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The impact of the Rural Minimum Living Standard Guarantee(Rural Dibao)Program on child nutrition outcomes

Journal of Integrative Agriculture 2024年第2期23卷 444-456页

作者： Dian chen Xiangming Fang Yu chen Xiaodong zheng Zhuo chen Rodney B.w.Smith Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China School of Public Health Georgia State UniversityAtlanta 30303USA School of Economics Zhejiang Gongshang UniversityHangzhou 310018China college of Public Health University of GeorgiaAthens 30602USA Department of Applied Economics University of MinnesotaSaint Paul 55108USA

The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural *** the importance of children’s nutrition in breaking poverty cycles,little is known about the impact of Rural Dibao on child nutrition *** china Family Panel Studies(cFPS),this paper examines the effects of Rural Dibao on child nutrition outcomes and investigates potential pathways and heterogeneous *** exploit propensity score matching and difference-in-differences techniques to evaluate the effects of the Rural Dibao program on child nutrition *** results suggest that Rural Dibao significantly impacts the nutrition outcomes of children up to 15 years of ***,our results suggest that Rural Dibao improves child height-to-age z-scores by 1.05 standard deviations and lowers the probability of stunting by 11.9 percentage *** analyses suggest that increased protein intake is the main pathway through which Rural Dibao participation contributes to better nutrition *** also find that the effect of the program is more pronounced among girls,children who are non-left-behind or live with highly educated mothers,and those from low-income families and poor *** findings suggest that Rural Dibao participation helps improve child nutrition outcomes through improving diet quality.

关键词： Rural Minimum Living Standard Guarantee nutrition height-to-age z-scores stunting rural china

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Exploring Trade-offs in Thermal Interface Materials:The Impact of Polymer-Filler Interfaces on Thermal conductivity and Thixotropy

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chinese Journal of Polymer Science 2024年第7期42卷 916-925,I0006页

作者： Bin Zhang zheng-Li Dou Yong-zheng Zhang Qiang Fu Kai wu college of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China

Effective thermal transport across solid-solid interfaces which is essential in thermal interface materials(TIMs),necessitates both optimal thixotropy and high thermal *** role of filler surface modification,a fundamental aspect of TIM fabrication,in the influence of these properties is not fully *** study employs the use of a silane coupling agent(ScA)to modify alumina,integrating experimental approaches with molecular dynamics simulations,to elucidate the interface effects on thixotropy and thermal conductivity in polydimethylsiloxane(PDMS)-based *** findings reveal that the variations of ScAs modify both interface binding energy and transition layer *** interface binding energy restricts macromolecular segmental relaxation near the interface,hindering desirable thixotropy and bond line *** the contrary,the thickness of the transition layer at the interface positively influences thermal conductivity,facilitating the transport of phonons between the polymer and ***,selecting an optimal ScA allows a balance between traditionally conflicting goals of high thermal conductivity and minimal bond line thickness,achieving an impressively low interface thermal resistance of just 2.45-4.29 K·mm^(2)·w^(-1)at275.8 kPa.

关键词： Thermal interface material Surface modification Thermal conductivity Thixotropy Interface thermal resistance

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continuous Expression of Interferon Regulatory Factor 4 Sustains cD8^(+)T cell Immunity against Tumor

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Research 2024年第3期2023卷 433-444页

作者： Anze Yu Jinfei Fu zheng Yin Hui Yan Xiang Xiao Dawei Zou Xiaolong Zhang Xiongbing Zu Xian c.Li wenhao chen Immunobiology and Transplant Science center Department of SurgeryHouston Methodist Research Institute and Institute for Academic MedicineHouston Methodist HospitalHoustonTXUSA Department of Urology First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Systems Medicine and Bioengineering Department Houston Methodist Neal Cancer CenterHoustonTXUSA Department of Radiology Houston Methodist HospitalWeill Cornell MedicineHoustonTXUSA Department of Urology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Surgery Weill Cornell MedicineCornell UniversityNew YorkNYUSA.

