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一株具有缓解酒精性肝损伤的发酵粘液乳杆菌及其功效评价研究

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食品与发酵工业 2024年第8期50卷 89-96页

作者：陈作国郑志瑶陈彩玲朱珺孙盛李理陈苏杭州娃哈哈集团有限公司杭州娃哈哈科技有限公司浙江省食品生物工程重点实验室浙江杭州310018

该研究从新疆奶疙瘩中分离鉴定一株发酵粘液乳杆菌(Limosilactobacillus fermentum)WHH2438,以商业菌株鼠李糖乳酪杆菌(Lacticaseibacillus rhamnosus)GG为对照,从抗氧化特性、改善肠道屏障功能、耐受性和黏附性等方面,进行体外功效评... 详细信息

该研究从新疆奶疙瘩中分离鉴定一株发酵粘液乳杆菌(Limosilactobacillus fermentum)WHH2438,以商业菌株鼠李糖乳酪杆菌(Lacticaseibacillus rhamnosus)GG为对照,从抗氧化特性、改善肠道屏障功能、耐受性和黏附性等方面,进行体外功效评价。之后以C57BL/6 J小鼠为实验对象,使用液体酒精饲料建立慢性酒精性肝损伤模型,验证菌株的缓解酒精性肝损伤功能。结果显示,该发酵粘液乳杆菌清除DPPH自由基和羟自由基能力显著优于LGG,在保护肠道细胞和肠道屏障方面也有优秀的能力。通过酒精性肝损伤功能动物剂量效价实验,发现菌株WHH2438高剂量组和灭活组的血清谷丙转氨酶和谷草转氨酶相比模型组明显下降、肝脏甘油三脂和还原型谷胱甘肽下降且接近对照,总体有较明显的改善效果,说明该菌株降低酒精对肝脏的氧化损伤,延缓酒精性脂肪肝的形成,具有良好的缓解酒精性肝损伤功能。综上,发酵粘液乳杆菌WHH2438具有良好的缓解慢性酒精性肝损伤功能,且菌株特性优良,能顺利到达肠道,并黏附于肠道上皮细胞,发挥益生功效。

关键词：乳酸菌发酵黏液乳杆菌酒精性肝损伤抗氧化耐酸耐胆盐黏附性

基于Kmeans聚类的配网变压器绕组材质辨识算法

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华北电力大学学报（自然科学版） 2024年第5期51卷 66-73页

作者：尹忠东陈俊晔沈子伦付瑜郑志曜王亚伟新能源电力系统国家重点实验室(华北电力大学) 北京102206 浙江华电器材检测研究院有限公司浙江杭州310000

近年来由于日益白热化的配电变压器市场竞争,不少中小型企业“以铝代铜”生产变压器,对电力系统的稳定性留下隐患。当前变压器材质无损辨识方法和技术欠缺,而谐波电阻法所需设备简便、成本低,有很高的工程实用价值,但缺乏科学严谨的算... 详细信息

近年来由于日益白热化的配电变压器市场竞争,不少中小型企业“以铝代铜”生产变压器,对电力系统的稳定性留下隐患。当前变压器材质无损辨识方法和技术欠缺,而谐波电阻法所需设备简便、成本低,有很高的工程实用价值,但缺乏科学严谨的算法支撑。为了准确高效地对变压器绕组材质进行辨识,在已有研究的基础上提出了一种基于Kmeans聚类的辨识算法,并对算法进行了优化。该方法对统计得到的变压器绕组谐波电阻进行聚类分析,再通过方差选择法、主成分分析(PCA)降维对算法进行优化,验证了优化算法的可行性,并利用优化算法展开现场应用。分析结果表明该算法能准确地鉴别变压器绕组材质,有广阔的工程应用前景。

关键词：谐波电阻变压器绕组方差选择法 Kmeans聚类 PCA降维

基于谐波效应的变压器绕组材质鉴别方法与实验验证

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华北电力大学学报（自然科学版） 2024年第3期51卷 83-91页

作者：尹忠东王亚伟韩泽荣龙江郑志曜夏越婷新能源电力系统国家重点实验室(华北电力大学) 北京102206 浙江华电器材检测研究院有限公司浙江杭州310000

为实现配电变压器绕组材质的快速准确辨识,在已有研究的基础上提出了一种基于谐波效应的变压器绕组材质无损鉴别方法并进行了实验验证。首先研究了谐波效应下的理论机理,根据变压器绕组谐波电阻的计算公式分析了基于谐波效应法进行变压... 详细信息

