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World Journal of Gastroenterology 2016年第13期22卷 3693-3700页

作者： Hui Jiang Na Ta Xiao-Yi Huang Ming-Hua Zhang Jing-Jing Xu Kai-lian zheng Gang Jin Jian-Ming zheng Department of Pathology Changhai Hospital Second Military Medical University Department of General Surgery Changhai Hospital Second Military Medical University

Perivascular epithelioid cell tumor(PEComa) of the pancreas is an unusual tumor deriving from mesenchyma. This paper described a case of pancreatic PEComa, which was initially suspected as neuroendocrine carcinoma by biopsy, and therefore surgical treatment was recommended due to undetermined diagnosis. Examination of the surgical specimen under a microscope showed that the tumor cell's morphology was epithelioid or spindle-shaped, and ranged in a nested pattern. Additionally, these cells had a large extent of acidophilic cytoplasm, no mitotic figures, and expressed HMB-45, melan-p, and smooth muscle actin immunohistochemically. Pathological examination indicated that PEComa originated from the pancreas, but symptoms related to tuberous sclerosis were absent. Since PEComa is extremely rare in the pancreas, it is likely to be ignored in differential diagnosis. In conclusion, our article highlighted the clinicopathological features of PEComa, and we conducted a literature review focusing on PEComa so as to deepen the understanding of this tumor type.

关键词： Pancreas Perivascular epithelioid cell tumor HMB-45 Immunohistochemistry Clinicopathological feature

Arabidopsis Di 19 Functions as a Transcription Factor and Modulates PR1, PR2, and PR5 Expression in Response to Drought Stress

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Molecular Plant 2013年第5期6卷 1487-1502页

作者： Wen-Xin Liu Fei-Cui Zhang Wen-zheng Zhang lian-Fen Song Wei-Hua Wu Yi-Fang Chen State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University National Plant Gene Research Centre (Beijing) #2 West Yuan Ming Yuan Rd Beijing 100193 China

The Arabidopsis Di19 （Drought-induced） gene family encodes seven Cys2/His2-type zinc-finger proteins, most with unknown functions. Here, we report that Di19 functioned as a transcriptional regulator and was involved in Arabidopsis responses to drought stress through up-regulation of pathogenesis-related PR1, PR2, and PR5 gene expres- sions. The Di19 T-DNA insertion mutant di19 was much more sensitive to drought stress, whereas the Di19-overexpressing lines were much more tolerant to drought stress compared with wild-type plants. Di19 exhibited transactivation activity in our yeast assay, and its transactivation activity was further confirmed in vivo. DNA-binding analysis revealed that Di19 could bind to the TACA（A/G）T element and chromatin immunoprecipitation （CHIP） assays demonstrated that Di19 could bind to the TACA（A/G）T element within the PR1, PR2, and PR5 promoters, qRT-PCR results showed that Di19 promoted the expressions of PR1, PR2, and PRS, and these heightened expressions were enhanced by CPK11, which interacted with Di19 in the nucleus. Similarly to the Di19-overexpressing line, PRI-, PR2-, and PRS-overexpressing lines also showed the drought-tolerant phenotype. The pre-treatment with salicylic acid analogs INA can enhance plants＇ drought tolerance. Taken together, these data demonstrate that Di19, a new type of transcription factor, directly up-regulates the expres- sions of PR1, PR2, and PR5 in response to drought stress, and its transactivation activity is enhanced by CPK11.

关键词： Arabidopsis Di19 transcription factor drought stress PRll PR2 PR5.

Flow of a Viscoelastic Fluid through a Porous Channel with Expanding or Contracting Walls

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Chinese Physics Letters 2011年第4期28卷 133-136页

作者： SI Xin-Hui zheng lian-Cun WANG Xin-Xin SI Xin-Yi YANG Jian-Hong Department of Mathematics and Mechanics University of Science and Technology BeijingBeijing 100083 Department of Mechanical Engineering University of Science and Technology BeijingBeijing 100083 College of Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098

The flow of a viscoelastic fluid in porous channels with expanding or contracting walls is *** a similar transformation,the governing equations are reduced to a nonlinear fifth-order differential *** homotopy analysis method is employed to obtain the expression for velocity *** analytical solutions are influenced by the permeation Reynolds number Re,the wall expansion ratio a and viscoelastic parameter *** are sketched and the effects of some values of parameters,especially the expansion ratio,on the velocity fields are discussed in detail.

