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Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy

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National Science Review 2024年第1期11卷 74-85页

作者： Chunjie Wang Lei Zhang Zhijuan Yang Dongxu Zhao zheng deng Jialu Xu Yumin Wu Yu Hao Ziliang Dong Liangzhu Feng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Center of Interventional Radiology & Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University Department of Interventional Radiology The First Afflliated Hospital of Soochow University

Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma(HCC) via transarterial chemoembolization(TACE). However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion(LPE) stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase(LOX). The obtained LOX-loaded CaCO3&hemin-stabilized LPE(LHCa-LPE) showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids(PUFAs), a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC.

关键词： CaCO3 nanoparticles Pickering emulsion ferroptosis lipid peroxidation transarterial ferro-embolization

Defect-manipulated magnetoresistance and above-room-temperature ferromagnetism in two-dimensional BaNi_(2)V_(2)O_(8)

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Chinese Chemical Letters 2024年第3期35卷 523-527页

作者： Pengfei Tan Chuanhui Zhu Jinjin Yang Shuang Zhao Tao Xia Mei-Huan Zhao Tao Han zheng deng Man-Rong Li Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-sen UniversityGuangzhou 510006China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Science Hainan UniversityHaikou 570228China

The intricate correlation between multiple degrees of freedom and physical properties is a fascinating area in solid state chemistry and condensed matter physics.Here,we report a quantum-magnetic system BaNi_(2)V_(2)O_(8)(BNVO),in which the spin correlation was modulated by unusual oxidation state,leading to different magnetic behavior.The BNVO was modified with topochemical reduction(TR)to yield TR-BNVO with partially reduced valance state of Ni^(+)in the two-dimensional NiO_(6)-honeycomb lattice.Accordingly,the antiferromagnetic order is suppressed by the introduction of locally interposed Ni^(+)and oxygen vacancies,resulting in a ferromagnetic ground state with the transition temperature up to 710 K.A positive magnetoresistance(7.5%)was observed in the TR-BNVO at 40 K under 7 T.These findings show that topological reduction is a powerful approach to engineer low-dimensional materials and accelerate the discovery of new quantum magnetism.

关键词： Layered honeycomb oxide Topochemical reduction Oxygen vacancies Ferromagnetism Magnetoresistance

Scattering of Water Waves by Dual Symmetric Inclined Floating Porous Barriers Using the DBEM

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China Ocean Engineering 2024年第1期38卷 156-168页

作者： WANG Li-xian deng Yan-wen YE Yang-sha deng zheng-zhi Key Laboratory of High Performance Ship Technology(Wuhan University of Technology) Ministry of EducationWuhan 430063China School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan 430063China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China Institute of Port Coastal and Offshore EngineeringZhejiang UniversityZhoushan 316021China

The scattering of normally incident water waves by two surface-piercing inclined perforated barriers in water with a uniform finite depth is investigated within the framework of linear water wave theory.Considering that thin barriers are zero-thickness,a novel numerical method involving the the coupling of the dual boundary element method(DBEM)with damping layers is applied.In order to effectively damp out the reflected waves,two damping layers,instead of pseudoboundaries are implemented near the two side boundaries of the computational domain.Thus,the modified linearized free surface boundary conditions are formulated and used for solving both the ordinary boundary integral equation as well as the hypersingular boundary integral equation for degenerate boundaries.The newly developed numerical method is validated against analytical methods using the matched eigenfunction expansion method for the special case of two vertical barriers or the inclined angle to the vertical being zero.The influence of the length of the two damping layers has been discussed.Moreover,these findings are also validated against previous results for several cases.After validation,the numerical results for the reflection coefficient,transmission coefficient and dissipation coefficient are obtained by varying the inclination angle and porosity-effect parameter.The effects of both the inclination angle and the porosity on the amplitudes of wave forces acting on both the front and rear barriers are also investigated.It is found that the effect of the inclination angle mainly shifts the location of the extremal values of the reflection and the transmission coefficients.Additionally,a moderate value of the porosity-parameter is quite effective at dissipating wave energy and mitigating the wave loads on dual barriers.

关键词： dual boundary element method inclined perforated floating breakwater reflection coefficient transmission coefficient damping layer

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面向应用的新一代稀磁半导体研究进展

物理学报 2024年第1期73卷 9-22页

作者：彭毅赵国强邓正靳常青中国科学院物理研究所北京100190 中国科学院大学物理学院北京100049

稀磁半导体具有能同时调控电荷与自旋的特性,是破解摩尔定律难题的候选材料之一.我们团队率先提出了稀磁半导体中自旋和电荷掺杂分离的机制,探索并研制了新一代稀磁半导体材料,为突破经典稀磁半导体材料的制备瓶颈提供了有效解决方案.以... 详细信息

