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Science Bulletin 2019年第13期64卷 873-876页

作者： Chong Wang zheng-xiang Li Peng Penga Sergei Pisarevsky Yebo Liu Uwe Kirscher Adam Nordsvan State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Earth Dynamics Research Group ARC Centre of Excellence for Core to Crust Fluid Systems (CCFS) and The Institute for Geoscience Research (TIGeR)School of Earth and Planetary SciencesCurtin UniversityWA 6845Australia University of Chinese Academy of Sciences. Beijing 100049 China Department of Geosciences Eberhard Karls University TuebingenTuebingen 72076Germany

It has been proposed by Zhang et al.[1] that the northern part of the North Chirm Craton (NCC) was connected to the north-western part of the North Australian Craton (NAC) in the Proterozoic, mainly based on the radial geometry of correlative -1.32 Ga dyke swarms in the two cratons (Fig. la). While the hypothetical connection between the NCC and the NAC was thought to be paleomagnetically permissible at ~1.80- 1.78Ga but w让h a slightly different configuration [2], the exact duration of either configuration is uncertain (e.g.,[2,3]).

关键词： paleomagnetic geological constraints

Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats

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World Journal of Gastroenterology 2021年第40期27卷 6888-6907页

作者： Mo-Fei Wang Song-Song Zhao Dil Momin Thapa Yu-Ling Song zheng xiang The Second Department of General Surgery The Affiliated Hospital of Inner Mongolia University for the NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Department of Educational Administration The First Affiliated Hospital of Liaoning Medical UniversityJinzhou 121000Liaoning ProvinceChina School of Pharmaceutical Science Liaoning UniversityShenyang 110032Liaoning ProvinceChina

BACKGROUND Fuzi(Radix aconiti lateralis)-Gancao(Radix glycyrrhizae)is one of the most classical drug pairs of traditional Chinese *** clinical practice,decoctions containing Fuzi-Gancao(F-G)are often used in the treatment of liver diseases such as hepatitis and liver *** To investigate the metabolomics of F-G in CCl4 induced acute liver injury in rats and its regulatory effect on the bile acid *** The pharmacodynamic effect of F-G on CCl4 induced acute liver injury in rats was evaluated,and an ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method for the simultaneous determination of 92 metabolites from multiple pathways was established to explore the protective metabolic mechanism of F-G in serum on the *** Twenty-four differential metabolites were identified in serum *** primary bile acid biosynthetic metabolic pathway was the major common pathway in the model group and F-G ***,a UPLC-MS/MS method for simultaneous determination of 11 bile acids,including cholic acid,ursodeoxycholic acid,glycochenodeoxycholic acid,glycochenodeoxycholic acid,taurocholic acid,glycocholic acid,chenodeoxycholic acid,deoxycholic acid,taurochenodeoxycholic acid,taurocholic acid,and glycinic acid,was established to analyze the regulatory mechanism of F-G in serum.F-G decreased the contents of these 11 bile acids in serum in a dose-dependent manner compared with those in the model control *** F-G could protect hepatocytes by promoting the binding of free bile acids to glycine and taurine,and reducing the accumulation of free bile acids in the liver.F-G could also regulate the compensatory degree of taurine,decreasing the content of taurine-conjugated bile acids to protect hepatocytes.

关键词： Radix aconiti lateralis Radix glycyrrhizae Liver injury Metabolites Bile acid Fuzi-Gancao

Determination of Crosslinking and Grafting in Polyurethane-acrylic Hybrid Material and Their Theoretical Calculations

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Chemical Research in Chinese Universities 2011年第1期27卷 154-157页

作者： JIANG Xu-bao ZHU Xiao-li ZHANG Zhi-guo KONG xiang-zheng TAN Ye-bang College of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China College of Chemistry and Chemical Engineering University of Jinan Jinan 250022 P. R. China

A theoretical method to calculate the mode of polyurethane（PU） prepolymers grafted to polyacrylic（PAC） was presented. Using hydroxyethyl acrylate（HEA） as coupling agent, polyurethane-acrylics（PU-AC） hybrid latexes were prepared with varying HEA level and the reaction of HEA with PU prepolymers at different temperatures, and PU grafted to PAC was experimentally determined. The results show that PU grafted to PAC regularly increased, and the non-grafted and linear free PU regularly decreased with increase in HEA/NCO（isocyanate group）. The grafted PU on PAC was not proportional to HEA. More than half of linear PU prepolymers were grafted to PAC when HEA was at a low level with HEA/NCO at 0.33. While grafted PU increased to 84.80%（mass fraction）, when HEA/NCO increased to 1.0. The results were interpreted based on the theoretical calculation of PU grafted to PAC by the present method.

关键词： Polyurethane Graft copolymer Hybrid latex Grafting calculation Coupling agent

Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection

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Cellular & Molecular Immunology 2018年第9期15卷 827-837页

作者： Yuan Liu Jian zheng Yinping Liu Liyan Wen Lei Huang zheng xiang Kwok-Tai Lam Aizhen Lv Huawei Mao Yu-Lung Lau Wenwei Tu Department of Pediatrics and Adolescent Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Medical Genetic Center Guangdong Women and Children HospitalGuangzhou 511400China Department of Radiology Georgia Regents UniversityAugustaGA 30912USA GRU Cancer Center Georgia Regents UniversityAugustaGA 30912USA Department of Pediatrics The University of Hong Kong—Shenzhen HospitalShenzhen 518053China

Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy *** together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses.

