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A method for support stiffness failure identification in a steel spring floating slab track of urban railway: a case study in China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 206-222页

作者： Junyuan zheng Caiyou ZHAO Duojia SHI Ping WANG Jian WANG Bolong jiang Xi SHENG Key Laboratoryof High-speed Railway Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 60031China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China 01 DYNA(Qingdao)Test&Data Co. Ltd.Qingdao 266000China Rail Transit Digital Construction and Measurement Technology National Engineering Research Center China Railway Design CorporationTianjin300308China Institute of Urban Smart Transportation&Safety Maintenance Shenzhen UniversityShenzhen 518060China

The extensive use of steel spring floating slab tracks has effectively addressed the challenge of alleviating the environmental vibrations induced by urban rail transit systems.However,under the combined action of train dynamic loads and complex environmental factors,problems,such as the fracture of steel spring vibration isolators and suspension vibrations induced by the uneven settlement of the base,often occur.The failure of isolator support stiffness is often hidden in its early stages and is challenging to identify by conventional detection methods.At the same time,it will aggravate the wheel-rail interaction,accelerate the deterioration of track structure,and even affect the driving safety.This study first establishes a detailed coupled train-floating slab track-foundation analytical model.Then the influence of the vibration isolator support stiffness failure on the dynamic indices of the floating slab track system response is analyzed.A set of defect identification methods that can detect the number of failed steel springs,severity of damage,and their location is proposed.Finally,an intelligent monitoring system for support stiffness of floating slab track is built by combining the density-based spatial clustering of applications with noise algorithm and statistical data analysis and is applied to a rail line in southern China.During a three-year monitoring campaign,a suspension failure and a fracture of a steel spring were each successfully detected and detailed failure information was obtained.Field investigation results were consistent with the damage identification results.After repair,the track structure dynamic response returned to the average pre-damage level and further deterioration had been arrested.The proposed damage identification methods and monitoring system provide an approach for intelligent identification of track structure support stiffness failures.

关键词： Floating slab track Support stiffness Detailed analytical model Failure identification Monitoring system

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Constructing extrinsic oxygen vacancy on the surface of photocatalyst as CO_(2)and electrons reservoirs to improve photocatalytic CO_(2)reduction activity

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Journal of Environmental Sciences 2024年第6期140卷 37-45页

作者： Zaiyong jiang Hao Li Zhimin Yuan zheng Wang Maohong Fan Wenkang Miao Hong He State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Chemistry&Chemical Engineering and Environmental Engineering Weifang UniversityWeifangShandong 261061China Departments of Chemical and Petroleum Engineering University of WyomingLaramieWY 82071USA Materials Genome Institute Shanghai UniversityShanghai 200444China

Constructing own oxygen vacancies in the photocatalysts is a very promising method to improve their photocatalytic CO_(2)reduction activity.However,some catalysts have excellent stabilities,making it difficult for them to construct their own oxygen vacancies.To simplify the above difficulty of stable photocatalysts,constructing extrinsic oxygen vacancies on their surface as a novel idea is proposed.Here,a stable TiO_(2)nanosheet is chosen as a research object,we uniformly deposited BiOCl quantum dots on their surface via a simple adsorption-deposition method.It is found that BiOCl quantum dots are able to simultaneously self-transform into defective BiOCl with many oxygen vacancies when the photocatalyst is performed photocatalytic CO_(2)reduction.These extrinsic oxygen vacancies can act as“CO_(2)and photo-generated electrons reservoirs”to improve CO_(2)capture and accelerate the separation of photogenerated electrons and holes.For the above reasons,the modified TiO_(2)showed obvious enhancement of photocatalytic CO_(2)reduction compared to pristine TiO_(2)and BiOCl.This work may open a new avenue to broaden the use of oxygen vacancies in the process of photocatalytic CO_(2)reduction.

关键词： Oxygen vacancy BiOCl Photocatalyst CO_(2)reduction TiO_(2)

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Efficient and reversible separation of NH_(3) by deep eutectic solvents with multiple active sites and low viscosities

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Chinese Journal of Chemical Engineering 2024年第3期67卷 97-105页

作者： Jiayin Zhang Lu zheng Siqi Fang Hongwei Zhang Zhenping Cai Kuan Huang Lilong jiang National Engineering Research Center of Chemical Fertilizer Catalyst(NERC-CFC) College of Chemical EngineeringFuzhou UniversityFuzhou 350002China Qingyuan Innovation Laboratory Quanzhou 362801China

