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NiCoFeCu medium-entropy alloy nanoparticles encapsulated in carbon nanotubes as catalysts for enhancing the hydrogen desorption of MgH2

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Rare Metals 2024年第11期 5868-5879页

作者： Ya-Fei Liu Yi-Ke huang yu-Sang Guo Meng-yuan yue hua-Xu Shao Yi-Jing Wang Key Laboratory of Advanced Energy Materials Chemistry (ministry of Education) Renewable Energy Conversion and Storage CenterCollaborative Innovation Center of Chemical Science and Engineering (Tianjin)College of Chemistry Nankai University

Recently,high/medium-entropy alloys（HEAs/MEA s） have been considered attractive catalysts due to their unique physicochemical ***,the synthesis of nano-sized HEAs/MEAs catalysts with desirable morphology presents significant ***,we report the synthesis of NiCoFeCu MEA nanoparticles encapsulated in nitrogen-doped carbon nanotubes（NCTs）via a straightforward one-step pyrolysis *** unique structure of NiCoFeCu/NCTs and the nano-sized MEA catalysts contributes to the improved hydrogen desorption kinetics of *** onset dehydrogenation temperature of the MgH2-NiCoFeCu/NCTs composite decreased to 173.4℃,a reduction of 117.4℃ compared to pure *** MgH2-NiCoFeCu/NCTs composite could release 6.50 wt% H2within 30 min at 325℃.Furthermore,an activation energy of 116.3 kJ·mol-1for the MgH2-NiCoFeCu/NCTs composite has been obtained,much lower than pure milled MgH2,demonstrating an enhanced hydrogen desorption ***,the exceptional dispersion capability of the carbon material contributes to outstanding cyclic stability without any loss of capacity even after 10 cycles of de/hydrogenation at300℃.

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金线莲苷的研究现状

天然产物研究与开发 2024年第2期36卷 348-356,367页

作者：张闻婷杨旻静梅瑜王继华广东省农业科学院作物研究所广州510640 仲恺农业工程学院农业与生物学院广州510225

金线莲苷(kinsenoside),一种从药用植物金线莲中提取的天然生物活性糖苷,已被证明具有显著的药理功效。本文通过收集金线莲苷的相关研究文章,尤其针对近几年更新发表的研究成果,整理分析后将金线莲苷的研究现状主要分为3方面,即:金线莲... 详细信息

金线莲苷(kinsenoside),一种从药用植物金线莲中提取的天然生物活性糖苷,已被证明具有显著的药理功效。本文通过收集金线莲苷的相关研究文章,尤其针对近几年更新发表的研究成果,整理分析后将金线莲苷的研究现状主要分为3方面,即:金线莲苷的基本信息,包括化学结构、来源物种及影响积累的因素;金线莲苷的分离提取、定性定量检测、人工合成方法总结;金线莲苷的药理作用,包括降血糖、降血脂、保肝作用及缓解骨病变等。鉴于金线莲苷的原材料资源匮乏,人工种植成本昂贵导致的市场应用受限,我们认为通过提高开唇兰属植物中金线莲苷的提取效率,开发更多含有金线莲苷的植物,或以栽培效率和人工合成技术的进步等方式解决生产实践问题。而在药理研究方面,我们支持通过在大型灵长类动物上进行剂量毒性试验,开发靶向治疗策略提高治疗准确性,以及精确金线莲苷使用的干预时间点等试验为金线莲苷在未来临床实践中的转化应用奠定基础。

关键词：金线莲苷提取检测人工合成药理作用

Effects of phytoestrogen genistein on myocardial ischemia/reperfusion injury and apoptosis in rabbits

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Acta Pharmacologica Sinica 2004年第3期25卷 52-58页

作者： En-sheng JI,hua yuE,yu-ming WU,Rui-rong HE1 department of Physiology,Institute ofBasic Medicine,Hebei Medicaluniversity,Shijiazhuang 050017,china department of Physiology Institute of Basic Medicine Hebei Medical University

