_(2)NC(NiPr)_(2)}_(2)Dy(μ-H)]_(2)(1Dy),was successfully isolated and the introduction of hydride bridges significantly reduces the intramolecular Dy(Ⅲ)…Dy(Ⅲ)distance to only 3.688(1)Å.To investigate the effect of such a short Dy(Ⅲ)…Dy(Ⅲ)distance on magnetism,we also prepared its dibromide-bridged analogue[{(Me_(3)Si)_(2)NC(NiPr)_(2)}_(2)Dy(μ-Br)]_(2)(2Dy),which has a much longer Dy(Ⅲ)…Dy(Ⅲ)distance of 4.605(4)Å.Surprisingly,2Dy demonstrates much larger effective energy barrier for magnetization reversal(U_(eff))and higher blocking temperature(T_(B)).The worse performance of 1Dy is attributed to the concerted effect of strong antiferromagnetic interactions between Dy(Ⅲ)ions(J_(total)=–2.683 cm^(–1))and the unparallel arrangement of magnetic principle axes of the Dy(Ⅲ)ions for 1Dy.

关键词： Single-molecule magnets lanthanides Guanidinate ligand Hydride bridge Magnetic properties Ab initio calculations