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Study on the anesthestic quality of intravenous infusion of shumianning Ⅱ in minipigs

畜牧与兽医 2012年第S2期44卷 38-39页

作者： Huang Yao-dong zheng ying-jie Hou Jiafa Department of Clinical Studies Veterinary College of Veterinary MedicineNanjing Agricultural University

Pigs are suitable experimental animals for many surgical techniques[1-4]. Shumianning Ⅱ is compound anesthetic which cantain ketamine,xylazine and midazolam and can be only used for swine anesthesia. The purpose of this study was to evaluate the effects of Shumianning Ⅱ administered by continuous rate infusion using microinjection pump[5]on anesthetic quality,cardiopulmonary function and biochemistrical values in *** anesthestic quality of shumianning Ⅱ was investigated in 6 Bama minipigs,aged 8. 7 ± 0. 2 mon,mean weight 23. 7 ± 5. 0 kg. Minipigs were induced with shumianning Ⅱ 0. 03 mL/kg from the ear vein,then received with constant rate infusions of shumianning Ⅱ 0. 03 mL/kg·h for 1h by microinjection pump. Heart rate (HR),respiratory rate (RR),rectal temperature (RT),non-invasive arterial blood pressure (NABP),pulse oxygen saturation (SpO2) and end-tidal pressure of carbon dioxide (P ET CO2) were measured and the effectiveness of analgesia,sedation and muscle relaxation were observed every 5 min; the biochemical parameters of ALP,ALT,AST,CREA,UREA,GLU and TP were measured before and 1 h,24 h,48 h,72 h,168 h after the administration of Shumianning Ⅱ; 5 mL blood sample from the precaval vein was collected at 1 min,3 min,5 min,10 min,25 min,40 min,45 min,60 min,70 min,80min,90 min and 100 min,respectively,then the plasma concentrations of ketamine,xylazine and midazolam were measured with high-performance liquid *** results showed that the status of HR,RR,RT,NABP,SpO2and P ET CO2were significantly different from the base value at some time points (P<0. 05),but all parameters were in the normal physiologic range. Levels of SpO2 at1 min and 5 min (P<0. 05) were significantly lower than the normal physiologic range. Cardiovascular and blood chemistry effects was small,only the level of GLU was higher than the base value (P<0. 05),while others were all not significantly *** the period of intravenous infusion of Shumianning Ⅱ,th

关键词： anesthestic quality shumianning intravenous infusion dog

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磁共振弥散加权成像及延迟强化技术评估缺血性心肌病预后的应用价值

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中国CT和MRI杂志 2024年第7期22卷 77-79,89页

作者：郑英杰耿建芳付力博杨鹏许珊柳州市人民医院放射科广西柳州545006 柳州市人民医院心血管内科广西柳州545006

目的探讨磁共振弥散加权成像(DWI)及延迟强化技术(LGE-CMR)评估缺血性心肌病(ICM)预后的应用价值。方法选择2018年6月-2021年6月在我院诊断为ICM的患者84例作为研究对象。根据LGE-CMR有无心肌延迟强化分为LGE阳性组和LGE阴性组。LGE阳... 详细信息

目的探讨磁共振弥散加权成像(DWI)及延迟强化技术(LGE-CMR)评估缺血性心肌病(ICM)预后的应用价值。方法选择2018年6月-2021年6月在我院诊断为ICM的患者84例作为研究对象。根据LGE-CMR有无心肌延迟强化分为LGE阳性组和LGE阴性组。LGE阳性组再根据LGE阳性节段数分为瘢痕心肌节段数<6和瘢痕心肌节段数≥6两个亚组。分析比较LGE阳性组和阴性组患者心功能参数值及ADC值,LGE阳性两个亚组患者延迟强化情况,并分析比较LGE阳性组和阴性组患者不良心血管事件发生率。不良心血管事件发生的危险因素采用多因素Logistic回归分析。采用ROC曲线分析预测ICM患者发生不良心血管事件的AUC、最佳诊断分界点、敏感度、特异度以及95%CI。结果LGE阳性组患者的心功能参数比LGE阴性组差,LGE阳性组患者的ADC值比LGE阴性组低,且在LGE阳性组中瘢痕心肌节段数≥6亚组的患者心功能参数和ADC值进一步降低(P<0.05)。瘢痕心肌节段数<6亚组患者瘢痕质量、瘢痕质量百分比、灰区质量和灰区质量百分比均小于瘢痕心肌节段数≥6亚组患者(P<0.05)。LGE阳性组发生不良心血管事件的概率高于LGE阴性组(P<0.05)。多因素Logistic回归分析结果显示LVEF、ADC值和瘢痕质量是不良心血管事件发生的危险因素。LVEF、ADC值和瘢痕质量联合预测ICM患者发生不良心血管事件的AUC为0.875(95%CI:0.775-0.976,P<0.001)。结论DWI及LGE-CMR可对ICM患者进行诊断及预后危险分层,可为治疗方案的制定提供参考。

