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Extracellular Signal-Regulated Kinase in Nucleus Accumbens Mediates Propofol Self-Administration in Rats

Neuroscience Bulletin 2016年第6期32卷 531-537页

作者： Benfu Wang Xiaowei Yang Anna Sun Lanman Xu Sicong Wang Wenxuan Lin Miaojun Lai Huaqiang Zhu Wenhua Zhou Qingquan lian Department of Anesthesiology and Pain Medicine the Second Affiliated Hospital of Wenzhou Medical University Laboratory of Behavioral Neuroscience Ningbo Addiction Research and Treatment CenterSchool of MedicineNingbo University Department of Infection and Liver Diseases the First Affiliated Hospital of Wenzhou Medical University

Abstract Clinical and animal studies have indicated that propofol has potential for abuse, but the specific neurobi- ological mechanism underlying propofol reward is not fully understood. The purpose of this study was to inves- tigate the role of extracellular signal-regulated kinase （ERK） signal transduction pathways in the nucleus accumbens （NAc） in propofol self-administration. We tested the expression of p-ERK in the NAc following the maintenance of propofol self-administration in rats. We also assessed the effect of administration of SCH23390, an antagonist of the D1 dopamine receptor, on the expression of p-ERK in the NAc in propofol self-administering rats, and examined the effects of intra-NAc injection of U0126, an MEK inhibitor, on propofol reinforcement in rats. The results showed that the expression of p-ERK in the NAc increased significantly in rats maintained on propofol, and pre-treatment with SCH23390 inhibited the propofol self- administration and diminished the expression of p-ERK in the NAc. Moreover, intra-NAc injection of U0126 （4 μg/ side） attenuated the propofol self-administration. The data suggest that ERK signal transduction pathways coupledwith D1 dopamine receptors in the NAc may be involved in the maintenance of propofol self-administration and its rewarding effects.

关键词： Dopamine receptor Drug reward ERK Anesthesiology Nucleus accumbens

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Study on WSN Localization Algorithm and Simulation Model for Intelligent Transportation System

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International Journal of Technology Management 2013年第2期 23-27页

作者： lian-zhou GAO Henan Vocational and Technical College of Communications ZhengZhou Henan 450005 China

This paper conducts research on the algorithm to improve the location of Wireless Sensor Network （WSN） in Intelligent Transportation System （ITS）. The localization algorithm introduced an improved RSSI vehicle localization algorithm based on multi-path effect and Gaussian white noise. The localization results under different values of Gaussian white noise and different density of beacon nodes are analyzes, and Kalman filtering algorithm is introduced to reduce the influence of signal noise. Finally, a simulation model of ITS is developed to test the algorithm based on mixed noise and Kalman filtering algorithm, which is used to simulate the localization of real vehicles. The simulation shows the algorithm has effect to improve location accuracy and to application

关键词： Intelligent Transportation System Wireless Sensor Network vehicle localization Gaussian white noise Kalman filteringalgorithm

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An HPLC-MS/MS method for the quantitative determination of platy-codin D in rat plasma and its application to the pharmacokinetics of Platycodi Radix extract

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Chinese Journal of Natural Medicines 2014年第2期12卷 154-160页

作者： ZHAN Qin ZHANG Feng GAO Shou-Hong CAI Fei JIANG Bo SUN lian-Na CHEN Wan-Sheng Department of Pharmacy Changzheng Hospital Second Military Medical University Modern Research Center for Traditional Chinese Medicine Second Military Medical University Department of Pharmacognosy School of Pharmacy Second Military Medical University

AIMS: To develop an HPLC-MS/MS method for the quantification of platycodin D(PD) in rat plasma, and to acquire the main pharmacokinetic parameters of PD after oral administration of pure PD or of Platycodi Radix extract(PRE) containing PD. METHOD: Plasma samples were pretreated with solid-phase extraction using an Oasis HLB SPE cartridge. Madecassoside was used as the internal standard(IS). Chromatographic separation was achieved on an ODS column(100 mm × 2.1 mm i.d., 3.5 μm) with a mobile phase consisting of acetonitrile/water(30 : 70, V/V) containing 0.1 mmol L 1ammonium acetate at a flow rate of 0.25 mL min 1. The detection was performed on a triple quadruple tandem mass spectrometer using an electrospray ionization(ESI) source with a chromatographic run time of 3.0 min. The detection was operated by multiple reaction monitoring(MRM) of the transitions of m/z 1 223.6→469.2 for PD and of m/z 973.6→469.2 for madecassoside(IS), respectively. RESULTS: The calibration curve was linear from 5 to 2 000 ng mL 1(r2>0.99) with a lower limit of quantification(LLOQ) of 5 ng mL 1. The intra- and inter-day precision(relative standard deviation, RSD) values were below 15% and the accuracy(relative error, RE) was from 15% to +15% at three quality control(QC) levels. Plasma concentrations of PD were determined for 24 h after i.v. administration of PD, and oral administration of PD and PRE, respectively. The absolute oral bioavailability of PD in rats was found to be(0.48 ± 0.19)% when administered PD, and to be(1.81 ± 0.89)% when administered PRE. CONCLUSION: The developed HPLC-MS/MS method was successfully applied to assess the pharmacokinetic parameters and oral bioavailability of PD in rats after administration of PD and Platycodi Radix extract.