AIM: To study the effect of genistein (GST) on rabbit heart ischemia/reperfusion (I/R) injury. METHODS: Rabbit heart I/R injury was induced by occluding the left anterior descending coronary artery for 45 min and reperfusing for 180 min. GST (1.0 mg/kg) was intravenously injected 5 min before heart ischemia. Hemodynamic data, infarct size, and cardiomyocytic apoptosis were measured. The pathologic changes of I/R myocardium were observed. RESULTS: during the I/R, heart rate, mean arterial blood pressure, myocardial oxygen consumption, left ventricu- lar (LV) –dp/dtmax and +dp/dtmax were decreased progressively. The infarct size was occupied 60.23 %±3.97 % (% of area at risk) in vehicle +I/R group while GST reduced the infarct size to 39.62 %±4.30 % (Pduced infarct size and apoptosis of myocytes in I/R rabbit heart.

关键词： genistein reperfusion injury apoptosis rabbits

Linggui Zhugan Decoction Improves High Glucose-Induced Autophagy in Podocytes

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Chinese Medical Sciences Journal 2024年第3期39卷 193-202页

作者： yuan-yuan Wang Jian Qin Ru-Lan Zhang min-Ji yu ming-hua Jin department of Traditional Chinese Medicine The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China department of Traditional Chinese Medicine The Seventh Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 518107China department of Traditional Chinese Medicine HuiYa Hospital of The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 516081China

Objective To explore the influence of Linggui Zhugan Decoction(LGZGD)on high glucose induced podocyte autophagy Methods LGZGD containing serum were prepared by intragastric administation of 4.2 g·kg^(-1)(low dose),8.4 g·kg^(-1)(medium dose),and 12.6 g·kg^(-1)(high dose)LGZGD into SD rats ***5 and AB8/13 cells were treated with 60 mmol/L glucose to establish diabetic nephropathy podocyte model in ***,MPC5 and AB8.13,were divided into control group,high glucose group,low dose LGZGD group,medium dose LGZGD group,and high dose LGZGD group,*** the three LGZGD groups,before LGZGD intervention,podocytes were treated with 60 mmol/L glucose for 3 *** treated with LGZGD containing serum,cells were collected to analyze cell migration using Transwell assay,proliferation using CCK8,apoptosis and cell cycle using flow cytometry,,autophagosome formation using transmission electron microscopy,and expression levels of Beclin-1,Atg5,LC3II/I,and P62 proteins using western *** Compared with the control group,the proliferation and migration of MPC5 and AB8.13 cells in high glucose group showed slightly decreased,whereas these parameters restored after intervention with low and medium concentrations of LGZGD,with the medium dose LGZGD having the best *** cytometry analysis showed that the medium dose LGZGD group had a lower apoptosis rate(P0.05)compared to the high dose *** glucose arrested podocytes in G1 phase,whereas LGZGD shifted podocytes from being predominant in G1 phase to increasing into *** dose LGZGD significanly reduced increased autophagosome formation due to high glucose in both podocytes(Pminstration of low and medium doses of LGZGD(Pduced apoptosis and enhanced autophagy in high glucose

关键词： diabetic nephropathy podocyte Linggui Zhugan decoction apoptosis autophagy

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo zheng-hua An Ke Gong Jin-yuan Liao Yan-Qiu Zhang yue huang Lu Li Xing Wen Fei Zhang Jing duan Chen-Wei Wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen huan-yu Wang Sheng Yang Xiao-Jing Liu min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-ming Song Shi-Jie zheng Bing Li Hong-Mei Zhang yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-yu Wang Zong-yuan Yang Zhi-Long Wen Zhi Chang yuan-yuan du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of Science and technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

The Isomeric Structures of H_2GeLiF, the Prototype Germylenoid

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Chinese chemical Letters 1999年第6期10卷 511-514页

作者： hua yu QIU Wan Yong MA Guan Bin LI Cong Hao DENG (department of chemical engineering. Shandong Institute of Light Industry. Jinan 250100 Institute of Theoretical Chemistry. Shandong university, Jinan 250100) Shandong Inst Light Ind Dept Chem Engn Jinan 250100 Peoples R China Shandong Univ Inst Theoret Chem Jinan 250100 Peoples R China

The structures of four isomeric forms of the model germylenoid, H2GeLiF. have been examined by ah initio MO theory. The most stable structure is suggested to be the p-complex *** other three species. three-membered ring 2, δ-complex 3 and tetrahedron 4. are also local minima on the potential energy surface. but are higher in energy.