关键词：磁共振扩散加权成像延迟强化技术缺血性心肌病预后

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Leiomyomatosis peritonealis disseminata associated with endocervicosis

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Chinese Medical Journal 2009年第4期122卷 474-477页

作者： LIU Jian-ying zheng jie LIAO Song-lin Department of Pathology Health Science Center of Peking University Beijing 100191 China

Leiomyomatosis peritonealis disseminata （LPD） is a rare but well-documented disorder mainly found in young women. Occasionally, LPD coexists with endometriosis and/or multi-cystic mesothelioma. Endocervicosis is another uncommon condition, which was recognized as a distinct entity by Clement and Young in 1992 and has been documented involving the lymph node, pelvic peritoneum, bladder and small intestine. We described a case with a unique combination of LPD and endocervicosis.

关键词： leiomyomatosis peritonealis disseminata endocervicosis immunohistochemistry

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上海市首次自腹泻患者中检出格隆柏沙门菌的表型和分子特征研究

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中国人兽共患病学报 2024年第8期40卷 732-738页

作者：王闻卿黄卫春苏靖华尤舒琪郑英杰杨博雯黄红郝莉鹏许学斌上海市浦东新区疾病预防控制中心微生物检验科上海200136 复旦大学浦东预防医学研究院上海200136 上海交通大学医学院附属上海儿童医学中心检验科上海200127 复旦大学公共卫生学院上海200032 上海市疾病预防控制中心病原生物检定所上海200336

目的研究上海市首次自腹泻患者中检出格隆柏沙门菌的表型和分子特征,为沙门菌病防控提供依据。方法对格隆柏分离株(2023JD76)进行生化鉴定、血清凝集试验、抗菌药物敏感性试验以及全基因组测序(whole genome sequencing,WGS)。收集全球... 详细信息

目的研究上海市首次自腹泻患者中检出格隆柏沙门菌的表型和分子特征,为沙门菌病防控提供依据。方法对格隆柏分离株(2023JD76)进行生化鉴定、血清凝集试验、抗菌药物敏感性试验以及全基因组测序(whole genome sequencing,WGS)。收集全球格隆柏沙门菌全基因组序列,进行血清分型、多位点序列分型(multilocus sequence typing,MLST)、耐药基因和毒力基因预测,分析2023JD76与全球株的系统进化关系。结果2023JD76血清分型符合抗原式(Salmonella Grumpensis,13,23:d:1,7),对20种抗菌药物均敏感,MLST型预测为2060(ST2060),携带氨基糖甙类药物耐药基因aac(6′)-Iaa和5类毒力基因,包括黏附基因csg、rat,分泌和转运基因sip、inv,伤寒毒素基因cdt、plt,侵袭性基因营养代谢因子mgt和抗菌肽抗性因子mig。36株全球格隆柏菌株共携带10种耐药基因,不同毒力基因携带率为58.33%~100%。进化树将全球格隆柏沙门菌基因组分为2个支系,支系Ⅰ以ST751(88.89%,16/18)为主,支系Ⅱ以ST2060(89.47%,17/19)为主。本次分离菌株2023JD76处于支系Ⅱ内,其序列型与全球人源粪便株和人源脑脊液株全基因组序列密切相关。结论本研究首次分离国内腹泻患者中的格隆柏沙门菌,不同地理来源菌株间耐药表型差异大,应加强监测以防范全球潜在的传播风险。

关键词：格隆柏沙门菌全基因组测序多位点序列分型耐药基因毒力基因

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An improved installation of 2-hydroxy-4-methoxybenzyl(iHmb)method for chemical protein synthesis

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Chinese Chemical Letters 2024年第5期35卷 145-150页

作者： ying Li Long-jie Wang Yong-Kang Zhou Jun Liang Bin Xiao Ji-Shen zheng The First Affiliated Hospital of USTC MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Chemistry University of Science and Technology of ChinaHefei 230027China