关键词： Platycodi Radix Platycodon grandiflorus Platycodin D HPLC-MS/MS Pharmacokinetics Rat plasma

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Effects of Zishen Yutai Pills on in vitro Fertilization-Embryo Transfer Outcomes in Patients with Diminished Ovarian Reserve:A Prospective,Open-Labeled,Randomized and Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 291-298页

作者： LI Xiu-fang WANG Zhong-qing XU Hai-yan LIU Hong SHENG Yan XU Jin LI Yuan-mei lian Fang The First Clinical College Shandong University of Traditional Chinese MedicineJinan 250014China Center for Reproductive Medicine Shandong UniversityJinan 250021China Medical College of Optometry and Ophthalmology Shandong University of Traditional Chinese MedicineJinan 250014China Department of Traditional Chinese Medicine Jinan Golden Time Health Nursing HospitalJinan 250000China Reproductive and Genetic Center of Integrated Traditional and Western Medicine Affiliated Hospital of Shandong University of Traditional ChineseJinan 250011China Medicine

Objective:To explore the effects of Zishen Yutai Pills(ZYPs)on the quality of oocytes and embryos,as well as pregnancy outcomes in patients with diminished ovarian reserve(DOR)receiving in vitro fertilizationembryo transfer(IVF-ET).The possible mechanisms,involving the regulation of bone morphogenetic protein 15(BMP15)and growth differentiation factor 9(GDF9),were also ***:A total of 120 patients with DOR who underwent their IVF-ET cycle were randomly allocated to 2 groups in a 1:1 *** patients in the treatment group(60 cases)received ZYPs from the mid-luteal phase of the former menstrual cycle by using gonadotropin-releasing hormone(Gn RH)antagonist *** patients in the control group(60 cases)received the same protocol but without *** primary outcomes were the number of oocytes retrieved and high-quality *** outcomes included other oocyte or embryo indices as well as pregnancy *** events were assessed by comparison of the incidence of ectopic pregnancy,pregnancy complications,pregnancy loss,and preterm *** of BMP15 and GDF9 in the follicle fluids(FF)were also quantified with enzymelinked immunosorbent ***:Compared with the control group,the numbers of oocytes retrieved and high-quality embryos were significantly increased in the ZYPs group(both P0.05).The administration of ZYPs did not increase the incidence of adverse *** expressions of BMP15 and GDF9 in the ZYPs group were significantly up-regulated compared with the control group(both P<0.05).Conclus

关键词： Zishen Yutai Pills diminished ovarian reserve in vitro fertilization-embryo transfer oocytes embryos

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Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-κB signaling pathway

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World Journal of Gastroenterology 2019年第24期25卷 3044-3055页

作者： Yan-Zhen Zhang Jian-Ning Yao lian-Feng Zhang Chun-Feng Wang Xue-Xiu Zhang Bing Gao Department of Second Gastroenterology the First Affiliated Hospital of Zhengzhou University

BACKGROUND The formation of liver fibrosis is mainly caused by the activation of hepatic stellate cells(HSCs)and the imbalance of extracellular matrix(ECM)production and *** treatment of liver fibrosis mainly includes removing the cause,inhibiting the activation of HSCs,and inhibiting ***-like receptor(NLR)family,caspase activation and recruitment domain(CARD)domain containing 5/NOD27/CLR16.1(NLRC5)is a highly conserved member of the NLR family and is involved in inflammation and immune responses by regulating various signaling pathways such as nuclear factor-κB(NF-κB)*** has been found that NLRC5 plays an important role in liver fibrosis,but its specific effect and possible mechanism remain to be fully *** To investigate the role of NLRC5 in the activation and reversion of HSCs induced with transforming growth factor-β(TGF-β)and MDI,and to explore its relationship with liver *** A total of 24 male C57BL/6 mice were randomly divided into three groups,including normal,fibrosis,and recovery ***-four hours after a liver fibrosis and spontaneous reversion model was established,the mice were sacrificed and pathological examination of liver tissue was performed to observe the degree of liver fibrosis in each ***-2 cells were cultured in vitro and treated with TGF-β1 and ***-time quantitative PCR(qPCR)and Western blot were used to analyze the expression levels of NLRC5,α-smooth muscle actin(α-SMA),and collagen type I alpha1(Col1a1)in each *** activity of NF-κB in each group of cells transfected with NLRC5-siRNA was *** Compared with the normal mice,the expression level of NLRC5 increased significantly(P<0.01)in the fibrosis group,but decreased significantly in the recovery group(P<0.01).In in vitro experiments,the content of NLRC5 was enhanced after TGF-β1 stimulation and decreased to a lower level when treated with MDI(P<0.01).The expression ofα-SMA and Col1a1 proteins and mRN

