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Gd Doped Hollow Nanoscale Coordination Polymers as Multimodal Imaging Agents and a Potential Drug Delivery Carriers

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Chinese Journal of Chemical Physics 2018年第5期31卷 717-724,736页

作者： gao-zheng Zhao Zhen Guo Qian-wang Chen Hefei National Laboratory for Physical Sciences at the Microscale Department of Materials Science&EngineeringUniversity of Science and Technology of ChinaHefei 230026China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology School of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China

Gd doped hollow nanoscale coordination polymers with multimodal imaging capabilities were synthesized by solvothermal method and further coated by silica *** in vitro tests demonstrated uncoated and silica-coated nanoprobes exhibit longitudinal relaxivities(r1)of 7.38 and 13.57(mmol/L)-1·s-1,and transverse relaxivities(r2)of 180.6 and 304.8(mmol/L)-1·s-1,showing fairly good dual T1&T2 contrast effects,and it also emits excellent multicolor uorescence under laser beams of various *** the com-bination of magnetic resonance imaging(MRI)(both T1 and T2)and uorescence optical imaging(FOI),the nanoprobes could correlate preoperative diagnosis with intraoperative ***,it also exhibits high drug loading capacity of 1166 mg/g and en-capsulation efficiency of 83.29%,which makes it a potential platform as drug *** MTT assay demonstrates the moderate toxicity of the NPs,and after the silica coating process,not only the MRI contrast effects but also the biocompatibility have been *** versatility of the highly integrated systems can make up for the limitations of each imaging modality and exhibit great potentials for cancer theranostics.

关键词： Coordination polymers Magnetic resonance imaging Fluorescence optical imaging Drug delivery potentials

Research and Trial Production of X80 Pipeline Steel with High Toughness Using Acicular Ferrite

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工程科学（英文版） 2005年第3期3卷 91-94页

作者： zheng Lei gao Shan Baoshan Iron ＆ Steel Co. Ltd. Shanghai 201900

The research and trial production of X80 pipeline steel in Baosteel is briefly introduced in this paper. It is shown that the X80 pipeline steel with high toughness using acicular ferrite microstructure is designed by ultra-low carbon, micro-alloying and Mo-low-alloying in the compositions, and can be produced by combining with the clean steel-making technology and thermal-mechanical controlled processing. The pipes made from the trial producing coils meet the requirements for grade X80 line pipe of the API spec.5L, and have high Charpy V-notch impact energy and good dynamic tear-resistance ability at low temperature. The X80 pipeline steel can be applied to the high-pressure transporting gas pipeline project.

关键词： X80 管道钢针状铁素体韧性微观结构

Long-term clinical effects of intravitreal injections of conbercept for the treatment of choroidal neovascularization in patients with pathological myopia

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1971-1977页

作者： Si Zhang Zi-Fang He Fei-Fei Chen Wen-Wen Zhang Ya-Jun Liu Hui Chen zheng-gao Xie Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina

AIM:To observe the long-term clinical efficacy of intravitreal injections of conbercept,a novel vascular growth factor inhibitor,for the treatment of pathological myopia choroidal neovascularization(PM-CNV).METHODS:A total of 67 eyes(from 67 patients;mean age,54.90±12.7y)with PM-CNV were retrospectively *** on the different schemes used for the administration of the drug,the patients were divided into two groups:group A(n=35;average age,53.31±13.6y;average diopter,9.25±1.72 D),which received only one injection of pro re nata(PRN;1+PRN regimen),and group B(n=32;average age,56.49±11.8y;average diopter,9.63±2.24 D),which received one injection per month for 3mo(3+PRN regimen).Best-corrected visual acuity(BCVA)analysis,intraocular pressure(IOP)examination,slit-lamp microscopy,fundus examination and optical coherence tomography were per formed at each *** recurrence and treatment times of CNV were *** patients were followed up for at least ***:The BCVA was increased in 29 eyes(82.9%)in group A and 30 eyes(93.75%)in group B;no increase or decrease was observed in 6(17.1%)and 2(6.25%)eyes in groups A and B,*** BCVA(log MAR)values before treatment(0.67±0.48 and 0.71±0.56)were significantly higher than those 12mo after treatment(0.31±0.26 and 0.33±0.17)in groups A and B,respectively(P<0.05).The mean central macular thickness(CMT)values had significantly decreased from 346.49±65.99 and 360.10±82.31μm at baseline to 257.29±40.47 and 251.97±48.26μm in groups A and B,respectively,after 12mo of treatment.A total of 21 eyes in group A needed reinjection(60%;average number of injections,2.51±0.98);the corresponding values in group B were 6 eyes(18.75%;average number of injections,3.74±1.22).There were no adverse ocular and systemic complications during the treatment and ***:Intravitreal injection of conbercept with 1+PRN or 3+PRN improve the visual acuity,reduce macular edema and reduce the level of CMT in patie

