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Rapid analysis of metal ions and organic compounds in strong acidic solutions by nano-ESI mass spectrometry

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Chinese Chemical Letters 2024年第2期35卷 516-520页

作者： Jiaquan Xu Ting Li zhendong yu Lili Song Xiu-Xiu Xu Hui Li Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation East China University of TechnologyNanchang 330013China Department of Rehabilitation Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Rapid analysis of metal ions and organic compounds in strong acidic solutions is of sustainable interest in multiple ***,complicated and time-consuming pretreatments are always required for MS analysis of the compounds in strong acidic ***,it will result in a weak signal and cause serious damage to the mass ***,a simple method inherited from nano-ESI MS was developed for rapid analysis of strong acidic ***(nL)strong acidic solution was first loaded in the nano-ESI emitter,followed by evaporation to remove the H+and leave the analytes on the wall of the nano-ESI *** evaporation process can be completed within 1 min because of the extremely tiny volume(≤1 nL)of the loaded ***,the dried analytes on the wall of the nano-ESI emitter were redissolved by loading a new solvent,followed by nano-ESI MS *** using this method,metal ions and organic compounds in the strong acidic solution can be detected with low sample consumption(1 nL),high speed(90%).Proof-of-concept applications of the present method have been successfully achieved for the analysis of gastric juice(pH of the sample=1),monitoring reaction catalyzed by strong acid(pH of the system=0),and micro-area analysis of ores(pH of the extraction solvent=0),showing great application potential in multiple fields.

关键词： Strong acidic solutions Nano-ESI MS Rapid analysis Reaction monitoring Micro-area analysis Gastric juice analysis

In vivo bioorthogonal labeling of rare-earth doped nanoparticles for improved NIR-II tumor imaging by extracellular vesiclemediated targeting

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Nano Research 2023年第2期16卷 2895-2904页

作者： Hui Li Yanfeng Zhong Shumin Wang Menglei Zha Wenxing Gu Guoyong Liu Bohan Wang zhendong yu yu Wang Kai Li yuxin Yin Jing Mu Xiaoyuan Chen Institute of Precision Medicine Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Central Laboratory Peking University Shenzhen HospitalShenzhen 518036China Department of Biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060China Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)61 Biopolis DriveProteosSingapore 138673Singapore

The development of efficient contrast agents for tumor-targeted imaging remains a critical challenge in the ***,we proposed a tumor-derived extracellular vesicle(EV)-mediated targeting approach to improve in vivo tumor imaging using ternary downconversion nanoparticles(DCNPs)with strong near infrared II(NIR-II)luminescence at 1,525 *** EVs were metabolically engineered with azide group,followed by in vivo labeling of DCNPs through copper-free click *** taking advantage of the homologous targeting property of tumor derived EVs,remarkable improvement in the tumor accumulation(6.5%injection dose(ID)/g)was achieved in the subcutaneous colorectal cancer model when compared to that of individual DCNPs via passive targeting(1.1%ID/g).Importantly,such bioorthogonal labeling significantly increased NIR-II luminescence signals and prolonged the retention at tumor *** work demonstrates the great potential of EVs-mediated bioorthogonal approach for in vivo labeling of NIR-II optical probes,which provides a robust tool for tumor-specific imaging and targeted therapy.

关键词： NIR-II rare earth-doped nanoparticles bioorthogonal labeling extracellular vesicles tumor imaging

Construction of truncated-octahedral LiMn2O4 for battery-like electrochemical lithium recovery from brine

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Green Energy & Environment 2023年第4期8卷 1081-1090页

作者： Guolang Zhou Linlin Chen Xiaowei Li Guiling Luo zhendong yu Jingzhou Yin Lei Fan Yanhong Chao Lei Jiang Wenshuai Zhu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang212013JiangsuChina School of Pharmacy Jiangsu UniversityZhenjiang212013JiangsuChina School of Chemistry and Chemical Engineering Huaiyin Normal UniversityHuai'an223001JiangsuChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002JiangsuChina Jiangsu Topfine New Materials Science&Technology Co. Ltd.Zhenjiang212013JiangsuChina