稀磁半导体具有能同时调控电荷与自旋的特性,是破解摩尔定律难题的候选材料之一.我们团队率先提出了稀磁半导体中自旋和电荷掺杂分离的机制,探索并研制了新一代稀磁半导体材料,为突破经典稀磁半导体材料的制备瓶颈提供了有效解决方案.以(Ba,K)(Zn,Mn)_(2)As_(2)等为代表的新一代稀磁半导体,通过等价态的Mn掺杂引入自旋、异价态的非磁性离子掺杂引入电荷,成功实现了230 K的居里温度,刷新了可控型稀磁半导体的居里温度记录.本文将重点介绍几种代表性的新一代稀磁半导体的设计与研制、新一代稀磁半导体的综合物性表征、大尺寸单晶生长以及基于单晶的安德烈夫异质结研制.我们团队通过新一代稀磁半导体的新材料设计研制、综合物性研究、简单原型器件构建的“全链条”模式研究,开拓了自旋电荷分别掺杂的稀磁半导体材料研究领域,充分展现了自旋和电荷掺杂分离的新一代稀磁半导体材料潜在应用前景.

关键词：新一代稀磁半导体自旋电荷掺杂分离高居里温度多组合异质结

Propagating slow sausage waves in a sunspot observed by the New Vacuum Solar Telescope

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Research in Astronomy and Astrophysics 2020年第8期20卷 157-162页

作者： Song Feng zheng deng Ding Yuan Zhi Xu Xiao Yang Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Institute of Space Science and Applied Technology Harbin Institute of TechnologyShenzhen 518055China Yunnan Observatories Chinese Academy of SciencesKunming 650011China

A sunspot is an ideal waveguide for a variety of magnetohydrodynamic waves,which carry a significant amount of energy to the upper atmosphere and could be used as a tool to probe the magnetic and thermal structure of a sunspot.In this study,we used the New Vacuum Solar Telescope and took highresolution image sequences simultaneously in both Ti O(7058±10?A)and Hα(6562±2.5?A)bandpasses.We extracted the area and total emission intensity variations of sunspot umbra and analyzed the signals with synchrosqueezing transform.We found that the area and emission intensity varied with both three and five minute periodicity.Moreover,the area and intensity oscillated in phase with each other,this fact hold in both Ti O and Hαdata.We interpret this oscillatory signal as a propagating slow sausage wave.The propagation speed is estimated at about 8 km s^-1.We infer that this sunspot's umbra could have temperature as low as 2800–3500 K.

关键词： Sun:sunspot Sun:oscillations magnetohydrodynamics(MHD) methods:data analysis

“吐故方能纳新”——基于退市新规的事件研究

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中央财经大学学报 2024年第2期 81-91页

作者：郑登津兰天琪赵瑞瑞中央财经大学会计学院清华大学经济管理学院

党的十九届五中全会提出要“全面实行股票发行注册制,建立常态化退市机制”,退市制度是资本市场的基础法律制度,完善的退市制度是建立良性市场生态的重要一环。本文以2020年12月31日退市新规的正式发布为研究事件,通过事件研究方法对退... 详细信息

党的十九届五中全会提出要“全面实行股票发行注册制,建立常态化退市机制”,退市制度是资本市场的基础法律制度,完善的退市制度是建立良性市场生态的重要一环。本文以2020年12月31日退市新规的正式发布为研究事件,通过事件研究方法对退市新规发布后的短期市场反应进行检验。结果发现:市场对退市新规的审议通过体现了充分的关注并予以积极反应,依据公司特征进行区分后发现,经营风险和监管风险较高的公司市场反应较差,而信息环境较好、投资者保护水平较高的公司市场反应更加正向;进一步地,退市新规对于国企与非国企上市公司影响并无显著差异,投资者对创业板上市公司的市场反应相对负面;此外,较之征求意见稿,退市新规正式版发布的市场反应更为显著。结论显示,退市新规的正式颁布优化市场环境,高质量公司更加受益于资本市场改革红利,为资本市场的深化改革和促进上市公司高质量发展提供了重要启示。

关键词：退市新规经营风险监管风险信息披露投资者保护

Colossal negative magnetoresistance in spin glass Na(Zn,Mn)Sb

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Journal of Semiconductors 2023年第3期44卷 62-67页

作者： Shuang Yu Yi Peng Guoqiang Zhao Jianfa Zhao Xiancheng Wang Jun Zhang zheng deng Changqing Jin Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physics University of Chinese Academy of SciencesBeijing 100190China

We report the study of magnetic and transport properties of polycrystalline and single crystal Na(Zn,Mn)Sb,a new member of“111”type of diluted magnetic materials.The material crystallizes into Cu2Sb-type structure which is isostructural to“111”type Fe-based superconductors.With suitable carrier and spin doping,the Na(Zn,Mn)Sb establishes spin-glass ordering with freezing temperature(Tf)below 15 K.Despite lack of long-range ferromagnetic ordering,Na(Zn,Mn)Sb single crystal still shows sizeable anomalous Hall effect below Tf.Carrier concentration determined by Hall effect measurements is over 1019 cm-3.More significantly,we observe colossal negative magnetoresistance(MR≡[ρ(H)−ρ(0)]/ρ(0))of-94%in the single crystal sample.

