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Prognostic role of C-reactive protein to albumin ratio in lung cancer:An updated systematic review and meta-analysis

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Chronic Diseases and Translational Medicine 2024年第1期10卷 31-39页

作者： zhendong Lu Siyun Fu Wei Li xiang Gao Jinghui Wang Department of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijingChina Cancer Research Center Beijing Chest HospitalBeijing Tuberculosis and Thoracic Tumor Research InstituteCapital Medical UniversityBeijingChina

Background: C-reactive protein to albumin ratio(CRP/Alb ratio,CAR)has been suggested as a potential prognostic biomarker in lung *** updated systematic review and meta-analysis aimed to assess the association between CAR and lung cancer prognosis in current ***: A systematic search of databases was conducted to identify relevant studies published up to April *** hazard ratios(HRs)and 95%confidence intervals(CIs)were calculated to assess the association between CAR and overall survival(OS)and progression-free survival(PFS)and recurrence-free survival(RF)in lung cancer ***: This meta-analysis includes 16 studies with a total of 5337 patients,indicating a significant association between higher CAR and poorer OS,PFS,and RFS in lung cancer patients,with a pooled HR of 1.78(95%CI=1.60-1.99),1.57(95%CI=1.36-1.80),and 1.97(95%CI=1.40-2.77),***: This updated meta-analysis provides evidence for the potential prognostic role of CAR in lung cancer,suggesting its utility as an effective and noninvasive biomarker for identifying high-risk patients and informing treatment decisions in a cost-effective ***,further large-scale studies will be necessary to establish the optimal cut-off value for CAR in lung cancer and confirm the present findings.

关键词： C-reactive protein to albumin ratio inflammation:biomarker lung cancer prognosis

肾上盏与肾中盏穿刺路径在经皮肾镜碎石术中的临床疗效对比

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巴楚医学 2024年第2期7卷 54-58页

作者：胡敬祖肖建华王婵张平陈晓波董自强向振东泌尿外科&三峡大学泌尿外科研究所湖北宜昌443003

目的:探讨超声引导下肾上盏和肾中盏穿刺路径在经皮肾镜取石术(PCNL)中的临床效果。方法:回顾性分析2022年5月—2023年10月于宜昌市中心人民医院行PCNL的220例上尿路结石患者的临床资料,根据穿刺路径分为两组,经肾上盏穿刺为观察组(n=10... 详细信息

目的:探讨超声引导下肾上盏和肾中盏穿刺路径在经皮肾镜取石术(PCNL)中的临床效果。方法:回顾性分析2022年5月—2023年10月于宜昌市中心人民医院行PCNL的220例上尿路结石患者的临床资料,根据穿刺路径分为两组,经肾上盏穿刺为观察组(n=108),经肾中盏穿刺为对照组(n=112)。对比两组患者的治疗效果及手术并发症。结果:观察组患者手术时间(46.42±9.73 min vs 69.13±15.78 min)、住院时间(5.13±1.20天vs 6.29±1.53天)均明显低于对照组(均P0.05)。两组患者术后并发症总发生率无明显差异(P>0.05)。结论:超声引导下经肾上盏穿刺路径行PCNL可缩短手术时间及住院时间,提高一期结石清除率,临床效果确切,安全有效。

关键词：经皮肾镜取石术超声引导肾结石肾上盏肾中盏

A mixed multi-step feedback RMPC for LPV Systems with bounded parameter measurement errors and parameter changes

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A mixed multi-step feedback RMPC for LPV Systems with bounde...

第36届中国控制会议

作者： Pengyuan Zheng zhendong xiang Yingwei Kang College of Automation Engineering Shanghai University of Electric Power

ISBN: (纸本)9781538629185

For linear parameter varying(LPV) systems with bounded parameter measurement errors and parameter changes,we predict the families of future models which can deal with the measurement errors by utilizing the information on system *** on multi-step control sets and parameter-dependent feedback control,a mixed multi-step feedback robust model predictive control(RMPC) is developed to introduce more freedom and thus reduce the *** proposed method achieves good control performance with guaranteed robust and stability properties,which is verified by simulation example.

关键词： Linear parameter varying systems Bounded measurement errors Bounded parameter changes Robust model predictive control Parameter-dependent feedback control Mixed multi-step feedback control

A novel videogrammetry-based full-field dynamic deformation monitoring method for variable-sweep wings

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Acta Mechanica Sinica 2024年第8期40卷 120-132页

作者： Liqiang Gao Yan Liu Bin Jiang zhendong Ge Haoyang Li xiang Guo Tao Suo Qifeng Yu School of Civil Aviation Northwestern Polytechnical UniversityXi’an710072China Shaanxi Key Laboratory of Impact Dynamics and Engineering Application Northwestern Polytechnical UniversityXi’an710072China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen518060China Institute of Intelligent Optical Measurement and Detection Shenzhen UniversityShenzhen518060China

The measurement of wing dynamic deformation in morphing aircraft is crucial for achieving closed-loop control and evaluating structural *** variable-sweep wings with active large deformation,this paper proposes a novel videogrammetric method for full-field dynamic deformation measurement.A stereo matching method based on epipolar geometry constraint and topological constraint is presented to find the corresponding targets between stereo *** addition,a new method based on affine transformation combined with adjacent closest point matching is developed,aiming to achieve fast and automatic tracking of targets in time-series images with large deformation.A calculation model for dynamic deformation parameters is established to obtain the displacement,sweep variable angle,and span *** verify the proposed method,a dynamic deformation measurement experiment is conducted on a variable-sweep wing *** results indicate that the actual accuracy of the proposed method is approximately 0.02%of the measured area(e.g.,0.32 mm in a 1.6 m scale).During one morphing course,the sweep variable angle,the span variation and the displacement increase gradually,and then *** maximum sweep variable angle is 36.6°,and the span variation is up to 101.13 *** overall configuration of the wing surface is effectively reconstructed under different morphing states.