The extraction of lithium from salt lakes or seawater has attracted worldwide attention because of the explosive growth of global demand for lithium products. The LiMn_(2)O_(4)-based electrochemical lithium recovery system is one of the strongest candidates for commercial application due to its high inserted capacity and low energy consumption. However, the surface orientation of LiMn_(2)O_(4)that facilitates Li diffusion happens to be prone to manganese dissolution making it a great challenge to obtain high lithium inserted capacity and long life simultaneously. Herein, we address this problem by designing a truncated octahedral LiMn_(2)O_(4)(Tr-oh LMO) in which the dominant(111) facets minimize Mn dissolution while a small portion of(100) facets facilitate the Li diffusion. Thus, this Tr-oh LMO-based electrochemical lithium recovery system shows excellent Li recovery performance with high inserted capacity(20.25 mg g^(-1)per cycle) in simulated brine. In addition, the dissolution rate of manganese per 30 cycles is only 0.44% and the capacity maintained 85% of the initial after 30 cycles. These promising findings accelerate the practical application of LiMn_(2)O_(4)in electrochemical lithium recovery.

关键词： LiMn_(2)O_(4) Crystal facets Electrochemistry Lithium recovery Brine

Genesis of S-type Granites in the Pengshan Sn-polymetallic Ore Field, Northern Jiangxi Province and its Implications

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Acta Geologica Sinica(English Edition) 2020年第6期94卷 1860-1873页

作者： YIN Qingqing XIANG Xinkui yu zhendong YANG Xiufeng WANG Tianchen ZHONG Bo TAN Rong LIAO Jianhai ZHU yuansong Sinosteel Tianjin Geological Academy Co. Ltd.Tianjin 300181China No.916 Geological Party Jiangxi Bureau of Geology&Mineral ExplorationJiujiangJiangxi 332100China Chinese Academy of Geological Sciences Beijing 100037China

The Pengshan Sn-polymetallic ore field is located in the southeastern part of the Yangtze block,spanning the southeast edge of the MLYDZ and the northern edge of the mid-segment of the Jiangnan Uplift,and on one side of the *** studies of LA-ICP-MS zircon U-Pb chronology and petrogeochemistry for Early Cretaceous acid granites from the Pengshan ore field were carried out in this *** report zircon U-Pb geochronology and whole-rock geochemistry for acid granites in the Pengshan ore *** zircon U-Pb ages of the muscovite-granite,biotite adamellite and granite-porphyry are 127.6±1.7 Ma,126.9±1.6 Ma and 126.6±2.0 Ma,*** granites in Pengshan are characterized by a high silicon content and are rich in *** belong to high-potassium,calc-alkaline,peraluminous *** rocks have a relatively high Rb/Ba ratio,and the data points for muscovite-granite and biotite adamellite all fall within the clay-rich sources region,near the pelite-derived end-member,showing that the Pengshan muscovite-granite and biotite adamellite mainly originated from the partial melting of metapelites with high *** transformation of the compressional and extensional tectonics in this region approximately 128 Ma obviously lags behind that in the mid-segment of the Jiangnan Uplift(135 Ma),but occurred earlier than the MLYDZ(126 Ma).The Pengshan ore field extends from the mid-segment of the Jiangnan Uplift to the *** the tectonic stress field is constrained by the combination of the two secondary tectonic units,the time of tectonic system transformation is closer to the MLYDZ because the spatial orientation of the area is enclosed in the *** geophysical and drilling data confirm the rationality of Pengshan-Ao'xia as a multi-center vertical zoning ore field,and show the scientificity of the prospecting idea of abutting joint between the north-west of Pengshan area and the south-east of Ao'xia area.

