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Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 268-276页

作者： zheng xueying GUO Liang LAI Siyi LI Fengyue LIANG Mingli LIU Wanting MENG Chun LIU Guanghui Department of Bioengineering College of Biological Science and BiotechnologyFuzhou UniversityFuzhou 350104China Eye Institute of Integrated Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhou 350004China Department of Ophthalmology Affiliated People's Hospital(Fujian Provincial People's Hospital)Fujian University of Traditional Chinese MedicineFuzhou 350004China

OBJECTIVE:To investigate the effects of emodin on alkali burn-induced corneal inflammation and ***:The ability of emodin to target vascular endothelial growth factor receptor 2(VEGFR2)was predicted by molecular *** effects of emodin on the invasion,migration,and proliferation of human umbilical vein endothelial cells(HUVEC)were determined by cell counting kit-8,Transwell,and tube formation *** of apoptosis was performed by flow ***31 levels were examined by *** abundance and phosphorylation state of VEGFR2,protein kinase B(Akt),signal transducer and activator of transcription 3(STAT3),and P38 were examined by immunoblot *** alkali burn was performed on 40 *** were divided randomly into two groups,and the alkali-burned eyes were then treated with drops of either 10μM emodin or phosphate buffered saline(PBS)four times a *** microscopy was used to evaluate inflammation and corneal neovascularization(CNV)in all eyes on Days 0,7,10,and *** mice were killed humanely 14 d after the alkali burn,and their corneas were removed and preserved at-80℃ until histological study or protein ***:Molecular docking confirmed that emodin was able to target *** findings revealed that emodin decreased the invasion,migration,angiogenesis,and proliferation of HUVEC in a dose-dependent *** mice,emodin suppressed corneal inflammatory cell infiltration and inhibited the development of corneal neovascularization induced by alkali *** to those of the PBS-treated group,lower VEGFR2 expression and CD31 levels were found in the emodintreated *** dramatically decreased the expression of VEGFR2,p-VEGFR2,p-Akt,p-STAT3,and p-P38 in VEGF-treated ***:This study provides a new avenue for evaluating the molecular mechanisms underlying corneal inflammation and *** might be a promising new therapeutic option for corneal alkal

关键词： alkali burn emodin corneal inflammation corneal neovascularisation vascular endothelial growth factor receptor-2 signal transduction

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Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo xueying zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou Ying Hu Hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu Guisen Li Gang Xu Chunbo Chen Huafeng Liu Yongjun Shi Yan Zha Yaozhong Kong Guobin Su Ying Tang Mengchun Gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina Guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

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糖尿病临床表型：从临床到基因的路径探索

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中华糖尿病杂志 2024年第10期16卷 1141-1146页

作者：涂芷馨王沁郑雪瑛翁建平骆斯慧中国科学技术大学附属第一医院(安徽省立医院)内分泌科先导医学与前沿技术研究所内分泌代谢病研究所合肥

糖尿病的发病机制和并发症呈现多样性, 涉及基因遗传、环境因素和生活方式等多个方面。研究指出糖尿病患者表现出不同的临床亚型, 这促使人们尝试对疾病进行重新分类。通过临床数据和遗传数据的聚类分析, 已经识别出不同的2型糖尿病亚... 详细信息

糖尿病的发病机制和并发症呈现多样性, 涉及基因遗传、环境因素和生活方式等多个方面。研究指出糖尿病患者表现出不同的临床亚型, 这促使人们尝试对疾病进行重新分类。通过临床数据和遗传数据的聚类分析, 已经识别出不同的2型糖尿病亚型, 这些亚型在疾病进展和并发症风险上存在差异。另外, 根据多组学数据, 特别是遗传结构的不同, 确定了与糖尿病风险相关的基因, 进一步揭示了疾病发病机制的临床异质性。总体而言, 糖尿病的精准分型将有助于更有效地预防、治疗和管理这一慢性代谢性疾病。

关键词：糖尿病表型精准医学遗传学

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Bi-functions of titanium and lanthanum co-doping to enhance theelectrochemical performance of spinel LiNi_(0.5)Mn_(1.5)O_(4)cathode

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Journal of Materiomics 2019年第2期5卷 156-163页

作者： xueying zheng Weijie Liu Qunting Qu Honghe zheng Yunhui Huang School of Materials Science and Engineering Tongji UniversityShanghai201804China College of Energy&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhouJiangsu215006PR China

Spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)cathode material doped with Ti and La co-doping were synthesized through a solid-state *** bi-functions of the Ti and La co-doping is *** the one hand,the stability of the LiNi_(0.5)Mn_(1.5)O_(4)crystal structure is enhanced and the Mn3t interference inside the material is reduced by the Ti *** the other hand,the co-doped La contributes to the formation of Li_(0.5)La_(0.5)TiO_(3)(LLTO)superionic conductor incorporated in the bulk LiNi_(0.5)Mn_(1.5)O_(4)phase,thereby enhancing the Li *** the help of XRD,FTIR,SEM and STEM techniques,La and Ti in the crystallographic structure and the dispersion of the LLTO superionic conductor in the bulk LNMO spinel are *** the optimized molar ratio of 20:1 between LNMO and LLTO,the composite exhibits the best electrochemical performances in terms of the reversible capacity,rate capability and cycling *** lithium ion diffusion coefficient in the bulk LNMO phase is tripled by the LLTO superionic conductor incorporation.

关键词： Lithium ion batteries Spinel LiNi_(0.5)Mn_(1.5)O_(4) Li0.5La0.5TiO3 Co-doping Superionic-conductor

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1型糖尿病患者全孕程持续葡萄糖监测参数及产前血糖水平与新生儿低血糖发生的相关性

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中华糖尿病杂志 2024年第1期16卷 77-83页

作者：李先铭龚一昕凌萍严晋华骆斯慧郑雪瑛杨黛稚王超凡中国科学技术大学附属第一医院内分泌科、中国科学技术大学内分泌与代谢病研究所、中国科学技术大学生命科学与医学部、中国科学院临床研究医院(合肥) 合肥230001 中山大学附属第三医院内分泌与代谢病学科、广东省糖尿病防治重点实验室广州510630

目的:探讨1型糖尿病(T1DM)患者全孕程持续葡萄糖监测(CGM)参数及产前血糖水平与新生儿低血糖发生的相关性。方法:本研究为多中心、前瞻性、观察性队列研究,自2015年1月至2017年12月在全国11家医院招募T1DM合并妊娠患者作为研究对象,采用... 详细信息

目的:探讨1型糖尿病(T1DM)患者全孕程持续葡萄糖监测(CGM)参数及产前血糖水平与新生儿低血糖发生的相关性。方法:本研究为多中心、前瞻性、观察性队列研究,自2015年1月至2017年12月在全国11家医院招募T1DM合并妊娠患者作为研究对象,采用CGM监测孕期血糖,记录产前2 h毛细血管血糖和新生儿结局。本研究纳入完成全孕程CGM的T1DM患者73例,根据分娩后新生儿血糖值(新生儿低血糖定义为新生儿血糖7.8 mmol/L、TAR 2>13.9 mmol/L)、葡萄糖低于目标范围时间(TBR)、血糖标准差(SDBG)、平均血糖波动幅度(MAGE)、变异系数(CV)]、产前2 h血糖水平、分娩时孕周以及新生儿结局[出生体重、出生身长、早产率、新生儿重症监护病房(NICU)入住率]的差异。组间比较采用独立样本 t检验、秩和检验、 χ^(2)检验和Fisher精确检验法。采用多因素logistic回归模型分析新生儿低血糖发生的影响因素。结果:相较新生儿血糖正常组,新生儿低血糖组孕母孕早期日间平均血糖[分别为(6.91±0.71)和(6.38±0.81)mmol/L, t=2.041, P<0.05]、孕早期TAR 2[分别为0.81%(0,4.36%)和0(0,0.64%), Z=2.064, P<0.05]、孕早期MAGE[分别为(6.42±3.24)和(4.60±1.67)mmol/L, t=2.137, P<0.05]、产前2 h血糖水平[分别为(7.75±2.22)和(6.13±2.10)mmol/L, t=2.324, P<0.05]升高,差异均具有统计学意义。新生儿低血糖组的早产率[分别为35.71%(5/14)和11.86%(7/59), χ^(2)=4.686, P<0.05]和NICU入住率[分别为71.43%(10/14)和32.20%(19/59), χ^(2)=5.725, P<0.05]高于新生儿血糖正常组,差异均具有统计学意义。多因素logistic回归分析提示,孕母产前2 h血糖是新生儿低血糖的独立影响因素(OR=2.23,95%CI 1.09~4.54, P<0.05)。结论:T1DM患者孕早期平均血糖、TAR和MAGE与新生儿低血糖的发生相关,产前2 h血糖水平与新生儿低血糖的发生独立相关。

关键词：糖尿病 1型持续葡萄糖监测产前血糖新生儿低血糖

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2020—2022年全球H5亚型高致病性禽流感疫情简况及分析