关键词： Morphing aircraft Variable-sweep wing Videogrammetry Large dynamic deformation Target matching and tracking

CPNE2 is transcriptionally regulated by ERG and BRD4 and promote prostate cancer progression

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CPNE2 is transcriptionally regulated by ERG and BRD4 and pro...

首届男性大健康中西医协同创新论坛暨第三届全国中西医结合男科青年学术论坛

作者： Zhe Hong Chengdang Xu zhendong xiang Denglong Wu 上海市同济医院

目的:CPNE2 is reported highly expressed in multiple cancer types, but its expression and function in prostate cancer is remain largely unknown. Here, we use IHC staining to show that CPNE2 is highly expressed in PCa tissues compared to paracancerous normal tissues, also, we demonstrate that CPNE2 promote PCa progression and metastasis in vitro and in ***, we identified that CPNE2 is a novel downstream target of ERG and BRD4 serves as an transcriptional *** target steap4 can increase the sensitivity of PCa to JQ1 treatment.

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FZD8 is transcriptionally regulated by ERG and BRD4 and promote bladder cancer progression

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FZD8 is transcriptionally regulated by ERG and BRD4 and prom...

首届男性大健康中西医协同创新论坛暨第三届全国中西医结合男科青年学术论坛

作者： Zhe Hong Chengdang Xu zhendong xiang Denglong Wu 上海市同济医院

目的:FZD8 is reported highly expressed in multiple cancer types, but its expression and function in prostate cancer is remain largely unknown. Here, we use IHC staining to show that FZD8 is highly expressed in PCa tissues compared to paracancerous normal tissues, also, we demonstrate that FZD8 promote PCa progression and metastasis in vitro and in ***, we identified that FZD8 is a novel downstream target of ERG and BRD4 serves as an transcriptional *** target steap4 can increase the sensitivity of PCa to JQ1 treatment.

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Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of DNA2 expression

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Inhibition of BRD4 suppresses tumor growth in prostate cance...

首届男性大健康中西医协同创新论坛暨第三届全国中西医结合男科青年学术论坛

作者： Zhe Hong Chengdang Xu zhendong xiang Denglong Wu 上海市同济医院

目的:Prostate cancer(PCa) is a malignant tumor with a high incidence in males. Localized tumors can be treated via surgery or radiation;however, it remains difficult to prevent disease progression. Bromodomain-containing protein 4(BRD4)is an epigenetic reader protein that binds to acetylated lysine on histones and has been reported to serve critical roles in numerous types of cancers. In the present study, it was demonstrated that BRD4 expression levels were significantly increased in cancerous prostate tissue specimens and cells,which were associated with clinical stage and metastasis. In addition, the present study reported that inhibition of BRD4 via short hairpin RNA or JQ1(a bromo-domain inhibitor)decreased PCa cell proliferation, induced G0/G1 cell cycle arrest and apoptosis, mitigated cell invasion and migration in vitro, and impaired tumor growth in vivo. Mechanistically, BRD4 inhibition-induced suppression of cell cycle progression was associated with the upregulation of p21 and cyclin D1. c-Myc and B-cell lymphoma-2(Bcl-2), important genes responsible for cell cycle regulation and anti-apoptotic functions, were downregulated in response to BRD4 inhibition. Furthermore, the present study revealed that c-Myc expression was negatively regulated by p21, and that the induction of p21 via BRD4 inhibition was mediated by forkhead box protein O1(DNA2),rather than p53. In summary, the results of the present study suggested that the aberrant expression of BRD4 in PCa may induce carcinogenesis. In addition, a mechanism by which BRD4 inhibition suppresses cell proliferation via the regulation of DNA2-p21-Myc signaling was proposed in the present study, which may contribute to the development of novel therapeutic approaches in the management of PCa.

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KCNS3 is transcriptionally regulated by ERG and BRD4 and promote prostate cancer progression

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KCNS3 is transcriptionally regulated by ERG and BRD4 and pro...

首届男性大健康中西医协同创新论坛暨第三届全国中西医结合男科青年学术论坛

作者： Zhe Hong Chengdang Xu zhendong xiang Denglong Wu 上海市同济医院

目的:KCNS3 is reported highly expressed in multiple cancer types, but its expression and function in prostate cancer is remain largely unknown. Here, we use IHC staining to show that KCNS3 is highly expressed in PCa tissues compared to paracancerous normal tissues, also, we demonstrate that KCNS3 promote PCa progression and metastasis in vitro and in ***, we identified that KCNS3 is a novel downstream target of ERG and BRD4 serves as an transcriptional *** target steap4 can increase the sensitivity of PCa to JQ1 treatment.

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PAX1 is transcriptionally regulated by ERG and BRD4 and promote CRPC progression

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PAX1 is transcriptionally regulated by ERG and BRD4 and prom...

首届男性大健康中西医协同创新论坛暨第三届全国中西医结合男科青年学术论坛

作者： Zhe Hong Chengdang Xu zhendong xiang Denglong Wu 上海市同济医院

目的:PAX1 is reported highly expressed in multiple cancer types, but its expression and function in prostate cancer is remain largely unknown. Here, we use IHC staining to show that PAX1 is highly expressed in PCa tissues compared to paracancerous normal tissues, also, we demonstrate that PAX1 promote PCa progression and metastasis in vitro and in ***, we identified that PAX1 is a novel downstream target of ERG and BRD4 serves as an transcriptional *** target steap4 can increase the sensitivity of PCa to JQ1 treatment.

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