关键词： zircon dating S-type granite Early Cretaceous syn-collisional dynamics Pengshan Sn-polymetallic ore field

Amorphous TiO_2-supported Keggin-type ionic liquid catalyst catalytic oxidation of dibenzothiophene in diesel

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Petroleum Science 2018年第4期15卷 870-881页

作者： zhendong yu Donghui Wang Suhang Xun Minqiang He Ruliang Ma Wei Jiang Hongping Li Wenshuai Zhu Huaming Li School of Chemistry and Chemical Engineering Jiangsu University School of Environment and Safety Engineering Institute of Environmental Health and Ecological SecurityJiangsu University Institute for Energy Research Jiangsu University

Supported ionic liquid(IL) catalysts [Cmim]PMoO/Am TiO(amorphous TiO) were synthesized through a one-step method for extraction coupled catalytic oxidative desulfurization(ECODS) system. Characterizations such as FTIR, DRS,wide-angle XRD, Nadsorption–desorption and XPS were applied to analyze the morphology and Keggin structure of the catalysts. In ECODS with hydrogen peroxide as the oxidant, it was found that ILs with longer alkyl chains in the cationic moiety had a better effect on the removal of dibenzothiophene. The desulfurization could reach 100% under optimal conditions, and GC–MS analysis was employed to detect the oxidized product after the reaction. Factors affecting the desulfurization efficiencies were discussed, and a possible mechanism was proposed. In addition, cyclic experiments were also conducted to investigate the recyclability of the supported catalyst. The catalytic activity of [Cmim]PMoO/Am TiOonly dropped from 100% to 92.9% after ten cycles, demonstrating the good recycling performance of the catalyst and its potential industrial application.

关键词： Supported ionic liquid catalyst Polyoxometallate Oxidative desulfurization Amorphous TiO_2 Dibenzothiophene

Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations

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Precision Clinical Medicine 2019年第4期2卷 235-245页

作者： Guodai Hong Xuemei Chen Xizhuo Sun Meiling Zhou Bing Liu ZhuLi zhendong yu Wenbin Gao Tao Liu Department of Biotherapy and Oncology Shenzhen Luohu People’s HospitalThe Third Affiliated Hospital(The Affiliated Luohu Hospital)of Shenzhen UniversityShenzhen 518001China The Key Laboratory of Biomedical Information Engineering of the Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Public Service Platform for Cell Quality Testing and Evaluation of Shenzhen Shenzhen 518001China Central Laboratory Peking University Shenzhen HospitalShenzhen 518036China

This study investigated the efficiency of natural killer(NK)cell immunotherapy on non-small cell lung cancer with and without EGFRmutations in order to evaluate the response rate(RR)and progression-free survival(PFS).Among the 48 patients recruited,24 were clinically confirmed to be EGFR mutation *** study group was treated with autologous NK cell *** of the lymphocyte number,serum tumourrelated biomarkers,circulating tumour cells(CTC),Karnofsky Performance Status(KPS)and survival curves were carried out before and after NK cell *** safety and short-term effects were evaluated,followed by median PFS and RR *** serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group(p<0.05).Theχ2 test showed a 75%RR of the study group A,significantly higher than that of the control group B(16.7%;p<0.01).The RR of groups C(58.3%)and D(41.7%)were not statistically *** p values of the 4 groups were 0.012,0.012,0.166 and 1 from group A to group D,*** median PFS was 9 months in EGFR mutation positive group undergoing NK cell infusion *** evaluating the changes in immune function,tumour biomarkers,CTC,KPS and PFS,we demonstrated that NK cell therapy had better clinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.

关键词： Natural killer cells immunotherapy EGFR mutation lung cancer clinical efficacy clinical trial

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汶川8.0级地震的根源和成因

大地测量与地球动力学 2009年第B08期29卷 66-71页

作者：虞震东湖北省环境科学研究院武汉430072

汶川8.0级地震的主要根源是2005年1月20日出现的太阳宇宙线耀斑引起的宇宙线GLE事件。其成因是:宇宙线环境增强使作用到地球的大量宇宙线在电离层产生电流系,再通过电磁感应在地球内部产生感应电流系,进而在地内铀、钍元素富集区产生燃... 详细信息

