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Internal transcribed spacer sequencing to explore the intrinsic composition of fungal communities in fungal esophagitis

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World Journal of Gastroenterology 2025年第7期31卷 26-38页

作者： Yi-Kang Song lin zheng Ai-Xin Liu Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000Hebei ProvinceChina

BACKGROUND Fungal esophagitis(FE)is caused by fungal invasion of the esophageal *** endoscopy,the esophageal mucosa shows edema,congestion,erosion,and ulceration,and bleeds easily when touched,and the surface of the mucosa is covered with small white spots like"bean curd residue".Clinical cases showing typical FE under endoscopic imaging but negative esophageal mucosal brush(referred to as suspected FE)have increased the difficulty and challenge of clinical diagnosis and *** present,the esophageal fungal flora of suspected case has not been thoroughly *** To characterize the fungal flora in FE,suspected FE,and the esophageal normal controls(NCs),and to identify marker species to improve detection of *** This was a case-control study.A total of 19 patients with FE,16 with suspected FE,and 10 NCs were selected by *** esophageal cell brush samples of each group were sequenced by internal transcribed spacer(ITS)1 and analyzed by *** In FE and suspected FE patients,species richness,species diversity and species evenness,as measured by the Chao1 index,Shannon index and Pielou index,were lower than in the NCs,and the comparison between the FE and NCs was the most significant(P<0.05).Compared with the NCs,the relative abundance of Candida in FE and suspected FE patients was significantly increased(P<0.001),while the relative abundance of Yarrowia was significantly decreased(P<0.05).Moreover,Yarrowia abundance in the FE group was significantly lower than in the NCs and suspected FE groups(P<0.001).The area under the curve for Candida in FE and suspected FE patients was 99.5%(P<0.05)and 81.3%(P<0.05),***,compared with FE patients,the relative abundance of Ascomycota and Candida in the esophageal flora of suspected FE patients was decreased,while the relative abundance of Yarrowia,Thermomyces and Pichia was *** ITS showed that composition of the fungal community was similar in the F

关键词： Fungal microbiota Esophagitis Candida Yarrowia Biomarker

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Spin-selective and frequency-shift meta-holography based on reconfigurable origami chiral metasurface

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 121-131页

作者： Zhibiao Zhu Lixin Jiang Zhe Qin Yongfeng Li Jiafu Wang Yuxiang Jia lin zheng Shaobo Qu Shaanxi Key Laboratory of Artificially-Structured Functional Materials and Devices Air Force Engineering UniversityXi’an710051China

Origami-based reconfigurable metasurfaces have emerged as a versatile paradigm for dynamically manipulating electromagnetic(EM) waves due to their advantages, such as low manufacturing cost, lightweight, and structural deformability. Three-dimensional(3D) deformation can intensify asymmetry among structures, making origami metasurfaces particularly suitable for realizing reconfigurable chiral responses. However, previous studies have primarily focused on modulating spectral properties,such as chiral switching and resonant frequency shifting. There remains ample room for further exploration in complex wavefront manipulation and holographic imaging applications. This paper proposes a simple and efficient deformation method for origami metasurfaces that transforms a spin-insensitive planar metasurface into a 3D metasurface by folding. The breaking of mirror symmetry induces a pronounced chiral response. The binary amplitude is modulated within each pixel. When folded at angles of +θ and-θ, the designed origami metasurface generates distinct images under left-handed circularly polarized(LCP)wave incidence. Meanwhile, holographic encryption is achieved under right-handed circularly polarized(RCP) wave ***, by leveraging origami's reconfigurability, the holographic imaging's operating frequency can be shifted. The experimental results agree well with the numerical calculations and full-wave simulations, demonstrating the broad application potential of this method in areas such as multi-channel imaging, information encryption technologies, and stealth.

关键词： hologram origami metasurface chiral response

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： lin zheng Zi-Yu Ye Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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后发企业复杂技术追赶战略——多重制度逻辑视角的双案例纵向对比分析

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科学学研究 2025年第2期43卷 371-381页

作者：郑爱琳蓝海林华南理工大学工商管理学院华南理工大学中国企业战略管理研究中心

复杂技术的追赶已成为我国技术追赶的关键。转型期中国的制度环境的动态性、复杂性与交互性等特征，是解释后发企业复杂技术追赶战略形成机理的重要情境基础。本研究通过广汽集团和比亚迪这两家新能源汽车行业的后发企业，探究多重制度... 详细信息