The 2-hydroxy-4-methoxybenzyl(Hmb)backbone modification can prevent amide bond-mediated sidereactions(e.g.,aspartimide formation,peptide aggregation)by installing the removable Hmb group into a peptide bond,thus improving the synthesis of long and challenging peptides and ***,its use is largely precluded by the limited Hmb’s installation *** this report,an improved installation of Hmb(iHmb)method was developed to achieve the flexible installation and the convenient removal of *** iHmb method involves two critical steps:(1)oxidative diazotization of the readily installed 2-hydroxy-4-methoxy-5-amino-benzyl(Hmab)to give 2-hydroxy-4-methoxy-5-diazonium-benzyl(Hmdab)by combining soamyl nitrite(IAN)/HBF_(4),and(2)reductive elimination of Hmdab to give the desired Hmb by 1,2-ethanedithiol(EDT).The iHmb method enables the installation of Hmb at any primary amino acid including the highly sterically hindered amino acids(e.g.,valine and isoleucine).The practicality and utility of the iHmb method was demonstrated by one-shot solid-phase synthesis of a challenging aspartimide-prone peptide,the mirror-image version of a hydrophobic peptide and a long-chain peptide up to ***,the iHmb method can be utilized to facilitate chemical protein ligation,as exemplified by the synthesis of the single-spanning membrane protein *** iHmb method expands the toolkit for peptide synthesis and ligation and facilitates the preparation of peptides/proteins.

关键词： Chemical protein synthesis Solid-phase peptide synthesis Removable backbone modification 2-Hydroxy-4-methoxybenzyl(Hmb)group Aspartimide-prone peptides Difficult peptides Membrane proteins

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北方稻区杂交粳稻发展现状及对策

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辽宁农业科学 2024年第5期 60-64页

作者：郑英杰王绍林于亚辉夏明陈广红张丽丽辽宁省盐碱地利用研究所辽宁盘锦124010

北方稻区是我国粳稻主要种植区域,与常规粳稻相比,杂交粳稻的发展相对缓慢。文中简要回顾了北方稻区杂交粳稻发展历程和现状,分析杂交粳稻育种研究和生产中存在的主要问题,针对这些问题,提出北方稻区杂交粳稻发展前景及对策,以期为促进... 详细信息

北方稻区是我国粳稻主要种植区域,与常规粳稻相比,杂交粳稻的发展相对缓慢。文中简要回顾了北方稻区杂交粳稻发展历程和现状,分析杂交粳稻育种研究和生产中存在的主要问题,针对这些问题,提出北方稻区杂交粳稻发展前景及对策,以期为促进北方稻区杂交粳稻选育和应用推广提供建议和参考。

关键词：杂交粳稻发展现状存在问题对策

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Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第4期30卷 291-298页

作者： LAI Yuan-yuan LIU Li-ying WU Yong-na HUANG Lei zheng Xiao-yan GAN Di YU Si-yi ZHONG ying LIANG Fan-rong ZHOU ying YANG jie Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu(610032)China Sichuan Jinxin Xi'nan Women's and Children's Hospital Chengdu(610032)China Yuan TCM Wellness Pte.Ltd.(999002) Pulse TCM SingaporeSingapore

Objective To investigate the immediate effects of electro-acupuncture(EA)on endometrial blood flow among recurrent implantation failure(RIF)*** Eighty RIF patients,enrolled from March 2022 to December 2022,were randomly allocated into either the EA group(40 cases)or the waiting-list(WL)group(40 cases)by using a random number *** EA group underwent acupuncture at points of Shenting(GV 24),Baihui(GV 4),Benshen(GB 13),bilateral Zigong(EX-CA 1),Huangshu(KI 16),Sanyinjiao(SP 6)and Xuehai(SP10),and electric acupuncture apparatus was connected to EX-CA 1,KI 16,SP 6,and SP 10 with disperse-dense waves at 4/20 Hz frequencies for 30 min after transvaginal ultrasound,while the WL group received no *** primary outcome measured was the endometrial volume blood *** secondary outcomes included the bilateral uterine artery index,endometrial volume,endometrial blood flow type,vascular distribution index(VI^(MV))for endometrial and ovary,clinical pregnancy rate,and embryo implantation *** In the EA group,there was a notable decrease in the bilateral pulsatility index and a significant improvement in the endometrial blood flow type post-EA(P0.05).Besides,no adverse events related to EA were *** EA can promptly ameliorate VI^(MV) for the endometrial and right ovary,and endometrial blood flow *** randomized controlled trials are warranted to investigate the long-term effects of EA on blood flow of RIF patients and its implications for pregnancy outcomes.(Trial registration ***2200057377