T-cell-based immunotherapy is gaining momentum in cancer treatment;however,our comprehension of the transcriptional regulation governing T cell antitumor activity remains *** objective of this study was to explore the function of interferon regulatory factor 4(IRF4)in antitumor cD8^(+)T cells using the TRAMP-c1 prostate cancer and B16F10 melanoma *** achieve this,we generated an Irf4^(GFP-DTR) mouse strain and discovered that cD8^(+)tumor-infiltrating lymphocytes(TILs)expressing high levels of *** exhibited a more differentiated PD-1high cell *** administering diphtheria toxin to tumor-bearing Irf4^(GFP-DTR) mice,we partially depleted ***^(+)TILs and observed an accelerated tumor *** specifically explore the function of IRF4 in antitumor cD8^(+)T cells,we conducted 3 adoptive cell therapy(AcT)***,depleting ***^(+)cD8^(+)TILs derived from AcT significantly accelerated tumor growth,emphasizing their crucial role in controlling tumor ***,deleting the Irf4 gene in antitumor cD8^(+)T cells used for AcT led to a reduction in the frequency and effector differentiation of cD8^(+)TILs,completely abolishing the antitumor effects of ***,we performed a temporal deletion of the Irf4 gene in antitumor cD8^(+)T cells during AcT,starting from 20 days after tumor implantation,which significantly compromised tumor ***,sustained expression of IRF4 is essential for maintaining cD8^(+)T cell immunity in the melanoma model,and these findings carry noteworthy implications for the advancement of more potent immunotherapies for solid tumors.

关键词： sustained immunity implantation

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Thiol-Disulfide Exchange coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in colitis

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Research 2024年第2期6卷 285-300页

作者： Junna Lu Tongfei Shi chengxin Shi Fangman chen chao Yang Xiaochun Xie zheng wang He Shen Jiaqi Xu Kam w.Leong Dan Shao School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong 510006China National Engineering Research center for Tissue Restoration and Reconstruction South China University of TechnologyGuangdong 510006China Department of Plastic and Aesthetic center The First Affliated Hospital of Zhejiang UniversityHangzhou 310000China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA School of Medicine South China University of TechnologyGuangzhouGuangdong 510006China cAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China cAS Key Laboratory for Biomedical Efects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

The cell-specific functions of nitric oxide(NO)in the intestinal microenvironment orchestrate its therapeutic effects in ulcerative *** most biomaterials show promise by eliciting the characteristics of NO,the insufficient storage,burst release,and pro-inflammatory side effects of NO remain as ***,we report the development of thiol-disulfide hybrid mesoporous organosilica nanoparticles(MONs)that improve the storage and sustained release of NO,broadening the therapeutic window of NO-based therapy against *** tailored NO-storing nanomaterials coordinated the release of NO and the immunoregulator dexamethasone(Dex)in the intestinal microenvironment,specifically integrating the alleviation of oxidative stress in enterocytes and the reversal of NO-exacerbated macrophage ***,such a synchronous operation was achieved by a self-motivated process wherein the thiyl radicals produced by NO release cleaved the disulfide bonds to degrade the matrix and release Dex via thiol-disulfide ***,the MON-mediated combination of NO and Dex greatly ameliorated intractable colitis compared with 5-aminosalicylic acid,even after delayed ***,our results reveal a key contribution of synergistic modulation of the intestinal microenvironment in NO-based colitis therapy and introduce thiol-disulfide hybrid nanotherapeutics for the management of inflammatory diseases and cancer.

关键词： sustained release disulfide

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Piezoelectric composite hydrogel with wireless electrical stimulation enhances motor functional recovery of spinal cord injury

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Journal of Materials Science & Technology 2024年第5期172卷 228-239页

作者： Zehao Li Guanlin Li Xinyu wang zheng Zhao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park of wuhan University of Technology Sanya 572000China

Electrical stimulation(ES)can restore motor function after spinal cord injury(ScI).However,traditional intraspinal ES has many disadvantages,such as the need for a complex circuitry device,an external power source,and a second surgery to remove the *** materials have received increasing at-tention due to their potential to convert ambient mechanical energy into ES without an external power source or implantation of ***,a novel polydopamine(PDA)coated barium titanate(BaTiO_(3))nanoparticles(BaTiO_(3)@PDA)incorporated silk fibroin(SF)hydrogel(SFBT)was *** SFBT hy-drogel was crosslinked by horseradish peroxidase(HRP)/hydrogel peroxide(H_(2)O_(2))to integrate the piezo-electric potency of BaTiO_(3)with the thermal sensitivity of HRP/H_(2)O_(2)for ScI *** hydrogel con-taining 5%(w/v)BaTiO_(3)@PDA nanoparticles(SFBT-5),which was selected for in vivo study,exhibited a short gelation time(5 min),suitable storage modulus(925±35 Pa),and wireless ES(average current of 124 nA).Moreover,Basso-Beattie-Bresnahan(BBB)scores test and footprint analysis demonstrated that the SFBT-5 hydrogel successfully enhanced motor functional recovery of *** histopathological assess-ments,the SFBT-5 hydrogel significantly accelerated spinal cord healing,as indicated by smaller lesion cavities(∼16.7%of the ScI group).Meanwhile,the SFBT-5 hydrogel accelerated neurogenesis,facilitated axon regrowth and synapse formation,and promoted ***,this study highlights the potential of piezoelectric hydrogels for ScI regeneration.