关键词： NLRC5 Hepatic stellate cells Liver fibrosis Recovery

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Characteristic analysis of 5D symmetric Hamiltonian conservative hyperchaotic system with hidden multiple stability

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Chinese Physics B 2024年第1期33卷 303-315页

作者：黄丽莲马衍昊李创 College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Advanced Marine Communication and Information Technology Ministry of Industry and Information TechnologyHarbin Engineering UniversityHarbin 150001China National Key Laboratory of Underwater Acoustic Technology Harbin Engineering UniversityHarbin 150001China

Conservative chaotic systems have unique advantages over dissipative chaotic systems in the fields of secure communication and pseudo-random number generator because they do not have attractors but possess good traversal and pseudorandomness. In this work, a novel five-dimensional(5D) Hamiltonian conservative hyperchaotic system is proposed based on the 5D Euler equation. The proposed system can have different types of coordinate transformations and time reversal symmetries. In this work, Hamilton energy and Casimir energy are analyzed firstly, and it is proved that the new system satisfies Hamilton energy conservation and can generate chaos. Then, the complex dynamic characteristics of the system are demonstrated and the conservatism and chaos characteristics of the system are verified through the correlation analysis methods such as phase diagram, equilibrium point, Lyapunov exponent, bifurcation diagram, and SE complexity. In addition, a detailed analysis of the multistable characteristics of the system reveals that many energy-related coexisting orbits exist. Based on the infinite number of center-type and saddle-type equilibrium points, the dynamic characteristics of the hidden multistability of the system are revealed. Then, the National Institute of Standards and Technology(NIST)test of the new system shows that the chaotic sequence generated by the system has strong pseudo-random. Finally, the circuit simulation and hardware circuit experiment of the system are carried out with Multisim simulation software and digital signal processor(DSP) respectively. The experimental results confirm that the new system has good ergodicity and realizability.

关键词： Hamilton conservative hyperchaotic system symmetry wide parameter range hide multiple stability

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An n–n type heterojunction enabling highly efficient carrier separation in inorganic solar cells

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Chinese Physics B 2022年第3期31卷 60-65页

作者： Gang Li Yuqian Huang Rongfeng Tang Bo Che Peng Xiao Weitao lian Changfei Zhu Tao Chen Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringSchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China Institute of Energy Hefei Comprehensive National Science CenterHefei 230026China

Carrier separation in a solar cell usually relies on the p–n junction. Here we show that an n–n type inorganic semiconductor heterojunction is also able to separate the exciton for efficient solar cell applications. The n–n type heterojunction was formed by hydrothermal deposition of Sb_(2)(S,Se)_(3) and thermal evaporation of Sb_(2)Se_(3). We found that the n–n junction is able to enhance the carrier separation by the formation of an electric field, reduce the interfacial recombination and generate optimized band alignment. The device based on this n–n junction shows 2.89% net efficiency improvement to 7.75%when compared with the device consisted of semiconductor absorber–metal contact. The study in the n–n type solar cell is expected to bring about more versatile materials utility, new interfacial engineering strategy and fundamental findings in the photovoltaic energy conversion process.

