检索结果-南通市图书馆

A Possible γ-Ray Pulsation from PSR J1740-5340B in the Globular Cluster NGC 6397

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第1期24卷 285-291页

作者： jiao zheng Pengfei Zhang Li Zhang Department of Astronomy School of Physics and AstronomyKey Laboratory of Astroparticle Physics of Yunnan ProvinceYunnan UniversityKunming 650091China

Recently, a new radio millisecond pulsar(MSP) J1740-5340B, hosted in the globular cluster(GC) NGC 6397,was reported with a 5.78 ms spin period in an eclipsing binary system with a 1.97 days orbital period. Based on a modified radio ephemeris updated by tool tempo2, we analyze the ~15 yr γ-ray data obtained from the Large Area Telescope on board the Fermi Gamma-ray Space Telescope and detect PSR J1740-5340B's γ-ray pulsation at a confidence level of ~4σ with a weighted H-test value of ~26. By performing a phase-resolved analysis, the γ-ray luminosity in on-pulse interval of PSR J1740-5340B is L_(γ)~ 3.8 × 10^(33) erg s^(-1) using NGC 6397's distance of 2.48 kpc. And γ-rays from the on-pulse part of PSR J1740-5340B contribute ~90% of the total observed γ-ray emissions from NGC 6397. No significant γ-ray pulsation of another MSP J1740-5340A in the GC is *** that the previous four cases of MSPs in GCs, more data in γ-ray, X-ray, and radio are encouraged to finally confirm the γ-ray emissions from MSP J1740-5340B, especially starving for a precise ephemeris.

关键词： gamma-rays:galaxies (stars:)pulsars:individual(PSR J1740-5340B) (Galaxy:)globular clusters:individual(NGC 6397)

Physical principles at bio-nano interfaces with active matter

在线全文

学校读者我要写书评

暂无评论

National Science Open 2024年第4期3卷 83-105页

作者： Xueqing Jin Haixiao Wan zheng jiao Jiaqi Li Li-Tang Yan State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Active matter is characterized by out-of-equilibrium behaviors,offering an attractive,alternative route for revolutionizing disease diagnostics and therapy.A better understanding of how active matter interacts with cell membranes is critical to elucidating the underlying physical mechanisms and broadening the potential biomedical *** review provides a conceptual framework on the physiochemical mechanisms underlying active matter-biomembrane *** briefly introduce the physical models of active matter and lipid membranes,and summarize the typical phenomena emerging from various active matter,including artificial active particles,cellular cytoskeletons,bacteria,and membrane ***,the remaining challenges and future perspectives of such non-equilibrium systems in living organisms are *** findings and fundamental principles discussed in this review shed light on the rational design of activity-mediated cellular interaction,and could trigger better strategies to design and develop novel functional systems and materials toward advantageous biomedical applications.

关键词： active matter cell membrane bio-nano interfaces nonequilibrium physics transmembrane transport

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

水利信息系统运维费支出标准建设研究

四川水利 2024年第5期45卷 164-166页

作者：郑姣四川省水利科学研究院成都610072

推进项目支出标准化建设,是建立现代预算制度的重要内容,是提高预算管理水平的重要抓手。随着近年来水利信息化项目大力推进,如何形成科学、规范的水利信息系统运维项目支出标准,成为一个亟待解决的问题。文章以水利信息系统运维项目支... 详细信息

推进项目支出标准化建设,是建立现代预算制度的重要内容,是提高预算管理水平的重要抓手。随着近年来水利信息化项目大力推进,如何形成科学、规范的水利信息系统运维项目支出标准,成为一个亟待解决的问题。文章以水利信息系统运维项目支出为例,分析四川省水利信息化运维项目支出标准现状及存在的问题,探讨该类项目支出标准化建设路径。

关键词：预算管理水利信息化运行维护项目支出标准

在线全文

学校读者我要写书评

暂无评论

药物容偏性的研究进展

中国医院药学杂志 2024年第16期44卷 1944-1949页

作者：戴紫燕金言焦正上海市胸科医院/上海交通大学医学院附属胸科医院药剂科上海200030 上海交通大学药学院上海200241

药物容偏性是药物即使漏服一剂或多剂,依然能维持药效的性质。容偏性与药物的药动学和药效学特征有关。一般而言,半衰期长或药效持续时间长的药物有较高的容偏性。容偏性较高的药物可降低不依从行为对治疗效果的影响,提高治疗成功的概... 详细信息

药物容偏性是药物即使漏服一剂或多剂,依然能维持药效的性质。容偏性与药物的药动学和药效学特征有关。一般而言,半衰期长或药效持续时间长的药物有较高的容偏性。容偏性较高的药物可降低不依从行为对治疗效果的影响,提高治疗成功的概率。该文比较了容偏性和依从性,并从药动学和药效学的角度,对容偏性现有评价方法进行综述,总结容偏性的研究方法及在药物全生命周期中的应用,为新药研发和临床合理用药提供参考。

关键词：容偏性药动学药效学建模和模拟依从性新药研发

在线全文

学校读者我要写书评

暂无评论

农村环境执法的困境与对策研究

黑龙江环境通报 2024年第5期37卷 129-131页

作者：焦政西藏大学政法学院拉萨850000

农村环境的恶化给民众的生产和生活带来了诸多负面影响,它不仅影响人们的身体健康和生活质量,还威胁着整个生态系统的健康和稳定。为了改善农村环境问题带来的诸多不良状况,加强农村环境问题的执法工作十分必要。针对这些问题,可以从建... 详细信息

农村环境的恶化给民众的生产和生活带来了诸多负面影响,它不仅影响人们的身体健康和生活质量,还威胁着整个生态系统的健康和稳定。为了改善农村环境问题带来的诸多不良状况,加强农村环境问题的执法工作十分必要。针对这些问题,可以从建立有效的执法协调机制、加强执法队伍建设、提高执法机构的专业性和建立有效的监督机制等方面进行优化,从而提高执法工作的效率和专业性。