关键词： electro-acupuncture recurrent implantation failure transvaginal ultrasound endometrial receptivityanalysis randomized controlledtrial

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Tunable Phase Structure of Side-chain Liquid Crystalline Polymers Enabled by Molecular Engineering of Dual Mesogenic Cores

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Chinese Journal of Polymer Science 2024年第10期42卷 1459-1469,I0009页

作者： Wen-Huan Yao Lan-Sheng Liu jie Zhao Yan-Xia Wang An-Zhi Ma zheng-Rui Ma Lan-ying Zhang Ruo-Chen Lan College of Chemistry and Chemical Engineering Hunan UniversityChangsha410082China Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-Environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Institute of Advanced Materials&Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China

A series of novel side-chain liquid crystalline(SCLC)copolymers were synthesized by attaching two distinct mesogenic units,namely a chiral cholesteryl-based monomer(M1)and an achiral biphenyl-based monomer(M2),to a poly(3-mercaptopropylmethylsiloxane)(PMMS)backbone via thiol-ene click *** influence of side chain composition on the self-assembly behavior and phase structures of these SCLC copolymers was systematically investigated using different *** indicate that three distinct liquid crystalline phases and four unique molecular configurations were identified within the polymer series,with the emergence of the liquid crystalline phase being a synergistic outcome of the two distinct side *** study underscores the critical influence of side chain dimensions,rigidity,and spatial volume on the self-assembly structures and phase characteristics of liquid crystalline polymers,providing valuable insights for the rational design and development of advanced functional materials with tailored properties.

关键词： Liquid crystalline copolymers Self-assembly Phase structure Chiral molar ratio

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Accelerating the solving of mechanical equilibrium caused by lattice misfit through deep learning method

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Advances in Manufacturing 2024年第3期12卷 512-521页

作者： Chen-Xi Guo Hui-ying Yang Rui-jie Zhang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083People’s Republic of China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing100083People’s Republic of China

Precipitation is a common phenomenon that occurs during heat *** is internal stress around the precipitate owing to the lattice misfit between the precipitate and *** internal stress has a significant influence not only on the precipitation kinetics but also on the material *** misfit stress can be obtained by numerically solving the mechanical equilibrium ***,this process is complex and *** developed a new approach based on deep learning to accelerate the solution *** training data were first generated by a phase-field model coupled with elastic mechanical equilibrium equations,which were solved using the finite difference *** obtained precipitate morphologies and corresponding stress distributions were input data for training the physics-informed(PI)UNet *** well-trained PI-UNet model can then be applied to predicting stress distributions with the precipitate morphology as the *** accuracy and efficiency are discussed in this *** results showed that the PI-UNet model was an appropriate approach for quickly predicting the misfit stress between the precipitate and matrix.

关键词： Precipitate Mechanical equilibrium Heat treatment Deep learning

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Size-controlled synthesis and near-infrared photothermal response of Cp^(*)Rh-based metalla[2]catenanes and rectangular metallamacrocycles

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Chinese Chemical Letters 2024年第6期35卷 337-343页

作者： ying Zhao Yin-Hang Chai Tian Chen jie zheng Ting-Ting Li Francisco Aznarez Li-Long Dang Lu-Fang Ma College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of PolymersDepartment of ChemistryFudan UniversityShanghai 200438China

A variety of research reports on novel supramolecular topologies have been published over the last ***,it is still a great challenge to tap into the inner functional properties of these ***,two tetranuclear metallamacrocycles 1 and 2 and four octonuclear[2]catenanes 3-6 were constructed successfully via a coordination-driven self-assembly strategy,by conscious design and use of the tetramethyl bidentate pyridine ligand L1,and the appropriate selection of six binuclear half-sandwich rhodium building units with different longitudinal *** complexes have been fully characterized by single crystal X-ray diffraction analysis and NMR ***,near-infrared photothermal studies of the obtained[2]catenanes reveal different photothermal response in solid and solution states,which may be attributed to a strong fluorescence quenching effect of the half-sandwich organometallic fragment and different conjugated effect of Cp^(*)Rh based building blocks in the interlocking *** photothermal conversion efficiencies of[2]catenanes 4-6 fall in the range 30.5%-16.5% *** contribution aims to play a key role in the experimental development of Cp^(*)-based photothermal materials.

关键词： Catenanes Photothermal materials Supramolecular topologies Half-sandwich fragment 3,3'-N-donor analogues

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