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Predictive Models of Adjuvant Chemotherapy for Patients with Stage II Colorectal Cancer： A Retrospective Study

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Chinese Medical Journal 2017年第17期130卷 2069-2075页

作者： Bo Wei Xiao-Ming zheng Pu-Run Lei Yong Huang zong-heng zheng Tu-Feng Chen Jiang-Long Huang Jia-Feng Fang Cheng-Hua Liang Hong-Bo Wei Department of Gastrointestinal Surgery The Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background：It remains controversial whether patients with Stage II colorectal cancer would benefit from adjuvant chemotherapy after radical *** aim of this study was to establish two mathematical models to identify the suitable patients for adjuvant ***：The current study comprised of two *** the first step,353 patients with Stage Ⅱ colorectal cancer who underwent surgical procedures at the Third Affiliated Hospital of Sun Yat-sen University between June 2006 and December 2015 were entered and followed up for 6-120 *** clinical data were collected and enrolled into the *** established two mathematical models by univariate and multivariate Cox regression analysis to identify the target patients;in the second step,230 patients under the same standard between January 2012 and December 2016 were entered and followed up for 3-62 months to verify the two models＆#39; ***：In the first step,totally 340 surgical patients with Stage Ⅱ colorectal cancer were finally enrolled in this *** analysis showed that tumor differentiation （TD）（P 〈 0.001）,lymphovascular invasion （LVI）（P 〈 0.001）,uncertain or positive margins （UPM）（P 〈 0.001）,and fewer lymph nodes （LNs）（〈12） retrieved （P 〈 0.001） were correlated with the overall survival （OS） and disease free survival （DFS）.We obtained two models：（1） OS risk score =1.116 ＆#215; TD ＆#177; 2.202 ＆#215; LVI ＋ 3.676 ＆#215; UPM ＋ 1.438 ＆#215; LN-0.493;（2） DFS risk score =0.789 ＆#215; TD ＋ 2.074 ＆#215; LVI ＋ 3.183 ＆#215; UPM ＋ 1.329 ＆#215; *** to the models and cutoff points [（0.07,1.33） and （-0.04,1.30）,respectively],patients can be divided into three groups：low-risk,moderate-risk,and ***,the high-risk group patients could benefit from adjuvant *** the second step,totally 221 patients were finally used to verify the models＆#39; *** results proved that the models were accurate and feasible （P 〈 0.05）.Conclusions：A

关键词： Adjuvant Chemotherapy Risk Factors Mathematical Models Colorectal Cancer

Numerical manifold method for steady-state nonlinear heat conduction using Kirchhoff transformation

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Science China(Technological Sciences) 2024年第4期67卷 992-1006页

作者： ZHANG LiMei KONG heng zheng Hong Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Municipal Construction Co. Ltd.Beijing 100048China

The numerical manifold method(NMM)introduces the mathematical and physical cover to solve both continuum and discontinuum problems in a unified *** this study,the NMM for solving steady-state nonlinear heat conduction problems is presented,and heat conduction problems consider both convection and radiation boundary ***,the nonlinear governing equation of thermal conductivity,which is dependent on temperature,is transformed into the Laplace equation by introducing the Kirchhoff *** transformation reserves linearity of both the Dirichlet and the Neumann boundary conditions,but the Robin and radiation boundary conditions remain ***,the NMM is employed to solve the Laplace equation using a simple iteration procedure because the nonlinearity focuses on parts of the problem domain ***,the temperature field is retrieved through the inverse Kirchhoff *** examples are analyzed,demonstrating the advantages of the Kirchhoff transformation over the direct solution of nonlinear equations using the NewtonRaphson *** study provides a new method for calculating nonlinear heat conduction.

关键词： numerical manifold method nonlinear heat conduction temperature-dependent thermal conductivity Kirchhoff transformation convection and radiation boundary conditions

Resilience-oriented Transmission Expansion Planning with Optimal Transmission Switching Under Typhoon Weather

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 129-138页

作者： Yang Yuan heng Zhang Haozhong Cheng zheng Wang Key Laboratory of Control of Power Transmission and Conversion Ministry of EducationElectrical Engineering DepartmentShanghai Jiao Tong UniversityShanghaiChina State Grid East China Branch ShanghaiChina

This paper presents resilience-oriented transmission expansion planning(RTEP)with optimal transmission switching(OTS)model under typhoon *** proposed model carefully considers the uncertainty of component vulnerability by constructing a typhoon-related box uncertainty set where component failure rate varies within a range closely related with typhoon ***,a min-max-min model is developed to enhance transmission network resilience,where the upper level minimizes transmission lines investment,the middle level searches for the probability distribution of failure status leading to max worst-case expected load-shedding(WCEL)under typhoon,and the lower level optimizes WCEL by economic dispatch(ED)and OTS.A nested decomposition algorithm based on benders decomposition is developed to solve the *** studies of modified IEEE 30-bus and 261-bus system of a Chinese region illustrate that:a)the proposed RTEP method can enhance resilience of transmission network with less investment than widely used RTEP method based on attacker and defender(DAD)model,b)the influence of OTS on RTEP is closely related with contingency severity and system scale and c)the RTEP model can be efficiently solved even in a large-scale system.

