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Nomogram to predict severe retinopathy of prematurity in Southeast China

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-Yong Li Hong-Wu He Ka-Lu Jin Ling-Xia Zhang Yang Zhou Zhi-Min Zhu Chen-Chen Jiang Hai-Jian Wu Sui-lian zheng Department of Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To define the predictive factors of severe retinopathy of prematurity(ROP)and develop a nomogram for predicting severe ROP in southeast ***:Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive factors of ROP infants were collected *** regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction,which was compared with WINROP model and Digirop-Birth ***:Infants from the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Infants from Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were found in 52 of 402 infants,12 of 76 infants,and 7 of 76 infants in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%confidence interval(CI),0.996-0.999;P<0.001],multiple births(OR,1.885;95%CI,1.013-3.506;P=0.045),and non-invasive ventilation(OR,0.288;95%CI,0.146-0.570;P<0.001)were identified as predictive factors for the prediction of severe ROP,by univariate analysis and multivariate *** predicting severe ROP based on the internal validation group,the areas under receiver operating characteristic curve(AUC)was 78.1(95%CI,64.2-92.0)for the nomogram,32.9(95%CI,15.3-50.5)for WINROP model,70.2(95%CI,55.8-84.6)for Digirop-Birth *** external validation group,AUC of the nomogram was also higher than that of WINROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WINROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of prematurity nomogram predictive factor birth weight multiple births non-invasive ventilation

Novel mutations and sequence variants in exons 3-9 of human T Cell Factor-4 gene in sporadic rectal cancer patients stratified by microsatellite instability

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World Journal of Gastroenterology 2007年第27期13卷 3747-3751页

作者： Wen-Jian Meng Ling Wang Chao Tian Yong-Yang Yu Bing Zhou Jun Gu Qing-Jie Xia Xiao-Feng Sun Yuan Li Rong Wang Xue-lian zheng Zong-Guang Zhou Department of Gastrointestinal Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Division of Digestive Surgery and Organ-Microcirculation West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Ophthalmologic Surgery Laboratory West China Hospital Sichuan University Chengdu 610041 Sichuan Province China National Key Laboratory of Biotherapy of West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Oncology Linkoping University Linkoping Sweden

AIM： To establish the role of human T Cell Factor-4 （hTCF-4） gene exons 3-9 mutation status in association with sporadic rectal cancer with microsatellite instability （MSI）. METHODS： Microsatellite markers were genotyped in 93 sporadic rectal cancer patients. Eleven cases were found to be high-frequency MSI （MSI-H）. Sequence analysis of the coding region of the exons 3-9 of hTCF-4 gene was carried out for the 11 MSI-H cases and 10 controls （5 microsatellite stability （MSS） cases and 5 cases with normal mucosa）. The sequencing and MSI identification were used. RESULTS： Several novel mutations and variants were revealed. In exon 4, one is a 4-position continuous alteration which caused amino acid change from Q131T and S132I （391insA, 392 G 〉 A, 393 A 〉 G and 395delC） and another nucleotide deletion （395delC） is present in MSI-H cases （5/10 and 4/10, respectively） but completely absent in the controls.CONCLUSION： Novel mutations in exon 4 of hTCF-4 gene were revealed in this study, which might be of importance in the pathogenesis of sporadic rectal cancer patients with MSI-H.

关键词： hTCF-4 Sporadic rectal cancer Microsatellite instability Mutation analysis

Nuclear body-localized ARID1 is required for male germline formation in Arabidopsis

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Nuclear body-localized ARID1 is required for male germline f...

Screening Methods for Waterlogging Tolerance at Maize (Zea mays L.) Seedling Stage

中国遗传学会第九次全国会员代表大会暨学术研讨会

作者： zheng Yan-hua He Hui Sheila McCormick zheng Bing-lian State Key Laboratory of Genetic Engineering and Institute of Plant Biology School of Life SciencesFudan University Plant Gene Expression Center USDA/ARS and Dept.of Plant and Microbial BiologyUC-BerkeleyAlbanyCA 94710

ARID(AT-Rich Interacting Domain)proteins in animals are involVed in cell cycle regulation Although the ARID domain is conserved and widely present in plants,the function Of plant ARID proteins has been largely *** role of ARID proteins in sperm cell formation in plants is panicularly intriguing given that mature pollen is composed of a vegetatiVe cell and two sperm cells which are established by two consecutive *** we show that a pollen-specific ARID

关键词： ARID Nuclear bodies Epigenetic regulation Male germline formation

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Agricultural Sciences in China 2010年第3期9卷 362-369页

作者： LIU Yong-zhong, TANG Bin, zheng Yong-lian, MA Ke-jun, XU Shang-zhong and QIU Fa-zhan National Key Laboratory of Crop Genetic Improvement/Huazhong Agricultural University, Wuhan 430070, P.R.China National Key Laboratory of Crop Genetic Improvement/Huazhong Agricultural University Wuhan 430070 P.R.China

Waterlogging strongly affects agronomic performance of maize （Zea mays L.）. In order to investigate the suitable selection criteria of waterflooding tolerant genotypes, and identify the most susceptible stage and the best continuous treatment time to waterlogging, 20 common maize inbred lines were subjected to successive artificial waterflooding at seedling stage, and waterlogging tolerance coefficient （WTC） was used to screen waterflooding tolerant genotypes. In addition, peroxidase （POD） activities and malondialdehyde （MDA） contents were measured for 6 of 20 lines. The results showed that the second leaf stage （V2） was the most susceptible stage, and 6 d after waterflooding was the best continuous treatment time. Dry weight （DW） of both shoots and roots of all lines were significantly reduced at 6 d time-point of waterlogging, compared to control. POD activities and MDA contents were negatively and significantly correlated, and the correlation coefficient was -0.9686 （P 〈 0.0001）. According to the results, WTC of shoot DW can be used for practical screening as a suitable index, which is significantly different from control and waterlogged plants happened 6 d earlier. Furthermore, leaf chlorosis, MDA content and POD activities could also be used as reference index for material screening. The implications of the results for waterlogging-tolerant material screening and waterlogging-tolerant breeding have been discussed in maize.