关键词： CTL influenza NK cell

Predictors of complications after prophylactic ileostomy reversal for rectal cancer:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1354-1362页

作者： Quan Lv Xin-Peng Shu Dong Peng Si-Qi Li zheng xiang Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Department of General Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma *** studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications *** To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with *** This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September *** variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was *** and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related *** The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(P<0.01),greater blood loss(P=0.017),and longer operative times(P<0.01)were more likely to experience postoperative *** incidence of stoma-related complications was 6.4%.Analysis of the study showed that a higher body mass index(BMI)(P<0.01),preoperative comorbid hypertension(P=0.049),time from primary surgery to ileostomy reversal(P<0.01)and longer operation time(P=0.010)were more likely to result in stomarelated complications *** logistic regression analysis revealed that a lower preoperative albumin level(P<0.01,OR=0.888,95%CI:0.828-0.958)was an independent risk factor for overall ***,multivariate analysis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related compl

关键词： Ileostomy Reversal Risk factors Complications Rectal cancer

Comparison of the spatio-temporal dynamics of vegetation between the Changbai Mountains of eastern Eurasia and the Appalachian Mountains of eastern North America

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Journal of Mountain Science 2018年第1期15卷 1-12页

作者： GUO Xiao-yi ZHANG Hong-yan WANG Ye-qiao HE Hong-shi WU zheng-fang JIN Ying-hua ZHANG zheng-xiang ZHAO Jian-jun School of Geographical Sciences Northeast Normal University Changchun 130024 China Department of Natural Resources Science University of Rhode Island Kingston Rhode Island 02881 USA School of Natural Resources University of Missouri-Columbia Columbia Missouri 65211-7270 USA

The Changbai Mountains and the Appalachian Mountains have similar spatial *** elevation,latitude,and moisture gradients of both mountain ranges offer regional insight for investigating the vegetation dynamics in eastern Eurasia and eastern North *** determined and compared the spatial patterns and temporal trends in the normalized difference vegetation index(NDVI)in the Changbai Mountains and the Appalachian Mountains using time series data from the Global Inventory Modeling and Mapping Studies 3^(rd) generation dataset from 1982 to *** spatial pattern of NDVI in the Changbai Mountains exhibited fragmentation,whereas NDVI in the Appalachian Mountains decreased from south to *** vegetation dynamics in the Changbai Mountains had an insignificant trend at the regional scale,whereas the dynamics in the Appalachian Mountains had a significant increasing *** increased in 55% of the area of the Changbai Mountains and in 95% of the area of the Appalachian *** peak NDVI occurred one month later in the Changbai Mountains than in the Appalachian *** results revealed a significant increase in NDVI in autumn in both mountain *** climatic trend in the Changbai Mountains included warming and decreased precipitation,and whereas that in the Appalachian Mountains included significant warming and increased *** and negative correlations existed between NDVI and temperature and precipitation,respectively,in both mountain ***,the spring temperature and NDVI exhibited a significant positive correlation in both mountain *** results of this study suggest that human actives caused the differences in the spatial patterns of NDVI and that various characteristics of climate change and intensity of human actives dominated the differences in the NDVI trends between the Changbai Mountains and the Appalachian ***,the vegetation dynamics of both mountain ranges were not identical

关键词： Changbai Mountains Appalachian Mountains Vegetation dynamics Vegetation index Climate factors Human activities

靶向成纤维细胞生长因子受体1信号改善类风湿关节炎的骨破坏

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中国组织工程研究 2025年第9期29卷 1905-1912页

作者：韩海慧冉磊孟晓辉辛鹏飞向峥边艳琴施杞肖涟波上海中医药大学上海市201203 上海市光华中西医结合医院上海市200052 上海市中医药研究院中西医结合关节炎研究所上海市200052

背景:尽管科研人员已注意到成纤维细胞生长因子受体1在类风湿关节炎骨破坏中展现出巨大潜力,但尚未有学者对成纤维细胞生长因子受体1在类风湿关节炎骨破坏中的研究进展作全面综述。目的:通过查阅国内外相关文献,综合分析成纤维细胞生长... 详细信息