The efficient separation and collection of ammonia(NH_(3))during NH_(3) synthesis process is essential to improve the economic efficiency and protect the environment.In this work,ethanolammonium hydrochloride(EtOHACl)and phenol(PhOH)were used to prepare a novel class of deep eutectic solvents(DESs)with multiple active sites and low viscosities.The NH_(3) separation performance of EtOHACl+PhOH DESs was analyzed completely.It is figured out that the NH_(3) absorption rates in EtOHACl+PhOH DESs are very fast.The NH_(3) absorption capacities are very high and reach up to 5.52 and 10.74 mol·kg1 at 11.2 and 100.4 kPa under 298.2 K,respectively.In addition,the EtOHACl+PhOH DESs present highly selective absorption of NH_(3) over N_(2) and H_(2) and good regenerative properties after seven cycles of absorption/desorption.The intrinsic separation mechanism of NH_(3) by EtOHACl+PhOH DESs was further revealed by spectroscopic analysis and quantum chemistry calculations.

关键词： Separation Absorption Ionic liquid Deep eutectic solvent Multiple active site Low viscosity

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Different mechanisms underlie similar species-area relationships in two tropical archipelagoes

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Plant Diversity 2024年第2期46卷 238-246页

作者： Shengchun Li Tieyao Tu Shaopeng Li Xian Yang Yong zheng Liang-Dong Guo Dianxiang Zhang Lin jiang Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China ECNU-Alberta Joint Lab for Biodiversity Study Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China School of Biological Sciences Georgia Institute of TechnologyAtlantaGA 30332USA jiangxi Academy of Forestry Nanchang 330032China Institute of Eco-Chongming(IEC) Shanghai 202162China State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou 510275China School of Geographical Sciences Fujian Normal UniversityFuzhou 350007China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Despite much research in the field of island biogeography,mechanisms regulating insular diversity remain elusive.Here,we aim to explore mechanisms underlying plant species-area relationships in two tropical archipelagoes in the South China Sea.We found positive plant species-area relationships for both coral and continental archipelagoes.However,our results showed that different mechanisms contributed to similar plant species-area relationships between the two archipelagoes.For coral islands,soil nutrients and spatial distance among communities played major roles in shaping plant community structure and species diversity.By contrast,the direct effect of island area,and to a lesser extent,soil nutrients determined plant species richness on continental islands.Intriguingly,increasing soil nutrients availability(N,P,K)had opposite effects on plant diversity between the two archipelagoes.In summary,the habitat quality effect and dispersal limitation are important for regulating plant diversity on coral islands,whereas the passive sampling effect,and to a lesser extent,the habitat quality effect are important for regulating plant diversity on continental islands.More generally,our findings indicate that island plant species-area relationships are outcomes of the interplay of both niche and neutral processes,but the driving mechanisms behind these relationships depends on the type of islands.

关键词： Coral and continental islands Plant diversity Soil nutrients Species-area relationships The sampling effect

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Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

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Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting jiang Muyuan Ma Shaojiang zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and context.However,its tumor-suppressive mechanisms remain largely unknown.Here,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its dysregulation.UTX expression and its association with clinicopathologic characteristics of PDA patients were analyzed using immunohistochemistry.UTX mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot analyses.The biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal models.UTX expression was reduced in human PDA cell lines and specimens.Low UTX expression was associated with poor differentiation and prognosis in PDA.Forced UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the opposite.Mechanistically,UTX expression was trans-activated by GATA6 activation.GATA6-mediated PDA progression could be blocked,at least partially,by silencing UTX expression.In conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and metastasis.Thus,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

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Nature-inspired design of droplet-synthesized polymeric nanoelectrode for photoelectrochemical microRNA sensing within single cells

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Science Bulletin 2024年第2期69卷 159-162页

作者： Si-Yuan Yu Yi-Li Liu zheng Li Dechen jiang Jing-Juan Xu Hong-Yuan Chen Wei-Wei Zhao State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Nanoelectrodes have been shown to be powerful tools for nanoscopic research on single entities,deepening the understanding of heterogeneity and stochastics for single molecules,nanoparticles and cells[1–3].However,despite their importance,current nanoelectrode preparations are highly restrained to flame/electrochemical etching,metal sputtering,electrochemical deposition,etc.[3],resulting in a limited range of materials(mainly gold,platinum and carbon)for potential-resolved detection of redox-active species(Table S1 online).The enrichment of preparation methods to introduce novel materials and mechanisms should prove significant for the development of nanoelectrodes.

