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Prognostic impact of splenectomy on advanced proximal gastric cancer with No. 10 lymph node metastasis

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Chinese Medical Journal 2009年第22期122卷 2757-2762页

作者： HUANG Chang-ming WANG Jia-bin LU hui-shan zheng chao-hui LI Ping XIE Jian-wei ZHANG Xiang-fu Department of Oncology Affiliated Union Hospital of Fujian Medical University Fuzhou Fujian 350001 China

Background This study evaluated the prognostic impact of D2 lymphadenectomy combined with splenectomy in patients with advanced proximal gastric cancer and lymph node metastasis at the splenic hilum （No. 10 lymph nodes）. Methods The clinical records of 216 patients with advanced proximal gastric cancer and No. 10 lymph node metastasis who underwent D2 curative resection were retrospectively analyzed. Seventy-three patients underwent simultaneous splenectomy （splenectomy group）, while 143 patients did not （spleen-preserving group）. Five-year survival rates, mean numbers of dissected No. 10 lymph nodes and metastatic No. 10 lymph nodes, and operative morbidity and mortality were calculated and compared between the two groups. Potential prognostic factors were evaluated by univariate and multivariate analysis.Results The 5-year survival rate was 30.0% for the splenectomy group and 19.7% for the spleen-preserving group （χ^2=14.73, P 〈0.05）. The mean numbers of dissected No. 10 lymph nodes and metastatic No. 10 lymph nodes in the splenectomy group were significantly greater than in the spleen-preserving group （P 〈0.05）. Multivariate analysis revealed that the depth of invasion, splenectomy, and type of gastrectomy were independent prognostic factors. The survival rate for T3 patients with and without splenectomy was 38.7% and 18.9%, respectively （χ^2 =15.03, P 〈0.05）. For patients undergoing total gastrectomy, survival rates were 33.4% and 20.7%, respectively （χ^2 =13.63, P〈0.05）. Operative morbidity and mortality in splenectomy group was 24.7% and 4.1%, respectively, and in the spleen-preserving group was 17.5% and 3.5%, respectively. The differences were not statistically significant （P 〉0.05）. Conclusions Splenectomy is beneficial for No. 10 lymph node dissection in patients with advanced proximal gastric cancer. To improve patient prognosis, total gastrectomy with splenectomy is recommended for patients with T3 proximal gastric cancer who have No. 10 lymph node met

关键词： stomach neoplasms lymphatic metastasis splenectomy gastrectomy prognosis

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论董仲舒的“馀义”言说

中山大学学报（社会科学版） 2019年第2期59卷 142-150页

作者：郑朝晖曲阜师范大学哲学系日照276826 广西大学哲学系南宁531499

《春秋繁露》是典型的融合性文本。董仲舒能够将不同学派的思想资源融为一体,与其"馀义"言说方式有关。馀义言说是"以比贯类、以辨付赘"的方法,亦即通过连环问答、数理描述、天人对话揭示人情与辞义、天志与名号之间的同一性。不同学派... 详细信息

《春秋繁露》是典型的融合性文本。董仲舒能够将不同学派的思想资源融为一体,与其"馀义"言说方式有关。馀义言说是"以比贯类、以辨付赘"的方法,亦即通过连环问答、数理描述、天人对话揭示人情与辞义、天志与名号之间的同一性。不同学派的思想资源能够融为一体,正是借助于"比例法"与"正义法"。

关键词：馀义连环问答数理描述天人对话文本融合

Type-dependent differential expression of neuropeptide Y in chicken hypothalamus (Gallus domesticus)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第11期8卷 839-844页

作者： CHEN Gui-qian HU Xiu-fang SUGAHARA Kunio CHEN Ji-shuang SONG Xue-mei zheng hui-chao JIANG Yong-qing HUANG Xin JIANG Jun-fang ZHOU Wei-dong Institute of Bioengineering Zhejiang Sci- Tech University Hangzhou 310018 China Institute of Animal Husbandry and Veterinary Science Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China Laboratory of Nutritional Biochemistry Department of Animal Science Faculty of Agriculture Utsunomiya University Utsunomiya 321-8505 Japan

Neuropeptide Y （NPY） is one of the most important orexigenic agents in central regulation of feeding behavior, body weight and energy homeostasis in domestic chickens. To examine differences in the hypothalamic NPY between layer-type and meat-type of chickens, which are two divergent kinds of the domestic chickens in feeding behavior and body weight, we detected mRNA levels of NPY in hypothalamic infundibular nucleus （IN）, paraventricular nucleus （PVN） and lateral hypothalamic area （LHA） of these two types of chickens using one-step real time RT-PCR. The meat-type chicken had more food daily （about 1.7 folds） and greater body weights （about 1.5 folds） and brain weights than the layer-type chicken at the age of 14 d. In the meat-type of chicken, NPY mRNA levels of the IN and PVN were significantly greater than those of the LHA, and were not significantly different between the lN and PVN. However, in the layer-type of chicken, NPY mRNA levels were significantly greater in the IN than those in the LHA and PVN, and were not significantly different between the PVN and LHA. In all these hypothalamic regions the layer-type of chicken had significantly higher NPY mRNA levels than the meat-type chicken did. These results suggest the expression of NPY in the hypothalamus has a type-dependent pattern in domestic chickens.