背景:尽管科研人员已注意到成纤维细胞生长因子受体1在类风湿关节炎骨破坏中展现出巨大潜力,但尚未有学者对成纤维细胞生长因子受体1在类风湿关节炎骨破坏中的研究进展作全面综述。目的:通过查阅国内外相关文献,综合分析成纤维细胞生长因子受体1在类风湿关节炎骨破坏中的机制。方法:以“成纤维细胞生长因子受体1,类风湿关节炎,骨破坏,骨细胞,成骨细胞,破骨细胞,软骨细胞,巨噬细胞,滑膜成纤维细胞,T细胞,血管内皮细胞”为检索词检索中国知网数据库,以“fibroblast growth factor receptor 1,rheumatoid arthritis,bone destruction,osteocytes,osteoblasts,osteoclasts,chondrocytes,macrophages,synovial fibroblasts,T cells,endothelial cells”为检索词检索PubMed数据库,检索时间范围重点为1992年4月至2024年1月。通过阅读文献题目、摘要及全文,根据纳入与排除标准进行筛选,最后纳入82篇文献进行综述。结果与结论:成纤维细胞生长因子受体1广泛表达于骨组织相关细胞,包括骨细胞、成骨细胞、破骨细胞等,可以通过调控这些细胞的功能来影响骨重塑过程和维持骨稳态,促进类风湿关节炎骨破坏的发生和发展。成纤维细胞生长因子受体1还可以在滑膜成纤维细胞和巨噬细胞中参与炎症反应,在内皮细胞中调控滑膜血管生成,从多个方面促进骨破坏。成纤维细胞生长因子受体1可能是类风湿关节炎骨破坏的一个重要参与因素,为进一步研究类风湿关节炎治疗靶点提供依据。

关键词：类风湿关节炎成纤维细胞生长因子受体1 骨破坏成骨细胞破骨细胞滑膜成纤维细胞血管内皮细胞

3D bioprinting of conductive hydrogel for enhanced myogenic differentiation

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Regenerative Biomaterials 2021年第5期8卷 14-24页

作者： Ying Wang Qingshuai Wang Shengchang Luo Zhoujiang Chen xiang zheng Ranjith Kumar Kankala Aizheng Chen Shibin Wang Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021P.R.China School of Pharmaceutical Engineering and Life Science Changzhou UniversityChangzhou 213164P.R.China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021P.R.China

Recently,hydrogels have gained enormous interest in three-dimensional(3D)bioprinting toward developing functional substitutes for tissue ***,it is highly challenging to transmit electrical signals to cells due to the limited electrical conductivity of the bioprinted ***,we demonstrate the 3D bioprinting-assisted fabrication of a conductive hydrogel scaffold based on poly-3,4-ethylene dioxythiophene(PEDOT)nanoparticles(NPs)deposited in gelatin methacryloyl(GelMA)for enhanced myogenic differentiation of mouse myoblasts(C2C12 cells).Initially,PEDOT NPs are dispersed in the hydrogel uniformly to enhance the conductive property of the hydrogel ***,the incorporated PEDOT NPs showed minimal influence on the printing ability of ***,C2C12 cells are successfully encapsulated within GelMA/PEDOT conductive hydrogels using 3D extrusion ***,the proliferation,migration and differentiation efficacies of C2C12 cells in the highly conductive GelMA/PEDOT composite scaffolds are demonstrated using various in vitro investigations of live/dead staining,F-actin staining,desmin and myogenin immunofluorescence ***,the effects of electrical signals on the stimulation of the scaffolds are investigated toward the myogenic differentiation of C2C12 cells and the formation of myotubes in ***,our findings demonstrate that the fabrication of the conductive hydrogels provides a feasible approach for the encapsulation of cells and the regeneration of the muscle tissue.

关键词： 3D bioprinting conductive hydrogel electrical stimulation myoblasts myogenic differentiation

Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-Ming Yin Li-Li Wu Shu-Sheng Li Xiao-Na Pan Xiao-Li Zhu Xu-Bao Jiang xiang zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

Deciphering H^(+)/Zn^(2+) co-intercalation mechanism of MOF-derived2D MnO/C cathode for long cycle life aqueous zinc-ion batteries

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Rare Metals 2022年第11期41卷 3729-3739页

作者： zheng-xiang Zhu Zhang-Wen Lin Zhong-Wei Sun Pei-Xin Zhang Chang-Ping Li Rui Dong Hong-Wei Mi College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen518060China Guangdong Engineering Technology Research Centre for Distributed and Intelligent Small Solar Energy Storage Shenzhen Hello Tech Energy Co.Ltd.Shenzhen518100China Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan523808China Shenzhen Wesmart Sensor Technology Co. Ltd.Shenzhen518118China

Poor conductivity,sluggish ion diffusion kinetics and short cycle life hinder the further development of manganese oxide in aqueous zinc-ion batteries(AZIBs).Exploring a cathode with high capacity and long cycle life is critical to the commercial development of ***,a two-dimensional(2D) MnO/C composite derived from metal organic framework(MOF) was *** 2D MnO/C cathode exhibits a remarkably cyclic stability with the capacity retention of 90.6% after 900 cycles at 0.5 A·g^(-1) and maintains a high capacity of 120.2 mAh·g^(-1)after 4500 cycles at 1.0 A·g^(-1).It is demonstrated that MnO is converted into Mn_(3)O_(4) through electrochemical activation strategy and shows a Zn^(2+)and H^(+)co-intercalation *** general,this work provides a new path for the development of high-performance AZIBs cathode with controllable morphology.

关键词： Aqueous zinc-ion battery MnO/C Morphology design H^(+)/Zn^(2+)co-insertion