关键词： Decomposition algorithm optimal transmission switching resilience transmission expansion planning uncertainty vulnerability

Rociletinib(CO-1686) enhanced efficacy of chemotherapeutic agents in ABCG2-overexpressing cancer cells in vitro and in vivo

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中国药理学与毒理学杂志 2019年第10期 891-892页

作者： ZENG Fan-pu WANG Fang zheng zong-heng CHEN Zhen Kenneth Kin Wah To ZHANG Hong HAN Qian FU Li-wu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Institute Sun Yat-Sen University Cancer Center

The abnormal expression and function of ATP-binding cassette subfamily G member 2(ABCG2) is correlated with development of multidrug resistance(MDR), and lead to lower response to ***, there is no FDA-approved commercial MDR modulator for clinical use. Here, We found rociletinib(CO-1686), a mutant-selective epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI), significantly improved the efficacy of substrate chemotherapeutic agents in ABCG2-overexpressing cancer cells and also in ABCG2-overexpressing S1-MI-80 cell xenografts in nude mice, without incurring additional toxicity. Mechanistic studies revealed that in ABCG2-overexpressing cancer cells, rociletinib inhibited ABCG2-mediated drug efflux, and increased intracellular accumulation of ABCG2 probe substrates. Moreover, rociletinib, inhibited the ATPase activity, and competed with [125 I] iodoarylazidoprazosin(IAAP) photolabeling of ABCG2. The expression of ABCG2 at protein and m RNA levels was not altered when ABCG2-overexpressing cells were treated with rociletinib. In addition, rociletinib did not inhibit Erb B downstream signaling of AKT and ERK and their phosphorylations. The all results showed that rociletinib increased the accumulation of substrates in cells by inhibiting the efflux function of ABCG2, and reversed ABCG2-related MDR. Therefore, rociletinib might be useful in developing combination chemotherapy in the patients with ABCG2-overexpressing MDR tumors.

关键词： rociletinib combination chemotherapy chemotherapeutic agents

Highly Aligned Graphene Aerogels for Multifunctional Composites

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Nano-Micro Letters 2024年第6期16卷 276-342页

作者： Ying Wu Chao An Yaru Guo Yangyang zong Naisheng Jiang Qingbin zheng Zhong‑Zhen Yu Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004People’s Republic of China School of Science and Engineering The Chinese University of Hong KongShenzhenShenzhenGuangdong 518172People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Stemming from the unique in-plane honeycomb lattice structure and the sp^(2)hybridized carbon atoms bonded by exceptionally strong carbon–carbon bonds,graphene exhibits remarkable anisotropic electrical,mechanical,and thermal *** maximize the utilization of graphene’s in-plane properties,pre-constructed and aligned structures,such as oriented aerogels,films,and fibers,have been *** unique combination of aligned structure,high surface area,excellent electrical conductivity,mechanical stability,thermal conductivity,and porous nature of highly aligned graphene aerogels allows for tailored and enhanced performance in specific directions,enabling advancements in diverse *** review provides a comprehensive overview of recent advances in highly aligned graphene aerogels and their *** highlights the fabrication methods of aligned graphene aerogels and the optimization of alignment which can be estimated both qualitatively and *** oriented scaffolds endow graphene aerogels and their composites with anisotropic properties,showing enhanced electrical,mechanical,and thermal properties along the alignment at the sacrifice of the perpendicular *** review showcases remarkable properties and applications of aligned graphene aerogels and their composites,such as their suitability for electronics,environmental applications,thermal management,and energy *** and potential opportunities are proposed to offer new insights into prospects of this material.

关键词： Highly aligned graphene aerogels Quantitative characterization of alignment Multifunctional composites Anisotropic properties Multifunctional applications

Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

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Petroleum Science 2024年第1期21卷 221-243页

作者： zheng-Qian Ma Xing-Yao Yin Zhao-Yun zong Yuan-Yuan Tan Ya-Ming Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is ***,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the ***,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical *** on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic ***,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked *** analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity ***,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip *** increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip *** comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness ***,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the or

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

Resilience-oriented Hardening and Expansion Planning of Transmission System Under Hurricane Impact

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1746-1760页

作者： Jing Zhou heng Zhang Haozhong Cheng Shenxi Zhang Lu Liu zheng Wang Xiaohu Zhang Key Laboratory of Control of Power Transmission and Conversion Ministry of EducationElectrical Engineering DepartmentShanghai Jiao Tong UniversityShanghai 200240China State Grid East China Branch Shanghai 200120China