复杂技术的追赶已成为我国技术追赶的关键。转型期中国的制度环境的动态性、复杂性与交互性等特征，是解释后发企业复杂技术追赶战略形成机理的重要情境基础。本研究通过广汽集团和比亚迪这两家新能源汽车行业的后发企业，探究多重制度逻辑与企业资源能力的协同影响企业技术追赶战略的机理。研究发现：(1)在不同追赶阶段中，企业根据自身资源能力对多重制度逻辑的要求选择性耦合，广汽集团形成了跟随-并跑-并跑的技术追赶战略路径，比亚迪形成了抢跑-抢跑-领跑的技术追赶战略路径。(2)后发企业复杂技术追赶战略的实施推动了多重制度逻辑演化与企业资源能力提升，从而推动了多重制度逻辑、企业资源能力、后发企业复杂技术追赶战略的共同演化。本研究的结论有助于深化对我国后发企业复杂技术追赶战略的机理认知，为政府和企业加快推进复杂技术突破提供实践启示。

关键词：多重制度逻辑后发企业复杂技术追赶战略新能源汽车企业

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绿色税制与碳税联动的效用模拟研究——基于灰色关联分析及CGE模型

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生态经济 2025年第03期41卷 13-23+74页

作者：陈淼林正广东财经大学财政税务学院澳大利亚国立大学商业与经济学院

论文首先通过2015—2020年我国碳排放量与绿色税制税收收入数据的灰色关联分析发现，现行环境保护税、消费税、车辆购置税的减排效用较好，而资源税则有待提高，但各税种均存在不同程度的缺陷。然后，基于2020年投入产出表绘制出相应的... 详细信息

论文首先通过2015—2020年我国碳排放量与绿色税制税收收入数据的灰色关联分析发现，现行环境保护税、消费税、车辆购置税的减排效用较好，而资源税则有待提高，但各税种均存在不同程度的缺陷。然后，基于2020年投入产出表绘制出相应的社会核算矩阵，并构建出加入碳税和碳排放模块的可计算一般均衡模型，研究碳税开征对我国经济的影响。结果表明：居民部门受到的冲击大于企业部门；重工业受到的冲击远大于其他行业，交通运输业、建筑业、服务业均受到不同程度的冲击，农业和轻工业受到的影响较小；化石能源方面，煤炭受到巨大冲击，石油也受到一定程度冲击，而天然气则受到轻微的正向影响。总体而言，现行绿色税制已然发挥了一定的碳减排效用，但仍存在许多待完善的问题；而碳税实施则应从税制内部融合角度，一方面弥补现行绿色税制的缺陷，另一方面依靠其他税种的税收优惠等政策组合来减轻碳税对经济的负向冲击。

关键词：绿色税制碳税可计算一般均衡模型(CGE) 灰色关联分析碳达峰碳中和

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Formation of Ti-N graded bioceramic layer by DC hollow-cathode plasma nitriding

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中国有色金属学会会刊：英文版 2004年第z1期14卷 319-322页

作者： zheng Chuan-lin Department of Mechanical Engineering Beijing Jiaotong University Beijing 100044 China

Ti-N graded ceramic layer was formed on titanium by using DC hollow-cathode plasma nitriding technique. The structure of Ti-N layer was analyzed using X-ray diffractometry(XRD) with Cu Kα radiation, and the microhardness( HV0.1) was measured from the surface to inner along the cross section of Ti-N layer. The results indicate that the Ti-N graded layer is composed of ε-Ti2 N, δ-TiN and α-Ti(N) phases. Mechanism discussion shows that hollow-cathode discharge can intensify gas ionization, increase current density and enhance the nitriding potential, which directly increases the thickness of the diffusion coatings compared with traditional nitriding methods.

关键词： Ti-N graded ceramic layer hollow-cathode plasma nitriding

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Parallel processing architecture of H.264 adaptive deblocking filters

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1160-1168页

作者： Hu WEI Tao lin zheng-hui lin Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

In H.264,computational complexity and memory access of deblocking filters are variable,dependent on video *** paper proposes a VLSI architecture of deblocking filters with adaptive dynamic power,which avoids redundant computations and memory accesses by precluding the blocks that can be *** vertical and horizontal edges are simulta-neously processed in an advanced scan order to speed up the *** a result,dynamic power of the proposed architecture can be reduced adaptively(up to about 89%) for different videos,and the off-chip memory access is improved when compared to previous ***,the processing capability of the proposed architecture is in particular appropriate for real-time deblocking of high-definition television(HDTV,1920×1080 pixels/frame,60 frames/s video signals) video operation at 62 *** the proposed architecture,power can be reduced by up to about 89% and processing time by from 25% to 81% compared with previous designs.