为实现配电变压器绕组材质的快速准确辨识,在已有研究的基础上提出了一种基于谐波效应的变压器绕组材质无损鉴别方法并进行了实验验证。首先研究了谐波效应下的理论机理,根据变压器绕组谐波电阻的计算公式分析了基于谐波效应法进行变压器绕组材质辨识的可行性。之后针对配电变压器常用联结组别的特征给出了对应的测试模型和等效电路,并对实验设备的误差影响进行了分析,最后利用不同绕组材质的配电变压器进行了实验验证并对该方法的工程实用性进行了说明。实验结果表明所述方法测试速度快、辨识准确度高,能够快速有效地进行配电变压器的绕组材质鉴别,具有广阔的工程应用前景。

关键词：配电变压器谐波效应电容补偿谐波电阻实验验证

Experimental study on workability and permeability of sandy soils conditioned with thickened foam

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 532-544页

作者： zhiyao Feng Shuying Wang Tongming Qu Xiangcou zheng Fanlin Ling School of Civil Engineering Central South UniversityChangsha410075China Tunnel and Underground Engineering Research Center Central South UniversityChangsha410075China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClearwater BayKowloon999077Hong KongChina Geo-Engineering Section Delft University of TechnologyDelft999025Netherlands

Water spewing and muck plugging often occur during earth pressure balance(EPB)shield machines tunnelling in water-rich sandy strata,even though the conventional foam has been employed to condition sandy *** this study,a novel thickened foaming agent suitable for EPB shield tunnelling in water-rich sandy strata is *** contrast to conventional foam-conditioned sands,the thickened foam-conditioned sand has a low permeability due to the consistent filling of soil pores with the thickened foam,and the initial permeability coefficient decreases by approximately two orders of *** also exhibits a suitable workability,which is attributed to the enhanced capability of the thickened foam to condition sandy *** addition,the effect of concentration on the stability of the foam is explained by the Gibbs-Marangoni effect,and conditioning mechanisms for the thickened foam on sands are discussed from the evolution of foam bubbles.

关键词： Earth pressure balance(EPB)shield Thickened foam Foam-conditioned sand Permeability Workability

Effect of surface oxygen vacancy defects on the performance of ZnO quantum dots ultraviolet photodetector

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Chinese Physics B 2021年第8期30卷 475-479页

作者： Hongyu Ma Kewei Liu Zhen Cheng zhiyao zheng Yinzhe Liu Peixuan Zhang Xing Chen Deming Liu Lei Liu Dezhen Shen State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of Sciences(CAS)Changchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The slower response speed is the main problem in the application of ZnO quantum dots(QDs)photodetector,which has been commonly attributed to the presence of excess oxygen vacancy defects and oxygen adsorption/desorption ***,the detailed mechanism is still not very ***,the properties of ZnO QDs and their photodetectors with different amounts of oxygen vacancy(VO)defects controlled by hydrogen peroxide(H_(2)O_(2))solution treatment have been *** H_(2)O_(2) solution treatment,VO concentration of ZnO QDs *** H_(2)O_(2) solution-treated device has a higher photocurrent and a lower dark ***,with the increase in VO concentration of ZnO QDs,the response speed of the device has been improved due to the increase of oxygen adsorption/desorption *** interestingly,the response speed of the device became less sensitive to temperature and oxygen concentration with the increase of VO *** findings in this work clarify that the surface VO defects of ZnO QDs could enhance the photoresponse speed,which is helpful for sensor designing.