关键词： n–n junction carrier separation solar cell antimony selenosulfide thin film

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Au对Al-1.7Cu合金均匀化的影响

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粉末冶金材料科学与工程 2016年第2期21卷 209-216页

作者：曹恋郑子樵李世晨中南大学材料科学与工程学院长沙410083

分别对Al-1.7Cu和Al-1.7Cu-Au(摩尔分数,%)合金铸锭在530℃/24 h条件下进行均匀化处理,采用X线衍射仪(XRD)、扫描电镜(SEM)、X线能谱仪(EDS)和电子探针(EPMA)等对合金的形貌与结构进行观察与分析,研究微合金化元素Au对该合金均匀化过程... 详细信息

分别对Al-1.7Cu和Al-1.7Cu-Au(摩尔分数,%)合金铸锭在530℃/24 h条件下进行均匀化处理,采用X线衍射仪(XRD)、扫描电镜(SEM)、X线能谱仪(EDS)和电子探针(EPMA)等对合金的形貌与结构进行观察与分析,研究微合金化元素Au对该合金均匀化过程的影响以及Au在铸态和均匀化态合金中的存在形式。结果表明:铸态Al-1.7Cu和Al-1.7Cu-Au合金均析出大量Al_2Cu相,但Al-Cu-Au合金还析出一定量的Al-Cu-Au相,该相主要沿晶界分布,其形貌与初生Al_2Cu相明显不同,为白色骨头状组织,化学计量比为Al_2(Cu_(0.5),Au_(0.5))均匀化后初生Al_2Cu相大部分回溶,而Al_2(Cu_(0.5),Au_(0.5))相为难溶相,只发生熔断球化,其中的部分Cu回溶,化学计量配比转变为Al_2(Cu_(0.25),Au_(0.75)):均匀化后Al-Cu合金的Cu完全固溶到Al基体中,而Al-Cu-Au合金中只有约90%的Cu固溶到Al基体中,约10%的Cu仍偏聚在Al_2(Cu_(0.25),Au_(0.75))相中。可见添加微量Au影响Al-Cu合金中Cu原子的扩散和偏聚情况。

关键词： Au Al-1.7Cu合金铸态均匀化 Al2Cu 空位结合能

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Effect of Yupingfeng granules on HA and Foxp3^+ Treg expression in patients with nasopharyngeal carcinoma

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 662-664页

作者： Ji-Hong Huang Zhong-Lin Mu Xue-Jun Zhou Qiong-lian Huang Feng Gao Xi Chen Hainan Medical University

Objective: To investigate the effect of Yupingfeng on hyaluronic acid(HA) and Foxp3+ Treg in patients with nasopharyngeal carcinoma. Methods: A total of 58 cases of nasopharyngeal carcinoma were divided into two groups, 30 cases in the treatment group, 28 cases in the control group. Patients in two groups were treated with synchronous radiotherapy and chemotherapy treatment, the treatment group was treated with the Yupingfeng granules through oral administration, 10 g/time, tid for 2 courses. The serum Foxp3+ Treg markers of each group were detected by flow cytometry assay before treatment and after treatment, and the level of HA in serum was detected by radio immunoassay. Results: After radiotherapy and chemotherapy, the contents of Foxp3+ Treg and HA were significantly decreased in two groups(P<0.05), and the decrease of treatment group was more significantly(P<0.01). Correlation analysis showed positive correlation between Foxp3+ Treg and HA(P<0.05). After treatment, the incidence of side effects in two groups was significantly decreased. And there was significant difference between two groups(P<0.05). Conclusions: Combined chemotherapy and radiotherapy with Yupingfeng treatment can decrease the levles of Foxp3+ Treg and HA in nasopharyngeal carcinoma patients. Yupingfeng can also effectively reduce the side effect due to radiation and chemotherapy.

关键词： Nasopharyngeal carcinoma Yupingfeng Foxp3 Treg HA

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大型局域网中VLAN间可靠通信的仿真设计

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计算机仿真 2015年第7期32卷 296-302页

作者：廉佐政王海珍齐齐哈尔大学计算中心黑龙江齐齐哈尔161006 齐齐哈尔大学计算机与控制工程学院黑龙江齐齐哈尔161006

VLAN间可靠通信中高宽带高速通信规划和设计问题,是网络规划与设计课程的教学重点。为了提高通信性能,设计并仿真了大型局域网VLAN间可靠通信实验,即先采用LITO模拟器设计以交换机为核心的三层架构组网模型,然后应用链路聚合、多生成树... 详细信息

VLAN间可靠通信中高宽带高速通信规划和设计问题,是网络规划与设计课程的教学重点。为了提高通信性能,设计并仿真了大型局域网VLAN间可靠通信实验,即先采用LITO模拟器设计以交换机为核心的三层架构组网模型,然后应用链路聚合、多生成树协议等网络可靠性技术以及VLAN、ospf协议实现各设备的配置,最后验证网络通信的可靠性,并对验证结果进行分析。结果分析显示模型实现了VLAN间的可靠通信,而且通过该模型的设计、仿真,增强学生理解和应用可靠性技术、VLAN技术、路由协议等知识的能力。

关键词：大型局域网模拟器交换机可靠通信

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