关键词： Deblocking filter Adaptive dynamic power Parallel processing Pipeline H.264

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A Novel Product Remaining Useful Life Prediction Approach Considering Fault Effects

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1762-1773页

作者： Jingdong lin zheng lin Guobo Liao Hongpeng Yin School of Automation Chongqing UniversityChongqing 400044China

In this paper,a novel remaining useful life prediction approach considering fault effects is *** Wiener process is used to construct the degradation process of single performance characteristic with the fault *** first passage time based remaining useful life distribution is calculated by assuming fault occurrence moment is a random variable and follows a certain *** maximization algorithm is employed to estimate model parameters,where the fault occurrence moment is considered as a missing ***,a Copula function is used to describe the dependence between the multiple performance characteristics and derive joint remaining useful life(RUL)distribution of product with the fault *** effectiveness of the proposed approach is verified by the experiments of turbofan engines.

关键词： Degradation process fault effects fault occurrence moment(FOM) performance characteristic(PC) remaining useful life(RUL)

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Macroblock-level decoding and deblocking method and its pipeline implementation in H.264 decoder SOC design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 36-41页

作者： WANG Shu-hui lin Tao lin zheng-hui Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200030 China

This paper presents a macroblock-level (MB-level) decoding and deblocking method for supporting the flexible macroblock ordering (FMO) and arbitrary slice ordering (ASO) bit streams in H.264 decoder and its SOC/ASIC implementation. By searching the slice containing the current macroblock in the bit stream and switching slices correctly, MBs can be decoded in the raster scan order, while the decoding process can immediately begin as long as the slice containing the current MB is available. This architectural modification enables the MB-level decoding and deblocking 3-stage pipeline, and saves about 20% of SDRAM bandwidth. Implementation results showed that the design achieves real-time decoding of 1080HD (1920×1088@30 fps) at a system clock of 166 MHz.

关键词： Flexible macroblock ordering (FMO) Arbitrary slice ordering (ASO) System-on-chip (SOC) Raster scan order Pipeline

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难治性肺炎支原体肺炎患儿并发塑型性支气管炎的影像学特征及T淋巴细胞亚群变化

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中华医院感染学杂志 2025年第2期35卷 260-264页

作者：郑春林喻耀华陈强胡向荣郑志东莆田市第一医院儿科福建莆田351100 莆田市第一医院麻醉科福建莆田351100

目的探讨难治性肺炎支原体肺炎(RMPP)患儿并发塑型性支气管炎(PB)的临床特征、影像学特征及T淋巴细胞亚群水平,为临床后续制定合理的治疗方案提供参考。方法回顾性分析2022年1月—2024年4月莆田市第一医院收治的102例RMPP患儿的临床资料... 详细信息

目的探讨难治性肺炎支原体肺炎(RMPP)患儿并发塑型性支气管炎(PB)的临床特征、影像学特征及T淋巴细胞亚群水平,为临床后续制定合理的治疗方案提供参考。方法回顾性分析2022年1月—2024年4月莆田市第一医院收治的102例RMPP患儿的临床资料,根据是否并发PB分为PB组33例和非PB组69例。比较两组患儿的临床特征、影像学特征及外周血检查结果。结果PB组与非PB组患儿热峰[(40.87±0.54)℃vs.(39.07±0.41)℃]、热程[(9.76±2.20)d vs.(8.05±1.34)d]及肺部啰音、呼吸困难、低氧血症、多次支气管镜介入占比比较有统计学差异(P<0.05)。PB组与非PB组患儿支气管黏液嵌塞征、累及胸膜病变、双肺实变、肺不张和胸腔积液占比比较有统计学差异(P<0.05),PB组占比分别为36.36%、15.15%、63.64%、24.24%和36.36%。PB组与非PB组患儿血清D-二聚体(D-D)、降钙素原(PCT)、C-反应蛋白(CRP)、肌酸激酶同工酶(CKMB)和乳酸脱氢酶(LDH)水平比较有统计学差异(P<0.05),且PB组患儿指标水平更高,分别为(6.01±3.19)μg/ml、(0.18±0.02)ng/ml、(46.15±14.04)mg/ml、(23.47±4.59)IU/L和(497.86±41.25)U/L。PB组与非PB组患儿T淋巴细胞亚群水平比较有统计学差异(P<0.05)。结论RMPP并发PB患儿的热峰高,热程及住院天数长,支气管镜介入次数多,多伴肺部啰音、呼吸困难及低氧血症,影像表现以支气管黏液嵌塞征、累及胸膜病变、双肺实变、肺不张、胸腔积液为主,且患儿多伴血清D-D、PCT、C RP、CK-MB、LDH水平异常升高及T淋巴细胞亚群异常紊乱,临床需根据上述表现,警惕RMPP患儿发生PB。

关键词：难治性肺炎支原体肺炎感染塑型性支气管炎临床特征影像学特征 T淋巴细胞亚群

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