关键词： pathological myopia choroidal neovascularization conbercept best-corrected visual acuity central macular thickness

Peripheral vascular bioresorbable scaffolds:Past,present,and future

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医学+（英文） 2024年第2期1卷 11-17页

作者： zheng gao Wentao Jiang Feng Ran Department of Vascular Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

As the world's population ages,peripheral vascular disease(PVD)has become one of the leading causes of death,caused by atherosclerosis and vascular *** typically affects the lower extremities,placing a significant financial burden on both individuals and healthcare systems *** bypass surgery has traditionally been the most common treatment for PVD,but the procedure carries a high rate of perioperative adverse events.

关键词： present future past bioresorbable peripheral scaffolds vascular

Translational Enhancer of Tobacco mosaic virus Enhancing Expression of Hepatitis B Surface Antigen in Transgenic Panax ginseng C. A. Meyer Callus

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Chemical Research in Chinese Universities 2008年第1期24卷 75-79页

作者： gao zheng-lun SHENG Jun HAO Shu-mei LIU Dan LIU Xiao-yu JI Hai-bin LI Juan ZHANG Xian-ping College of Life Science Jilin University Changchun 130012 P R. China Changchun Institute of Biological Product Changchun 130062 P. R China Changchun University of Science and Technology Changchun 130022 P. R. China Jilin Institute for Food and Drug Control Changchun 130062 P R. China

The 5＇-nontranslated leader（omega sequence） of Tobacco mosaic virus（TMV） was used as a translational enhancer sequence in the expression of the hepatitis B surface antigen（HBsAg） gene in transgenic ginseng callus cultures. The adr subtype HBsAg gene was placed under the control of the Cauliflower mosaic virus（CaMV） 35S promoter linking to the TMV leader sequence. The antisense omega sequence was used in a control construct. The resulting constructs cloned in the binary vector pBI121 were used to transform the ginseng callus tissue via the Agrobacterium-mediated procedure. The integration and expression of the HBsAg gene were evaluated by PCR and western blot, respectively. Enzyme-linked immunoassays（ELISA） using a monoclonal antibody directed against human serum-derived HBsAg revealed a three to four-fold enhanced expression of HBsAg in ginseng cells conferred by the TMV omega element.

关键词： Translational enhancer Omega sequence Hepatitis B surface antigen Ginseng callus

Ruthenium(Ⅱ)-cored supramolecular organic framework-mediated recyclable visible light photoreduction of azides to amines and cascade formation of lactams

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Chinese Chemical Letters 2019年第7期30卷 1383-1386页

作者： Yi-Peng Wu Meng Yan Zhong-zheng gao Jun-Li Hou Hui Wang Dan-Wei Zhang Junliang Zhang Zhan-Ting Li Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Centre of Chemistry for Energy Materials(iChEM) Fudan University

Ru(bpy)3]2+-cored supramolecular organic framework SMOF-1, assembled from a [Ru(bpy)3]2+-derived hexaarmed molecule and cucurbit[8]uril, has been demonstrated to heterogeneously catalyze visible light-induced reduction of phenyl, benzyl, 2-phenylethyl and 3-phenylpropyl azides in acetonitrile to produce the corresponding amines in good to high yields. For the last two kinds of azides that bear a CO2Me group at the para-position of the benzene ring, cascade reactions take place to generate the corresponding lactams in high yields. Compared with homogeneous control [Ru(bpy)3]Cl2, SMOF-1 exhibits remarkably increased photocatalysis activity as a result of synergistic effect of the [Ru(bpy)3]2+ units that form cubic cages to host the azide molecules and related intermediates. Moreover, SMOF-1 displays high recyclability and considerable photocatalysis activity after 3 to 12 runs.