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中国兽医杂志 2024年第7期60卷 34-40页

作者：王慧强张跃程敏姮殷雨晴郑雪莹李志军北京市动物疫病预防控制中心北京大兴102629

为了解近年全球H5亚型高致病性禽流感(HPAI)疫情具体情况,本文通过对农业农村部畜牧兽医局发布的“一周国际动物疫情动态”和“疫情发布”中的HPAI疫情信息进行统计和分析,对2020—2022年全球H5亚型HPAI疫情的发生和流行情况,空间、时... 详细信息

为了解近年全球H5亚型高致病性禽流感(HPAI)疫情具体情况,本文通过对农业农村部畜牧兽医局发布的“一周国际动物疫情动态”和“疫情发布”中的HPAI疫情信息进行统计和分析,对2020—2022年全球H5亚型HPAI疫情的发生和流行情况,空间、时间和群间分布,以及给养禽业造成的危害进行较为全面的了解。结果显示,2020年全球H5亚型HPAI疫情以H5N8亚型为主;自2021年5月份,呈现H5N1亚型疫情逐渐增多、H5N8亚型疫情逐渐减少的趋势,至11月份,形成以H5N1亚型疫情为主、H5N8亚型疫情零星发生的局面。H5N1亚型HPAI疫情逐渐演变为全球大流行,在欧洲形成“重灾区”,非洲和亚洲疫情也较为严重。2022年存在2次明显的H5亚型HPAI跨洲际传播,分别是2月份从欧洲传播到北美洲和10月份从北美洲传播到南美洲,经分析认为这2次跨洲际传播与候鸟迁徙有密切联系。结果表明,本轮H5N1亚型HPAI疫情全球大流行持续时间长、传播范围广,给世界养禽业造成巨大危害和深远影响。

关键词：全球 H5亚型高致病性禽流感疫情分析

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Association between population migration and epidemic control of coronavirus disease 2019

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Science China(Life Sciences) 2020年第6期63卷 936-939页

作者： Yu Ding Sihui Luo xueying zheng Ping Ling Tong Yue Zhirong Liu Jianping Weng The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Institute of Public Health University of Science and Technology of ChinaHefei 230026China Joint Laboratory of Public Health USTC and Anhui NHCHefei 230001China Anhui Provincial Center for Disease Control and Prevention Hefei 230601China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China

Dear Editor,In January 2020,a widespread outbreak of coronavirus disease 2019(COVID-19)occurred after the beginning of the largest annual migration in China,which is known as the Spring Festival *** in January 20,2020,the Chinese government took a series of unprecedented measures to contain the spread of *** of the role of Wuhan as a central transportation hub.

关键词： Association between population migration and epidemic control of coronavirus disease 2019

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Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice

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Genes & Diseases 2024年第1期11卷 57-59页

作者： Chunhong Liu Xinzhi Li Zhicheng Yao xueying Li zheng Chen HIT Center for Life Sciences School of Life Science and TechnologyHarbin Institute of TechnologyHarbinHeilongjiang150001China Department of General Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510530China

Hepatocellular carcinoma(HcC)is a key cause of morbidity and mortality,which is a global health *** the molecular and cellular mechanisms of HcC progression is helpful to find either early markers for diagnosis or nov... 详细信息

关键词： diagnosis mortality carcinoma

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Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019(COVID-19): a population-based surveillance study

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National Science Review 2020年第10期7卷 1527-1539页

作者： xueying zheng Sihui Luo Yong Sun Mingfeng Han Jian Liu Liangye Sun Liangming Zhang Ping Ling Yu Ding Tengchuan Jin Zhirong Liu Jianping Weng The First Affiliated Hospital of USTC Division of Life Science and Medicine University of Science and Technology of China Key Laboratory for Medical and Health of the 13th Five-Year Plan Anhui Provincial Center for Disease Control and Prevention Fuyang No.2 People's Hospital Anqing Hospital Affiliated to Anhui Medical University (Anqing Municipal Hospital) Lu'an People's Hospital Department of Infectious Disease the First Affiliated Hospital of USTCDivision of Life Science and Medicine University of Science and Technology of China Division of Life Science and Medicine University of Science and Technology of China

In this population-based study, we identified 307 confirmed COVID-19 cases from massive surveillance,including 129 551 individuals screened at fever clinics or returning from Hubei and 3710 close contacts of confirmed COVID-19 patients. Among them, 17 patients were asymptomatic at initial clinical *** asymptomatic patients on admission accounted for a small proportion of all patients(5.54%) with relatively weak transmissibility, and the detection rate was 0.35 per 100 close contacts. Moreover, the dynamics of symptoms of the 307 patients showed that the interval from symptom remission to the final negativity of viral nucleic acid was 5.0 days(interquartile range 2.0 to 11.0 days), with 14 patients(4.56%)having re-detectable viral RNA after discharge. Overall, our findings suggested asymptomatic carriers and presymptomatic patients only accounted for a small proportion of COVID-19 patients. Also, the asymptomatic phase during recovery from COVID-19 implied that negativity in viral RNA is necessary as a de-isolation criterion and follow-up is recommended.