关键词： electrode deepening restrained

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O_(2) adsorption on Fe_(3)O_(4) (110) surface and effect of gangue element Al doping: combined study of binding experiment and ab initio molecular dynamics

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Journal of Iron and Steel Research(International) 2024年第4期31卷 810-827页

作者： zheng-jian Liu Hui-qing jiang Yao-zu Wang Jian-liang Zhang Hong-mei Qiao An-yang zheng Fang-yu Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China Beijing Shougang Co. Ltd.Qian'an 064404HebeiChina Department of Physics National University of Defense TechnologyChangsha 410128HunanChina

At high temperature,the chemical reaction mechanism at the interface of magnetite and the influence mechanism of gangue element Al on the oxidation performance of magnetite are not clear.In addition,due to the limitation of existing experimental equipment,it is difficult to clarify the interface reaction mechanism in the oxidation process and the influence mechanism of Al on the surface oxidation reaction of Fe_(3)O_(4) at an atomic scale at high temperature.The surface oxidation reaction mechanism of magnetite and the influence mechanism of Al on the oxidation of magnetite were studied by experiments and AIMD(ab initio molecular dynamics).The experimental results show that the existence of Al_(2)O_(3) will reduce the initial oxidation temperature and comprehensive oxidation performance of magnetite.The AIMD results show that aluminum can accelerate the interface reaction rate of Fe_(3)O_(4) in the high-temperature oxidation atmosphere,but the strong Al-O binding ability is not conducive to the transfer of O atoms in the oxidation process.

关键词： Ironmaking Magnetite oxidation Interface reaction Adsorption-Gangue aluminum AIMD

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Lensless opto-electronic neural network with quantum dot nonlinear activation

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Photonics Research 2024年第4期12卷 682-690页

作者： WANXIN SHI XI jiang zheng HUANG XUE LI YUYANG HAN SIGANG YANG HAIzheng ZHONG HONGWEI CHEN Beijing National Research Center for Information Science and Technology(BNRist) Department of Electronic EngineeringTsinghua UniversityBeijing 100084China China Mobile Research Institute Beijing 100053China MIIT Key Laboratory for Low-dimensional Quantum Structure and Devices School of Materials Sciences&EngineeringBeijing Institute of TechnologyBeijing 100081China

With the swift advancement of neural networks and their expanding applications in many fields, optical neural networks have gradually become a feasible alternative to electrical neural networks due to their parallelism, high speed, low latency, and power consumption. Nonetheless, optical nonlinearity is hard to realize in free-space optics, which restricts the potential of the architecture.

关键词： network neural networks

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Transcription factor OsSPL10 interacts with OsJAmyb to regulate blast resistance in rice

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The Crop Journal 2024年第1期12卷 301-307页

作者： Zaofa Zhong Lijing Zhong Xiang Zhu Yimin jiang Yihong zheng Tao Lan Haitao Cui College of Life Science Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Plant Protection Shandong Agricultural UniversityTai’an 271018ShandongChina

Transcription factors(TFs)play essential roles in transcriptional reprogramming during activation of plant immune responses to pathogens.OsSPL10(SQUAMOSA promoter binding protein-like10)is an important TF regulating trichome development and salt tolerance in rice.Here we report that knockout of OsSPL10 reduces whereas its overexpression enhances rice resistance to blast disease.OsSPL10 positively regulates chitin-induced immune responses including reactive oxygen species(ROS)burst and callose deposition.We show that OsSPL10 physically associates with OsJAmyb,an important TF involved in jasmonic acid(JA)signaling,and positively regulates its protein stability.We then prove that OsJAmyb positively regulates resistance to blast.Our results reveal a molecular module consisting of OsSPL10 and OsJAmyb that positively regulates blast resistance.

关键词： Immunity Jasmonate Oryza sativa OsSPL10 Transcription factor

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CRISPR/Cas9 system and its applications in nervous system diseases

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Genes & Diseases 2024年第2期11卷 675-686页

作者： Haibin jiang Mengyan Tang Zidi Xu Yanan Wang Mopu Li Shuyin zheng jianghu Zhu Zhenlang Lin Min Zhang The Second School of Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China The First School of Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Pediatrics The Second School of MedicineThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China Key Laboratory of Perinatal Medicine of Wenzhou WenzhouZhejiang 325027China Key Laboratory of Structural Malformations in Children of Zhejiang Province WenzhouZhejiang 325000China Zhejiang Provincial Clinical Research Center for Pediatric Disease WenzhouZhejiang 325027China

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system is an acquired immune system of many bacteria and archaea,comprising CRISPR loci,Cas genes,and its associated proteins.This system can recognize exogenous DNA and utilize the Cas9 protein's nuclease activity to break DNA double-strand and to achieve base insertion or deletion by subsequent DNA repair.In recent years,multiple laboratory and clinical studies have revealed the therapeutic role of the CRISPR/Cas9 system in neurological diseases.This article reviews the CRISPR/Cas9-mediated gene editing technology and its potential for clinical application against neurological diseases.

关键词： CRISPR/Cas9 Gene editing Mutation Neurological diseases Therapeutics

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