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T2-weighted imaging-based radiomic-clinical machine learning model for predicting the differentiation of colorectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 819-832页

作者： Hui-Da zheng Qiao-Yi huang Qi-Ming huang Xiao-Ting Ke Kai Ye Shu Lin Jian-hua Xu Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Computed Tomography/Magnetic Resonance Imaging The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Centre of Neurological and Metabolic Research The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Group of Neuroendocrinology Garvan Institute of Medical ResearchSydneyNSW 2010Australia

BACKGROUND The study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported *** a non-invasive model to predict the differentiation grade of CRC is of great *** To develop and validate machine learning-based models for predicting the differ-entiation grade of CRC based on T2-weighted images(T2WI).METHODS We retrospectively collected the preoperative imaging and clinical data of 315 patients with CRC who underwent surgery from March 2018 to July *** were randomly assigned to a training cohort(n=220)or a validation cohort(n=95)at a 7:3 *** were delineated layer by layer on high-resolution *** absolute shrinkage and selection operator regression was applied to screen for radiomic *** and clinical models were constructed using the multilayer perceptron(MLP)*** radiomic features and clinically relevant variables(selected based on a significance level of P<0.05 in the training set)were used to construct radiomics-clinical *** performance of the three models(clinical,radiomic,and radiomic-clinical model)were evaluated using the area under the curve(AUC),calibration curve and decision curve analysis(DCA).RESULTS After feature selection,eight radiomic features were retained from the initial 1781 features to construct the radiomic *** different classifiers,including logistic regression,support vector machine,k-nearest neighbours,random forest,extreme trees,extreme gradient boosting,light gradient boosting machine,and MLP,were used to construct the model,with MLP demonstrating the best diagnostic *** AUC of the radiomic-clinical model was 0.862(95%CI:0.796-0.927)in the training cohort and 0.761(95%CI:0.635-0.887)in the validation *** AUC for the radiomic model was 0.796(95%CI:0.723-0.869)in the training cohort and 0.735(95%CI:0.604-0.866)in the validation *** clinical model achieved an AUC of 0.7

关键词： Radiomics Colorectal cancer Differentiation grade Machine learning T2-weighted imaging

Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao Rong Song-hua Liu Ming-zheng Tang Zhi-Hang Wu Guo-Rong Ma Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer

Health risks and sources of trace elements and black carbon in PM_(2.5)from 2019 to 2021 in Beijing

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Journal of Environmental Sciences 2024年第8期142卷 69-82页

作者： Chenjie hua Wei Ma Feixue zheng Yusheng Zhang Jiali Xie Li Ma Boying Song Chao Yan Hongyan Li Zhen Liu Qian Liu Markku Kulmala Yongchun Liu Aerosol and Haze Laboratory Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Institute for Atmospheric and Earth System Research Faculty of ScienceUniversity of HelsinkiHelsinki 00014Finland School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

A comprehensive health risk assessment of PM_(2.5)is meaningful to understand the current status and directions regarding further improving air quality from the perspective of human *** this study,we evaluated the health risks of PM_(2.5)as well as highly toxic inorganic components,including heavy metals(HMs)and black carbon(BC)based on longterm observations in Beijing from 2019 to *** results showed that the relative risks of chronic obstructive pulmonary disease,lung cancer,acute lower respiratory tract infection,ischemic heart disease,and stroke decreased by 4.07%-9.30%in 2020 and 2.12%-6.70%in2021 compared with ***,they were still at high levels ranging from 1.26 to 1.77,in particular,stroke showed the highest value in *** had the highest hazard quotient(HQ,from 2.18 to 2.56)for adults from 2019 to 2021,while Ni,Cr,Pb,As,and BC showed high carcinogenic risks(CR>1.0×10^(-6))for *** HQ values of Mn and As and the CR values of Pb and As showed constant or slight upwards trends during our observations,which is in contrast to the downward trends of other HMs and PM_(2.5).Mn,Cr,and BC are crucial toxicants in PM_(2.5).A significant shrink of southern region sourcesof HMs and BCshrank suggests the increased importance of local ***,dust,and biomass burning are the major contributors to the non-carcinogenic risks,while traffic emissions and industry are the dominant contributors to the carcinogenic risks in Beijing.