关键词： Supramolecular organic framework Visible light photocatalysis Recyclability Azide reduction Amine Lactam

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机动飞行中旋翼尾迹畸变效应实验

空气动力学学报 2007年第4期25卷 526-530页

作者：徐进高正南京航空航天大学直升机旋翼动力学重点实验室南京210016

为准确计算机动飞行时的旋翼他轴响应,气动模型应计入尾迹畸变效应。体现此效应的关键在于推出时变的尾迹弯曲参数KR。本文通过烟流实验,得出随旋翼前进比、拉力系数和机动角速率变化的KR表达式,并分析指出,国外文献采用固定KR值不足以... 详细信息

为准确计算机动飞行时的旋翼他轴响应,气动模型应计入尾迹畸变效应。体现此效应的关键在于推出时变的尾迹弯曲参数KR。本文通过烟流实验,得出随旋翼前进比、拉力系数和机动角速率变化的KR表达式,并分析指出,国外文献采用固定KR值不足以体现机动效应。为了给理论预测提供参考,本文还测量了机动旋翼的空气动力时间历程,表明旋翼轴接受准阶跃输入后,同轴及他轴的空气动力响应有过冲,且俯仰速率愈大,过冲幅值愈大;本实验中他轴响应为主响应的15%。

关键词：机动飞行旋翼尾迹畸变尾迹弯曲参数他轴响应

EGB761 on retinal light injury in rats

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Chinese Medical Journal 2012年第13期125卷 2306-2309页

作者： QIU Qing-hua XIE zheng-gao XU Xian LIANG Shu-xian gao Yan Department of Ophthalmology Shanghai Jiao Tong University Affiliated First People's Hospital Shanghai 200080 China Department of Ophthalmology Northern Jiangsu People's Hospital Affiliated to Yangzhou University Yangzhou Jiangsu 225001 China Shanxi Eye Hospital Taiyuan Shanxi 030002 China

Background Retinal light injury can lead to degeneration of the photoreceptor cell layer. It has been hypothesized that the mechanism for this process is the photochemical damage. Ginkgo balboa extract （Ginkgo biloba extract EGB761） EGB761 is a free radical scavenger. The purpose of this study was to investigate the possible effect of orally administered EGB761 on retinal light damage of mouse photoreceptor cells. Methods Kunming mice were randomly chosen for the following groups containing 20 animals in each： control group, light damage group, saline control group, and drug treatment group. The drug treatment group and saline control group were given daily gavage of EGB761 （150 ***.d-1） one week before light exposure. At 7, 14, and 30 days after light exposure, animals were sacrificed and eyes were examined by light microscopy, electron microscopy, and retinal histopathology using in situ detection of apoptotic cells. Results In the light damage group after 7 days there was visible edema, and the outer nuclear layer appeared withered with deeply stained dead cells, leaving only a thin nuclear layer of 7-8 cells. After 14 days, the photoreceptor cell layer disappeared, leaving only the outer nuclear layer of 1-3 cells with an average thickness of （37.988＋1.207） pm. The average thickness of the retina was （126.32~2.31） pm. In the drug treatment group, the photoreceptor cell layer and outer nuclear layer damage were significantly lower than the saline group （t=-21.993, P 〈0.001）, demonstrating that EGB761, especially at 14 days after light exposure, can reduce retinal light damage in *** Oral administration of EGB761 can partially inhibit apoptosis of photoreceptor cells, resulting in increased photoreceptor cell survival.

关键词： Ginkgo biloba extract light damage photoreceptor cells retina

Effects of long-term fertilization with different substitution ratios of organic fertilizer on paddy soil

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Pedosphere 2022年第4期32卷 637-648页

作者： Weifeng SONG Aiping SHU Jiai LIU Wenchong SHI Mingcong LI Wenxue ZHANG Zuzhang LI Guangrong LIU Fusheng YUAN Shuxin ZHANG Zengbing LIU zheng gao State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai'anChina College of Life Sciences Shandong Agricultural UniversityTai'anChina Institute of Soil and Fertilizer&Resource and Environment/National Engineering and Technology Research Center for Red Soil Improvement Nanchang330200China

In recent years,the abuse of chemical fertilizers has caused numerous environmental problems,such as soil acidification and *** chemical fertilizers with organic fertilizers can effectively alleviate these ***,the effects of alternative organic fertilizers remain *** explore the effects of organic fertilizer substitution on rice yield and paddy soil physicochemical properties and bacterial community structure,we conducted a 5-year experiment using different proportions of organic fertilizer substitution in a double-cropping rice field in Jiangxi,*** results showed that replacing chemical fertilizers with organic fertilizers can reduce soil acidification,increase soil organic matter content,nutrient contents,and enzyme activities,improve soil physicochemical properties and microbial community,and enhance soil *** organic substitution also had positive effects on rice *** findings enhance our understanding of the effects of different alternative organic fertilization methods and have important theoretical significance for the promotion of the use of organic fertilizers in the future.

关键词： bacterial community double-cropping rice organic matter rice yield soil acidification,soil property