汶川8.0级地震的主要根源是2005年1月20日出现的太阳宇宙线耀斑引起的宇宙线GLE事件。其成因是:宇宙线环境增强使作用到地球的大量宇宙线在电离层产生电流系,再通过电磁感应在地球内部产生感应电流系,进而在地内铀、钍元素富集区产生燃烧腔,进一步引起地下核裂变燃烧和地下氢聚变燃烧,燃烧腔里面的高温高压最终把燃烧腔的围岩炸裂,从而产生大地震。汶川大地震地区的地下观测资料及地震波层析成像分析证实在汶川大地震震源下确实存在异常高温区。据此,本文提出了预警大地震的一条新思路。

关键词：汶川地震根源成因宇宙线环境大GLE事件地下核燃烧

双歧杆菌表面分子对LPS在小鼠体内调节胸腺细胞凋亡的观察

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中华微生物学和免疫学杂志 1999年第3期19卷 180-183页

作者：余振东胡宏同济医科大学附属协和医院检验科重庆医科大学检验系

目的研究双歧杆菌表面分子细胞壁肽聚糖（ＷＰＧ）、脂磷壁酸（ＬＴＡ）对ＬＰＳ体内诱导小鼠胸腺细胞凋亡的调节。方法用ＤＮＡ凝胶电泳、ＴＵＮＥＬ法检测ＷＰＧ、ＬＴＡ对ＬＰＳ体内诱导小鼠胸腺细胞凋亡的影响，并分别用生物活性法... 详细信息

目的研究双歧杆菌表面分子细胞壁肽聚糖（ＷＰＧ）、脂磷壁酸（ＬＴＡ）对ＬＰＳ体内诱导小鼠胸腺细胞凋亡的调节。方法用ＤＮＡ凝胶电泳、ＴＵＮＥＬ法检测ＷＰＧ、ＬＴＡ对ＬＰＳ体内诱导小鼠胸腺细胞凋亡的影响，并分别用生物活性法和Ｇｒｉｅｓｓ反应测定ＷＰＧ、ＬＴＡ、ＬＰＳ体外诱生ＴＮＦ－α、ＮＯ２－的含量。结果ＷＰＧ、ＬＴＡ可显著抑制ＬＰＳ体内诱导的小鼠胸腺细胞的凋亡。ＷＰＧ、ＬＴＡ单独刺激巨噬细胞时所诱生的ＴＮＦ－α、ＮＯ的量显著低于ＬＰＳ刺激时所产生的这两种活性介质的量，而ＷＰＧ、ＬＴＡ与ＬＰＳ共同应用时可显著降低ＬＰＳ诱导巨噬细胞产生的ＴＮＦ－α、ＮＯ的量；诱生型一氧化氮合成酶抑制剂Ｓ－甲基异硫脲硫酸盐体外可抑制巨噬细胞产生的ＮＯ的量，在体内可部分抑制ＬＰＳ诱导的小鼠胸腺细胞的凋亡。结论ＷＰＧ、ＬＴＡ与ＬＰＳ共同应用时，可抑制ＬＰＳ诱导的巨噬细胞产生的ＴＮＦ－α、ＮＯ的量。

关键词：双歧杆菌表面分子脂多糖细胞凋亡胸腺细胞

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基于形态学的棉花种子破损检测

农业机械学报 2009年第4期40卷 169-172页

作者：李伟于振东陈涛荀一中国农业大学工学院北京100083

以"中棉35"棉花种子为对象,应用图像处理技术,提出了基于形态学的破损识别方法。采用链码算子获取轮廓信息并进行傅里叶算子平滑,根据曲率特征定位轮廓尖端点后,通过轮廓的对称性识别局部破损棉种;基于统计思想,根据大小、形状特征的差... 详细信息

以"中棉35"棉花种子为对象,应用图像处理技术,提出了基于形态学的破损识别方法。采用链码算子获取轮廓信息并进行傅里叶算子平滑,根据曲率特征定位轮廓尖端点后,通过轮廓的对称性识别局部破损棉种;基于统计思想,根据大小、形状特征的差异识别严重破损棉种。选取完好、破损棉种各200粒进行识别试验,结果表明破损棉种识别率达到94%。

关键词：棉花种子表面破损图像处理形态学