关键词： equation viscoelastic expansion

Isolating the Mutator Transposable Element Insertional Mutant Gene mio16 of Maize Using Double SelectedAmplification of Insertion Flanking Fragments (DSAIFF)

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Journal of Integrative Agriculture 2012年第10期11卷 1592-1600页

作者： ZHONG Wen-juan ZHANGMei-dong YANG Liu-qi WANG Ming-chun zheng Yong-lian YANG Wen-peng GAO You-jun National Key Laboratory of Crop Genetic Improvement/Huazhong Agricultural University Institute of Upland Food Crops Guizhou Academy of Agricultural Sciences/Guizhou Center of Maize Engineering Techniques

Mutator transposable element （Mu） has been used as an effective tool to clone maize （Zea mays L.） genes. One opaque endosperm mutant （miol6） was identified in a pool of Mu inserted mutants. A modified method, termed the double selected amplification of insertion flanking fragments （DSAIFF）, was employed to isolate the Mu flanking fragments （MFFs） of miol6. The target site duplications （TSDs） isolated from the Msp I and Mse I digested MFFs had a same 9-bp sequence and were confirmed to be the flanking sequence of one identically inserted gene. Co-segregation analysis suggested that the MFFs were associated with the mutant opaque endosperm, and miol6 was mapped in silico onto the physical position ranged from 229 965 021 to 229 965 409 bp of the maize chromosome 4.09 bin. The full-length cDNA of the wild-type gene was obtained by an RT-PCR primer-scanning technique, and Mio16 was found to putatively encode a homolog of the Arabidopsis MAP3K delta-1 protein kinase. RT-PCR result the mRNA expression of miol6 region anchored by primers Mu20 and af276 was not interrupted by Mu insertion. Further researches will be done to elucidate how the expression of miol6 is alternated by Mu insertion.

关键词： maize (Zea mays L.) Mutator (Mu) transposable element Mu flanking fragments (MFFs) double selected amplification of insertion flanking fragments (DSAIFF) miol6

Mortality in patients with COVID-19 requiring extracorporeal membrane oxygenation:A meta-analysis

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World Journal of Clinical Cases 2022年第8期10卷 2457-2467页

作者： Ye Zhang Lei Wang Zhi-Xian Fang Jing Chen Jia-lian zheng Ming Yao Wen-Yu Chen Department of General Practice Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Respiration Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Oncology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pain Medicine Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)has become a worldwide pandemic and significant public health *** effectiveness of extracorporeal membrane oxygenation(ECMO)in treating COVID-19 patients has been called into *** To conduct a meta-analysis on the mortality of COVID-19 patients who require *** This analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes 2020(PRISMA)and has been registered at the International Prospective Register of Systematic Reviews(number CRD42020227414).A quality assessment for all the included articles was performed by the Newcastle-Ottawa Scale(NOS).Studies with tenor more COVID-19 patients undergoing ECMO were *** random-effects model was used to obtain the pooled incidence of mortality in COVID-19 patients receiving *** source of heterogeneity was investigated using subgroup and sensitivity *** We identified 18 articles with 1494 COVID-19 patients who were receiving *** score of the quality assessment ranged from 5 to 8 on the *** majority of patients received veno-venous ECMO(93.7%).Overall mortality was estimated to be 0.31[95%confidence interval(CI):0.24-0.39;I2=84.8%]based on random-effect pooled *** were significant differences in mortality between location groups(33.0%vs 55.0%vs 37.0%vs 18.0%,P<0.001),setting groups(28.0%vs 34.0%,P<0.001),sample size(37.0%vs 31.0%,P<0.001),and NOS groups(39.0%vs 19.0%,P<0.001).However,both subgroup analyses based on location,setting,and sample size,and sensitivity analysis failed to identify the source of *** funnel plot indicated no evident asymmetry,and the Egger’s(P=0.95)and Begg’s(P=0.14)tests also revealed no significant publication *** With more resource assessment and risk-benefit analysis,our data reveal that ECMO might be a feasible and effective treatment for COVID-19 patients.

关键词： COVID-19 Extracorporeal membrane oxygenation SARS-CoV-2 Meta-analysis Veno-venous extracorporeal membrane oxygenation Mortality

Using the Phosphomannose Isomerase (PMI) Gene from Saccharomyces cerevisiae for Selection in Rice Transformation

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Journal of Integrative Agriculture 2012年第9期11卷 1391-1398页

作者： WANG Tao LIU liang-yu TANG Yong-yan ZHANG Xiao-bo ZHANG Mei-dong zheng Yong-lian ZHANG Fang-dong National Key Laboratory of Crop Genetic Improvement Ministry of Science and Technology/Huazhong Agricultural University Wuhan 430070P. R. China

The phosphomannose isomerase （PMI） gene from Saccharomyces cerevisiae acted as selectable marker and mannose acted as selective agent for the production of transgenic plants of rice （Oryza sativa L.） via Agrobacterium-mediated transformation. The concentration of mannose during the selection was stepwise increased, 5 g L-1 mannose combined with 15 g L-1 sucrose and 500 mg L-1 cefotaxime was used in the initial selection stage, then the concentration of mannose was increased to 11 g L-1, the highest transformation rate was 20.0%. The integration of PMI gene was confirmed by PCR, and the result of RT-PCR assay proved that the intron of PMI gene can be excised correctly during RNA splicing. 13- Glucuronidase （GUS） activity analysis confirmed the expression of GUS gene. All those means the PMI gene from yeast can be used as a selectable marker in rice transformation.