关键词： Silk fibroin Barium titanate Piezoelectric hydrogel Spinal cord injury Electrical stimulation

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Effect of microalloying on wettability and interface characteristics of Zr-based bulk metallic glasses with w substrate

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china Foundry 2024年第4期21卷 352-359页

作者： Zhen Zhang Lin-na Feng Jin-he wang zheng-kun Li Hua-meng Fu Hong Li zheng-wang Zhu Hai-feng Zhang School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Shi-changxu Innovation center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110004China

The infiltration casting method is widely employed for the preparation of ex-situ composite ***,the production of composite materials using this method must necessitates a comprehensive understanding of the wettability and interface characteristics between the reinforcing phase and the bulk metallic glasses(BMGs).This work optimized the composition of Zr-based BMGs through microalloying methods,resulting in a new set of Zr-based BMGs with excellent glass-forming *** experiments between the Zr-based BMGs melts and w substrates were conducted using the traditional sessile drop method,and the interfaces were characterized utilizing a scanning electron microscope(SEM)equipped with energy dispersive X-ray spectroscopy(EDS).The work demonstrates that the microalloying method substantially enhances the wettability of the Zr-based BMGs ***,the incorporation of Nb element impedes the formation of w-Zr phases,but the introduction of Nb element does not alter the extent of interdiffusion between the constituent elements of the amorphous matrix and w element,indicating that the influence of Nb element on the diffusion of individual elements is minute.

关键词： Zr-based BMGs infiltration casting method wettability interface characteristics w-Zr phases

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Ultrasound-driven self-decomposition porphyrins as metal-free cO precursors for gas and sonodynamic synergistic therapy

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Science china chemistry 2024年第5期67卷 1624-1635页

作者： Shuxin Liu Jinjuan Ma Xiang Xu Aiguo wang Nan zheng School of chemical Engineering Dalian University of TechnologyDalian 116024China Department of comparative Medicine Laboratory Animal center Dalian Medical UniversityDalian 116000China cancer Hospital of Dalian University of Technology Shenyang 116000China

carbon monoxide(cO) is an endogenous therapeutic gas with an anti-tumor effect. The precise delivery and controlled release of cO in tumor tissues play crucial roles in anti-cancer treatment. However, efficient in situ generation of cO from metal-free cOreleasing molecules(cORMs) remains a formidable challenge. Herein, we develop ultrasound(US)-driven self-decomposition porphyrin as organic and metal-free US-cORMs, which can spatiotemporally control the cO release(347 mmol cO/mol porphyrin) efficiently under physiologically harmless US conditions(1.0 MHz, 1.5 w/cm^(2), 50% duty cycle, 50 min). Moreover,porphyrin as a sonosensitizer can also generate reactive oxygen species(ROS) under US treatment to achieve sonodynamic therapy(SDT). Advanced functions of such porphyrin-based cORMs in cO gas-sonodynamic synergistic treatment have been demonstrated by evaluating the in vitro and in vivo anti-tumor effects.

关键词： porphyrin sonodynamic therapy metal-free cO precursors ultrasound-driven gas therapy

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Soil type and wetting intensity control the enhancement extent of N_(2)O efflux in soil with drought and rewetting cycles

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International Soil and water conservation Research 2024年第1期12卷 137-144页

作者： Panpan Jiao Lei Yang Zhongwu Li Peng zheng Xiaodong Nie School of Geographical Sciences Hunan Normal UniversityChangsha 410081China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau The Research Center of Soil and Water Conservation and Ecological EnvironmentChinese Academy of Sciences and Ministry of EducationYangling 712100China Institute of Soil and water conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling 712100China University of chinese Academy of Sciences Beijing 100049China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China