关键词： ZnO quantum dots ultraviolet photodetector oxygen vacancy

Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

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中华神经外科杂志(英文) 2024年第03期

作者： Ge Peicong Yin Zihan Tao Chuming Zeng Chaofan Yu Xiaofan Lei Shixiong Li Junsheng Zhai Yuanren Ma Long He Qiheng Liu Chenglong Liu Wei Zhang Bojian zheng zhiyao Mou Siqi Zhao Zhikang Wang Shuang Sun Wei Guo Min zheng Shuai Zhang Jia Deng Xiaofeng Liu Xingju Ye Xun Zhang Qian Wang Rong Zhang Yan Zhang Shaosen Wang Chengjun Yang Ziwen Zhang Nijia Wu Mingxing Sun Jian Zhou Yujia Shi Zhiyong Ma Yonggang Zhou Jianpo Yu Shaochen Li Jiaxi Lu Junli Gao Faliang Wang Wenjing Chen Yanming Zhu Xingen Zhang Dong Zhao Jizong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China National Clinical Research Center for Neurological Diseases Beijing China Department of Neurosurgery Beijing Hospital National Center of Gerontology Beijing China Department of Radiology Beijing Tiantan Hospital Beijing China Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China Department of Neurology Beijing Tiantan Hospital Beijing China Department of Neurosurgery Beijing Friendship Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Childrens Hospital Capital Medical University Beijing China Department of Neurosurgery The Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing China Department of Neurosurgery Beijing Changping District Hospital Beijing China Department of Neurosurgery Dongfang Hospital Beijing University of Chinese Medicine Beijing China Department of Neurosurgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of NeuroInterventional Surgery Binzhou Medical University Hospital Binzhou Shandong China Department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurosurgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Xi’an China Department of Neurosurgery West China Hospital Sichuan University Chengdu China Department of Neurosurgery Center for Rehabilitation Medicine Zhejiang Provincial Peoples Hospital Affiliated Peoples Hospital Hangzhou Medical College Hangzhou Zhejiang China Beijing Institute of Hepatology Beijing YouAn Hospital Capital Medical University Beijing China Department of Neu

Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic *** The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD *** The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.

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组合式三相逆变器同步控制方法

农业工程学报 2015年第5期31卷 146-151页

作者：郑志曜孙钦斐王江波杨仁刚中国农业大学信息与电气工程学院北京100083

为实现组合式三相逆变器输出电压的同步控制,该文以三台单相储能逆变器Y/△连接为例,对其离网模式及离并网预同步过程时的同步控制方法进行研究。该文在离网模式下采用基于CAN(controller area network)总线通信的基准时间同步与相位调... 详细信息

为实现组合式三相逆变器输出电压的同步控制,该文以三台单相储能逆变器Y/△连接为例,对其离网模式及离并网预同步过程时的同步控制方法进行研究。该文在离网模式下采用基于CAN(controller area network)总线通信的基准时间同步与相位调整同步的主从同步控制方法;在此基础上,针对离并网预同步过程,该文提出了一种基于改进的二阶广义积分锁相环的频率调整同步控制方法,引入了逻辑判断控制器,实现了三相逆变器电压输出相位差时刻满足120°,保证了离网模式及离并网预同步过程时输出电压的同步,为离并网无冲击切换打下基础。最后,实际试验验证了该方法的可靠性和实用性。

关键词：拓扑电储能组合式三相逆变器同步控制离网模式离并网预同步 CAN总线改进锁相环

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降胆固醇乳酸菌的筛选、鉴定与益生特性评价

中国食品学报 2020年第12期20卷 239-247页

作者：郑志瑶王伟军陈波刘建新任大喜浙江大学动物科学学院奶业科学研究所杭州310058 浙江一鸣食品股份有限公司浙江温州325000

目的:从婴儿粪便和发酵食品中筛选具有高效降胆固醇能力且益生特性优异的乳酸菌。方法:从20份婴儿粪便、8份传统发酵泡菜和4份金华火腿样品中初步筛选到乳酸菌102株,采用气相色谱法测定供试菌株的降胆固醇能力,菌株ZY08和I631的降胆固... 详细信息