关键词： phosphomannose isomerase selectable marker Saccharomyces cerevisiae transformation rice

具有离散和分布时滞系统的鲁棒有限时间能量-峰值控制

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东北大学学报（自然科学版） 2016年第11期37卷 1536-1540页

作者：郑连伟东北大学理学院辽宁沈阳110819

研究了不确定线性时滞系统在有限时间能量-峰值性能指标约束下的鲁棒控制问题.系统的系数矩阵包含范数有界的不确定性,状态包含离散时滞和分布时滞.引入一个含参数的Lyapunov泛函,通过检验它的指数增长情况,为状态和输出定界,据此得到... 详细信息

研究了不确定线性时滞系统在有限时间能量-峰值性能指标约束下的鲁棒控制问题.系统的系数矩阵包含范数有界的不确定性,状态包含离散时滞和分布时滞.引入一个含参数的Lyapunov泛函,通过检验它的指数增长情况,为状态和输出定界,据此得到了闭环系统对于所有允许的不确定性有限时间有界以及满足预先指定的能量-峰值性能指标的充分条件,同时给出了状态反馈控制率.这些条件是有特征值约束的线性矩阵不等式,通过把特征值约束转换成非线性矩阵不等式,设计了锥补偿线性化(CCL)算法来求解这样的矩阵不等式,最后用数值算例验证了所得方法的有效性.

关键词：分布时滞有限时间有界性能量-峰值性能锥补偿线性化算法线性矩阵不等式

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不确定线性时滞系统的一种鲁棒镇定方法

东北大学学报（自然科学版） 2010年第8期31卷 1070-1073页

作者：郑连伟东北大学理学院辽宁沈阳110004

利用Lyapunov泛函方法研究了不确定线性时滞系统的鲁棒镇定问题.不确定性是范数有界的时变矩阵.为了估计Lyapunov泛函的导数,首先建立了两个对称矩阵Schur补之间的一个不等式,据此得到了一个关于不确定二次函数上界的不等式.通过对不确... 详细信息

利用Lyapunov泛函方法研究了不确定线性时滞系统的鲁棒镇定问题.不确定性是范数有界的时变矩阵.为了估计Lyapunov泛函的导数,首先建立了两个对称矩阵Schur补之间的一个不等式,据此得到了一个关于不确定二次函数上界的不等式.通过对不确定二次函数的估计和矩阵运算,把Lyapunov泛函导数的负定性转化为线性矩阵不等式的可行性问题,从而得到了系统可以鲁棒镇定的充分条件,同时用线性矩阵不等式的解构造了鲁棒状态反馈控制器的增益矩阵.数值算例表明,这种鲁棒镇定方法具有较小的保守性.

关键词：时滞系统鲁棒镇定 Lyapunov泛函线性矩阵不等式不确定性 Schur补

KKM Type Theorems and Coincidence Theorems in Topological Spaces

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Journal of Mathematical Research and Exposition 2008年第2期28卷 403-412页

作者： zheng lian DING Xie Ping Department of Mathematics Yangtze Normal University Chongqing 408100 China Department of Mathematics Sichuan Normal University Sichuan 610066 China

A class of finitely continuous topological spaces(in short,FC-spaces)is introduced. Some new KKM type theorems and coincidence theorems involving admissible set-valued map- pings and the set-valued mapping with compactly local intersection property are proved in FC- *** applications,some new fixed point theorems are obtained in *** theorems improve and generalize many known results in recent literature.

关键词： FC-space KKM type theorem coincidence theorem admissible set-valued map compactly local intersection property

Relationship of demoralization with anxiety, depression, and demographics of Chinese dialysis patients

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Journal of Integrative Nursing 2021年第4期3卷 155-160页

作者： Cai-Lan ZHUANG Juan-lian zheng Lei GAO Ying-Ling HUANG Wen-Jing HU Department of Nursing Huizhou First HospitalHuizhouGuangdong ProvinceChina Dialysis Center Huizhou First HospitalHuizhouGuangdong ProvinceChina Department of Nephrology Huizhou First HospitalHuizhouGuangdong ProvinceChina

Objective:The purpose of this study is to investigate the demoralization level of dialysis patients in China and analyze the influencing *** and Methods:A convenience sample of 278 dialysis patients from a tertiary hospital participated in a cross-sectional descriptive study using a structured questionnaire including assessments of demographic data,Demoralization Scale-II(DS-II),and Hospital Anxiety and Depression *** main analysis consisted of descriptive statistics,correlation coefficients,and multiple linear ***:The mean standard deviation DS-II score was 11.87(7.72).Dialysis patients had a high level of *** from multiple linear regression indicated that demoralization was positively correlated with marital status(β=0.141;P=0.001),employment status(β=0.113;P=0.006),anxiety(β=0.393;P<0.001),and depression(β=0.224;P<0.001).These variables explained 57.1%of the variance in patient ***:Demoralization is common in dialysis patients and is associated with marital status,employment status,anxiety,and ***-care providers might regularly assess demoralization in dialysis patients,and develop related interventions to improve the quality of life.

关键词： Anxiety demoralization depression hemodialysis peritoneal dialysis