关键词： PM_(2.5) Heavy metals Black carbon Health risk Source apportionment

Metamorphic P-T conditions and ages of garnet-biotite schists in the Dahongshan Group from the southwestern Yangtze Block

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Acta Geochimica 2024年第4期43卷 707-718页

作者： Jun-xiao Ma Guang-shu Yang Yong-feng Yan Xiao-Fei Xu Yun-hua Ren Hui Zhao Xiao-jun zheng Yuan Qin Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Geological Team 306 of Yunnan Non-Ferrous Metals Geological Bureau Kunming 650217China Yunnan Provincial Bureau of Non-Ferrous Geology Kunming 650051China

The Dahongshan Group,situated at the southwestern margin of the Yangtze Block,represents a geological unit characterized by relatively high-grade metamorphism in the *** paper investigates the garnet-biotite schist from the Laochanghe Formation of the Dahongshan Group,employing an integrated approach that includes petrological analysis,phase equilibrium modeling,and zircon U-Pb *** schist is mainly composed of garnet,biotite,plagioclase,quartz,rutile,and *** equilibrium modeling revealed the peak metamorphic conditions of 8-9 kbar and 635-675°*** further integrating the prograde metamorphic profile of garnet and geothermobarometric results,a clockwise P-T metamorphic evolution path is constructed,which includes an increase in temperature and pressure during the prograde ***-ICP-MS zircon U-Pb dating and zircon Ti thermometry constrains the post-peak metamorphic age of 831.2±7.2 *** with previously reported results,it is revealed that the southwestern margin of the Yangtze Block experienced a large-scale regional metamorphism during the Neoproterozoic(890-750 Ma),which is related to the collisional orogenic *** may be associated with the late-stage assembly of the Rodinia supercontinent or with local compression and subduction processes during the breakup of the Rodinia supercontinent.

关键词： Southwestern Yangtze Block Dahongshan Group Phase equilibrium modeling Zircon U-Pb dating Neoproterozoic metamorphism

Performance Limits and Advancements in Single 2D Transition Metal Dichalcogenide Transistor

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Nano-Micro Letters 2024年第12期16卷 134-188页

作者： Jing Chen Ming-Yuan Sun Zhen-hua wang zheng Zhang Kai Zhang Shuai wang Yu Zhang Xiaoming Wu Tian-Ling Ren Hong Liu Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084People’s Republic of China BNRist Tsinghua UniversityBeijing 100084People’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shenzhen Research Institute of Shandong University Shenzhen 518057People’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan 250100People’s Republic of China

Two-dimensional(2D)transition metal dichalcogenides(TMDs)allow for atomic-scale manipulation,challenging the conventional limitations of semiconductor *** capability may overcome the short-channel effect,sparking significant advancements in electronic devices that utilize 2D *** the dimension and performance limits of transistors based on 2D TMDs has gained substantial *** review provides a comprehensive investigation into these limits of the single 2D-TMD *** delves into the impacts of miniaturization,including the reduction of channel length,gate length,source/drain contact length,and dielectric thickness on transistor operation and *** addition,this review provides a detailed analysis of performance parameters such as source/drain contact resistance,subthreshold swing,hysteresis loop,carrier mobility,on/off ratio,and the development of p-type and single logic *** review details the two logical expressions of the single 2D-TMD logic transistor,including current and *** also emphasizes the role of 2D TMD-based transistors as memory devices,focusing on enhancing memory operation speed,endurance,data retention,and extinction ratio,as well as reducing energy consumption in memory devices functioning as artificial *** review demonstrates the two calculating methods for dynamic energy consumption of 2D synaptic *** review not only summarizes the current state of the art in this field but also highlights potential future research directions and *** underscores the anticipated challenges,opportunities,and potential solutions in navigating the dimension and performance boundaries of 2D transistors.

关键词： Two-dimensional transistors Dimension limits Performance limits Memory devices Artificial synapses

THE GLOBAL EXISTENCE AND ANALYTICITY OF A MILD SOLUTION TO THE 3D REGULARIZED MHD EQUATIONS

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Acta Mathematica Scientia 2024年第3期44卷 973-983页

作者：肖存涛邱华姚正安 School of Mathematics and Statistics Guangdong University of TechnologyGuangzhou510090China Department of Mathematics South China Agricultural UniversityGuangzhou510642China School of Mathematics Sun Yat-sen UniversityGuangzhou510275China

In this paper,we study the three-dimensional regularized MHD equations with fractional Laplacians in the dissipative and diffusive *** establish the global existence of mild solutions to this system with small initial... 详细信息

关键词： regularized MHD equations fractional Laplacian global well-posedness analyticity decay rate

Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian Zhan-Jun Chen Yong-Sheng wang Xiao-Yan Hu Xiao-Biao Hu Yong-hua zheng Pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND Obstructive sleep apnea-hypopnea syndrome(OSAHS)is primarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base *** mid-frequency anti-snoring device is a new technology based on sublingual nerve *** principle is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave ***,there is a lack of clinical application and imaging *** We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August *** underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime *** the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth Sleepiness Scale ***,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring ***-sectional area measurements in different states were taken at the narrowest airway point in the soft palate posterior and retrolingual *** Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea *** lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth Sleepiness Scale scores *** computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake ***,during mid-frequency anti-snoring device treatment,these areas increased compared to *** The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in pat

关键词： Mid-frequency anti-snoring device Obstructive sleep apnea-hypopnea syndrome Sleep monitoring Oropharyngeal computed tomography Curative effect

1959-2021年间热带雨林区域的蒸发皿蒸发量呈下降趋势

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Journal of Plant Ecology 2024年第1期17卷 1-16页

作者： Yan Jin Ying Zhang Xin Yang Mou Zhang Xin-Bo Guo Yun Deng Yue-hua Hu hua-zheng Lu zheng-Hong Tan School of Ecology and Environmental Science Yunnan UniversityKunming 650091China International Center for Climate and Environment Sciences Institution of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaMenglun 666303China Center for Plant Ecology Core Botanical GardensChinese Academy of SciencesMenglaMenglun 666303China

蒸发皿蒸发量(E_(pan))是衡量大气蒸发需求的重要指标。基于物理模型对西双版纳热带植物园中热带雨林综合气象观测场(XTBG气象站)的气象资料进行分析,有助于提高我们对西双版纳热带雨林区域水文循环状况的认识。本文利用1959-2021年的... 详细信息

蒸发皿蒸发量(E_(pan))是衡量大气蒸发需求的重要指标。基于物理模型对西双版纳热带植物园中热带雨林综合气象观测场(XTBG气象站)的气象资料进行分析,有助于提高我们对西双版纳热带雨林区域水文循环状况的认识。本文利用1959-2021年的观测资料,研究了E_(pan)的长期变化趋势,并进行了趋势检验、周期性评价和突变分析等相关分析。基于1979-2008年D20 E_(pan)数据和相关气象资料,利用Penman-Monteith和PenPan模型对E_(pan)进行模拟,采用偏微分归因法分析了影响E_(pan)的主导因素。研究结果表明,E_(pan)具有明显的周期变化,19 a为第一主周期。而且,西双版纳地区存在明显的‘蒸发悖论’现象。E_(pan)在1959-2008年和2009-2018年均呈下降趋势,其中1959-2008年下降幅度达到显著水平,为-3.404 mm·a^(-2)。通过对比分析,认为PenPan模型更适合用于模拟西双版纳地区的E_(pan)。为了确定影响E_(pan)的主要气象因子,选取了D20蒸发皿完整监测时期的数据(1979-2008)进行归因计算。太阳净辐射和饱和蒸汽压差的减小趋势可以有效抵消气温上升对E_(pan)的促进作用。因此,净辐射和饱和蒸汽压差的变化是西双版纳‘蒸发悖论’现象的主要触发因素。

关键词：蒸发皿蒸发量蒸发悖论 PenPan模型偏微分归因法驱动因素

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立体耦合光子晶体薄板微腔的高Q值特性研究

物理学报 2010年第12期59卷 8548-8553页

作者：江斌刘安金陈微邢名欣周文君郑婉华中国科学院半导体研究所

利用微腔之间的立体耦合,提出了基于无源材料硅的双层光子晶体薄板H1(DLPCS-H1)腔,薄板之间为空气层.使用三维时域有限差分方法和Padé近似方法分析了DLPCS-H1腔的偶极模的场分布和品质因子.通过对中间空气层高度的优化使DLPCS-H1腔的... 详细信息

利用微腔之间的立体耦合,提出了基于无源材料硅的双层光子晶体薄板H1(DLPCS-H1)腔,薄板之间为空气层.使用三维时域有限差分方法和Padé近似方法分析了DLPCS-H1腔的偶极模的场分布和品质因子.通过对中间空气层高度的优化使DLPCS-H1腔的偶极模的品质因子得到了显著的提高,大约为单层光子晶体薄板H1腔的偶极模的品质因子的4倍.此外,还研究了三层光子晶体薄板H1腔,它的偶极模的品质因子约为单层光子晶体薄板H1腔的偶极模的品质因子的7倍.

关键词：双层光子晶体薄板微腔偶极模品质因子 Padé近似