climate change alters the intensity and frequency of drought and rewetting(D/w)events;however,the influence patterns of D/w on soil N_(2)O efflux in the water-limited area were not fully ***,the impacts of D/w cycles varying in different extent of rewetting and frequency to N_(2)O efflux in two kinds of soil on the Loess Plateau were *** incubation conditions consisted of 1)D/w treatments with four 7-day cycles from 10%water holding capacity(wHc)to 60%wHc or 90%wHc,2)constant moisture of 60%wHc and 90%*** pulse of N_(2)O efflux rate under 10-60%wHc treatment was higher than that under 10-90%wHc treatment in calcic cambisols,while opposite trend was observed in earth-cumuli-orthic ***,the pulse of N_(2)O efflux rate decreased as cycle number increased for different wetting intensities and soil *** direct N_(2)O efflux under 10-60%wHc and 10-90%wHc treatments were 5.49 and 1.89μg N_(2)O-N g^(-1)soil in calcic cambisols,with those being 1.92 and 10.85μg N_(2)O-N g^(-1)soil in earth-cumuli-orthic anthrosols,*** N loss in earth-cumuli-orthic anthrosols was approximately 5.74 times greater than that in calcic cambisols under 10-90%wHc treatment,whereas the N loss under 10-60%wHc treatment was about 2.86 times greater in calcic cambisols than that in earth-cumuli-orthic *** study suggested that extreme rainfall events can enhance the N_(2)O efflux and N loss in agricultural soils on the Loess Plateau in terms of soil type and wetting intensity,which should not be ignored in the N fertilizer management.

关键词： Drought/rewetting cycles N_(2)O efflux wetting intensity Microbial biomass N Dissolved organic N Loess plateau

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Influence of Micro/Nano-Ti Particles on the corrosion Behavior of AZ31-Ti composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 484-498页

作者： Jinchao Jiao Jin Zhang Yong Lian Shengli Han Kaihong zheng Fusheng Pan Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 10083China Beijing Key Laboratory for corrosion Erosion and Surface Technology Beijing 100083China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China National Engineering Research center for Magnesium Alloys Chongqing UniversityChongqing 404100China

Adding Ti particles to magnesium alloy simultaneously enhances its strength and ***,how these particles influence on Mg alloy’s corrosion performance is seldom *** corrosion behavior of AZ31-Ti composites containing titanium nanoparticles(1.5 and 5 wt%)and micron particles(10 wt%)prepared by powder metallurgical in 3.5 wt%Nacl solution was *** results indicate that Ti particles serve as the primary location for the cathodic hydrogen reduction reaction,resulting in intense galvanic corrosion between the Ti and Mg *** nanoparticles distributed at the interface of the original AZ31 powder were in a discontinuous mesh structure,thus failing to act as a barrier against *** corrosion products with the existence of numerous cracks gradually peel off during the corrosion process and cannot protect the *** average corrosion rate P_(w) of AZ31,AZ31-1.5%Ti,AZ31-5%Ti,and AZ31-10%Ti after 7 days of immersion is 27.55,105.65,283.67,and 99.35 mm/y,***,AZ31-Ti composites can be considered as potential candidates for degradable fracturing ***,it is recommended to improve their corrosion resistance through surface treatment.

关键词： AZ31-Ti composite Nano-Ti Micro-Ti corrosion behavior Scanning Kelvin probe force microscopy(SKPFM)

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Modeling of Rectangular Microchannel Heat Sink with Non-Uniform channels and Multi-Objective Optimization

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Journal of Thermal Science 2024年第5期33卷 1701-1711页

作者： SHANG Xueshuo wANG Yixin LI Qingwen wANG Rui cUI zheng SHAO wei Institute of Advanced Technology Shandong UniversityJi'nan 250014China Institute of Thermal Science and Technology Shandong UniversityJi'nan 250014China Shandong Institute of Advanced Technology Ji'nan 250100China

Rectangular microchannel heat sinks(McHS)are widely used to cool high-heat-flux electronic ***,previous studies focused mainly on McHS with uniform channels(Ucs).This study considers a microchannel heat sink with non-uniform channels(NUcs).A mathematical model is developed based on energy equations and the Darcy flow *** expressions for total thermal resistance and coolant pressure drop are derived using the thermoelectric *** and numerical simulations are performed to verify the mathematical *** non-uniformity increases,total coolant pressure drop decreases but at the cost of higher thermal *** overall performance of NUcs is better than that of Ucs because of their lower ratio of pumping power to cooling *** transfer performance of NUcs changes little for more than 120 channels and depends mainly on channel arrangement.A multi-objective optimization is conducted to minimize the thermal resistance and pumping power of an *** optimal NUc saves 64%pumping power compared with a conventional Uc for the total thermal resistance of 0.1℃/w,indicating that the use of non-uniform channels could be very helpful to reduce the flow resistance of McHS.

关键词： microchannel heat sink non-uniform channel mathematical model multi-objective optimization

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