关键词： Germylenoid p-complex ab initio

CHAOTIC　ANALYSIS　OF　SUBHARMONIC　RESONANT　WAVES　IN　UNDAMPED　AND　DAMPED　STRINGS

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Journal of Hydrodynamics 1995年第1期7卷 92-104页

作者： Albert C. J. Luo, Ray P. S. Han (department of Mechanical & Industrial engineering,university of Manitoba,Winnipeg,Manitoba R3T 2N2, Canada)Xiang yu-min(department of Physics ,Sichuan Instutue of Industry and chemical technology,Zigong,Sichuan 643033, P. Univ of Manitoba Winnipeg Canada

The chaotic phenomena of subharmonic resonant waves in undamped and damped strings are investigated in this paper. The model consistS of a constant-tension, stretched string whose partial differential equation is derived by taking into account its exact configuration. Simplification via a Taylor series expansion of the curvature term and then employing the Galerkin method, an ordinary differential equation for the nonlinear dyamics is obtained. For the undamped case, we can formulate the Hamiltonian energy form of the conservative string, under the influence of an external periodic excitation. This permits the subharmonic resonant condition for this system to be derived. We truncate the resulting infinite number of subharmonic resonant waves to just two waves by renormalizing the Hamiltonian energy function near the subharmonic resonant orbit of the system. Adopting the renormalization group technique for the nit6raction of the two subharmonic resonant waves, an approximate chaotic condition associated with the subharmonic resonance of this system is determined. For the case fo the damped string, the minimum condition for the bifurcation of the subharmonic resonant wave is computed using the incremental energy balance method. For model verification, we carried out numerical simulations and they show good agreement with our analytical results.

关键词： chaos subharmonic resonant waves undamped and damped strings,incremental energy balance method renormalization group technique.

Investigating the molecular mechanism of Chelidonii Herba against liver cancer using network pharmacology and molecular docking validation

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Integrative Medicine Discovery 2024年第22期8卷 1-12页

作者： ming-Zhi Yang Zi-Xuan Yang Zhang yu Ju-min Xie hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003China

Background:The molecular mechanism of Chelidonii Herba in treating hepatocellular carcinoma was investigated using network pharmacology and molecular docking ***:The main active components of Chelidonii Herba were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database,and the targets of these active ingredients were identified using the SwissTargetPrediction *** related to liver cancer were sourced from GeneCards,Therapeutic Targets Database,and Online Mendelian Inheritance in Man *** targets between the active components of Chelidonii Herba and liver cancer were determined using the jvenn online *** protein interaction network was analyzed via STRING database and visualized using Cytoscape *** targets were identified and further analyzed within the protein interaction *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted for the intersection targets using the DAVID database to correlate gene *** bubble diagrams for Gene Ontology enrichment analysis and circular diagrams for Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were generated using CNSknowall and SangerBox online *** docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.5.7 software,*** survival and pan-cancer analysis of core targets were conducted using the GEPIA2 online ***:Twelve active components of Chelidonii Herba were identified through screening.A total of 103 intersection targets and 12 core targets were found between these active constituents of Chelidonii Herba and liver *** Herba may exert its effects on liver cancer through these 12 core *** signaling pathways are implicated,including chemical carcinogen-receptor activation,endocrine resistance,HIF-1 signaling pathway,and proteoglycans in ***

关键词： Chelidonii Herba liver cancer network pharmacology molecular docking

Reductive Cleavage of S-S Bond by Samarium Diiodide: Synthesis of β-Thioesters and β-Thionitriles

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Chinese chemical Letters 1999年第1期10卷 7-8页

作者： hua Jiang JIANG Yong min ZHANG(department of Chemistry, Hangzhou university, Hangzhou, Zhejiang, 310028) Hangzhou Univ Dept Chem Hangzhou 310028 Peoples R China

The reduction of disulfides by samarium diiodide led to sa arium thiolates (ArSSml2).This new thiolate anion species reacted smoothly with α, β -unsaturated esters (nitriles) to give 1,4-addition products β -thioes... 详细信息

关键词： β-thioesters β-thionitriles samarium diiodide synth esis