关键词： epidemiology public health surveillance asymptomatic COVID-19 SARS-CoV-2

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基于智能手机APP的院内外综合管理对妊娠期糖尿病的效果研究

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中华糖尿病杂志 2024年第4期16卷 430-437页

作者：王璟龚一昕王沁李先铭刘昱婕康蓉王群华陈素玉骆斯慧翁建平郑雪瑛中国科学技术大学附属第一医院内分泌科内分泌代谢病研究所、中国科学院临床研究医院合肥230001 中国科学技术大学附属第一医院妇产科合肥230001

目的探讨使用智能手机应用程序(APP)对妊娠期糖尿病(GDM)患者进行孕期院内外综合管理对其孕期血糖水平及妊娠结局的影响。方法为回顾性队列研究,选取2022年1至12月于中国科学技术大学附属第一医院产科分娩并注册我国首个GDM院内外管理... 详细信息

目的探讨使用智能手机应用程序(APP)对妊娠期糖尿病(GDM)患者进行孕期院内外综合管理对其孕期血糖水平及妊娠结局的影响。方法为回顾性队列研究,选取2022年1至12月于中国科学技术大学附属第一医院产科分娩并注册我国首个GDM院内外管理互联网服务平台——糖妈妈APP的GDM患者为研究对象,计算其注册APP到完成当次分娩时间段内的APP总体使用活跃度(由血糖监测频率、线上沟通频率、课程学习频率总和组成),并基于此结果将GDM患者分为高活跃度组和低活跃度组。收集研究对象年龄、教育程度、控糖方式、产次,体重和身高并计算孕前体重指数(BMI),糖化血红蛋白(HbA_(1c))并计算HbA_(1c)达标率(HbA_(1c)<6%),孕产妇结局[妊娠期体重增加(GWG)、剖宫产],新生儿结局[大于胎龄儿(LGA)、巨大儿、新生儿高胆红素血症]及新生儿住院费用。采用两独立样本t检验、Mann-WhitneyU检验、卡方检验和Fisher精确检验进行组间比较,采用logistic回归模型分析APP总体使用活跃度对不良妊娠结局的影响。结果共纳入GDM患者616例。其中,高活跃度组308例,低活跃度组308例。与低活跃度组相比,高活跃度组GDM患者孕晚期HbA1c较低[分别为(5.6±0.4)%和(5.5±0.4)%,t=-2.341,P=0.020],孕晚期HbA1c达标率较高[分别为81.1%(154/190)和89.9%(186/207),χ^(2)=6.243,P=0.012],GWG较少[分别为(12.7±5.7)和(11.1±5.7)kg,t=-3.469,P=0.001];高活跃度组剖宫产[分别为53.9%(166/308)和45.1%(139/308),χ^(2)=4.734,P=0.030]、LGA[分别为23.1%(71/308)和11.7%(36/308),χ^(2)=13.855,P<0.001]、巨大儿[分别为14.3%(44/308)和8.8%(27/308),χ^(2)=4.601,P=0.032]及新生儿高胆红素血症[分别为14.9%(46/308)和9.1%(28/308),χ^(2)=4.976,P=0.026]发生率较低,新生儿住院费用较少[分别为5740.0(4465.8,7292.6)元和5304.9(4219.0,5901.2)元,Z=-2.383,P=0.017]。logistic回归分析结果显示,校正孕妇年龄、孕前BMI、教育程度、控糖方式、产次后,GDM患者APP总体使用活跃度高是孕晚期HbA1c达标率增加(OR=2.20,95%CI 1.17~4.12,P=0.014),以及LGA(OR=0.43,95%CI 0.27~0.68,P<0.001)及巨大儿(OR=0.59,95%CI 0.35~0.99,P=0.044)、新生儿高胆红素血症发生率降低(OR=0.56,95%CI 0.34~0.93,P=0.025)的影响因素。结论糖妈妈APP的使用频率增加与GDM患者孕期血糖水平降低和不良妊娠结局风险降低有关。

关键词：糖尿病,妊娠妊娠结局远程医疗血糖管理大于胎龄儿

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