关键词： Neuropeptide Y (NPY) Hypothalamus Message RNA (mRNA) Meat-type chicken Layer-type chicken

用太阳光谱测量空气中NO_2浓度的方法研究

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物理学报 2000年第12期49卷 2507-2513页

作者：周斌刘文清郑朝晖张玉钧宋炳超王锋平中国科学院安徽光学精密机械研究所合肥230031

根据Noxon方法 ,利用NO2 在 430— 45 0nm范围内的吸收特性 ,测量空气中NO2 的浓度 .介绍了一种利用光学差分吸收原理 ,以太阳光为光源 ,二极管阵列为探测器 ,黄山光明顶上的太阳光谱为参考光谱测量大气中NO2 浓度的新光学方法 .

关键词：太阳光谱环境空气质量监测二氧化氮浓度

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压铸模具选材和辅助设计专家系统

铸造 2012年第2期61卷 156-160页

作者：郑慧超褚作明陈东金康王晓辉机械科学研究总院先进制造技术研究中心先进成形技术与装备国家重点实验室北京100083

基于数据库技术和模块化设计方法,采用产生式规则知识表达方法,将选材和设计的大量相关数据、专家经验知识和判据构成知识库,并利用语言编程方法建立了专家系统的整体框架。研究开发了理论依据充分、先进实用的热作模具选材及设计专家系... 详细信息

基于数据库技术和模块化设计方法,采用产生式规则知识表达方法,将选材和设计的大量相关数据、专家经验知识和判据构成知识库,并利用语言编程方法建立了专家系统的整体框架。研究开发了理论依据充分、先进实用的热作模具选材及设计专家系统,实现了热作模具选材和设计的信息存储、快速查询及专家推荐等功能,为实现模具生产工艺制定提供依据和指导。

关键词：模具材料选材用材压铸模设计专家系统

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper chao Li Li Zhang zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Unveiling an ancient whole-genome duplication event in Stentor,the model unicellular eukaryotes

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Science China Life Sciences 2025年

作者： Weibo zheng chao Li Zhaorui Zhou Xiao Chen Michael Lynch Ying Yan School of Life Sciences Ludong University Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Biodesign Center for Mechanisms of Evolution Arizona State University Marine College Shandong University

Whole-genome duplication(WGD) events are widespread across eukaryotes and have played a significant role in moulding the genetic architectures of diverse organisms. In the present study, the newly sequenced genome of a giant ciliated protist, Stentor roeselii, provides an opportunity for the analysis of the collinearity and retention of reciprocal best-hit genes between two Stentor species. As a main result, we have unveiled a previously undetected ancient WGD event shaping the genome of its congener, Stentor coeruleus, a model protist used in cytological and evolutionary studies. Genomes of two congeners, S. coeruleus and S. roeselii, are compared and analyzed, revealing that:(i)the former exhibits a much higher retention rate of colinear-gene pairs(28%) than does S. roeselii, and in S. coeruleus, 75% of genes that have a RBH hit in S. roeselii, have paralogs with high amino-acid identity, consistent with a WGD event in the lineage leading to S. coeruleus;(ii) the S. roeselii genome possesses extremely short intergenic regions, implying that the lengths of intergenic regions are under strong selection;(iii) the unique characteristics of introns may have been shaped in the common ancestor of heterotrichs;(iv) gene families that play a role in activities of multiple protein kinases and voltage-gated ion channels expanded rapidly in the ancestor of both taxa, possibly relating to the remarkable regenerative ability in Stentor. This study offers new insights into the evolutionary dynamics of ciliate genomes,with implications for understanding of the processes underlying the evolution of genomic complexity.

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-hui zheng Bo Shao chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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港口总体规划环评与规划互动的理念与实践

环境影响评价 2017年第3期39卷 31-34页

作者：谢燕郑超蕙交通运输部规划研究院环境资源所北京100028

与规划编制开展全程互动是规划环评的首要技术原则。基于我国数十个港口总体规划环评的经验,以宁波-舟山港规划环评为案例,探讨了港口规划环评与规划全程互动的目的与意义,提出了互动的三个主要阶段,即规划启动时的"理念互通"阶段、规... 详细信息

与规划编制开展全程互动是规划环评的首要技术原则。基于我国数十个港口总体规划环评的经验,以宁波-舟山港规划环评为案例,探讨了港口规划环评与规划全程互动的目的与意义,提出了互动的三个主要阶段,即规划启动时的"理念互通"阶段、规划方案研究时的"协同工作"阶段和规划报告完成后的"评估优化"阶段,分析了各阶段互动的方式和预期成果,以期探讨在港口规划环评中开展全程互动的机制与有效模式。

关键词：互动规划环境影响评价港口总体规划