关键词： maize (Zea mays L.) waterlogging tolerance screening method selection criteria

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老年人的厌氧菌感染

中华老年医学杂志 1989年第2期8卷 72-74页

作者：郑德联上海医科大学华山医院

报道1979年7月至1987年4月间，我院老年人厌氧菌感染的临床与实验室研究结果。所有患者均自脓液或血液检获厌氧菌，计局灶感染19例，败血症3例。厌氧菌的检出率分别为37.3%和2%，同期需氧菌检出率分别为41.2%和9.3%。25株厌氧菌进行了... 详细信息

报道1979年7月至1987年4月间，我院老年人厌氧菌感染的临床与实验室研究结果。所有患者均自脓液或血液检获厌氧菌，计局灶感染19例，败血症3例。厌氧菌的检出率分别为37.3%和2%，同期需氧菌检出率分别为41.2%和9.3%。25株厌氧菌进行了药物敏感度测定，结果提示厌氧菌为老年人感染的常见和重要致病菌。对厌氧菌感染的诱发因素、特点、治疗与预后等进行了讨论。

关键词：厌氧菌感染肺浓肿脑脓肿

采用双曲柄调距机构的垂直轴风力发电机机理研究与样机设计

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机械设计 2016年第8期33卷 100-104页

作者：廉正光天津职业大学机电工程与自动化学院天津300410

针对传统垂直轴风力发电机存在的低速启动力矩小和风能利用效率低的问题,提出了一种新型可变桨距的垂直轴风力发电机机理。该风力发电机采用双曲柄调距机构及双偏心轴牵引机构实现桨叶桨距角的周期性变化和牵引点位置的调整。首先对该... 详细信息

针对传统垂直轴风力发电机存在的低速启动力矩小和风能利用效率低的问题,提出了一种新型可变桨距的垂直轴风力发电机机理。该风力发电机采用双曲柄调距机构及双偏心轴牵引机构实现桨叶桨距角的周期性变化和牵引点位置的调整。首先对该机构进行运动学分析,证明其调距功能满足正弦规律,然后对机构进行了详细设计并完成了原理样机的制造和测试,证明文中所提出的风力发电机机理正确可行。该文的研究和设计工作为今后新型垂直轴风力发电机的探索和研制提供了有益参考。

关键词：变桨距调距机构垂直轴风力发电机风电效率

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马克思主义方法论在思政教育研究中的创新

山西财经大学学报 2023年第S2期45卷 133-135页

作者：金正连重庆工业职业技术学院重庆401120

学校在开展思想政治教育活动时,需要转变学生的一些思想政治观念,同时也要对学生的思想观和价值观进行积极的培养。教师要充分借助马克思主义方法论进行教学,提高自己的专业性以及对马克思主义方法论的理解,从而促进思想教育的发展与创新。

关键词：马克思主义方法论思想政治教育创新精神

“思想道德修养与法律基础”课案例教学法的再思考

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中国青年政治学院学报 2008年第3期27卷 134-138页

作者：郑彩莲温州大学美术与设计学院浙江温州325035

"思想道德修养与法律基础"课案例教学法应融合传统案例教学法与实践教学法的优点于一体,重点突出对案例问题的引导、案例的编制、案例问题的回答及考核模式的多样化等,以切实提高该课的实效性,使该课真正发挥其应有的育人功能,成为深受... 详细信息

"思想道德修养与法律基础"课案例教学法应融合传统案例教学法与实践教学法的优点于一体,重点突出对案例问题的引导、案例的编制、案例问题的回答及考核模式的多样化等,以切实提高该课的实效性,使该课真正发挥其应有的育人功能,成为深受学生欢迎的课程。

关键词： “思想道德修养与法律基础”课案例教学法实践教学法

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全钒液流电池新型交错蛇型流道研究

工程热物理学报 2020年第5期41卷 1166-1171页

作者：孙洁郑梦莲俞自涛浙江大学能源学院热工与动力系统研究所杭州310027 能源清洁利用国家重点实验室杭州310027

本文在传统全钒液流电池交叉型流道和蛇型流道的基础上提出了新型交错蛇型流道。基于全钒液流电池三维瞬态模型模拟结果,总结了新型交错蛇型流道与传统蛇型流道和交叉型流道对电解液渗入量、电解液在电极中分布的均匀性以及泵损失等参... 详细信息

本文在传统全钒液流电池交叉型流道和蛇型流道的基础上提出了新型交错蛇型流道。基于全钒液流电池三维瞬态模型模拟结果,总结了新型交错蛇型流道与传统蛇型流道和交叉型流道对电解液渗入量、电解液在电极中分布的均匀性以及泵损失等参数的影响规律。研究结果表明,交错蛇型流道的设计在确保电解液全部渗入和一次性渗入渗出电极的同时也在电极中具有较大的当地速度和反应离子浓度,这些优势使交错蛇型流道的电池性能优于传统交叉型和传统蛇型流道电池。

关键词：全钒液流电池蛇型流道三维瞬态模型传质过程