关键词： colossal negative magnetoresistance spin glass diluted magnetic materials

基于孔雀石绿/核酸适配体的免标记荧光法检测中药中的赭曲霉素A

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中国中药杂志 2024年第7期49卷 1818-1825页

作者：杨圆圆邓峥嵘高仕超郭丽敏山西中医药大学山西晋中030619

该文报道了一种基于孔雀石绿/核酸适配体的免标记荧光法检测中药中的赭曲霉素A(OTA)。孔雀石绿本身荧光信号微弱,与赭曲霉素A的核酸适配体作用后,G-四链体结构的核酸适配体为孔雀石绿提供一个保护的微环境,使其荧光信号显著增强。再加入... 详细信息

该文报道了一种基于孔雀石绿/核酸适配体的免标记荧光法检测中药中的赭曲霉素A(OTA)。孔雀石绿本身荧光信号微弱,与赭曲霉素A的核酸适配体作用后,G-四链体结构的核酸适配体为孔雀石绿提供一个保护的微环境,使其荧光信号显著增强。再加入OTA之后,核酸适配体会优先与OTA结合,从而使孔雀石绿游离于核酸适配体之外,其荧光信号随之减弱。基于此,该文以OTA的核酸适配体为识别元件,孔雀石绿为荧光探针,建立了一种基于核酸适配体的荧光法检测中药中的OTA。并对金属离子、核酸适配体和孔雀石绿的浓度等影响实验结果的主要因素进行了进一步的优化。在最佳实验条件下对OTA进行了检测,实验发现,随着OTA浓度的增大,荧光信号逐渐减弱,在20~1000 nmol·L^(-1),OTA浓度与荧光信号比值ΔF/F呈线性相关(ΔF=F_(0)-F,F_(0)为核酸适配体/孔雀石绿的荧光信号,F为OTA/核酸适配体/孔雀石绿的荧光信号),检出限为7.1 nmol·L^(-1),R^(2)=0.995。为考察该方法的特异性,该实验选择了3种与OTA结构相似的物质以及2种可能和OTA共存的真菌毒素进行交叉反应率实验和特异性实验。交叉反应率实验表明这些干扰物不会引起检测体系明显的荧光信号变化,而特异性实验显示了当干扰物与OTA混合后,混合物产生的荧光信号与OTA的荧光信号接近,说明即使与干扰物共存,OTA的检测也不会受到影响,说明方法具有良好的特异性;方法也展现了良好的重复性和稳定性。仅对中药进行简单的离心和稀释,方法即可用于中药葛根、苦参、香加皮中OTA的检测,回收率在91.50%~121.3%。该方法不需要复杂的中药预处理,操作简单,检测成本低,检测时间短,而且方法将核酸适配体应用于中药质量鉴定中,进一步拓展了核酸适配体的应用范围。

关键词：核酸适配体孔雀石绿赭曲霉素A 荧光免标记

Pressure-Induced Intermetallic Charge Transfer and Semiconductor- Metal Transition in Two-Dimensional AgRuO_(3)

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CCS Chemistry 2023年第4期5卷 934-946页

作者： Chuanhui Zhu Jinjin Yang Pengfei Shan Mei-Huan Zhao Shuang Zhao Cuiying Pei Bowen Zhang zheng deng Mark Croft Yanpeng Qi Lihong Yang Yonggang Wang Xiaojun Kuang Long Jiang Dao-Xin Yao Jin-Guang Cheng Man-Rong Li Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-sen UniversityGuangzhou 510275 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210 College of Chemistry and Bioengineering Guilin University of TechnologyGuilin 541004 Department of Physics and Astronomy RutgersThe State University of New JerseyPiscatawayNJ 08854 ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210 Shanghai Key Laboratory of High-Resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210 Center for High Pressure Science and Technology Advanced Research(HPSTAR) Beijing 100094 Guangdong Key Laboratory of Magnetoelectric Physics and Devices School of PhysicsSun Yat-sen UniversityGuangzhou 510275

The intricate correlation between charge degrees of freedom and physical properties is a fascinating area of research in solid state chemistry and condensed matter physics.Herein,we report on the pressureinduced successive charge transfer and accompanied resistive evolution in honeycomb layered ruthenate AgRuO_(3).Structural revisiting and spectroscopic analyses affirm the ilmenite type R-3 structure with mixed valence cations as Ag^(+1/+2)Ru^(+4/+5)O_(3) at ambient pressure.In-situ pressure-and temperature-dependent resistance variation reveals a successive insulatormetal-insulator transition upon pressing,accompanied by unprecedented charge transfer between Ag and Ru under applied pressure,and a further structural phase transition in the insulator region at higher pressure.These phenomena are also corroborated by in-situ pressure-dependent Raman spectra,synchrotron X-ray diffraction,bond valence sums,and electronic structure calculations,emphasizing the dominated rare Ag2+,and near zero thermal expansion in the ab-plane in the metallic zone mostly due to the Jahn-Teller effect of d9-Ag2+.The multiple electronic instabilities in AgRuO_(3) may offer new possibilities toward novel and unconventionally physical and chemical behaviors in strongly correlated honeycomb lattices.

关键词： intermetallic charge transfer semiconductor-metal transition honeycomb layered ruthenates high pressure