目的:从婴儿粪便和发酵食品中筛选具有高效降胆固醇能力且益生特性优异的乳酸菌。方法:从20份婴儿粪便、8份传统发酵泡菜和4份金华火腿样品中初步筛选到乳酸菌102株,采用气相色谱法测定供试菌株的降胆固醇能力,菌株ZY08和I631的降胆固醇能力显著高于(P<0.05)标准菌株(ATCC 43121);采用16S rDNA测序对这2株乳酸菌进行鉴定,评价菌株的酸耐受性、胆盐耐受能力、抗生素敏感性及抗菌活性。结果:筛选得到2株高效降胆固醇乳酸菌:植物乳杆菌ZY08和发酵乳杆菌I631,胆固醇降低率分别为67.45%和63.19%。在pH 1.5和pH 3.0的条件下培养6 h,菌株ZY08和I631的活菌数均大于6 lg(CFU/mL)。2株菌对3,5及1.0 g/L胆盐具有一定的耐受性,胆盐耐受能力均在80%以上(胆盐含量为3 g/L);对常见的8种抗生素(青霉素、氨苄青霉素、头孢唑林、丁胺卡那、庆大霉素、红霉素、复方新诺明、氯霉素)都不具备耐药性,对人体健康不存在潜在威胁;2株菌的代谢产物对4种肠道致病菌(金黄色葡萄球菌、单核细胞增生李斯特菌、大肠杆菌O157∶H7、鼠伤寒沙门氏菌)具有一定的抑制作用。结论:获得具有高效降胆固醇能力的植物乳杆菌ZY08和发酵乳杆菌I631,为功能性乳制品的开发提供菌株来源。

关键词：乳酸菌降低胆固醇筛选益生特性

不同釉质黏结剂对牙龈卟啉单胞菌和变形链球菌的影响

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中国组织工程研究 2024年第3期28卷 329-335页

作者：李志耀胡铮李晅陆珮珺上海市徐汇区牙病防治所口腔外科上海市200032 上海交通大学医学院附属第九人民医院口腔正畸科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海市200011 上海市口腔医院口腔正畸科上海市颅颌面发育与疾病重点实验室上海市200001 复旦大学附属儿科医院口腔科上海市201103

背景:光固化型和含氟光固化型釉质黏结剂对酸蚀后的牙釉质表面有一定封闭作用,含氟光固化型釉质黏结剂还能通过释放氟离子实现防龋功能,但缺乏对氟化物较长时间释放的研究,尤其缺乏经历1-3个月氟化物释放后局部致病菌量的变化信息。目的... 详细信息

背景:光固化型和含氟光固化型釉质黏结剂对酸蚀后的牙釉质表面有一定封闭作用,含氟光固化型釉质黏结剂还能通过释放氟离子实现防龋功能,但缺乏对氟化物较长时间释放的研究,尤其缺乏经历1-3个月氟化物释放后局部致病菌量的变化信息。目的:分析青少年正畸治疗患者上前牙使用不同组分釉质黏结剂黏结固定矫治器引发的龈下菌斑中牙龈卟啉单胞菌和变形链球菌表达变化。方法:选择2016年1-12月就诊于上海市口腔医院接受正畸治疗的青少年患者90例,其中男43例,女47例,平均年龄(13.27±1.12)岁。采用随机数字表法将90例患者分为3组:化学固化组应用Unite™黏结树脂进行固定矫治器的黏结,光固化组应用Transbond XT光固化树脂进行固定矫治器的黏结,含氟光固化组应用GC光固化正畸黏结用水门汀进行固定矫治器的黏结,每组30例。在黏结托槽当天(初始黏结)及第1,2,3个月复诊时收集患者上前牙龈下菌斑标本,应用PCR技术检测牙龈卟啉单胞菌和变形链球菌的增殖表达量。结果与结论:①组内比较:随着黏结时间的增加,化学固化组3个月复诊时的牙龈卟啉单胞菌增殖表达显著高于初始黏结时(P0.05);②组间比较:1个月复诊时,光固化组、含氟光固化组牙龈卟啉单胞菌增殖表达低于化学固化组(P<0.05);2,3个月复诊时,含氟光固化组牙龈卟啉单胞菌增殖表达低于光固化组、化学固化组(P<0.05)。1,2,3个月复诊时,光固化组、含氟光固化组变形链球菌增殖表达低于化学固化组(P<0.05),含氟光固化组变形链球菌增殖表达低于光固化组(P<0.05)。③结果显示,在固定正畸中,使用不同组分的釉质黏结剂黏结托槽后,短期内对患者口内牙龈卟啉单胞菌和变形链球菌的增殖表达有不同程度影响,其中含氟光固化釉质黏结剂在托槽黏结初期有助于减少牙釉质脱矿、龋病和牙周炎症的发生。

关键词：口腔正畸固定矫治器釉质黏结剂牙龈卟啉单胞菌变形链球菌