In this paper,we propose a two-stage transmission hardening and planning(TH&P)model that can meet the load growth demand of normal scenarios and the resilience requirements of hurricane-induced damage *** better measure the resilience requirements,the proposed TH&P model includes two resilience assessment indexes,namely,the load shedding(LS)under the damage scenario and the average connectivity degree(ACD)at different *** first-stage model,which aims to meet the load growth demand while minimizing the LS,is formulated as a mixed-integer linear program(MILP)to minimize the total planning and hardening cost of transmission lines,the operating cost of generators,and the penalty cost of wind power and load shedding in both normal and damage *** second-stage model aims to further improve the ACD when the ACD of the scheme obtained from the first-stage model cannot reach the ***,the contribution of each transmission line to the ACD is calculated,and the next hardened line is determined to increase the *** process is repeated until the ACD meets the *** studies of the modified IEEE RTS-24 and two-area IEEE reliability test system-1996 indicate the proposed TH&P model can meet the requirements for both normal and damage scenarios.

关键词： Hardening hurricane disaster resilience transmission expansion planning

How do high-voltage cathode and PEO electrolyte get along well?EIS analysis mechanism&potentiometric control strategy

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Journal of Energy Chemistry 2024年第9期96卷 424-436页

作者： Xiaodong Bai Chaoliang zheng heng Zhang Jian Liu Panpan Wang Baojia Xia Jianling Li State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 201800China

PEO-based all-solid-state electrolytes are extensively utilized and researched owing to their exceptional safety,low-mass-density,and ***,the low oxidation potential of PEO makes the interface problem with the high-voltage cathode extremely *** this work,the impedance of PEO-based all-solid-state batteries with high-voltage cathode(NCM811)was studied at different *** Nyquist plots displayed a gyrate arc at low-frequencies for NCM811/PEO *** on the kinetic modeling,it was deduced that there is a decomposition reaction of PEO-matrix in addition to de-embedded reaction of NCM811,and the PEO intermediate product(dehydra-PEO)adsorbed on the electrode surface leading to low-frequency inductive ***,the distribution of relaxation time shows the dehydra-PEO results in the kinetic tardiness of the charge transfer process in the temporal ***,an artificial interface layer(CEI_(x))was modified on the surface of NCM811 to regulate the potential of cathode/electrolyte interface to prevent the high-voltage deterioration of ***/CEI_(x)/PEO batteries exhibit capacity retentions of 96.0%,84.6%,and 76.8%after undergoing 100 cycles at cut-off voltages of 4.1,4.2,and 4.3 V,***,here the failure mechanism of high-voltage PEO electrolyte is investigated by EIS and a proposed solving strategy is presented.

关键词： PEo-based electrolyte High-voltage cathode Electrochemical impedance spectroscopy Mechanism research Electrochemical characteristic

Using NH_(2)-MIL-125(Ti)for efficient removal of Cr(Ⅵ)and Rh B from aqueous solutions:Competitive and cooperative behavior in the binary system

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Journal of Environmental Sciences 2024年第2期136卷 437-450页

作者： Lei zheng Lixia Sun Jiangbo Qiu Junling Song Luyi Zou Yue Teng Yongzhong zong Hongyan Yu School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China Kunming South Water Co. Ltd.Kunming 650501China Jiangsu Key Laboratory of Anaerobic Biotechnology Jiangnan UniversityWuxi 214122China

The coexistence of inorganic and organic contaminants is a challenge for real-life water treatment ***,in this research,we used NH_2-MIL-125(Ti)to evaluate the single adsorption of hexavalent chromium(Cr(Ⅵ))or Rhodamine B(RhB)in an aqueous solution and further investigate simultaneous adsorption experiments to compare the adsorption behavior *** main influencing factors,for example,reaction time,initial concentration,reaction temperature,and pH were studied in *** all reaction systems,the pseudo-second-order kinetic and Langmuir isotherm models were well illuminated the adsorption progress of Cr(Ⅵ)and *** studies showed that the adsorption process was spontaneous and *** compared to the single system,the adsorption capacity of Cr(Ⅵ)in the binary system gradually decreased as the additive amount of RhB increased,whereas the adsorption capacity of RhB in the binary system was expanded *** the binary reaction system contained 100 mg/L Cr(Ⅵ),the removal rate of RhB increased to 97.58%.The formation of Cr(Ⅵ)-RhB and Cr(Ⅲ)-RhB complexes was the cause that provided facilitation for the adsorption of *** findings prove that the interactions during the water treatment process between contaminants may obtain additional benefits,contributing to a better adsorption capacity of co-existing contaminant.

关键词： Adsorption Heavy metal ion Organic dye Simultaneous removal Mechanism studies