关键词：环境保护环境执法农村环境

法治现代化进程下藏族习惯法的法律规制路径探析

在线全文

学校读者我要写书评

暂无评论

安徽冶金科技职业学院学报 2024年第1期34卷 52-54页

作者：焦政王立西藏大学西藏拉萨850000

藏族习惯法作为藏族社会传统法治文化的一部分,在藏族社会经济发展和社会稳定等方面具有重要作用,而其存在和发展也对国家法治现代化在民族地区的建设程度产生了一定程度的削弱,因此有必要对藏族习惯法进行法律规制。针对藏族习惯法在... 详细信息

藏族习惯法作为藏族社会传统法治文化的一部分,在藏族社会经济发展和社会稳定等方面具有重要作用,而其存在和发展也对国家法治现代化在民族地区的建设程度产生了一定程度的削弱,因此有必要对藏族习惯法进行法律规制。针对藏族习惯法在面临国家法治现代化建设时所面临的转型困境,应从加强民族立法、对民间调解机制的引导以及推进法治教育等层面,来加强对藏族习惯法的法律规制。

关键词：藏族习惯法国家法民族法治建设

在线全文

学校读者我要写书评

暂无评论

云南春季典型冰雹天气的云微物理特征

应用气象学报 2024年第2期35卷 182-195页

作者：郑皎郭欣付丹红李英发郭学良云南省红河州气象局蒙自661199 北京市人工影响天气中心北京100089 中国科学院大气物理研究所北京100029

冰雹形成的天气和云微物理机制是人工防雹的基础。采用观测和数值模拟相结合的方法,研究2023年3月28日云南南部红河州典型冰雹过程的天气和微物理特征。结果表明:此次天气过程与青藏高原南支西风槽波动和南亚副热带高压外围西南暖湿气... 详细信息

冰雹形成的天气和云微物理机制是人工防雹的基础。采用观测和数值模拟相结合的方法,研究2023年3月28日云南南部红河州典型冰雹过程的天气和微物理特征。结果表明:此次天气过程与青藏高原南支西风槽波动和南亚副热带高压外围西南暖湿气流输送的协同作用密切相关;地面降雹以小于10 mm的小冰雹粒子为主,最大冰雹尺度达到20 mm;冰雹云微物理结构显示为暖底云,暖雨过程活跃;双偏振雷达差分反射率、差分相移率和相关系数显示,冰雹初始形成区存在接近球形的冰雹和过冷雨滴,说明冰雹胚胎的形成与过冷雨滴冻结有关;冰雹在下落过程中雷达回波增强,偏振雷达参数显示冰雹的水平取向显著增加,形状由球状向盘状转变,冰雹在下落过程得到进一步增长,形状也发生变化。这些观测宏微观特征与数值模拟的冰雹形成机制有较好的一致性。

关键词：冰雹春季形成过程双偏振雷达数值模拟

A Two-color Single-molecule Sequencing Platform and Its Clinical Applications

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第1期22卷 169-175页

作者： Fang Chen Bin Liu Meirong Chen Zefei Jiang Zhiliang Zhou Ping Wu Meng Zhang Huan Jin Linsen Li Liuyan Lu Huan Shang Lei Liu Weiyue Chen Jianfeng Xu Ruitao Sun Guangming Wang jiao zheng Jifang Qi Bo Yang Lidong Zeng Yan Li Hui Lv Nannan Zhao Wen Wang Jinsen Cai Yongfeng Liu Weiwei Luo Juan Zhang Yanhua Zhang Jicai Fan Haitao Dan Xuesen He Wei Huang Lei Sun Qin Yan GeneMind Biosciences Co. Ltd.Shenzhen 518000China

DNA sequencers have become increasingly important research and diagnostic tools over the past 20 *** this study,we developed a single-molecule desktop sequencer,GenoCare 1600(GenoCare),which utilizes amplification-free library preparation and two-color sequencing-by-synthesis chemistry,making it more user-friendly compared with previous single-molecule sequencing platforms for clinical *** the GenoCare platform,we sequenced an Escherichia coli standard sample and achieved a consensus accuracy exceeding 99.99%.We also evaluated the sequencing performance of this platform in microbial mixtures and coronavirus disease 2019(COVID-19)samples from throat *** findings indicate that the GenoCare platform allows for microbial quantitation,sensitive identification of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus,and accurate detection of virus mutations,as confirmed by Sanger sequencing,demonstrating its remarkable potential in clinical application.

关键词： GenoCare Single-molecule sequencing SARS-CoV-2 Microbial quantitation Variant detection

Support vector classifier based on principal component analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2008年第1期19卷 184-190页

作者： zheng Chunhong jiao Licheng Li Yongzhao School of Electronic Engineering Xidian Univ. Xi'an 710071 P. R. China

Support vector classifier （SVC） has the superior advantages for small sample learning problems with high dimensions, with especially better generalization ability. However there is some redundancy among the high dimensions of the original samples and the main features of the samples may be picked up first to improve the performance of SVC. A principal component analysis （PCA） is employed to reduce the feature dimensions of the original samples and the pre-selected main features efficiently, and an SVC is constructed in the selected feature space to improve the learning speed and identification rate of SVC. Furthermore, a heuristic genetic algorithm-based automatic model selection is proposed to determine the hyperparameters of SVC to evaluate the performance of the learning machines. Experiments performed on the Heart and Adult benchmark data sets demonstrate that the proposed PCA-based SVC not only reduces the test time drastically, but also improves the identify rates effectively.

关键词： support vector classifier principal component analysis feature selection genetic algorithms